Therapeutic Area: Infectious Disease
Diagnosis and Tracking of SARS-CoV-2 Infection By T-Cell Receptor Sequencing
Gittelman RM., et al.
February 2021
Authors and Affiliates
Rachel M. Gittelman 1, Enrico Lavezzo 2, Thomas M. Snyder 1, H. Jabran Zahid 3, Rebecca Elyanow 1, Sudeb Dalai 1,4, Ilan Kirsch 1, Lance Baldo 1, Laura Manuto 2, Elisa Franchin 2, Claudia Del Vecchio 2, Monia Pacenti 5, Caterina Boldrin 5, Margherita Cattai 5, Francesca Saluzzo 2, Andrea Padoan 6, Mario Plebani 6, Fabio Simeoni 7, Jessica Bordini 8, Nicola I. Lorè 9, Dejan Lazarevic 7, Daniela M. Cirillo 9, Paolo Ghia 8,10, Stefano Toppo 2,11, Jonathan M. Carlson 3, Harlan S. Robins 1, Giovanni Tonon 7,8, Andrea Crisanti 2,12;
1 Adaptive Biotechnologies, Seattle, WA, USA
2 Department of Molecular Medicine, University of Padova, Padua, Italy
3 Microsoft Research, Redmond, WA, USA
4 Division of Infectious Diseases and Geographic Medicine, Stanford University School of Medicine
5 Azienda Ospedale Padova, Microbiology and Virology Unit, Padua, Italy
6 Department of Medicine, University of Padova, Padua, Italy
7 Center for Omics Sciences, IRCCS Ospedale San Raffaele, Milan, Italy
8 Division of Experimental Oncology, IRCCS Ospedale San Raffaele, Milan, Italy
9 Division of Immunology, Transplantation and Infectious Disease, IRCCS Ospedale San Raffaele, Milan, Italy
10 Università Vita- Salute San Raffaele, Milan, Italy
11 CRIBI Biotech Center, University of Padova, Padua, Italy
12 Department of Life Sciences, Imperial College London, London, UK
Antigen-driven clonal selection shapes the persistence of HIV-1 infected CD4+ T cells in vivo
Authors and Affiliates
Francesco R Simonetti 1, Hao Zhang 2, Garshasb P Soroosh 1, Jiayi Duan 1, Kyle Rhodehouse 1, Alison L Hill 3, Subul A Beg 1, Kevin McCormick 4, Hayley E Raymond 4, Christopher L Nobles 4, John K Everett 4, Kyungyoon J Kwon 1, Jennifer A White 1, Jun Lai 1, Joseph B Margolick 5, Rebecca Hoh 6, Steven G Deeks 6, Frederic D Bushman 4, Janet D Siliciano 1, Robert F Siliciano 1;
1 Department of Medicine, Johns Hopkins University, Baltimore, United States of America.
2 Department of Molecular Microbiology and immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, United States of America.
3 Department for Organismic and Evolutionary Biology, Harvard University, Cambridge, United States of America.
4 Department of Microbiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, United States of America.
5 Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltiomore, United States of America.
6 Division of HIV, Infectious Diseases, and Global Medicine, UCSF, San Francisco, United States of America.
Identification of HLA-A*02:01-restricted candidate epitopes derived from the non-structural polyprotein 1a of SARS-CoV-2 that may be natural targets of CD8 + T cell recognition in vivo
Takagi A, Matsui M.
December 2020
Authors and Affiliates
Akira Takagi 1, Masanori Matsui 2;
1 School of Medical Technology, Faculty of Health and Medical Care, Saitama Medical University, 1397-1 Yamane, Hidaka-city, Saitama 350-1241, Japan.
2 Department of Microbiology, Faculty of Medicine, Saitama Medical University, 38 Morohongo, Moroyama-cho, Iruma-gun, Saitama 350-0495, Japan mmatsui@saitama-med.ac.jp.
Diagnostic differentiation of Zika and dengue virus exposure by analyzing T cell receptor sequences from peripheral blood of infected HLA-A2 transgenic mice
Hassert M., et al.
December 2020
Authors and Affiliates
Mariah Hassert 1, Kyle J Wolf 1, Ahmad Rajeh 2, Courtney Shiebout 2, Stella G Hoft 1, Tae-Hyuk Ahn 2 3, Richard J DiPaolo 1, James D Brien 1, Amelia K Pinto 1;
1 Department of Molecular Microbiology and Immunology, Saint Louis University- School of Medicine, Saint Louis, Missouri, United States of America.
2 Program in Bioinformatics and Computational Biology, Saint Louis University, Saint Louis, Missouri, United States of America.
3 Department of Computer Science, Saint Louis University, Saint Louis, Missouri, United States of America.
Public and private human T-cell clones respond differentially to HCMV antigen when boosted by CD3 copotentiation
Becher LRE., et al.
December 2020
Authors and Affiliates
Laura R E Becher 1,2, Wendy K Nevala 2, Shari Lee Sutor 2, Megan Abergel 3,4,5, Michele M Hoffmann 1, Christopher A Parks 1, Larry R Pease 1, Adam G Schrum 3,4,5, Svetomir N Markovic 2, Diana Gil 3,4,5;
1Department of Immunology, Mayo Clinic Graduate School of Biomedical Sciences, and.
2Department of Oncology, Mayo Clinic, Rochester, MN; and.
3Department of Surgery, School of Medicine.
4Department of Molecular Microbiology & Immunology, School of Medicine, and.
