Therapeutic Area: Infectious Disease

Antibody and T-cell responses by ultra-deep T-cell receptor immunosequencing after COVID-19

Chung A, et al.
British Journal of Haematology
September 2022
Authors and Affiliates
Alfred Chung 1, Barbara Banbury 2, Marissa Vignali 2, Chiung-Yu Huang 3, Sireesha Asoori 1, Rachel Johnson 4, Theodore Kurtz 5, Shagun Arora 1, Sandy W Wong 1, Nina Shah 1, Thomas G Martin 1, Jeffrey L Wolf 1; 1 Division of Hematology/Oncology, University of California San Francisco, San Francisco, California, USA. 2 Adaptive Biotechnologies Corp, Seattle, Washington, USA. 3 Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, California, USA. 4 American University of the Caribbean School of Medicine, St. Maarten. 5 Department of Laboratory Medicine, University of California San Francisco, San Francisco, California, USA.

SARS-CoV-2-specific T cell responses in patients with multisystem inflammatory syndrome in children

Lam KP, et al.
Clinical Immunology
September 2022
immuneAccess
Authors and Affiliates
Ki Pui Lam 1, Marcos Chiñas 2, Amélie M Julé 3, Maria Taylor 1, Marina Ohashi 4, Mehdi Benamar 1, Elena Crestani 1, Mary Beth F Son 1, Janet Chou 1, Catherine Gebhart 4, Talal Chatila 1, Jane Newburger 5, Adrienne Randolph 6, Maria Gutierrez-Arcelus 2, Lauren A Henderson 7; 1 Division of Immunology, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, USA. 2 Division of Immunology, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA. 3 Division of Immunology, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, USA; Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA. 4 HLA-Lab, American Red Cross, Dedham, MA, USA. 5 Department of Cardiology, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, USA. 6 Division of Critical Care Medicine, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, USA. 7 Division of Immunology, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, USA. Electronic address: lauren.henderson@childrens.harvard.edu.

CTL Clonotypes with Higher TCR Affinity Have Better Ability to Reduce the HIV Latent Reservoir

Lima NS, et al.
Journal of Immunology
August 2022
Authors and Affiliates
Noemia S Lima 1,2,3, Hiroshi Takata 1,2,4, Szu-Han Huang 5,6, Alexander Haregot 1,2, Julie Mitchell 1,2,4, Stephen Blackmore 1,2, Ayanna Garland 1,2, Aaron Sy 1,2, Pearline Cartwright 7, Jean-Pierre Routy 8, Nelson L Michael 1, Victor Appay 9,10, R Brad Jones 5,6, Lydie Trautmann 11,2,4; 1 U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD 20910. 2 Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD 20817. 3 Human Immunology Section, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20814. 4 Vaccine and Gene Therapy Institute, Oregon Health & Science University, Beaverton, OR 97006. 5 Department of Medicine, Division of Infectious Diseases, Weill Cornell Medicine, New York, NY 10021. 6 Department of Microbiology, Immunology, and Tropical Medicine, George Washington University School of Medicine and Health Sciences, Washington, DC 20037. 7 Vaccine and Gene Therapy Institute-Florida, Port St. Lucie, FL 34987. 8 Division of Hematology and Chronic Viral Illness Service, McGill University, Montreal, Quebec H3A 0G4, Canada. 9 Centre d'Immunologie et des Maladies Infectieuses, Sorbonne Université, INSERM, Paris 75005, France; and. 10 International Research Center of Medical Sciences, Kumamoto University, Kumamoto 860-8555, Japan. 11 U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD 20910; trautmly@ohsu.edu.

