Therapeutic Area: Infectious Disease
Bivalent intra-spike binding provides durability against emergent Omicron lineages: Results from a global consortium
Callaway HM, et al.
February 2023
Authors and Affiliates
Heather M. Callaway 1, Kathryn M. Hastie 1, Sharon L. Schendel 1, Haoyang Li 1, Xiaoying Yu 1, Jeremy Shek 1, Tierra Buck 1, Sean Hui 1, Dan Bedinger 2, Camille Troup 2, S. Moses Dennison 3, Kan Li 3, Michael D. Alpert 4, Charles C. Bailey 4, Sharon Benzeno 5, Jody L. Bonnevier 6, Jin-Qiu Chen 7, Charm Chen 7, Hyeseon Cho 8,9, Peter D. Crompton 8,9, Vincent Dussupt 10,11, Kevin C. Entzminger 12, Yassine Ezzyat 13, Jonathan K. Fleming 12, Nick Geukens 14, Amy E. Gilbert 5, Yongjun Guan 15,16, Xiaojian Han 17, Christopher J. Harvey 13,18, Julia M. Hatler 6, Bryan Howie 5, Chao Hu 17, Ailong Huang 19, Maya Imbrechts 14, Aishun Jin 17, Nik Kamachi 7, Gladys Keitany 5, Mark Klinger 5, Jay K. Kolls 20, Shelly J. Krebs 10,11, Tingting Li 17, Feiyan Luo 17, Toshiaki Maruyama 12, Michael A. Meehl 13, Letzibeth Mendez-Rivera 10,11, Andrea Musa 5, C.J. Okumura 12, Benjamin E.R. Rubin 5, Aaron K. Sato 21, Meiying Shen 22, Anirudh Singh 13, Shuyi Song 17, Joshua Tan 8, Jeffrey M. Trimarchi 4,23, Dhruvkumar P. Upadhyay 13,24, Yingming Wang 17, Lei Yu 25, Tom Z. Yuan 21, Erik Yusko 5, Bjoern Peters 1,26, Georgia Tomaras 3 and Erica Ollmann Saphire 1,26,27∗;
1 Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, La Jolla, CA 92037, USA
2 Carterra, 825 N. 300 W. Ste. C309, Salt Lake City, UT 84103, USA
3 Center for Human Systems Immunology, Departments of Surgery, Immunology, and Molecular Genetics and Microbiology and Duke Human Vaccine Institute, Duke University, Durham, NC 27701, USA
4 Emmune, Inc., 14155 US Highway 1, Juno Beach, FL 33408, USA
5 Adaptive Biotechnologies, 1551 Eastlake Ave East, Seattle, WA 98102, USA
6 Bio-techne, 614 McKinley Place NE, Minneapolis, MN 55413, USA
7 ACRO Biosystems, 1 Innovation Way, Newark, DE 19711, USA
8 Antibody Biology Unit, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852, USA
9 Malaria Infection Biology and Immunity Section, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852, USA
10 Emerging Infectious Diseases Branch, Walter Reed Army Institute of Research, Silver Spring, MD, USA
11 Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD, USA
12 Abwiz Bio, Inc., 9823 Pacific Heights Blvd. Suite J, San Diego, CA 92121, USA
13 Jounce Therapeutics, Inc., 780 Memorial Drive, Cambridge, MA 02139, USA
14 PharmAbs, The KU Leuven Antibody Center, KU Leuven, 3000 Leuven, Belgium
15 Antibody BioPharm, Inc., 401 Professional Dr Ste 241, Gaithersburg, MD 20879, USA
16 Shanghai Life Technology Co., Ltd., 781 Cai Lun Rd, Ste 801, Pudong, Shanghai 201203, China
17 Department of Immunology, College of Basic Medicine, Chongqing Medical University, Chongqing 400010, China
18 Phenomic AI, 661 University Avenue, Suite 1300 MaRS Centre, West Tower, Toronto, ON M5G 0B7, Canada
19 Key Laboratory of Molecular Biology for Infectious Diseases (Ministry of Education), Institute for Viral Hepatitis, Department of Infectious Diseases, The Second Affiliated Hospital, Chongqing Medical University, Chongqing 400010, China
20 Tulane School of Medicine, Center for Translational Research in Infection and Inflammation, New Orleans, LA 70112, USA
21 Twist Bioscience, 681 Gateway Blvd., South San Francisco, CA 94080, USA
