Therapeutic Area: Infectious Disease

Immunopathological signatures in multisystem inflammatory syndrome in children and pediatric COVID-19

Sacco K, et al.
Nature Medicine
February 2022
immuneAccess
Authors and Affiliates
Keith Sacco #,1, Riccardo Castagnoli #,1,2, Svetlana Vakkilainen #,1, Can Liu #,3,4, Ottavia M Delmonte 1, Cihan Oguz 5,6, Ian M Kaplan 7, Sara Alehashemi 1, Peter D Burbelo 8, Farzana Bhuyan 1, Adriana A de Jesus 1, Kerry Dobbs 1, Lindsey B Rosen 1, Aristine Cheng 1, Elana Shaw 1, Mikko S Vakkilainen 9, Francesca Pala 1, Justin Lack 3,5, Yu Zhang 1, Danielle L Fink 10, Vasileios Oikonomou 1, Andrew L Snow 11, Clifton L Dalgard 12,13, Jinguo Chen 14, Brian A Sellers 14, Gina A Montealegre Sanchez 15, Karyl Barron 16, Emma Rey-Jurado 17, Cecilia Vial 17, Maria Cecilia Poli 17,18, Amelia Licari 2, Daniela Montagna 2,19, Gian Luigi Marseglia 2, Francesco Licciardi 20, Ugo Ramenghi 20, Valentina Discepolo 21, Andrea Lo Vecchio 21, Alfredo Guarino 21, Eli M Eisenstein 22, Luisa Imberti 23, Alessandra Sottini 23, Andrea Biondi 24, Sayonara Mató 25, Dana Gerstbacher 26, Meng Truong 1, Michael A Stack 1, Mary Magliocco 27, Marita Bosticardo 1, Tomoki Kawai 1, Jeffrey J Danielson 1, Tyler Hulett 28, Manor Askenazi 28, Shaohui Hu 28, NIAID Immune Response to COVID Group; Chile MIS-C Group; Pavia Pediatric COVID-19 Group; Jeffrey I Cohen 29, Helen C Su 1, Douglas B Kuhns 10, Michail S Lionakis 1, Thomas M Snyder 7, Steven M Holland 1, Raphaela Goldbach-Mansky 1, John S Tsang 3 30, Luigi D Notarangelo 31; 1 Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA. 2 Pediatric Clinic, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy; Department of Clinical, Surgical, Diagnostic and Pediatric Sciences, University of Pavia, Pavia, Italy. 3 Multiscale Systems Biology Section, Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA. 4 Graduate Program in Biological Sciences, University of Maryland, College Park, MD, USA. 5 NIAID Collaborative Bioinformatics Resource (NCBR), National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA. 6 Advanced Biomedical Computational Science, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research, Inc, Frederick, MD, USA. 7 Adaptive Biotechnologies, Seattle, WA, USA. 8 National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD, USA. 9 Department of Computer Science, Aalto University, Helsinki, Finland. 10 Applied/Developmental Research Directorate, Frederick National Laboratory for Cancer Research, Frederick, MD, USA. 11 Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. 12 Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. 13 The American Genome Center, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. 14 Trans-NIH Center for Human Immunology, Autoimmunity, and Inflammation (CHI), National Institutes of Health, Bethesda, MD, USA. 15 Intramural Clinical Management and Operation Branch (ICMOB), Division of Clinical Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA. 16 Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA. 17 Facultad de Medicina Clínica Alemana Universidad del Desarrollo, Santiago, Chile. 18 Unidad de Inmunología y Reumatología, Hospital de niños Dr. Roberto del Río, Santiago, Chile. 19 Laboratory of Immunology and Transplantation, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy. 20 Department of Pediatric and Public Health Sciences, Regina Margherita Children's Hospital, A.O.U. Città Della Salute E Della Scienza Di Torino, University of Turin, Turin, Italy. 21 Department of Translational Medical Sciences, Section of Pediatrics, University of Naples Federico II, Napoli, Italy. 22 Department of Pediatrics, Hadassah-Hebrew University Medical Center, Mount Scopus, Jerusalem, Israel. 23 CREA Laboratory (AIL Center for Hemato-Oncologic Research), Diagnostic Department, ASST Spedali Civili di Brescia, Brescia, Italy. 24 Pediatric Department and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN, University of Milano Bicocca, Fondazione MBBM, Ospedale San Gerardo, Monza, Italy. 25 Randall Children's Hospital at Legacy Emanuel, Portland, OR, USA. 26 Division of Pediatric Rheumatology, Stanford Children's Hospital, Stanford, CA, USA. 27 Molecular Development of the Immune System Section, Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA. 28 CDI Laboratories, Antygen Division, Baltimore, MD, USA. 29 Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA. 30 NIH Center for Human Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA. 31 Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA. luigi.notarangelo2@nih.gov. # Contributed equally.

