Genetic T-cell receptor diversity at 1 year following allogeneic hematopoietic stem cell transplantation

Buhler et al.
Leukemia
November 2019
Authors and Affiliates
Buhler S1, Bettens F2, Dantin C3, Ferrari-Lacraz S2, Ansari M4, Mamez AC3, Masouridi-Levrat S3, Chalandon Y3, Villard J5; 1 Transplantation Immunology Unit and National Reference Laboratory for Histocompatibility, Department of Diagnostic, Geneva University Hospitals, Geneva, Switzerland. stephane.buhler@hcuge.ch. 2 Transplantation Immunology Unit and National Reference Laboratory for Histocompatibility, Department of Diagnostic, Geneva University Hospitals, Geneva, Switzerland. 3 Service of Haematology, Department of Oncology, Geneva University Hospitals and Faculty of Medicine, University of Geneva, Geneva, Switzerland. 4 Pediatric Department, Onco-Hematology Unit, Geneva University Hospitals and Cansearch research laboratory, Geneva Medical School, Geneva, Switzerland. 5 Transplantation Immunology Unit and National Reference Laboratory for Histocompatibility, Department of Diagnostic, Geneva University Hospitals, Geneva, Switzerland. jean.villard@hcuge.ch.

Differential skewing of donor-unrestricted and γδ T cell repertoires in tuberculosis-infected human lungs

Ogongo et al.
Journal of Clinical Investigation
November 2019
Authors and Affiliates
Ogongo P1,2,3, Steyn AJ1, Karim F1, Dullabh KJ4, Awala I4, Madansein R4, Leslie A1,5, Behar SM6; 1 Africa Health Research Institute, and. 2 School of Laboratory Medicine, Nelson Mandela School of Medicine, University of KwaZulu-Natal, Durban, South Africa. 3 Institute of Primate Research, National Museums of Kenya, Nairobi, Kenya. 4 Department of Cardiothoracic Surgery, Nelson Mandela School of Medicine, University of KwaZulu-Natal, Durban, South Africa. 5 Department of Infection and Immunity, University College London, London, United Kingdom. 6 Department of Microbiology and Physiological Systems, University of Massachusetts Medical School, Worcester, Massachusetts, USA.

Safety and feasibility of virus-specific T cells derived from umbilical cord blood in cord blood transplant recipients

Abraham et al.
Blood Advances
July 2019
Authors and Affiliates
Allistair A. Abraham,1,* Tami D. John,2,3,* Michael D. Keller,1 C. Russell N. Cruz,1 Baheyeldin Salem,1 Lauren Roesch,1 Hao Liu,4 Fahmida Hoq,1 Bambi J. Grilley,2,3 Adrian P. Gee,2,3 Hema Dave,1 David A. Jacobsohn,1 Robert A. Krance,2,3 Elizabeth. J. Shpall,2,3 Caridad A. Martinez,2,3 Patrick J. Hanley,1,† and Catherine M. Bollard1,† 1Center for Cancer and Immunology Research, Children’s National Health System and Department of Pediatrics, The George Washington University, Washington, DC; 2Center for Cell and Gene Therapy, Baylor College of Medicine, Houston Methodist Hospital, Houston, TX; 3Texas Children’s Hospital, Houston, TX; and 4Department of Biostatistics, Indiana University School of Medicine, Indianapolis, IN

TRAV1-2+ CD8+ T-cells including oligoconal expansions of MAIT cells are enriched in the airways in human tuberculosis