22 Department of Endocrine Breast Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400010, China
23 Department of Biological Sciences, Lehigh University, 111 Research Drive, Bethlehem, PA 18015, USA
24 Amgen, Inc., 360 Binney St., Cambridge, MA 02141, USA
25 Guangzhou Eighth People’s Hospital & Guangzhou Medical University, Guangzhou 510060, China
26 Department of Medicine, University of California San Diego, La Jolla, CA 92039, USA
Erica Ollmann Saphire: gro.ijl@acire
∗Corresponding author gro.ijl@acire
27 Lead contact
Impaired SARS-CoV-2 variant neutralization and CD8+ T cell responses following 3 doses of mRNA vaccines in myeloma: correlation with breakthrough infections
Authors and Affiliates
Maryam I Azeem 1, Ajay K Nooka 2, Uma Shanmugasundaram 1, Narayanaiah Cheedarla 1, Sayalee Potdar 3, Renee Julia Manalo 3, Alberto Moreno 3, Jeffrey M Switchenko 3, Suneethamma Cheedarla 4, Deon Bryant Doxie 5, Roman Radzievski 3, Madison Leigh Ellis 3, Kelly E Manning 3, Bushra Wali 3, Rajesh M Valanparambil 2, Kathryn T Maples 3, Essence Baymon 3, Jonathan L Kaufman 6, Craig C Hofmeister 2, Nisha S Joseph 3, Sagar Lonial 7, John D Roback 3, Alessandro Sette 8, Rafi Ahmed 2, Mehul S Suthar 2, Andrew S Neish 3, Madhav V Dhodapkar 3, Kavita M Dhodapkar 9;
1 Emory University, Atlanta, Georgia, United States.
2 Emory University School of Medicine, Atlanta, GA, United States.
3 Emory University, Atlanta, GA, United States.
4 Emory University, ATLANTA, GA, United States.
5 Vanderbilt University, Atlanta, Georgia, United States.
6 Emory U. Sch. of Med., Atlanta, Ga, United States.
7 Winship Cancer Institute, Emory University, Atlanta, GA, United States.
8 La Jolla Institute for Immunology, La Jolla, CA, United States.
9 Emory University, United States.
T cell repertoire profiling in allografts and native tissues in recipients with COVID-19 after solid organ transplantation: Insight into T cell-mediated allograft protection from viral infection
Authors and Affiliates
Jianing Fu 1, Dylan Rust 2, Zhou Fang 1, Wenyu Jiao 1, Stephen Lagana 3, Ibrahim Batal 3, Bryan Chen 1, Sarah Merl 1,3, Rebecca Jones 1, Megan Sykes 1,4,5, Joshua Weiner 1,5.
1 Columbia Center for Translational Immunology, Department of Medicine, Columbia University, New York, NY, United States.
2 Columbia University Vagelos College of Physicians and Surgeons, New York, NY, United States.
3 Department of Pathology, Columbia University, New York, NY, United States.
4 Department of Microbiology and Immunology, Columbia University, New York, NY, United States.
5 Department of Surgery, Columbia University, New York, NY, United States.
Durable immune responses after BNT162b2 vaccination in home-dwelling old adults
Lena Hansen et al.
January 2023
Authors and Affiliates
Lena Hansen 1, Karl Albert Brokstad 1 2, Amit Bansal 1, Fan Zhou 1, Geir Bredholt 3, Therese Bredholt Onyango 1, Helene Heitmann Sandnes 3, Rebecca Elyanow 4, Anders Madsen 1, Mai-Chi Trieu 1, Marianne Sævik 5, Hanne Søyland 5, Jan Stefan Olofsson 1, Juha Vahokoski 1, Nina Urke Ertesvåg 1, Elisabeth Berg Fjelltveit 1, Shahin Shafiani 4, Camilla Tøndel 3 6 7, Heidi Chapman 4, Ian Kaplan 4, Kristin G I Mohn 1 5, Nina Langeland 3 5 8, Rebecca Jane Cox 1 9.
1 Influenza Centre, Department of Clinical Science, University of Bergen, Bergen, Norway.
2 Department of Safety, Chemistry and Biomedical Laboratory Sciences, Western Norway University of Applied Sciences, Bergen, Norway.
