Therapeutic Area: Infectious Disease

Expanded cellular clones carrying replication-competent HIV-1 persist, wax, and wane

Wang et al.
Papers
Proceedings of the National Academy of Sciences
February 2018
Authors and Affiliates
Zheng Wanga, Evelyn E. Gurulea, Timothy P. Brennana, Jeffrey M. Geroldb, Kyungyoon J. Kwona, Nina N. Hosmanea, Mithra R. Kumara, Subul A. Bega, Adam A. Capoferria, Stuart C. Raya, Ya-Chi Hoc, Alison L. Hillb, Janet D. Silicianoa, and Robert F. Silicianoa,d aDepartment of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205; bProgram for Evolutionary Dynamics, Harvard University, Cambridge, MA 02138; cDepartment of Microbial Pathogenesis, Yale University School of Medicine, New Haven, CT 06536; and dHoward Hughes Medical Institute, The Johns Hopkins University School of Medicine, Baltimore, MD 21205

Unique phenotypes and clonal expansions of human CD4 effector memory T cells re-expressing CD45RA

Tian et al.
Nature Communications
Papers
November 2017
Authors and Affiliates
Yuan Tian1, Mariana Babor1, Jerome Lane1, Veronique Schulten1, Veena S. Patil1, Grégory Seumois1, Sandy L. Rosales1, Zheng Fu2, Gaelle Picarda3, Julie Burel1, Jose Zapardiel-Gonzalo1, Rashika N. Tennekoon1,4, Aruna D. De Silva1,4, Sunil Premawansa5, Gayani Premawansa6, Ananda Wijewickrama7, Jason A. Greenbaum2, Pandurangan Vijayanand1, Daniela Weiskopf1, Alessandro Sette1 & Bjoern Peters1 1Division of Vaccine Discovery, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA. 2Bioinformatics Core Facility, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA. 3Division of Immune Regulation, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA. 4Genetech Research Institute, Colombo 00800, Sri Lanka. 5Department of Zoology and Environment Sciences, Science Faculty, University of Colombo, Colombo 00700, Sri Lanka. 6North Colombo Teaching Hospital, Ragama 11010, Sri Lanka. 7National Institute of Infectious Diseases, Gothatuwa, Angoda 10620, Sri Lanka.

Adipose Tissue is Enriched for Activated and Late-differentiated CD8+ T cells, and Shows Distinct CD8+ Receptor Usage, Compared to Blood in HIV-infected Persons

Koethe et al.
Journal of Acquired Immune Deficiency Syndromes
Papers
October 2017
Authors and Affiliates
John R. Koethe, MD, MS1,2, Wyatt McDonnell, BS3,4, Arion Kennedy, PhD5, Chike O. Abana, BS3, Mark Pilkinton, MD, PhD1,2, Ian Setliff, BS3,4, Ivelin Georgiev, PhD3,4, Louise Barnett, BS1, Cindy C. Hager, BS1, Rita Smith, BS1, Spyros A. Kalams, MD1,3, Alyssa Hasty, PhD2,5, Simon Mallal, MBBS1,3 1Division of Infectious Diseases, Vanderbilt University Medical Center, Nashville, Tennessee, 2VA Tennessee Valley Healthcare System, Nashville Tennessee, 3Department of Pathology, Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, Tennessee, 4Vanderbilt Vaccine Center, Vanderbilt University Medical Center, Nashville, Tennessee, 5Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, Tennessee

Immunosequencing identifies signatures of cytomegalovirus exposure history and HLA-mediated effects on the T cell repertoire

Emerson et al.
Nature Genetics
Papers
April 2017
immuneAccess
Authors and Affiliates
Ryan O Emerson1,4, William S DeWitt1,2,4, Marissa Vignali1, Jenna Gravley3, Joyce K Hu1, Edward J Osborne1, Cindy Desmarais1, Mark Klinger1, Christopher S Carlson3, John A Hansen3, Mark Rieder1,5 & Harlan S Robins1,2,5 1Adaptive Biotechnologies, Seattle, Washington, USA. 2Computational Biology Program, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA. 3Fred Hutchinson Cancer Research Center, Seattle, Washington, USA. 4These authors contributed equally to this work. 5These authors jointly directed this work.

