Therapeutic Area: Oncology

John W Mellors 1, Shuang Guo 2, Asma Naqvi 1, Leah D Brandt 1, Ling Su 2, Zhonghe Sun 2, Kevin W Joseph 1, Dimiter Demirov 2, Elias K Halvas 1, Donna Butcher 2, Beth Scott 3, Aaron Hamilton 3, Marintha Heil 3, Baktiar Karim 2, Xiaolin Wu 2, Stephen H Hughes 4; 1 Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA. 2 Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, MD, USA. 3 Roche Molecular Diagnostics, Pleasanton, CA, USA. 4 HIV Dynamics and Replication Program, CCR, National Cancer Institute, Frederick, MD, USA.

L Federico 1, D J McGrail 2, S-E Bentebibel 3, C Haymaker 4, A Ravelli 3, M-A Forget 3, T Karpinets 5, P Jiang 6, A Reuben 6, M V Negrao 6, J Li 5, R Khairullah 6, J Zhang 5, A Weissferdt 7, A A Vaporciyan 8, M B Antonoff 8, G Walsh 8, S-Y Lin 2, A Futreal 5, I Wistuba 4, J Roth 8, L A Byers 6, P-O Gaudreau 9, N Uraoka 4, A F Cruz 4, H Dejima 4, R N Lazcano 4, L M Solis 4, E R Parra 4, J J Lee 10, S Swisher 8, T Cascone 6, J V Heymach 6, J Zhang 11, B Sepesi 12, D L Gibbons 13, C Bernatchez 14; 1 Therapeutics Discovery Division. 2 Department of Systems Biology. 3 Department of Melanoma Medical Oncology. 4 Department of Translational Molecular Pathology. 5 Department of Genomic Medicine. 6 Department of Thoracic and Head & Neck Medical Oncology. 7 Department of Pathology. 8 Department of Thoracic and Cardiovascular Surgery, The University of Texas MD Anderson Cancer Center; Houston, Texas, 77030, USA. 9 Department of Oncology, Queens' University and the Canadian Cancer Trials Group; Kingston, Ontario, Canada. 10 Department of Biostatistics. 11 Department of Genomic Medicine; Department of Thoracic and Head & Neck Medical Oncology. Electronic address: jzhang20@mdanderson.org. 12 Department of Thoracic and Cardiovascular Surgery, The University of Texas MD Anderson Cancer Center; Houston, Texas, 77030, USA. Electronic address: bsepesi@mdanderson.org. 13 Department of Thoracic and Head & Neck Medical Oncology; Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center; Houston, Texas, 77030, USA. Electronic address: dlgibbon@mdanderson.org. 14 Department of Melanoma Medical Oncology. Electronic address: cbernatchez@mdanderson.org.

Adi Diab 1, Omid Hamid 2, John A Thompson 3, Willeke Ros 4, Ferry A L M Eskens 5, Toshihiko Doi 6, Siwen Hu-Lieskovan 7, Samuel J Klempner 8, Bishu Ganguly 9, Catherine Fleener 10, Xiao Wang 11, Tenshang Jo 11, Ken Liao 12, Shahram Salek-Ardakani 13, Carrie Turich Taylor 9, Jeffrey Chou 14, Anthony B El-Khoueiry 15; 1 Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center adiab@mdanderson.org. 2 Research, The Angeles Clinic and Research Institute, A Cedars-Sinai Affiliate. 3 Medicine/Medical Oncology, University of Washington. 4 Netherlands Cancer Institute. 5 Department of Medical Oncology, Erasmus MC Cancer Institute. 6 Department of Experimental Therapeutics, National Cancer Center Hospital East. 7 David Geffen School of Medicine at UCLA. 8 Oncology, Massachusetts General Hospital. 9 Pfizer Inc. 10 Translational Medicine, Xencor Inc. 11 Pfizer (United States). 12 Clinical Pharmacology, Pfizer (United States). 13 Cancer Immunology Discovery, Pfizer (United States). 14 WRDM, Pfizer (United States). 15 Division of Medical Oncology, USC Norris Comprehensive Cancer Center.