Evidence of SARS-CoV-2-Specific T-Cell-Mediated Myocarditis in a MIS-A Case

Vannelle KM, et al.
Frontiers in Immunology
February 2022
immuneAccess
Authors and Affiliates
Kevin M Vannella 1,2, Cihan Oguz 3,4, Sydney R Stein 1,2, Stefania Pittaluga 5, Esra Dikoglu 5, Arjun Kanwal 6, Sabrina C Ramelli 7, Thomas Briese 8, Ling Su 9, Xiaolin Wu 9, Marcos J Ramos-Benitez 1,2,10, Luis J Perez-Valencia 1,2, Ashley Babyak 1,2, Nu Ri Cha 11, Joon-Yong Chung 5, Kris Ylaya 5, Ronson J Madathil 12, Kapil K Saharia 13, Thomas M Scalea 14, Quincy K Tran 15, Daniel L Herr 16, David E Kleiner 5, Stephen M Hewitt 5, Luigi D Notarangelo 17, Alison Grazioli 18, Daniel S Chertow 1,2; 1 Emerging Pathogens Section, Critical Care Medicine Department, Clinical Center, National Institutes of Health, Bethesda, MD, United States. 2 Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, United States. 3 National Institute of Allergy and Infectious Diseases Collaborative Bioinformatics Resource, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research, Inc., Frederick, MD, United States. 4 Advanced Biomedical Computational Science, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research, Inc., Frederick, MD, United States. 5 Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, United States. 6 Division of Cardiology, Westchester Medical Center, Valhalla, NY, United States. 7 Critical Care Medicine Department, Clinical Center, National Institutes of Health, Bethesda, MD, United States. 8 Center for Infection and Immunity, Columbia University Mailman School of Public Health, New York, NY, United States. 9 Cancer Research Technology Program, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research, Inc., Frederick, MD, United States. 10 Postdoctoral Research Associate Training Program, National Institute of General Medical Sciences, National Institutes of Health, Bethesda, MD, United States. 11 Department of Transfusion Medicine, Clinical Center, National Institutes of Health, Bethesda, MD, United States. 12 Department of Surgery, Division of Cardiac Surgery, University of Maryland School of Medicine, Baltimore, MD, United States. 13 Department of Medicine, Division of Infectious Disease, University of Maryland School of Medicine, Baltimore, MD, United States. 14 Department of Surgery, Program in Trauma, R. Adams Cowley Shock Trauma Center, University of Maryland School of Medicine, Baltimore, MD, United States. 15 Department of Emergency Medicine, R. Adams Cowley Shock Trauma Center, University of Maryland School of Medicine, Baltimore, MD, United States. 16 Department of Medicine, Program in Trauma, R. Adams Cowley Shock Trauma Center, University of Maryland School of Medicine, Baltimore, MD, United States. 17 Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, United States. 18 Kidney Diseases Branch, Kidney Disease Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, United States.