Multidisciplinary study of the secondary immune response in grandparents re-exposed to chickenpox

Ogunjimi et al.
Papers
Scientific Reports
April 2017
Authors and Affiliates
B. Ogunjimi 1,2,3,4,5,6, J. Van den Bergh4, P. Meysman6,7,8, S. Heynderickx4,9, K. Bergs10, H. Jansen10, E. Leuridan11, A. Vorsters11, H. Goossens10,12, K. Laukens6,7,8, N. Cools4, Viggo Van Tendeloo4,6,9, N. Hens1,2,6, P. Van Damme6,11, Evelien Smits4,6,9,13 & Ph. Beutels1,6,14 1Centre for Health Economics Research & Modeling Infectious Diseases (CHERMID), Vaccine & Infectious Disease Institute (VAXINFECTIO), University of Antwerp, Antwerp, Belgium. 2Interuniversity Institute for Biostatistics and Statistical Bioinformatics, Hasselt University, Hasselt, Belgium. 3Department of Pediatrics, Antwerp University Hospital, Edegem, Belgium. 4Laboratory of Experimental Hematology (LEH), Vaccine & Infectious Disease Institute (VAXINFECTIO), University of Antwerp, Antwerp, Belgium. 5Department of Pediatrics, Ghent University Hospital, Ghent, Belgium. 6Antwerp Unit for Data Analysis and Computation in Immunology and Sequencing (AUDACIS), Antwerp, Belgium. 7Advanced Database Research and Modelling (ADReM), Department of Mathematics and Computer Science, University of Antwerp, Antwerp, Belgium. 8Biomedical Informatics Research Network Antwerp (BIOMINA), University of Antwerp/Antwerp University Hospital, Edegem, Belgium. 9Center for Cell Therapy and Regenerative Medicine, Antwerp University Hospital, Edegem, Belgium. 10Department of Laboratory Medicine, Antwerp University Hospital, Edegem, Belgium. 11Centre for the Evaluation of Vaccination (CEV), Vaccine & Infectious Disease Institute (VAXINFECTIO), University of Antwerp, Antwerp, Belgium. 12Laboratory of Medical Microbiology, Vaccine & Infectious Disease Institute (VAXINFECTIO), University of Antwerp, Antwerp, Belgium. 13Center for Oncological Research Antwerp, University of Antwerp, Antwerp, Belgium. 14School of Public Health and Community Medicine, The University of New South Wales, Sydney, Australia.

Selective expansion of high functional avidity memory CD8 T cell clonotypes during hepatitis C virus reinfection and clearance

Abdel-Hakeem et al.
Papers
PLOS Pathogens
February 2017
immuneAccess
Authors and Affiliates
Mohamed S. Abdel-Hakeem1,2,3, Maude Boisvert1, Julie Bruneau1,4, Hugo Soudeyns3,5, Naglaa H. Shoukry1,6 1Centre de Recherche du Centre Hospitalier de l’Universite de Montreal (CRCHUM), Montreal, Quebec, Canada, 2Department of Microbiology and Immunology, Faculty of Pharmacy, Cairo University, Cairo, Egypt, 3Departement de microbiologie, infectiologie et immunologie, Universite de Montreal, Montreal, Quebec, Canada, 4Departement de me decine familiale et de medecine d’urgence, Universite de Montreal, Montreal, Quebec,Canada, 5Centre hospitalier universitaire Sainte-Justine, Montreal, Quebec, Canada, 6Departement de medecine, Universite de Montreal, Montreal, Quebec, Canada

Successive annual influenza vaccination induces a recurrent oligoclonotypic memory response in circulating T follicular helper cells

Herati et al.
Papers
Science Immunology
February 2017
immuneAccess
Authors and Affiliates
Ramin Sedaghat Herati,1,2 Alexander Muselman,1,2 Laura Vella,2,3 Bertram Bengsch,2,4 Kaela Parkhouse,5 Daniel Del Alcazar,1,2 Jonathan Kotzin,2,4 Susan A. Doyle,6 Pablo Tebas,1 Scott E. Hensley,2,4,5 Laura F. Su,1,2 Kenneth E. Schmader,6 E. John Wherry2,4 1Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA. 2Institute for Immunology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA. 3Department of Medicine, Children’s Hospital of Philadelphia, Philadelphia, PA 19104, USA. 4Department of Mi- crobiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA. 5Wistar Institute, Philadelphia, PA 19104, USA. 6Division of Geriatrics, De- partment of Medicine, Duke University Medical Center and Geriatric Research, Educa- tion, and Clinical Center, Durham VA Medical Center, Durham, NC 27705, USA.