Comprehensive mapping of immune perturbations associated with severe COVID-19

Kuri-Cervantes L, et al.
Science Immunology
August 2022
Authors and Affiliates
Leticia Kuri-Cervantes #,1,2, M Betina Pampena #,1,2, Wenzhao Meng 3, Aaron M Rosenfeld 3, Caroline A G Ittner 4, Ariel R Weisman 4, Roseline S Agyekum 4, Divij Mathew 1,5, Amy E Baxter 1,5, Laura A Vella 2,6, Oliva Kuthuru 2,5, Sokratis A Apostolidis 2,5,7, Luanne Bershaw 2,5, Jeanette Dougherty 2,5, Allison R Greenplate 2,5, Ajinkya Pattekar 2,8, Justin Kim 2,5, Nicholas Han 2,5, Sigrid Gouma 1,2, Madison E Weirick 1,2, Claudia P Arevalo 1,2, Marcus J Bolton 1,2, Eileen C Goodwin 1,2, Elizabeth M Anderson 1,2, Scott E Hensley 1,2, Tiffanie K Jones 4, Nilam S Mangalmurti 2,4, Eline T Luning Prak 3, E John Wherry 9,5,10, Nuala J Meyer 11, Michael R Betts 12,2; 1 Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. 2 Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. 3 Department of Pathology and Laboratory Medicine, Perelman School of Medicine, Philadelphia, PA19104, USA. 4 Division of Pulmonary, Allergy and Critical Care, Center for Translational Lung Biology, Lung Biology Institute, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA. 5 Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA. 6 Division of Infectious Diseases, Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, 19104, USA. 7 Division of Rheumatology, Department of Medicine, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania, 19104, USA. 8 Division of Gastroenterology, Department of Medicine, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania, 19104, USA. 9 Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. betts@pennmedicine.upenn.edu nuala.meyer@pennmedicine.upenn.edu wherry@pennmedicine.upenn.edu. 10 Parker Institute for Cancer Immunotherapy at the University of Pennsylvania, Philadelphia, Pennsylvania, 19104, USA. 11 Division of Pulmonary, Allergy and Critical Care, Center for Translational Lung Biology, Lung Biology Institute, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA. betts@pennmedicine.upenn.edu nuala.meyer@pennmedicine.upenn.edu wherry@pennmedicine.upenn.edu. 12 Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. betts@pennmedicine.upenn.edu nuala.meyer@pennmedicine.upenn.edu wherry@pennmedicine.upenn.edu. # Contributed equally.

Combination anti-HIV antibodies provide sustained virological suppression

Sneller MS, et al.
Nature
August 2022
Authors and Affiliates
Michael C Sneller #,1, Jana Blazkova #,1, J Shawn Justement 1, Victoria Shi 1, Brooke D Kennedy 1, Kathleen Gittens 2, Jekaterina Tolstenko 1, Genevieve McCormack 1, Emily J Whitehead 1, Rachel F Schneck 1, Michael A Proschan 3, Erika Benko 4, Colin Kovacs 4, Cihan Oguz 5,6, Michael S Seaman 7, Marina Caskey 8, Michel C Nussenzweig 8,9, Anthony S Fauci 1, Susan Moir #,1, Tae-Wook Chun #,10; 1 Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD, USA. 2 Critical Care Medicine Department, Clinical Center, NIH, Bethesda, MD, USA. 3 Biostatistics Research Branch, NIAID, NIH, Bethesda, MD, USA. 4 Maple Leaf Medical Clinic, Toronto, Ontario, Canada. 5 NIAID Collaborative Bioinformatics Resource, NIAID, NIH, Bethesda, MD, USA. 6 Advanced Biomedical Computational Science, Frederick National Laboratory for Cancer Research, Frederick, MD, USA. 7 Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA. 8 Laboratory of Molecular Immunology, The Rockefeller University, New York, NY, USA. 9 Howard Hughes Medical Institute, The Rockefeller University, New York, NY, USA. 10 Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD, USA. twchun@nih.gov. # Contributed equally.

Comprehensive analysis of TCR repertoire of COVID-19 patients in different infected stage

Wang G, et al.
Genes & Genomics
May 2022
Authors and Affiliates
Guangyu Wang #,1, Yongsi Wang #,2, Shaofeng Jiang #,3, Wentao Fan 2, Chune Mo 1, Weiwei Gong 1, Hui Chen 2, Dan He 2, Jinqing Huang 3, Minglin Ou 4,5, Xianliang Hou 6; 1 Central Laboratory, Guangxi Health Commission Key Laboratory of Glucose and Lipid Metabolism Disorders, The Second Affiliated Hospital of Guilin Medical University, Guilin, 541199, China. 2 Guangzhou Huayin Health Medical Group Co., Ltd, Guangzhou, China. 3 Guangxi Key Laboratory of Tumor Immunology and Microenvironmental Regulation, Guilin Medical University, Guilin, 541199, Guangxi, China. 4 Central Laboratory, Guangxi Health Commission Key Laboratory of Glucose and Lipid Metabolism Disorders, The Second Affiliated Hospital of Guilin Medical University, Guilin, 541199, China. minglinou@glmc.edu.cn. 5 Guangxi Key Laboratory of Tumor Immunology and Microenvironmental Regulation, Guilin Medical University, Guilin, 541199, Guangxi, China. minglinou@glmc.edu.cn. 6 Central Laboratory, Guangxi Health Commission Key Laboratory of Glucose and Lipid Metabolism Disorders, The Second Affiliated Hospital of Guilin Medical University, Guilin, 541199, China. houxianliang@zju.edu.cn. # Contributed equally.