3 Department of Clinical Science, University of Bergen, Bergen, Norway.
4 Adaptive Biotechnologies, Seattle, WA, USA.
5 Department of Medicine, Haukeland University Hospital, Bergen, Norway.
6 Department of Pediatrics, Haukeland University Hospital, Bergen, Norway.
7 Department of Research and Innovation, Haukeland University Hospital, Bergen, Norway.
8 National Advisory Unit for Tropical Infectious Diseases, Haukeland University Hospital, Bergen, Norway.
9 Department of Microbiology, Haukeland University Hospital, Bergen, Norway.
Cross-reactivity of SARS-CoV-2- and influenza A-specific T cells in individuals exposed to SARS-CoV-2
Chaisawangwong W, et al.
JCI Insight
November 2022
Authors and Affiliates
Worarat Chaisawangwong 1, Hanzhi Wang 2, Theodore Kouo 3, Sebastian F Salathe 1, Ariel Isser 4,5, Joan Glick Bieler 1, Maya L Zhang 2, Natalie K Livingston 4, Shuyi Li 1, Joseph J Horowitz 6, Ron E Samet 7, Israel Zyskind 8, Avi Z Rosenberg 1, Jonathan P Schneck 1,4,5,9,10;
1 Department of Pathology, School of Medicine.
2 Department of Biomedical Engineering, Whiting School of Engineering.
3 Department of Pediatrics, Division of Emergency Medicine.
4 Department of Biomedical Engineering, School of Medicine, and.
5 Institute for Cell Engineering, School of Medicine, Johns Hopkins University, Baltimore, Maryland, USA.
6 ExpressCare Urgent Care, Bel Air, Maryland, USA.
7 Department of Anesthesiology, University of Maryland School of Medicine, Baltimore, Maryland, USA.
8 Department of Pediatrics, NYU Langone Medical Center, New York, New York, USA; Maimonides Medical Center, New York, New York, USA.
9 Institute for Nanobiotechnology and.
10 Department of Medicine, School of Medicine, Johns Hopkins University, Baltimore, Maryland, USA.
The effect of induction immunosuppression for kidney transplant on the latent HIV reservoir
Benner SE, et al.
JCI Insight
November 2022
Authors and Affiliates
Sarah E Benner 1, Yolanda Eby 1, Xianming Zhu 1, Reinaldo E Fernandez 2, Eshan U Patel 1,3, Jessica E Ruff 1, Feben Habtehyimer 2, Haley A Schmidt 1, Charles S Kirby 1, Sarah Hussain 2, Darin Ostrander 2, Niraj M Desai 4, Sander Florman 5, Meenakshi M Rana 6, Rachel Friedman-Moraco 7, Marcus R Pereira 8, Shikha Mehta 9, Peter Stock 10, Alexander Gilbert 11, Michele I Morris 12, Valentina Stosor 13, Sapna A Mehta 14, Catherine B Small 15, Karthik Ranganna 16, Carlos Aq Santos 17, Saima Aslam 18, Jennifer Husson 19, Maricar Malinis 20, Nahel Elias 21, Emily A Blumberg 22, Brianna L Doby 23,24, Allan B Massie 14, Melissa L Smith 25, Jonah Odim 26, Thomas C Quinn 2,26, Gregory M Laird 27, Robert F Siliciano 2, Dorry L Segev 4,14, Andrew D Redd 2,26, Christine M Durand 2, Aaron Ar Tobian 1;
1 Department of Pathology and.
2 Department of Medicine, Division of Infectious Diseases, Johns Hopkins School of Medicine, Baltimore, Maryland, USA.
3 Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.
4 Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
5 Recanati/Miller Transplantation Institute and.
6 Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
7 Department of Medicine, Emory University, Atlanta, Georgia, USA.
8 Department of Medicine, Columbia University Irving Medical Center, New York, New York, USA.
9 Department of Medicine, University of Alabama Heersink School of Medicine, Birmingham, Alabama, USA.
10 Department of Surgery, University of California, San Francisco, San Francisco, California, USA.
11 Medstar Transplant Institute, Georgetown University School of Medicine, Washington, DC, USA.
12 Department of Medicine, Division of Infectious Diseases, University of Miami Miller School of Medicine, Miami, Florida, USA.
13 Departments of Medicine and Surgery, Divisions of Infectious Diseases and Organ Transplantation, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.
14 Department of Surgery, New York University Grossman School of Medicine, NYU Langone Health, New York, New York, USA.
15 Department of Medicine, Division of Infectious Diseases, Weill Cornell Medicine, New York, New York, USA.
16 Department of Medicine, Drexel University, Philadelphia, Pennsylvania, USA.
17 Divison of Infectious Diseases, Rush University Medical Center, Chicago, Illinois, USA.
18 Department of Medicine, University of California, San Diego, San Diego, California, USA.
19 Institute of Human Virology, University of Maryland School of Medicine, Baltimore, Maryland, USA.
20 Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, USA.