Wong et al.
Communications Biology
June 2019
Authors and Affiliates
Wong EB#1,2,3,4, Gold MC#5,6,7, Meermeier EW5, Xulu BZ1, Khuzwayo S1, Sullivan ZA1, Mahyari E8, Rogers Z1, Kløverpris H1,4,9, Sharma PK6, Worley AH6, Lalloo U10, Baijnath P10,11, Ambaram A11, Naidoo L11, Suleman M11,12, Madansein R13,14, McLaren JE15, Ladell K15, Miners KL15, Price DA15,16, Behar SM17, Nielsen M18,19, Kasprowicz VO1,20,21, Leslie A1,4, Bishai WR22, Ndung'u T1,19,20,21,23, Lewinsohn DM5,6,7. Author information 1 1Africa Health Research Institute, KwaZulu-Natal, South Africa. 2 2Division of Infectious Diseases, Massachusetts General Hospital, Boston, MA USA. 3 3Harvard Medical School, Boston, MA USA. 4 4Division of Infection and Immunity, University College London, London, UK. 5 5Department of Pulmonary & Critical Care Medicine, Oregon Health & Science University, Portland, OR USA. 6 6VA Portland Health Care System, Portland, OR USA. 7 7Department of Molecular Microbiology & Immunology, Oregon Health & Science University, Portland, OR USA. 8 8Division of Bioinformatics and Computational Biology (BCB), Department of Medical Informatics and Clinical Epidemiology (DMICE), Oregon Health & Science University, Portland, OR USA. 9 9Institute for Immunology and Microbiology, University of Copenhagen, Copenhagen, Denmark. 10 10Durban University of Technology, Durban, South Africa. 11 Department of Pulmonology, Inkosi Albert Luthuli Hospital, Durban, South Africa. 12 12Department of Pulmonology & Critical Care, Nelson R. Mandela School of Medicine, University of KwaZulu-Natal, Durban, South Africa. 13 13Department of Cardiothoracic Surgery, Nelson R. Mandela School of Medicine, University of KwaZulu-Natal, Durban, South Africa. 14 14Centre for AIDS Programme of Research in South Africa (CAPRISA), Durban, South Africa. 15 15Institute of Infection & Immunity, Cardiff University School of Medicine, Cardiff, Wales UK. 16 16Human Immunology Section, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland USA. 17 17Department of Microbiology and Physiological Systems, University of Massachusetts Medical School, Worcester, MA USA. 18 18Center for Biological Sequence Analysis, Department of Bio and Health Informatics, Technical University of Denmark, Lyngby, Denmark. 19 19Instituto de Investigaciones Biotecnológicas, Universidad Nacional de San Martín, Buenos Aires, Argentina. 20 20HIV Pathogenesis Programme, Doris Duke Medical Research Institute, Nelson R. Mandela School of Medicine, University of KwaZulu-Natal, Durban, South Africa. 21 21The Ragon Institute of MGH, MIT, and Harvard, Harvard Medical School, Cambridge, MA USA. 22 22Division of Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore, MD USA. 23 23Max Planck Institute for Infection Biology, Berlin, Germany. # Contributed equally

Cytomegalovirus Exposure in the Elderly Does Not Reduce CD8 T Cell Repertoire Diversity

Lindau et al.
Journal of Immunology
January 2019
Authors and Affiliates
Lindau P1,2, Mukherjee R3, Gutschow MV2, Vignali M4, Warren EH5,6, Riddell SR5,6, Makar KW7, Turtle CJ5,6, Robins HS8,4 1 Molecular and Cellular Biology Graduate Program, University of Washington School of Medicine, Seattle, WA 98195; plindau@uw.edu hrobins@fredhutch.org. 2 Herbold Computational Biology Program, Fred Hutchinson Cancer Research Center, Seattle, WA 98109. 3 Ben Towne Center for Childhood Cancer Research, Seattle Children's Research Institute, Seattle, WA 98101. 4 Adaptive Biotechnologies, Seattle, WA 98102. 5 Program in Immunology, Fred Hutchinson Cancer Research Center, Seattle, WA 98109. 6 Department of Medicine, University of Washington, Seattle, WA 98195; and. 7 Bill and Melinda Gates Foundation, Seattle, WA 98109. 8 Herbold Computational Biology Program, Fred Hutchinson Cancer Research Center, Seattle, WA 98109; plindau@uw.edu hrobins@fredhutch.org.

Microphysiologic Human Tissue Constructs Reproduce Autologous Age-Specific BCG and HBV Primary Immunization in vitro

Sanchez-Schmitz et al.
Frontiers in Immunology
November 2018
Authors and Affiliates
Sanchez-Schmitz G1,2,3, Stevens CR1, Bettencourt IA1, Flynn PJ1, Schmitz-Abe K2,3,4,5, Metser G1, Hamm D6, Jensen KJ7,8,9, Benn C7,8, Levy O1,2,3,5 1 Division of Infectious Diseases, Boston Children's Hospital, Boston, MA, United States. 2 Precision Vaccines Program, Boston Children's Hospital, Boston, MA, United States. 3 Harvard Medical School, Harvard University, Boston, MA, United States. 4 Division of Newborn Medicine, Boston Children's Hospital, Boston, MA, United States. 5 Broad Institute of Harvard and MIT, Cambridge, MA, United States. 6 Adaptive Biotechnologies, Seattle, WA, United States. 7 Research Center for Vitamins and Vaccines, Bandim Health Project, Statens Serum Institut, Copenhagen, Denmark. 8 Bandim Health Project, Indepth Network, Bissau, Guinea-Bissau. 9 Department of Biotechnology and Biomedicine, Technical University of Denmark, Kgs Lyngby, Denmark.