Xinjian Liu #,1,2, Xuhui Bao #,1, Mengjie Hu 1, Hanman Chang 1, Meng Jiao 1, Jin Cheng 3, Liyi Xie 4, Qian Huang 3, Fang Li 1, Chuan-Yuan Li 5,6,7; 1 Department of Dermatology, Duke University Medical Center, Durham, NC, USA. 2 Department of Biochemistry, Molecular Cancer Research Center, School of Medicine, Sun Yat-sen University, Shenzhen, Guangdong, China. 3 Molecular Diagnostic Laboratory of Cancer Center, Shanghai General Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China. 4 Department of Radiation Oncology, Fudan University Shanghai Cancer Center, Shanghai, China. 5 Department of Dermatology, Duke University Medical Center, Durham, NC, USA. Chuan.Li@duke.edu. 6 Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC, USA. Chuan.Li@duke.edu. 7 Duke Cancer Institute, Duke University Medical Center, Durham, NC, USA. Chuan.Li@duke.edu. # Contributed equally.

Sixue Liu,1,14 Hannah M. Knochelmann,2,3,14 Shirley H. Lomeli,1 Aayoung Hong,1 Mary Richardson,4 Zhentao Yang,1 Raymond J. Lim,5,6 Yan Wang,1 Camelia Dumitras,5 Kostyantyn Krysan,5,7 Cynthia Timmers,8 Martin J. Romeo,9 Carsten Krieg,10 Elizabeth C. O’Quinn,9 Joshua D. Horton,12 Steve M. Dubinett,5,6,7 Chrystal M. Paulos,3,11,15 David M. Neskey,9,12,13,15 and Roger S. Lo1,6,7,15,16,*; 1 Division of Dermatology, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA 2 Department of Microbiology and Immunology, Medical University of South Carolina, Charleston, SC 29425, USA 3 Division of Surgical Oncology, Department of Surgery, Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA 30322, USA 4 Department of Pathology, Medical University of South Carolina, Charleston, SC 29425, USA 5 Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA 6 Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA 7 Jonsson Comprehensive Cancer Center, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA 8 Incyte Pharmaceuticals, Wilmington, DE 19803, USA 9 Hollings Cancer Center, Medical University of South Carolina, Charleston, SC 29425, USA 10 Department of Immunology and Microbiology, Medical University of South Carolina, Charleston, SC 29425, USA 11 Department of Microbiology and Immunology, Emory University, Atlanta, GA 30322, USA 12 Department of Otolaryngology – Head and Neck Surgery, Medical University of South Carolina, Charleston, SC 29425, USA 13Department of Cell and Molecular Pharmacology and Experimental Therapeutics, Medical University of South Carolina, Charleston, SC 29425, USA 14 These authors contributed equally 15 Senior author 16 Lead contact * Correspondence: rlo@mednet.ucla.edu

Peter M. K. Westcott 1, Nathan J. Sacks 1, Jason M. Schenkel 1,2,3, Zackery A. Ely 1, Olivia Smith 1, Haley Hauck 1, Alex M. Jaeger 1, Daniel Zhang 1, Coralie M. Backlund 1, Mary C. Beytagh 1, J. J. Patten 1, Ryan Elbashir 1, George Eng 1,4, Darrell J. Irvine 1,5,6,7,8, Omer H. Yilmaz 1,4,9 and Tyler Jacks 1,9; 1 David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA. 2 Department of Pathology, Brigham and Women’s Hospital, Boston, MA, USA. 3 Harvard Medical School, Boston, MA, USA. 4 Department of Pathology, Massachusetts General Hospital, Boston, MA, USA. 5 Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA. 6 Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology and Harvard University, Cambridge, MA, USA. 7 Department of Materials Science and Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA. 8 Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, MA, USA. 9 Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA.

Isaac Quiros-Fernandez 1, Mansour Poorebrahim 1, Elham Fakhr 1, Angel Cid-Arregui 2; 1 Targeted Tumor Vaccines Group, Clinical Cooperation Unit Applied Tumor Immunity, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120 Heidelberg, Germany. 2 Targeted Tumor Vaccines Group, Clinical Cooperation Unit Applied Tumor Immunity, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120 Heidelberg, Germany. Electronic address: a.cid@dkfz-heidelberg.de.

