Therapeutic Area: Infectious Disease

AZD1222/ChAdOx1 nCoV-19 vaccination induces a polyfunctional spike protein-specific Th1 response with a diverse TCR repertoire

Swanson PA, et al.
October 2021
immuneAccess
Authors and Affiliates
Phillip A Swanson 2nd 1, Marcelino Padilla 1, Wesley Hoyland 1, Kelly McGlinchey 2, Paul A Fields 3, Sagida Bibi 4, Saul N Faust 5, Adrian B McDermott 1, Teresa Lambe # 6, Andrew J Pollard # 4, Nicholas M Durham # 7, Elizabeth J Kelly # 8, AstraZeneca/Oxford/VRC Study Group; 1 Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. 2 Discovery, Research and Early Development, Oncology R&D, AstraZeneca, Gaithersburg, MD 20878, USA. 3 Adaptive Biotechnologies, Seattle, WA 98102, USA. 4 Oxford Vaccine Group, Department of Paediatrics, University of Oxford, and the NIHR Oxford Biomedical Research Centre, Oxford OX4 6PG, UK. 5 NIHR Southampton Clinical Research Facility and Biomedical Research Centre, University Hospital Southampton NHS Foundation Trust; Faculty of Medicine and Institute for Life Sciences, University of Southampton, Southampton SO16 6YD, UK. 6 The Jenner Institute, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7DQ, UK; Chinese Academy of Medical Science (CAMS) Oxford Institute (COI), University of Oxford, Oxford OX3 7FZ, UK. 7 Translational Medicine, Oncology R&D, AstraZeneca, Gaithersburg, MD 20878, USA. 8 Translational Medicine, Microbial Sciences, Biopharmaceuticals R&D, AstraZeneca, Gaithersburg, MD 20878, USA. # Contributed equally.

Deep learning identifies antigenic determinants of severe SARS-CoV-2 infection within T-cell repertoires

Sidhom JW and Baras AS
Scientific Reports
July 2021
Authors and Affiliates
John-William Sidhom 1,2,3, Alexander S Baras 4,5,6; 1 Bloomberg Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA. jsidhom1@jhmi.edu. 2 The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA. jsidhom1@jhmi.edu. 3 Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA. jsidhom1@jhmi.edu. 4 Bloomberg Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA. 5 The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA. 6 Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.

Distinct populations of antigen specific tissue resident CD8 T cells in human cervix mucosa

Peng T, et al.
July 2021
immuneAccess
Authors and Affiliates
Tao Peng 1, Khamsone Phasouk 2, Emily Bossard 2, Alexis Klock 3, Lei Jin 2, Kerry J Laing 3, Christine Johnston 3, Noel A Williams 2, Julie L Czartoski 2, Dana Varon 3, Annalyssa N Long 4, Jason H Bielas 5, Thomas M Snyder 6, Harlan Robins 6, David M Koelle 7, M Juliana McElrath 2, Anna Wald 7, Lawrence Corey 5, Jia Zhu 7; 1 Department of Medicine and Pathology, University of Washington, Seattle, United States of America. 2 Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seatlle, United States of America. 3 Department of Medicine, University of Washington, Seattle, United States of America. 4 Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, United States of America. 5 Fred Hutchinson Cancer Research Center, Seattle, United States of America. 6 Research, Adaptive Biotechnologies, Seattle, United States of America. 7 Department of Laboratory Medicine, and Pathology, University of Washington, Seattle, United States of America.

Immunogenicity of Ad26.COV2.S vaccine against SARS-CoV-2 variants in humans

Alter G, et al.
Nature
June 2021
immuneAccess
Authors and Affiliates
Galit Alter 1,2,9, Jingyou Yu 1,9, Jinyan Liu 1,9, Abishek Chandrashekar 1,9, Erica N. Borducchi 1,9, Lisa H. Tostanoski 1,9, Katherine McMahan 1,9, Catherine Jacob-Dolan 1,3,9, David R. Martinez 4, Aiquan Chang 1,3, Tochi Anioke 1, Michelle Lifton 1, Joseph Nkolola 1, Kathryn E. Stephenson 1, Caroline Atyeo 2,3, Sally Shin 2, Paul Fields 5, Ian Kaplan 5, Harlan Robins 5, Fatima Amanat 6, Florian Krammer 6, Ralph S. Baric 4, Mathieu Le Gars 7, Jerald Sadoff 7, Anne Marit de Groot 7, Dirk Heerwegh 8, Frank Struyf 8, Macaya Douoguih 7, Johan van Hoof 7, Hanneke Schuitemaker 7 and Dan H. Barouch 1,2,3; 1 Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, MA, USA. 2 Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA. 3 Harvard Medical School,Boston, MA, USA. 4 University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. 5 Adaptive Biotechnologies, Seattle, WA, USA. 6 Icahn School of Medicine at Mount Sinai, New York, NY, USA. 7 Janssen Vaccines & Prevention, Leiden, The Netherlands. 8 Janssen Research & Development, Beerse, Belgium. 9 These authors contributed equally: Galit Alter, Jingyou Yu, Jinyan Liu, Abishek Chandrashekar, Erica N. Borducchi, Lisa H. Tostanoski, Katherine McMahan, Catherine Jacob-Dolan.