Viral genetics modulate orolabial HSV-1 shedding in humans

Ramchandani et al.
Journal of Infectious Diseases
November 2018
Authors and Affiliates
Ramchandani MS1, Jing L1, Russell RM1, Tran T1, Laing KJ1, Magaret AS2,3,4, Selke S2,3, Cheng A3, Huang ML2, Xie H2, Strachan E5, Greninger AL2, Roychoudhury P2, Jerome KR2,4, Wald A1,6,2,4, Koelle DM1,2,7,4,8 1 Department of Medicine, University of Washington, Seattle, USA. 2 Department of Laboratory Medicine, University of Washington, Seattle, USA. 3 Department of Biostatistics, University of Washington, Seattle, USA. 4 Vaccine and Infectious Diseases Division, Fred Hutchinson Cancer Research Center, Seattle, USA. 5 Department of Psychiatry, University of Washington, Seattle, USA. 6 Department of Epidemiology, University of Washington, Seattle, USA. 7 Global Health, University of Washington, Seattle, USA. 8 Benaroya Research Institute, Seattle, USA.

CD4+T cells mediate protection against Zika associated severe disease in a mouse model of infection

Hassert et al.
Papers
PLOS Pathogens
September 2018
Authors and Affiliates
Mariah Hassert1, Kyle J. Wolf1, Katherine E. Schwetye2, Richard J. DiPaolo1, James D. Brien1, Amelia K. Pinto1 1Department of Molecular Microbiology and Immunology, Saint Louis University, St Louis, Missouri, United States of America, 2Department of Pathology, Saint Louis University, St. Louis, Missouri, United States of America

CD1b Tetramers Identify T Cells that Recognize Natural and Synthetic Diacylated Sulfoglycolipids from Mycobacterium tuberculosis

James et al.
Cell Chemical Biology
Papers
April 2018
Authors and Affiliates
Charlotte A. James,1,2 Krystle K.Q. Yu,1 Martine Gilleron,3 Jacques Prandi,3 Vijayendar R. Yedulla,4 Zuzanna Z. Moleda,4 Eleonora Diamanti,5 Momin Khan,5 Varinder K. Aggarwal,5 Josephine F. Reijneveld,6 Peter Reinink,6 Stefanie Lenz,6 Ryan O. Emerson,7 Thomas J. Scriba,8 Michael N.T. Souter,9,10 Dale I. Godfrey,9,10 Daniel G. Pellicci,9,10 D. Branch Moody,11 Adriaan J. Minnaard,4 Chetan Seshadri,1 and Ildiko Van Rhijn6,11 1Department of Medicine, University of Washington Medical Center, 750 Republican Street, Suite E663, Seattle, WA 98115, USA 2Department of Pathology, Molecular Medicine and Mechanisms of Disease Program, University of Washington, Seattle, WA 98195, USA 3Institut de Pharmacologie et Biologie Structurale, IPBS, Universite ́ de Toulouse, CNRS, UPS, Toulouse, France 4Stratingh Institute for Chemistry, University of Groningen, 9747AG Groningen, the Netherlands 5School of Chemistry, University of Bristol, Bristol BS8 1TS, UK 6Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, 3584CL Utrecht, the Netherlands 7Adaptive Biotechnologies, Seattle, WA 98102, USA 8South African Tuberculosis Vaccine Initiative and Institute of Infectious Disease and Molecular Medicine, Division of Immunology, Department of Pathology, University of Cape Town, Cape Town 7935, South Africa 9Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Melbourne, VIC 3000, Australia 10Australian Research Council Centre of Excellence for Advanced Molecular Imaging, University of Melbourne, Melbourne, VIC 3010, Australia 11Department of Rheumatology, Allergy & Immunology, Brigham and Women’s Hospital, 60 Fenwood Road, Room 6006V, Boston, MA 02115, USA

Cross-reactive microbial peptides can modulate HIV-specific CD8+ T cell responses

Pohlmeyer et al.
Papers
PLOS ONE
February 2018
Authors and Affiliates
Christopher W. Pohlmeyer1, Sarah B. Laskey1, Sarah E. Beck2, Daniel C. Xu1, Adam A. Capoferri1, Caroline C. Garliss1, Megan E. May1, Alison Livingston1, Walt Lichmira3, Richard D. Moore1, M. Sue Leffell1, Nicholas J. Butler4, Jennifer E. Thorne4, John A. Flynn1, Robert F. Siliciano1,5, Joel N. Blankson1,2 1Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America, 2Department of Molecular and Comparative Pathobiology. Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America, 3Spondylitis Association of America, Philadelphia, Pennsylvania United States of America, 4Department of Ophthalmology. Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America, 5Howard Hughes Medical Institute, Baltimore, Maryland, United States of America