Tianshi Lu 1,6, Ze Zhang 1,6, James Zhu 1, Yunguan Wang 1, Peixin Jiang 2, Xue Xiao 1, Chantale Bernatchez 3, John V. Heymach 2, Don L. Gibbons 2, Jun Wang 4, Lin Xu 1, Alexandre Reuben 2 and Tao Wang 1,5; 1 Quantitative Biomedical Research Center, Department of Population and Data Sciences, University of Texas Southwestern Medical Center, Dallas, TX, USA. 2 Department of Thoracic/Head and Neck Medical Oncology, MD Anderson Cancer Center, Houston, TX, USA. 3 Department of Melanoma Medical Oncology, MD Anderson Cancer Center, Houston, TX, USA. 4 Department of Pathology, New York University Grossman School of Medicine, New York, NY, USA. 5 Center for the Genetics of Host Defense, University of Texas Southwestern Medical Center, Dallas, TX, USA. 6 These authors contributed equally: Tianshi Lu, Ze Zhang

Hema Dave 1, Madeline Terpilowski 2, Mimi Mai 3, Keri Toner 4, Melanie Grant 5, Maja Stanojevic 1, Christopher Andrew Lazarski 2, Abeer Shibli 1, Stephanie Ann Bien 6, Philp Maglo 1, Fahmida Hoq 7, Reuven Schore 4, Martha J Glenn 8, Boyu Hu 9, Patrick J Hanley 2, Richard F Ambinder 10, Catherine M Bollard 4; 1 Children's National Hospital, Washington, District of Columbia, United States. 2 Children's National Medical Center, Washington, District of Columbia, United States. 3 The George Washington school of Medicine, United States. 4 The George Washington University School of Medicine, United States. 5 Emory University School of Medicine, United States. 6 Adaptive Biotechnologies, Seattle, Washington, United States. 7 CNMC, Laytonsville, Maryland, United States. 8 University of Utah, Huntsman Cancer Institute, Salt Lake City, Utah, United States. 9 Huntsman Cancer Institute/University of Utah, Salt Lake City, Utah, United States. 10 Johns Hopkins University School of Medicine, Baltimore, Maryland, United States.