21 Department of Surgery and Transplant Center, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA.
22 Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.
23 Positive Rhetoric LLC, Bowling Green, Kentucky, USA.
24 Department of Public Health Sciences, College of Health, Education, and Social Transformation, New Mexico State University, Las Cruces, New Mexico, USA.
25 Department of Biochemistry and Molecular Genetics, University of Louisville, Louisville, Kentucky, USA.
26 Division of Intramural Research, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, Maryland, USA.
27 AccelevirDx, Baltimore, Maryland, USA.
Distorted TCR repertoires define multisystem inflammatory syndrome in children
Malik A, et al.
PLOS ONE
November 2022
Authors and Affiliates
Amna Malik 1, Eszter N Tóth 2, Michelle S Teng 2, Jacob Hurst 2, Eleanor Watt 3, Lauren Wise 4, Natalie Kent 4, Jack Bartram 5, Louis Grandjean 6, Margarita Dominguez-Villar 7, Stuart Adams 4, Nichola Cooper 1;
1Department of Immunology and Inflammation, Centre for Haematology, Imperial College London, London, United Kingdom.
2Etcembly Ltd, Magdalen Centre, Robert Robinson Way, Oxford, United Kingdom.
3Molecular and Cellular Immunology Department, UCL Great Ormond Street Institute of Child Health, London, United Kingdom.
4SIHMDS-Haematology, Great Ormond Street Hospital for Children, London, United Kingdom.
5Department of Haematology, Great Ormond Street Hospital for Children, London, United Kingdom.
6Paediatric Infectious Diseases, Great Ormond Street Hospital for Children, London, United Kingdom.
7Department of Infectious Diseases, Imperial College London, London, United Kingdom.
Selective retention of virus-specific tissue-resident T cells in healed skin after recovery from herpes zoster
Authors and Affiliates
Kerry J Laing 1, Werner J D Ouwendijk 2, Victoria L Campbell 3, Christopher L McClurkan 3, Shahin Mortazavi 3, Michael Elder Waters 3, Maxwell P Krist 3, Richard Tu 3, Nhi Nguyen 3, Krithi Basu 3, Congrong Miao 4, D Scott Schmid 4, Christine Johnston 3,5, Georges M G M Verjans 2, David M Koelle 3,5,6,7,8;
1 Department of Medicine, University of Washington, Seattle, WA, USA. laingk@uw.edu.
2 HerpeslabNL of the Department of Viroscience, Erasmus Medical Center, Rotterdam, The Netherlands.
3 Department of Medicine, University of Washington, Seattle, WA, USA.
4 Centers for Disease Control and Prevention, Division of Viral Diseases, Atlanta, GA, USA.
5 Vaccine and Infectious Diseases Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.
6 Department of Laboratory Medicine and Pathology, University of Washington, Seattle, WA, USA.
7 Department of Global Health, University of Washington, Seattle, WA, USA.
8 Department of Translational Research, Benaroya Research Institute, Seattle, WA, USA.
Humoral and Cellular Immune Response to Covid-19 Vaccination in Patients with Chronic Graft-versus-Host Disease on Immunosuppression
Manjappa S, et al.
September 2022
Authors and Affiliates
Shivaprasad Manjappa 1, Huy Q Phi 2, Lik Wee Lee 3, Lynn Onstad 2, Darcy B Gill 3, Laura Connelly-Smith 1, Elizabeth F Krakow 1, Mary E Flowers 1, Paul A Carpenter 4, Joshua A Hill 5, Stephanie J Lee 6;
1 Clinical Research Division, Fred Hutchinson Cancer Center, Seattle, WA; Department of Medicine, University of Washington, Seattle, WA.
2 Clinical Research Division, Fred Hutchinson Cancer Center, Seattle, WA.
3 Adaptive Biotechnologies, Seattle, WA.
4 Clinical Research Division, Fred Hutchinson Cancer Center, Seattle, WA; Department of Pediatrics, University of Washington, Seattle, WA.
5 Clinical Research Division, Fred Hutchinson Cancer Center, Seattle, WA; Department of Medicine, University of Washington, Seattle, WA; Vaccine and Infectious Diseases Division, Fred Hutchinson Cancer Center, Seattle, WA.
6 Clinical Research Division, Fred Hutchinson Cancer Center, Seattle, WA; Department of Medicine, University of Washington, Seattle, WA. Electronic address: sjlee@fredhutch.org.