Multiple early factors anticipate post-acute COVID-19 sequelae

Su Y, et al.
Cell
February 2022
Authors and Affiliates
Yapeng Su 1, Dan Yuan 2, Daniel G Chen 3, Rachel H Ng 2, Kai Wang 4, Jongchan Choi 4, Sarah Li 4, Sunga Hong 4, Rongyu Zhang 2, Jingyi Xie 5, Sergey A Kornilov 4, Kelsey Scherler 4, Ana Jimena Pavlovitch-Bedzyk 6, Shen Dong 7, Christopher Lausted 4, Inyoul Lee 4, Shannon Fallen 4, Chengzhen L Dai 4, Priyanka Baloni 4, Brett Smith 4, Venkata R Duvvuri 4, Kristin G Anderson 8, Jing Li 6, Fan Yang 9, Caroline J Duncombe 10, Denise J McCulloch 11, Clifford Rostomily 4, Pamela Troisch 4, Jing Zhou 12, Sean Mackay 12, Quinn DeGottardi 13, Damon H May 13, Ruth Taniguchi 13, Rachel M Gittelman 13, Mark Klinger 13, Thomas M Snyder 13, Ryan Roper 4, Gladys Wojciechowska 14, Kim Murray 4, Rick Edmark 4, Simon Evans 4, Lesley Jones 4, Yong Zhou 4, Lee Rowen 4, Rachel Liu 4, William Chour 4, Heather A Algren 15, William R Berrington 15, Julie A Wallick 15, Rebecca A Cochran 15, Mary E Micikas 15, ISB-Swedish COVID-19 Biobanking Unit 4; Terri Wrin 16, Christos J Petropoulos 16, Hunter R Cole 17, Trevan D Fischer 17, Wei Wei 4, Dave S B Hoon 17, Nathan D Price 4, Naeha Subramanian 18, Joshua A Hill 19, Jennifer Hadlock 4, Andrew T Magis 4, Antoni Ribas 20, Lewis L Lanier 21, Scott D Boyd 9, Jeffrey A Bluestone 7, Helen Chu 22, Leroy Hood 23, Raphael Gottardo 24, Philip D Greenberg 8, Mark M Davis 25, Jason D Goldman 26, James R Heath 27; 1 Institute for Systems Biology, Seattle, WA 98109, USA; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA; Clinical Research Division, Program in Immunology, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA. Electronic address: suyapeng.tju@gmail.com. 2 Institute for Systems Biology, Seattle, WA 98109, USA; Department of Bioengineering, University of Washington, Seattle, WA 98105, USA. 3 Institute for Systems Biology, Seattle, WA 98109, USA; Department of Microbiology and Department of Informatics, University of Washington, Seattle, WA 98195, USA. 4 Institute for Systems Biology, Seattle, WA 98109, USA. 5 Institute for Systems Biology, Seattle, WA 98109, USA; Molecular Engineering & Sciences Institute, University of Washington, Seattle, WA 98105, USA. 6 Institute for Immunity, Transplantation and Infection, Stanford University School of Medicine, Stanford, CA 94305, USA. 7 Diabetes Center, University of California, San Francisco, San Francisco, CA 94143, USA. 8 Clinical Research Division, Program in Immunology, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA; Departments of Immunology and Medicine, University of Washington, Seattle, WA 98109, USA. 9 Department of Pathology, Stanford University, Stanford, CA 94304, USA. 10 Division of Global Health, University of Washington, Seattle, WA 98105, USA. 11 Division of Allergy and Infectious Diseases, Department of Medicine, University of Washington, Seattle, WA 98109, USA. 12 Isoplexis Corporation, Branford, CT 06405, USA. 13 Adaptive Biotechnologies, Seattle, WA 98109, USA. 14 Institute for Systems Biology, Seattle, WA 98109, USA; Medical University of Białystok, Białystok 15089, Poland. 15 Swedish Center for Research and Innovation, Swedish Medical Center, Seattle, WA 98109, USA; Providence St. Joseph Health, Renton, WA 98057, USA. 16 Monogram Biosciences, South San Francisco, CA 94080, USA. 17 St. John's Cancer Institute at Saint John's Health Center, Santa Monica, CA 90404, USA. 18 Institute for Systems Biology, Seattle, WA 98109, USA; Department of Global Heath and Department of Immunology, University of Washington, Seattle, WA 98109, USA. 19 Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA; Division of Allergy and Infectious Diseases, Department of Medicine, University of Washington, Seattle, WA 98109, USA. 20 Department of Medicine, University of California, Los Angeles, and Parker Institute for Cancer Immunotherapy, Los Angeles, CA 90095, USA. 21 Department of Microbiology and Immunology, University of California, San Francisco, and Parker Institute for Cancer Immunotherapy, San Francisco, CA 94143, USA. 22 Division of Global Health, University of Washington, Seattle, WA 98105, USA; Division of Allergy and Infectious Diseases, Department of Medicine, University of Washington, Seattle, WA 98109, USA. 23 Institute for Systems Biology, Seattle, WA 98109, USA; Providence St. Joseph Health, Renton, WA 98057, USA. 24 Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA; Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA; Department of Statistics, University of Washington, Seattle, WA 98195, USA; Biomedical Data Sciences, Lausanne University Hospital, University of Lausanne, Lausanne, 1011, Switzerland. 25 Institute for Immunity, Transplantation and Infection, Stanford University School of Medicine, Stanford, CA 94305, USA; Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA; The Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, CA 94305, USA. 26 Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA; Division of Allergy and Infectious Diseases, Department of Medicine, University of Washington, Seattle, WA 98109, USA; Swedish Center for Research and Innovation, Swedish Medical Center, Seattle, WA 98109, USA; Providence St. Joseph Health, Renton, WA 98057, USA. Electronic address: jason.goldman@swedish.org. 27 Institute for Systems Biology, Seattle, WA 98109, USA; Department of Bioengineering, University of Washington, Seattle, WA 98105, USA. Electronic address: jim.heath@isbscience.org.