Yan Lan 1, Mahmoud Moustafa 2, Maximillian Knoll 3, Chunxiao Xu 4, Jennifer Furkel 3, Adam Lazorchak 4, Tsz-Lun Yeung 4, Sayed-Mohammad Hasheminasab 5, Molly H Jenkins 4, Sarah Meister 3, Huakui Yu 4, Julian Schlegel 3, Bo Marelli 4, Zili Tang 3, Guozhong Qin 4, Carmen Klein 3, Jin Qi 4, Cheng Zhou 6, George Locke 7, Damir Krunic 8, Melissa G Derner 4, Christian Schwager 3, Rachel E Fontana 4, Katharina Kriegsmann 9, Feng Jiang 4, Katrin Rein 3, Mark Kriegsmann 10, Juergen Debus 3, Kin-Ming Lo 4, Amir Abdollahi 11; 1 Department of TIP OIO, EMD Serono Research & Development Institute, 45 Middlesex Turnpike, Billerica, MA 01821, USA; an affiliate of Merck KGaA, Darmstadt, Germany. Electronic address: yan.lan@emdserono.com. 2 German Cancer Consortium (DKTK) Core-Center, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany; Divisions of Molecular & Translational Radiation Oncology, Heidelberg Faculty of Medicine (MFHD) and Heidelberg University Hospital (UKHD), Heidelberg Ion-Beam Therapy Center (HIT), 69120 Heidelberg, Germany; Heidelberg Institute of Radiation Oncology (HIRO), National Center for Radiation Research in Oncology (NCRO), German Cancer Research Center (DKFZ) and Heidelberg University Hospital (UKHD), 69120 Heidelberg, Germany; CCU Translational Radiation Oncology, National Center for Tumor Diseases (NCT), German Cancer Research Center (DKFZ) and Heidelberg University Hospital (UKHD), 69120 Heidelberg, Germany; Department of Clinical Pathology, Suez Canal University, Ismailia 41522, Egypt. 3 German Cancer Consortium (DKTK) Core-Center, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany; Divisions of Molecular & Translational Radiation Oncology, Heidelberg Faculty of Medicine (MFHD) and Heidelberg University Hospital (UKHD), Heidelberg Ion-Beam Therapy Center (HIT), 69120 Heidelberg, Germany; Heidelberg Institute of Radiation Oncology (HIRO), National Center for Radiation Research in Oncology (NCRO), German Cancer Research Center (DKFZ) and Heidelberg University Hospital (UKHD), 69120 Heidelberg, Germany; CCU Translational Radiation Oncology, National Center for Tumor Diseases (NCT), German Cancer Research Center (DKFZ) and Heidelberg University Hospital (UKHD), 69120 Heidelberg, Germany. 4 Department of TIP OIO, EMD Serono Research & Development Institute, 45 Middlesex Turnpike, Billerica, MA 01821, USA; an affiliate of Merck KGaA, Darmstadt, Germany. 5 German Cancer Consortium (DKTK) Core-Center, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany; Divisions of Molecular & Translational Radiation Oncology, Heidelberg Faculty of Medicine (MFHD) and Heidelberg University Hospital (UKHD), Heidelberg Ion-Beam Therapy Center (HIT), 69120 Heidelberg, Germany; Heidelberg Institute of Radiation Oncology (HIRO), National Center for Radiation Research in Oncology (NCRO), German Cancer Research Center (DKFZ) and Heidelberg University Hospital (UKHD), 69120 Heidelberg, Germany; CCU Translational Radiation Oncology, National Center for Tumor Diseases (NCT), German Cancer Research Center (DKFZ) and Heidelberg University Hospital (UKHD), 69120 Heidelberg, Germany; Department of Dermatology, Venereology and Allergology, Charité Universitätsmedizin, Berlin, Germany. 6 German Cancer Consortium (DKTK) Core-Center, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany; Divisions of Molecular & Translational Radiation Oncology, Heidelberg Faculty of Medicine (MFHD) and Heidelberg University Hospital (UKHD), Heidelberg Ion-Beam Therapy Center (HIT), 69120 Heidelberg, Germany; Heidelberg Institute of Radiation Oncology (HIRO), National Center for Radiation Research in Oncology (NCRO), German Cancer Research Center (DKFZ) and Heidelberg University Hospital (UKHD), 69120 Heidelberg, Germany; CCU Translational Radiation Oncology, National Center for Tumor Diseases (NCT), German Cancer Research Center (DKFZ) and Heidelberg University Hospital (UKHD), 69120 Heidelberg, Germany; Department of Radiation Oncology, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China. 7 Department of Translational Medicine, EMD Serono Research & Development Institute, Billerica, MA 01821, USA; an affiliate of Merck KGaA, Darmstadt, Germany. 8 Light Microscopy Facility, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany. 9 Department of Hematology, Oncology, and Rheumatology, Heidelberg University Hospital (UKHD), 69120 Heidelberg, Germany. 10 Department of Pathology, Heidelberg University Hospital (UKHD), 69120 Heidelberg, Germany. 11 German Cancer Consortium (DKTK) Core-Center, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany; Divisions of Molecular & Translational Radiation Oncology, Heidelberg Faculty of Medicine (MFHD) and Heidelberg University Hospital (UKHD), Heidelberg Ion-Beam Therapy Center (HIT), 69120 Heidelberg, Germany; Heidelberg Institute of Radiation Oncology (HIRO), National Center for Radiation Research in Oncology (NCRO), German Cancer Research Center (DKFZ) and Heidelberg University Hospital (UKHD), 69120 Heidelberg, Germany; CCU Translational Radiation Oncology, National Center for Tumor Diseases (NCT), German Cancer Research Center (DKFZ) and Heidelberg University Hospital (UKHD), 69120 Heidelberg, Germany. Electronic address: a.amir@dkfz.de.