Clonal analysis of immunodominance and cross-reactivity of the CD4 T cell response to SARS-CoV-2

Low JS, et al.
Science
June 2021
immuneAccess
Authors and Affiliates
Jun Siong Low 1, Daniela Vaqueirinho 1, Federico Mele 1, Mathilde Foglierini 1, Josipa Jerak 1, Michela Perotti 1, David Jarrossay 1, Sandra Jovic 1, Laurent Perez 1, Rosalia Cacciatore 2, Tatiana Terrot 3, Alessandra Franzetti Pellanda 4, Maira Biggiogero 4, Christian Garzoni 4, Paolo Ferrari 5,6,7, Alessandro Ceschi 3,5,8,9, Antonio Lanzavecchia 10, Federica Sallusto 11,12, Antonino Cassotta 11; 1 Institute for Research in Biomedicine, Università della Svizzera Italiana, 6500 Bellinzona, Switzerland. 2 Laboratory of Immunogenetics, Department of Transfusion Medicine and Immuno-Hematology, Fondazione I.R.C.C.S. Policlinico S. Matteo, 27100 Pavia, Italy. 3 Clinical Trial Unit, Ente Ospedaliero Cantonale, 6500 Bellinzona, Switzerland. 4 Clinic of Internal Medicine and Infectious Diseases, Clinica Luganese Moncucco, 6900 Lugano, Switzerland. 5 Faculty of Biomedical Sciences, Università della Svizzera italiana, 6900 Lugano, Switzerland. 6 Department of Internal Medicine, Ente Ospedaliero Cantonale, 6500 Bellinzona, Switzerland. 7 Prince of Wales Hospital Clinical School, University of New South Wales, Sydney, New South Wales 2052, Australia. 8 Division of Clinical Pharmacology and Toxicology, Institute of Pharmacological Sciences of Southern Switzerland, Ente Ospedaliero Cantonale, 6900 Lugano, Switzerland. 9 Department of Clinical Pharmacology and Toxicology, University Hospital Zurich, 8091 Zurich, Switzerland. 10 National Institute of Molecular Genetics, 20122 Milano, Italy. 11 Institute for Research in Biomedicine, Università della Svizzera Italiana, 6500 Bellinzona, Switzerland. federica.sallusto@irb.usi.ch antonino.cassotta@irb.usi.ch. 12 Institute of Microbiology, ETH Zürich, 8093 Zurich, Switzerland.

Functional characterization of CD4+ T-cell receptors cross-reactive for SARS-CoV-2 and endemic coronaviruses

Dykema AG, et al.
Journal of Clinical Investigation
May 2021
immuneAccess
Authors and Affiliates
Arbor G Dykema 1, Boyang Zhang 2, Bezawit A Woldemeskel 3, Caroline C Garliss 3, Laurene S Cheung 4, Dilshad Choudhury 1, Jiajia Zhang 1, Luis Aparicio 1, Sadhana Bom 1, Rufiaat Rashid 1, Justina X Caushi 1, Emily Han-Chung Hsiue 1, Katherine Cascino 3, Elizabeth A Thompson 5, Abena K Kwaa 3, Dipika Singh 1, Sampriti Thapa 1, Alvaro A Ordonez 6, Andrew Pekosz 7, Franco R D'Alessio 3, Jonathan D Powell 1, Srinivasan Yegnasubramanian 1, Shibin Zhou 5, Drew M Pardoll 1, Hongkai Ji 2, Andrea L Cox 5, Joel N Blankson 3, Kellie N Smith 4; 1 Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, United States of America. 2 Department of Biostatistics, Johns Hopkins University School of Medicine, Baltimore, United States of America. 3 Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, United States of America. 4 The Bloomberg-Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University School of Medicine, Baltimore, United States of America. 5 Johns Hopkins University School of Medicine, Baltimore, United States of America. 6 Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, United States of America. 7 Department of Molecular Microbiology and Immunology, Johns Hopkins University School of Medicine, Baltimore, United States of America.

Single-cell analysis shows that adipose tissue of persons with both HIV and diabetes is enriched for clonal, cytotoxic, and CMV-specific CD4+ T cells

Wanjalla CN., et al.
February 2021
Authors and Affiliates
Celestine N. Wanjalla 1,2,5,14, Wyatt J. McDonnell 1,2,3,4,11, Ramesh Ram 10, Abha Chopra 10, Rama Gangula 15, Shay Leary 10, Mona Mashayekhi 6, Joshua D. Simmons 15, Christian M. Warren 15, Samuel Bailin 1, Curtis L. Gabriel 8, Liang Guo 12, Briana D. Furch 15, Morgan C. Lima 15, Beverly O. Woodward 15, LaToya Hannah 6, Mark A. Pilkinton 12, Daniela T. Fuller 12, Kenji Kawai 12, Renu Virmani 12, Aloke V. Finn 12, Alyssa H. Hasty 9,13, Simon A. Mallal 1,2,4,5,7,10, Spyros A. Kalams 1,2,4,5, John R. Koethe 1,2,5,13,15; 1 Division of Infectious Diseases, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA 2 Center for Translational Immunology and Infectious Disease, Vanderbilt University Medical Center, Nashville, TN, USA 3 Vanderbilt Vaccine Center, Vanderbilt University Medical Center, Nashville, TN, USA 4 Department of Pathology, Microbiology, and Immunology, Vanderbilt University, Nashville, TN, USA 5 Tennessee Center for AIDS Research, Vanderbilt University Medical Center, Nashville, TN, USA 6 Division of Diabetes, Endocrinology and Metabolism, Vanderbilt University Medical Center, Nashville, TN, USA 7 VANTAGE, Vanderbilt University Medical Center, Nashville, TN, USA 8 Division of Gastroenterology, Hepatology and Nutrition, Vanderbilt University, Nashville, TN, USA 9 Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN, USA 10 Institute for Immunology and Infectious Diseases, Murdoch University, Perth, WA, Australia 11 10x Genomics, Pleasanton, CA, USA 12 CVPath Institute, Gaithersburg, MD, USA 13 Veterans Affairs Tennessee Valley Healthcare System, Nashville, TN, USA