Serial Analysis of the T-Cell Receptor β-Chain Repertoire in People Living With HIV Reveals Incomplete Recovery After Long-Term Antiretroviral Therapy

Towlerton AMH, et al.
Frontiers in Immunology
May 2022
Authors and Affiliates
Andrea M H Towlerton 1, Shashidhar Ravishankar 1, David G Coffey 1,2,3, Camille E Puronen 1,2, Edus H Warren 1,2; 1 Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA, United States. 2 Division of Medical Oncology, University of Washington, Seattle, WA, United States. 3 Division of Hematology, University of Miami, Miami, FL, United States.

Longitudinal analysis of T-cell receptor repertoires reveals shared patterns of antigen-specific response to SARS-CoV-2 infection

Gittelman RM, et al.
JCI Insight
May 2022
immuneAccess
Authors and Affiliates
Rachel M Gittelman 1, Enrico Lavezzo 2, Thomas M Snyder 1, H Jabran Zahid 3, Cara L Carty 1, Rebecca Elyanow 1, Sudeb C Dalai 1, Ilan Kirsch 1, Lance Baldo 1, Laura Manuto 2, Elisa Franchin 2, Claudia Del Vecchio 2, Monia Pacenti 4, Caterina Boldrin 4, Margherita Cattai 4, Francesca Saluzzo 5, Andrea Padoan 6, Mario Plebani 6, Fabio Simeoni 7, Jessica Bordini 8, Nicola I Lorè 5, Dejan Lazarević 7, Daniela Maria Cirillo 5, Paolo Ghia 9, Stefano Toppo 2, Jonathan M Carlson 3, Harlan S Robins 1, Andrea Crisanti 10, Giovanni Tonon 7; 1 Computational Biology, Adaptive Biotechnologies, Seattle, United States of America. 2 Department of Molecular Medicine, University of Padova, Padua, Italy. 3 eScieince Group, Microsoft Research, Redmond, United States of America. 4 Azienda Ospedale Padova, Microbiology and Virology Unit, Azienda Ospedale Padova, Microbiology and Virology Unit, Padua, Italy. 5 Division of Immunology, Transplantation and Infectious Disease, IRCCS San Raffaele Scientific Institute, Milan, Italy. 6 Department of Medicine, University of Padova, Padua, Italy. 7 Center for Omics Sciences, COSR, IRCCS San Raffaele Scientific Institute, Milan, Italy. 8 Division of Experimental Oncology, IRCCS San Raffaele Scientific Institute, Milan, Italy. 9 Division of Molecular Oncology, Università Vita-Salute San Raffaele, Milan, Italy. 10 Department of Life Sciences, Imperial College London, London, United Kingdom.

Lack of association between pandemic chilblains and SARS-CoV-2 infection

Gehlhausen JR, et al.
PNAS
March 2022
Authors and Affiliates
Jeff R Gehlhausen 1, Alicia J Little 1, Christine J Ko 1,2, Marc Emmenegger 3, Carolina Lucas 4, Patrick Wong 4, Jon Klein 4, Peiwen Lu 4, Tianyang Mao 4, Jillian Jaycox 4, Eric Wang 4, Yale IMPACT Team; Nelson Ugwu 1, Cate Muenker 5, Dilgash Mekael 1, Rhonda Q Klein 1,6, Robert Patrignelli 7, Richard Antaya 1, Jennifer McNiff 1,2, William Damsky 1,2, Kathy Kamath 8, John Shon 8, Aaron M Ring 4, Inci Yildirim 5,9,10, Saad Omer 5,9,11, Albert I Ko 5,11, Adriano Aguzzi 3, Akiko Iwasaki 12,4,13,14; 1 Yale Department of Dermatology, Yale University, New Haven, CT 06510. 2 Yale Department of Pathology, Yale University, New Haven, CT 06510. 3 Institute of Neuropathology, University Hospital of Zürich, 8091 Zürich, Switzerland. 4 Yale Department of Immunobiology, Yale University, New Haven, CT 06510. 5 Department of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, CT 06510. 6 Modern Dermatology, Westport, CT 06880. 7 Patrignelli Dermatology Private Practice, Trumbull, CT 06611. 8 Serimmune, Inc., Santa Barbara, CA 93117. 9 Yale Institute for Global Health, Yale University, New Haven, CT 06510. 10 Department of Pediatrics, Section of Infectious Diseases, Yale University School of Medicine, New Haven, CT 06510. 11 Yale Department Medicine, Section of Infectious Diseases, Yale University, New Haven, CT 06510. 12 Yale Department of Dermatology, Yale University, New Haven, CT 06510; akiko.iwasaki@yale.edu. 13 Department of Molecular Cellular and Developmental Biology, Yale University, New Haven, CT 06510. 14 HHMI, Chevy Chase, MD 20815.