Broad TCR repertoire and diverse structural solutions for recognition of an immunodominant CD8+ T cell epitope

Song et al.
Nature Structural & Molecular Biology
Papers
February 2017
immuneAccess
Authors and Affiliates
InYoung Song1,2, Anna Gil1, Rabinarayan Mishra1, Dario Ghersi3, Liisa K Selin1,2,5, and Lawrence J Stern1,2,4,5 1Department of Pathology, University of Massachusetts Medical School, Worcester, Massachusetts, USA. 2Graduate Program in Immunology and Microbiology, University of Massachusetts Medical School, Worcester, Massachusetts, USA. 3School of Interdisciplinary Informatics, University of Nebraska at Omaha, Omaha, Nebraska, USA. 4Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, Massachusetts, USA. 5These authors contributed equally to this work.

Novel E2 Glycoprotein Tetramer Detects Hepatitis C Virus−Specific Memory B Cells

Boisvert et al.
Journal of Immunology
Papers
November 2016
immuneAccess
Authors and Affiliates
Maude Boisvert,*,1 Wanrui Zhang,†,1 Elizabeth J. Elrod,† Nicole F. Bernard,‡,x Jean-Pierre Villeneuve,*,{ Julie Bruneau,*,‖ Joseph Marcotrigiano,# Naglaa H. Shoukry,*,{ and Arash Grakoui†,** *Centre de Recherche du Centre Hospitalier de l’Universite ́ de Montre ́al, Montreal, Quebec H2X 0A9, Canada; †Yerkes National Primate Research Center, Emory Vaccine Center, Atlanta, GA 30329; ‡Research Institute of the McGill University Health Centre, Montreal, Quebec H4A 3J1, Canada; xDivision of Experimental Medicine, McGill University, Mon- treal, Quebec H3A 1A3, Canada; {De ́partement de Me ́decine,‖ Faculte ́ de Me ́decine, Uni- versite ́ de Montre ́al, Montreal, Quebec H3T 1J4, Canada; De ́partement de Me ́decine Familiale et de Me ́decine D’Urgence, Faculte ́ de Me ́decine, Universite ́ de Montre ́al, Mon- treal, Quebec H3T 1J4, Canada; #Center for Advanced Biotechnology and Medicine, De- partment of Chemistry and Chemical Biology, Rutgers University, Piscataway, NJ 08854; and **Division of Infectious Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, GA 30329 Maude Boisvert, Wanrui Zhang, Elizabeth J. Elrod, Nicole F. Bernard, Jean-Pierre Villeneuve, Julie Bruneau, Joseph Marcotrigiano, Naglaa H. Shoukry and Arash Grakoui

IL-15 promotes activation and expansion of CD8+ T cells in HIV-1 infection

Younes et al.
JCI
Papers
June 2016
Authors and Affiliates
Souheil-Antoine Younes,1 Michael L. Freeman,1 Joseph C. Mudd,2Carey L. Shive,1 Arnold Reynaldi,3 Soumya Panigrahi,1 Jacob D. Estes,4Claire Deleage,4 Carissa Lucero,4 Jodi Anderson,5 Timothy W. Schacker,5 Miles P. Davenport,3 Joseph M. McCune,6 Peter W. Hunt,7Sulggi A. Lee,7 Sergio Serrano-Villar,8 Robert L. Debernardo,9 Jeffrey M. Jacobson,10 David H. Canaday,1 Rafick-Pierre Sekaly,11 Benigno Rodriguez,1 Scott F. Sieg,1 and Michael M. Lederman1 1Center for AIDS Research, Department of Medicine, Case Western Reserve University and University Hospitals, Case Medical Center, Cleveland, Ohio, USA. 2Immunopathogenesis Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, Maryland, USA. 3Kirby Institute for Infection and Immunity, University of New South Wales, Sydney, New South Wales, Australia. 4AIDS and Cancer Virus Program, Leidos Biomedical Research Inc., Frederick National Laboratory for Cancer Research, Frederick, Maryland, USA. 5Department of Medicine, University of Minnesota, Minneapolis, Minnesota, USA. 6Division of Experimental Medicine and7HIV/AIDS Division, Department of Medicine, UCSF, San Francisco, California, USA. 8Department of Infectious Diseases, University Hospital Ramón y Cajal, Madrid, Spain. 9Lerner College of Medicine, Cleveland Clinic, Cleveland, Ohio, USA. 10Lewis Katz School of Medicine, Temple University, Philadelphia, Pennsylvania, USA. 11Department of Pathology, Case Western Reserve University, Cleveland, Ohio, USA.