5Department of Bioengineering, College of Engineering, University of Missouri, Columbia, MO.
A large-scale database of T-cell receptor beta (TCRB) sequences and binding associations from natural and synthetic exposure to SARS-CoV-2
Authors and Affiliates
Sean Nolan, Marissa Vignali, Mark Klinger, Jennifer N. Dines, Ian M. Kaplan, Emily Svejnoha, Tracy Craft, Katie Boland, Mitch Pesesky, Rachel M. Gittelman, Thomas M. Snyder, Christopher J. Gooley, Simona Semprini, Claudio Cerchione, Massimiliano Mazza, Ottavia M. Delmonte, Kerry Dobbs, Gonzalo Carreño-Tarragona, Santiago Barrio, Vittorio Sambri, Giovanni Martinelli, Jason D. Goldman, James R. Heath, Luigi D. Notarangelo, Jonathan M. Carlson, Joaquin Martinez-Lopez, and Harlan S. Robins
Magnitude and Dynamics of the T-Cell Response to SARS-CoV-2 Infection at Both Individual and Population Levels
Snyder TM., et al.
September 2020
Authors and Affiliates
Thomas M. Snyder,1, Rachel M. Gittelman,1, Mark Klinger,1 Damon H. May,1 Edward J. Osborne,1 Ruth Taniguchi,1 H. Jabran Zahid,2 Ian M. Kaplan,1 Jennifer N. Dines,1 Matthew T. Noakes,1 Ravi Pandya,2 Xiaoyu Chen,1 Summer Elasady,1 Emily Svejnoha,1 Peter Ebert,1 Mitchell W. Pesesky,1 Patricia De Almeida,1 Hope O'Donnell,1 Quinn DeGottardi,1 Gladys Keitany,1 Jennifer Lu,1 Allen Vong,1 Rebecca Elyanow,1 Paul Fields,1 Julia Greissl,2 Lance Baldo,1 Simona Semprini,3 Claudio Cerchione,4 Massimiliano Mazza,4 Ottavia M. Delmonte,5 Kerry Dobbs,5 Gonzalo Carreño-Tarragona,6 Santiago Barrio,6 Luisa Imberti,7 Alessandra Sottini,7 Eugenia Quiros-Roldan,7 Camillo Rossi,7 Andrea Biondi,8 Laura Rachele Bettini,8 Mariella D’Angio,8 Paolo Bonfanti,9 Miranda F. Tompkins,10 Camille Alba,10 Clifton Dalgard,11 Vittorio Sambri,3 Giovanni Martinelli,4 Jason D. Goldman,12 James R. Heath,13 Helen C. Su,5 Luigi D. Notarangelo,5 Joaquin Martinez-Lopez,6 Jonathan M. Carlson,2 and Harlan S. Robins1;
1 Adaptive Biotechnologies, Seattle, WA, USA
2 Microsoft Research, Redmond, WA, USA
3 Unit of Microbiology - The Great Romagna Hub Laboratory, Pievesestina ITALY and DIMES, University of Bologna, Bologna, Italy
4 Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) IRCCS, Meldola, Italy
5 Immune Deficiency Genetics Section, Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
6 Hematology Department, Hospital 12 de Octubre, i+12, CNIO, Complutense University, Madrid, Spain
7 Laboratorio CREA, Department of Infectious and Tropical Diseases, and Medical Officer, ASST Spedali Civili di Brescia and University of Brescia, Brescia, Italy
8 Department of Pediatrics and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale San Gerardo, Monza, IT
9 Department of Infectious Diseases, University of Milano-Bicocca-Ospedale San Gerardo, Monza, IT
10 The American Genome Center, Uniformed Services University of the Health Sciences, Bethesda, MD, USA
11 Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA
12 Swedish Medical Center, Seattle, WA, USA, and Division of Allergy and Infectious Diseases, University of Washington, Seattle, WA, USA
13 Institute for Systems Biology, Seattle, WA, USA
Maternal T Cells in the Human Placental Villi Support an Allograft Response during Noninfectious Villitis
Authors and Affiliates
Elizabeth Ann L. Enninga,* Patrick Raber,† Reade A. Quinton,‡ Rodrigo Ruano,* Nadia Ikumi,x Clive M. Gray,x Erica L. Johnson,{ Rana Chakraborty,*,‖,# and Sarah E. Kerr**; *Department of Obstetrics and Gynecology, Mayo Clinic, Rochester, MN 55905; †Adaptive Biotechnologies, Seattle, WA 98102; ‡Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN 55905; xDivision of Immunology, In- stitute of Infectious Disease and Molecular Medicine, Department of Pathology, University of Cape Town, Cape Town, South Africa 7791; {Division of Infectious Diseases, Department of Pediatrics, Emory University School of Medicine, Atlanta, GA 30322; ‖Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, MN 55905; #Department of Immunology, Mayo Clinic, Rochester, MN 55905; and **Hospital Pathology Associates, Minneapolis, MN 55407
CD8+γδ T Cells Are More Frequent in CMV Seropositive Bone Marrow Grafts and Display Phenotype of an Adaptive Immune Response
Authors and Affiliates
Ahmed Gaballa ,1 Lucas C. M. Arruda ,1 Emelie Rådestad ,1 and Michael Uhlin 1,2,3
1Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden 2Department of Applied Physics, Science for Life Laboratory, Royal Institute of Technology, Stockholm, Sweden 3Department of Immunology and Transfusion Medicine, Karolinska University Hospital, Stockholm, Sweden