HLA-dependent variation in SARS-CoV-2 CD8+ T cell cross-reactivity with human coronaviruses

Buckely PR, et al.
immunology
February 2022
Authors and Affiliates
Paul R Buckley 1,2, Chloe H Lee 1,2, Mariana Pereira Pinho 1, Rosana Ottakandathil Babu 1,2, Jeongmin Woo 1,2, Agne Antanaviciute 1,2, Alison Simmons 1, Graham Ogg 1, Hashem Koohy 1,2; 1 MRC Human Immunology Unit, Medical Research Council (MRC) Human Immunology Unit, MRC Weatherall Institute of Molecular Medicine (WIMM), John Radcliffe Hospital, University of Oxford, Oxford, United Kingdom. 2 MRC WIMM Centre for Computational Biology, Medical Research Council (MRC) Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Oxford, United Kingdom.

SARS-CoV-2 mRNA vaccination elicits a robust and persistent T follicular helper cell response in humans

Mudd PA, et al.
Cell
January 2022
Authors and Affiliates
Philip A Mudd 1, Anastasia A Minervina 2, Mikhail V Pogorelyy 2, Jackson S Turner 3, Wooseob Kim 3, Elizaveta Kalaidina 4, Jan Petersen 5, Aaron J Schmitz 3, Tingting Lei 3, Alem Haile 6, Allison M Kirk 2, Robert C Mettelman 2, Jeremy Chase Crawford 2, Thi H O Nguyen 7, Louise C Rowntree 7, Elisa Rosati 8, Katherine A Richards 9, Andrea J Sant 9, Michael K Klebert 6, Teresa Suessen 10, William D Middleton 10, SJTRC Study Team; Joshua Wolf 11, Sharlene A Teefey 10, Jane A O'Halloran 12, Rachel M Presti 13, Katherine Kedzierska 7, Jamie Rossjohn 14, Paul G Thomas 15, Ali H Ellebedy 16; 1 Department of Emergency Medicine, Washington University School of Medicine, Saint Louis, MO 63110, USA; Center for Vaccines and Immunity to Microbial Pathogens, Washington University School of Medicine, Saint Louis, MO 63110, USA. Electronic address: pmudd@wustl.edu. 2 Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA. 3 Department of Pathology and Immunology, Washington University School of Medicine, Saint Louis, MO 63110, USA. 4 Division of Allergy and Immunology, Department of Internal Medicine, Washington University School of Medicine, Saint Louis, MO 63110, USA. 5 Infection and Immunity Program & Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, Victoria 3800, Australia. 6 Clinical Trials Unit, Washington University School of Medicine, Saint Louis, MO 63110, USA. 7 Department of Microbiology and Immunology, University of Melbourne, at Peter Doherty Institute for Infection and Immunity, Parkville, Victoria 3052, Australia. 8 Institute of Clinical Molecular Biology, Christian-Albrecht University of Kiel, Kiel 24105, Germany. 9 David H. Smith Center for Vaccine Biology and Immunology, Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, NY 14642, USA. 10 Mallinckrodt Institute of Radiology, Washington University School of Medicine, Saint Louis, MO 63110, USA. 11 Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, TN 38105, USA. 12 Division of Infectious Diseases, Department of Internal Medicine, Washington University School of Medicine, Saint Louis, MO 63110, USA. 13 Center for Vaccines and Immunity to Microbial Pathogens, Washington University School of Medicine, Saint Louis, MO 63110, USA; Clinical Trials Unit, Washington University School of Medicine, Saint Louis, MO 63110, USA; Division of Infectious Diseases, Department of Internal Medicine, Washington University School of Medicine, Saint Louis, MO 63110, USA; Andrew M. and Jane M. Bursky Center for Human Immunology and Immunotherapy Programs, Washington University School of Medicine, Saint Louis, MO 63110, USA. 14 Infection and Immunity Program & Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, Victoria 3800, Australia; Institute of Infection and Immunity, Cardiff University, School of Medicine, Heath Park, Cardiff CF14 4XN, UK. 15 Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA. Electronic address: paul.thomas@stjude.org. 16 Center for Vaccines and Immunity to Microbial Pathogens, Washington University School of Medicine, Saint Louis, MO 63110, USA; Department of Pathology and Immunology, Washington University School of Medicine, Saint Louis, MO 63110, USA; Andrew M. and Jane M. Bursky Center for Human Immunology and Immunotherapy Programs, Washington University School of Medicine, Saint Louis, MO 63110, USA. Electronic address: ellebedy@wustl.edu.

