Therapeutic Area: Infectious Disease

Longitudinal change trend of the TCR repertoire reveals the immune response intensity of the inactivated COVID-19 vaccine

Ren C, et al.
Molecular Immunology
October 2023
Authors and Affiliates
Chengsi Ren 1, Ruili Ji 2, Yizhe Li 3, Jinyong He 4, Wei Hu 4, Xiangyun Teng 5, Jiahui Gao 4, Yue Wu 4, Jianhua Xu 6; 1 Department of Laboratory Medicine, Shunde Hospital of Guangzhou University of Chinese Medicine, Foshan, China. Electronic address: zyyrcs@163.com. 2 Department of Laboratory Medicine, Shunde Hospital of Guangzhou University of Chinese Medicine, Foshan, China. Electronic address: jiruili0302@163.com. 3 West China TianFu Hospital,Sichuan University, Chengdu, China. Electronic address: liyizhe1203@163.com. 4 Department of Laboratory Medicine, Shunde Hospital of Guangzhou University of Chinese Medicine, Foshan, China. 5 Medical Laboratory Center, Maoming Hospital of Guangzhou University of Chinese Medicine, Maoming, China; Translational Medicine Research Center, Maoming Hospital of Guangzhou University of Chinese Medicine, Maoming, China. 6 Department of Laboratory Medicine, Shunde Hospital of Guangzhou University of Chinese Medicine, Foshan, China; Medical Laboratory Center, Maoming Hospital of Guangzhou University of Chinese Medicine, Maoming, China; Translational Medicine Research Center, Maoming Hospital of Guangzhou University of Chinese Medicine, Maoming, China. Electronic address: jhxu1976@gzucm.edu.cn.

HLA variants and TCR diversity against SARS-CoV-2 in the pre-COVID-19 era

Buhler S, et al.
HLA
August 2023
Authors and Affiliates
Stéphane Buhler 1, Zuleika Calderin Sollet 1, Florence Bettens 1, Antonia Schäfer 1, Marc Ansari 2,3, Sylvie Ferrari-Lacraz 1, Jean Villard 1; 1 Transplantation Immunology Unit and National Reference Laboratory for Histocompatibility, Department of Diagnostic, Geneva University Hospitals, Geneva, Switzerland. 2 CANSEARCH Research Platform for Pediatric Oncology and Hematology, Faculty of Medicine, Department of Pediatrics, Gynecology and Obstetrics, University of Geneva, Geneva, Switzerland. 3 Division of Pediatric Oncology and Hematology, Department of Women, Child and Adolescent, University Geneva Hospitals, Geneva, Switzerland.

COVID-19 vaccination produces exercise-responsive SARS-CoV-2-specific T-cells regardless of infection history

Smith KA, et al.
Journal of Health and Sports Science
August 2023
Authors and Affiliates
Kyle A Smith 1, Tiffany M Zúñiga 1, Forrest L Baker 2, Helena Batatinha 1, Charles R Pedlar 3, Shane C Burgess 4, Michael P Gustafson 5, Emmanuel Katsanis 6, Richard J Simpson 7; 1 School of Nutritional Sciences and Wellness, The University of Arizona, Tucson, AZ 85721, USA. 2 School of Nutritional Sciences and Wellness, The University of Arizona, Tucson, AZ 85721, USA; Department of Pediatrics, The University of Arizona, Tucson, AZ 85724, USA. 3 Faculty of Sport, Allied Health and Performance Science, St. Mary's University, Twickenham TW1 4SX, UK; Institute of Sport Exercise and Health, University College London, London WC1E 7HU, UK. 4 Department of Animal and Comparative Biomedical Sciences, The University of Arizona, Tucson, AZ 85721, USA; The University of Arizona Cancer Center, The University of Arizona, Tucson, AZ 85719, USA. 5 Laboratory Medicine and Pathology, Mayo Clinic Arizona, Phoenix, AZ 85054, USA. 6 Department of Pediatrics, The University of Arizona, Tucson, AZ 85724, USA; The University of Arizona Cancer Center, The University of Arizona, Tucson, AZ 85719, USA; Department of Immunobiology, The University of Arizona, Tucson, AZ 85724, USA; Department of Medicine, The University of Arizona, Tucson, AZ 85724, USA; Department of Pathology, The University of Arizona, Tucson, AZ 85724, USA. 7 School of Nutritional Sciences and Wellness, The University of Arizona, Tucson, AZ 85721, USA; Department of Pediatrics, The University of Arizona, Tucson, AZ 85724, USA; Department of Immunobiology, The University of Arizona, Tucson, AZ 85724, USA; Department of Medicine, The University of Arizona, Tucson, AZ 85724, USA. Electronic address: rjsimpson@arizona.edu.

GRT-R910: a self-amplifying mRNA SARS-CoV-2 vaccine boosts immunity for ≥6 months in previously-vaccinated older adults

Palmer CD, et al.
Nature Communications
August 2023
Authors and Affiliates
Christine D Palmer 1, Ciaran D Scallan 1, Lauren D Kraemer Tardif 1, Melissa A Kachura 1, Amy R Rappaport 1, Daniel O Koralek 1, Alison Uriel 2, Leonid Gitlin 1, Joshua Klein 1, Matthew J Davis 1, Harshni Venkatraman 1, Meghan G Hart 1, Jason R Jaroslavsky 1, Sonia Kounlavouth 1, Martina Marrali 1, Charmaine N Nganje 1, Kyounghwa Bae 1, Tiffany Yan 1, Katharyn Leodones 1, Milana Egorova 1, Sue-Jean Hong 1, Jenchun Kuan 1, Silvia Grappi 3, Pedro Garbes 1, Karin Jooss 4, Andrew Ustianowski 2; 1 Gritstone bio, Inc., Emeryville, CA, USA. 2 North Manchester General Hospital & University of Manchester, Manchester, UK. 3 VisMederi Srl., Siena, Italy. 4 Gritstone bio, Inc., Emeryville, CA, USA. kjooss@gritstone.com.

Achievement of operational tolerance in a pediatric liver transplant recipient following successful hematopoietic stem cell transplantation from a different donor

Algeri M, et al.
American Journal of Transplantation
August 2023
Authors and Affiliates
Mattia Algeri 1, Enrico Velardi 1, Marco Spada 2, Federica Galaverna 1, Roberto Carta 1, Luciana Vinti 1, Giuseppe Palumbo 3, Stefania Gaspari 1, Andrea Pietrobattista 4, Emilia Boccieri 1, Marco Becilli 1, Paola Francalanci 5, Valentina Bertaina 1, Pietro Merli 1, Franco Locatelli 6; 1 Department of Pediatric Hematology and Oncology,Cell and Gene Therapy,Bambino Gesù Children's Hospital,IRCCS,Rome,Italy. 2 Hepatobiliopancreatic Surgery, Liver and Kidney Transplantation Unit, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy. 3 Department of Pediatric Hematology and Oncology,Cell and Gene Therapy,Bambino Gesù Children's Hospital,IRCCS,Rome,Italy; University Department of Pediatrics, Bambino Gesù Children's Hospital, University of Rome Tor Vergata, Rome, Italy. 4 Department of Pathology, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy. 5 Hepatology and Liver Transplant Unit, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy. 6 Department of Pediatric Hematology and Oncology,Cell and Gene Therapy,Bambino Gesù Children's Hospital,IRCCS,Rome,Italy; Department of Life Sciences and Public Health, Catholic University of the Sacred Heart, Rome, Italy. Electronic address: franco.locatelli@opbg.net.

Persistent SARS-CoV-2-specific immune defects in kidney transplant recipients following third mRNA vaccine dose

Werbel WA, et al.
American Journal of Transplantation
August 2023
Authors and Affiliates
William A Werbel 1, Andrew H Karaba 2, Teresa Po-Yu Chiang 3, Allan B Massie 4, Diane M Brown 2, Natasha Watson 5, Maggie Chahoud 2, Elizabeth A Thompson 2, Aileen C Johnson 6, Robin K Avery 2, Willa V Cochran 2, Daniel Warren 3, Tao Liang 2, Miguel Fribourg 7, Christopher Huerta 8, Hady Samaha 8, Sabra L Klein 8, Maria P Bettinotti 9, William A Clarke 9, Ioannis Sitaras 10, Nadine Rouphael 8, Andrea L Cox 11, Justin R Bailey 2, Andrew Pekosz 10, Aaron A R Tobian 9, Christine M Durand 2, Nancy D Bridges 5, Christian P Larsen 6, Peter S Heeger 12, Dorry L Segev 4; CPAT investigators; 1 Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA. Electronic address: wwerbel1@jhmi.edu. 2 Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA. 3 Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA. 4 Department of Surgery, New York University Grossman School of Medicine, New York, New York, USA; Department of Population Health, New York University Grossman School of Medicine, New York, New York, USA. 5 National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA. 6 Department of Surgery, Emory University, Atlanta, Georgia, USA. 7 Translational Transplant Research Center, Icahn School of Medicine at Mount Sinai, New York, New York, USA. 8 Department of Medicine, Emory University, Atlanta, Georgia, USA. 9 Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA. 10 W. Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA. 11 Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA; Department of Medicine, Emory University, Atlanta, Georgia, USA; Bloomberg Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA. 12 Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, California, USA.

Multimodal, broadly neutralizing antibodies against SARS-CoV-2 identified by high-throughput native pairing of BCRs from bulk B cells

Keitany GJ, et al.
August 2023
Authors and Affiliates
Gladys J. Keitany,1,4 Benjamin E.R. Rubin,1,4 Meghan E. Garrett,1 Andrea Musa,1 Jeff Tracy,1 Yu Liang,1 Peter Ebert,1 Amanda J. Moore,1 Jonathan Guan,1 Erica Eggers,1 Ninnia Lescano,1 Ryan Brown,1 Adria Carbo,1 Hussein Al-Asadi,1 Travers Ching,1 Austin Day,1 Rebecca Harris,1 Charles Linkem,1 Dimitry Popov,1 Courtney Wilkins,1 Lianqu Li,2 Jiao Wang,2 Chuanxin Liu,2 Li Chen,2 Jennifer N. Dines,1 Caroline Atyeo,3 Galit Alter,3 Lance Baldo,1 Anna Sherwood,1 Bryan Howie,1 Mark Klinger,1 Erik Yusko,1 Harlan S. Robins,1 Sharon Benzeno,1 and Amy E. Gilbert1,5 1 Adaptive Biotechnologies, Seattle, WA 98109, USA 2 GenScript ProBio Biotech, Nanjing, Jiangsu Province, China 3 Ragon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA 4 These authors contributed equally 5 Lead contact