Expansion of Human Papillomavirus-Specific T Cells in Periphery and Cervix in a Therapeutic Vaccine Recipient Whose Cervical High-Grade Squamous Intraepithelial Lesion Regressed

Shibata T, et al.
Frontiers in Immunology
January 2022
immuneAccess
Authors and Affiliates
Takeo Shibata 1,2, Sumit Shah 1, Teresa Evans 1, Hannah Coleman 1, Benjamin J Lieblong 1, Horace J Spencer 3, Charles M Quick 1, Toshiyuki Sasagawa 2, Owen W Stephens 4, Erich Peterson 4, Donald Johann Jr 5, Yong-Chen Lu 1, Mayumi Nakagawa 1; 1 Department of Pathology, University of Arkansas for Medical Sciences, Little Rock, AR, United States. 2 Department of Obstetrics and Gynecology, Kanazawa Medical University, Uchinada, Japan. 3 Department of Biostatistics, University of Arkansas for Medical Sciences, Little Rock, AR, United States. 4 Department of Biomedical Informatics, University of Arkansas for Medical Sciences, Little Rock, AR, United States. 5 Department of Internal Medicine (Hematology-Oncology Division), University of Arkansas for Medical Sciences, Little Rock, AR, United States.

A simple assay to quantify mycobacterial lipid antigen-specific T cell receptors in human tissues and blood

Zhou AX, et al.
January 2022
Authors and Affiliates
Angela X Zhou 1,2, Thomas J Scriba 3, Cheryl L Day 4, Deanna A Hagge 5, Chetan Seshadri 1,2; 1 Department of Medicine, University of Washington, Seattle, Washington, United States of America. 2 Tuberculosis Research and Training Center, University of Washington, Seattle, Washington, United States of America. 3 South African Tuberculosis Vaccine Initiative, Institute of Infectious Disease and Molecular Medicine and Division of Immunology, Department of Pathology, University of Cape Town, Cape Town, South Africa. 4 Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, Georgia, United States of America. 5 Mycobacterial Research Laboratories, Anandaban Hospital, Kathmandu, Nepal.

Identification of conserved SARS-CoV-2 spike epitopes that expand public cTfh clonotypes in mild COVID-19 patients