T cell immunity is key to the pandemic endgame: How to measure and monitor it

Schwarz M, et al,
April 2023
Authors and Affiliates
Megan Schwarz 1,2, Slim Mzoughi 1,2, Daniel Lozano-Ojalvo 3, Anthony T Tan 4, Antonio Bertoletti 4, Ernesto Guccione 1,2,5; 1 Department of Oncological Sciences, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, NY, USA. 2 Center for Therapeutics Discovery, Department of Oncological Sciences and Pharmacological Sciences, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, USA. 3 Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, NY, USA. 4 Programme in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore. 5 Bioinformatics for Next Generation Sequencing (BiNGS) Shared Resource Facility, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Clonally expanded HIV-1 proviruses with 5′-leader defects can give rise to nonsuppressible residual viremia

White JA, et al.
April 2023
immuneAccess
Authors and Affiliates
Jennifer A White 1, Fengting Wu 1, Saif Yasin 2, Milica Moskovljevic 1, Joseph Varriale 1, Filippo Dragoni 1, Angelica Camilo-Contreras 1, Jiayi Duan 1, Mei Y Zheng 2, Ndeh F Tadzong 2, Heer B Patel 2, Jeanelle Mae C Quiambao 2, Kyle Rhodehouse 1, Hao Zhang 3, Jun Lai 1, Subul A Beg 1, Michael Delannoy 4, Christin Kilcrease 1, Christopher J Hoffmann 1, Sébastien Poulin 5, Frédéric Chano 5, Cécile Tremblay 6,7, Jerald Cherian 1, Patricia Barditch-Crovo 1, Natasha Chida 1, Richard D Moore 1, Michael F Summers 2,8, Robert F Siliciano 1,8, Janet D Siliciano 1, Francesco R Simonetti 1; 1 Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA. 2 Department of Chemistry and Biochemistry, University of Maryland, Baltimore County, Baltimore, Maryland, USA. 3 Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA. 4 Institute for Basic Biomedical Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA. 5 Clinique L'Agora, Montreal, Canada. 6 Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CHUM), Montreal, Canada. 7 Département de Microbiologie, Immunologie et Infectiologie, Université de Montréal, Montreal, Canada. 8 Howard Hughes Medical Institute, Baltimore, Maryland, USA.

T cell receptor repertoires associated with control and disease progression following Mycobacterium tuberculosis infection

Musvosvi M, et al.
April 2023
immuneAccess
Authors and Affiliates
Munyaradzi Musvosvi #1, Huang Huang #2, Chunlin Wang 2, Qiong Xia 2, Virginie Rozot 1, Akshaya Krishnan 3, Peter Acs 3, Abhilasha Cheruku 3, Gerlinde Obermoser 3, Alasdair Leslie 4,5,6, Samuel M Behar 7, Willem A Hanekom 1,4,5, Nicole Bilek 1, Michelle Fisher 1, Stefan H E Kaufmann 8,9,10, Gerhard Walzl 11, Mark Hatherill 1, Mark M Davis #2,12,13, Thomas J Scriba #14; 1 South African Tuberculosis Vaccine Initiative, Institute of Infectious Disease and Molecular Medicine, and Division of Immunology, Department of Pathology, University of Cape Town, Cape Town, South Africa. 2 Institute for Immunity, Transplantation and Infection, Stanford University School of Medicine, Stanford, CA, USA. 3 Human Immune Monitoring Center, Stanford University, Stanford, CA, USA. 4 Africa Health Research Institute, Durban, South Africa. 5 School of Laboratory Medicine and Medical Sciences, College of Health Sciences, University of KwaZulu-Natal, Durban, South Africa. 6 Department of Infection and Immunity, University College London, London, UK. 7 Department of Microbiology and Physiological Systems, University of Massachusetts Chan Medical School, Worcester, MA, USA. 8 Max Planck Institute for Infection Biology, Berlin, Germany. 9 Max Planck Institute for Multidisciplinary Sciences, Göttingen, Germany. 10 Hagler Institute for Advanced Study, Texas A&M University, College Station, TX, USA. 11 DST-NRF Centre of Excellence for Biomedical Tuberculosis Research, South African Medical Research Council Centre for Tuberculosis Research; Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa. 12 Howard Hughes Medical Institute, Stanford University, Stanford, CA, USA. 13 Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA, USA. 14 South African Tuberculosis Vaccine Initiative, Institute of Infectious Disease and Molecular Medicine, and Division of Immunology, Department of Pathology, University of Cape Town, Cape Town, South Africa. thomas.scriba@uct.ac.za. #Contributed equally.