Lu X, et al.
November 2021
Authors and Affiliates
Xiuyuan Lu 1, Yuki Hosono 1,2,3, Masamichi Nagae 1,2, Shigenari Ishizuka 1,2, Eri Ishikawa 1,2, Daisuke Motooka 4, Yuki Ozaki 4, Nicolas Sax 5, Yuichi Maeda 3,6, Yasuhiro Kato 3,7, Takayoshi Morita 3,7, Ryo Shinnakasu 8, Takeshi Inoue 8, Taishi Onodera 9, Takayuki Matsumura 9, Masaharu Shinkai 10, Takashi Sato 10, Shota Nakamura 4, Shunsuke Mori 11,12, Teru Kanda 13, Emi E Nakayama 14, Tatsuo Shioda 14,15, Tomohiro Kurosaki 8,15,16, Kiyoshi Takeda 6,15,17, Atsushi Kumanogoh 3,7,15, Hisashi Arase 11,12,15, Hironori Nakagami 18, Kazuo Yamashita 5, Yoshimasa Takahashi 9, Sho Yamasaki 1,2,15,19,20; 1 Laboratory of Molecular Immunology, Immunology Frontier Research Center, Osaka University, Suita, Japan. 2 Department of Molecular Immunology, Research Institute for Microbial Diseases, Osaka University, Suita, Japan. 3 Department of Respiratory Medicine and Clinical Immunology, Graduate School of Medicine, Osaka University, Suita, Japan. 4 Department of Infection Metagenomics, Genome Information Research Center, Research Institute for Microbial Diseases, Osaka University, Suita, Japan. 5 KOTAI Biotechnologies, Inc., Suita, Japan. 6 Laboratory of Immune Regulation, Department of Microbiology and Immunology, Graduate School of Medicine, Osaka University, Suita, Japan. 7 Department of Immunopathology, Immunology Frontier Research Center, Osaka University, Suita, Japan. 8 Laboratory of Lymphocyte Differentiation, Immunology Frontier Research Center, Osaka University, Suita, Japan. 9 Research Center for Drug and Vaccine Development, National Institute of Infectious Diseases, Tokyo, Japan. 10 Tokyo Shinagawa Hospital, Tokyo, Japan. 11 Department of Immunochemistry, Research Institute for Microbial Diseases, Osaka University, Suita, Japan. 12 Laboratory of Immunochemistry, Immunology Frontier Research Center, Osaka University, Suita, Japan. 13 Division of Microbiology, Faculty of Medicine, Tohoku Medical and Pharmaceutical University, Sendai, Japan. 14 Department of Viral Infections, Research Institute for Microbial Diseases, Osaka University, Suita, Japan. 15 Center for Infectious Disease Education and Research, Osaka University, Suita, Japan. 16 Laboratory of Lymphocyte Differentiation, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan. 17 Department of Mucosal Immunology, Immunology Frontier Research Center, Osaka University, Suita, Japan. 18 Department of Health Development and Medicine, Graduate School of Medicine, Osaka University, Suita, Japan. 19 Division of Molecular Immunology, Medical Mycology Research Center, Chiba University, Chiba, Japan. 20 Division of Molecular Design, Research Center for Systems Immunology, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan.

T cell receptor repertoires as potential diagnostic markers for patients with COVID-19

Hou X, et al.
November 2021
Authors and Affiliates
Xianliang Hou 1, Wentao Fan 2, Guangyu Wang 3, Xiaoyan Chen 4, Chune Mo 1, Yongsi Wang 2, Weiwei Gong 1, Xuyan Wen 5, Hui Chen 2, Dan He 2, Lijun Mo 6, Shaofeng Jiang 7, Minglin Ou 8, Haonan Guo 9, Hongbo Liu 10; 1 Central Laboratory, Guangxi Health Commission Key Laboratory of Glucose and Lipid Metabolism Disorders, the Second Affiliated Hospital of Guilin Medical University, Guilin, 541199, China. 2 Guangzhou Huayin Health Medical Group Co., Ltd (Guangzhou, China). 3 College of Laboratory Medicine, Guilin Medical University, Guilin, 541199, China. 4 Department of State owned Assets Management, Affiliated Hospital of Guilin Medical University, Guilin, 541001, China. 5 Department of pathology, Affiliated Hospital of Guilin Medical University, Guilin, 541001. 6 Clinical Laboratory, the Second Affiliated Hospital of Guilin Medical University, Guilin, 541199. 7 Guangxi Key Laboratory of Tumor Immunology and Microenvironmental Regulation, Guilin Medical University, Guilin, Guangxi, 541199, China. 8 Central Laboratory, Guangxi Health Commission Key Laboratory of Glucose and Lipid Metabolism Disorders, the Second Affiliated Hospital of Guilin Medical University, Guilin, 541199, China. Electronic address: minglinou@glmc.edu.cn. 9 Department of Clinical Laboratory, The Affiliated Hospital of Guilin Medical University, Guilin, Guangxi, 541001, China. Electronic address: guohaonan@glmc.edu.cn. 10 Department of Laboratory Medicine, the Second Affiliated Hospital of Guilin Medical University, Guilin, 541199, China. Electronic address: hbliu@glmc.edu.cn.