Functional analysis of peripheral and intratumoral neoantigen-specific TCRs identified in a patient with melanoma

Bräunlein E, et al.
September 2021
Authors and Affiliates
Eva Bräunlein 1, Gaia Lupoli 1, Franziska Füchsl 1, Esam T Abualrous 2, Niklas de Andrade Krätzig 3,4, Dario Gosmann 1, Lukas Wietbrock 5, Sebastian Lange 3,4,6, Thomas Engleitner 3,4, Huan Lan 2, Stefan Audehm 1, Manuel Effenberger 7, Melanie Boxberg 8,9, Katja Steiger 8,10,11, Yinshui Chang 1, Kai Yu 1, Cigdem Atay 1,11, Florian Bassermann 1,4,11, Wilko Weichert 8,9,10,11, Dirk H Busch 7, Roland Rad 3,4,6,11, Christian Freund 2, Iris Antes 5, Angela M Krackhardt 12,4,11; 1 Klinik und Poliklinik für Innere Medizin III, Klinikum rechts der Isar der Technischen Universität München, München, Germany. 2 Laboratory of Protein Biochemistry, Institute for Chemistry and Biochemistry, Freie Universität Berlin, Berlin, Germany. 3 Institute of Molecular Oncology and Functional Genomics, TUM School of Medicine, Klinikum rechts der Isar der Technischen Universität München, München, Germany. 4 Center for Translational Cancer Research (TranslaTUM), TUM School of Medicine, Klinikum rechts der Isar der Technischen Universität München, München, Germany. 5 TUM School of Life Sciences and Center for Integrated Protein Science Munich, Klinikum rechts der Isar der Technischen Universität München, München, Germany. 6 Department of Medicine II, Klinikum rechts der Isar, TUM School of Medicine, Klinikum rechts der Isar der Technischen Universität München, München, Germany. 7 Institute for Medical Microbiology Immunology and Hygiene, Technische Universität München, München, Germany. 8 Institute of Pathology, School of Medicine, Klinikum rechts der Isar der Technischen Universität München, München, Germany. 9 MRI-TUM-Biobank at the Institute of Pathology, School of Medicine, Klinikum rechts der Isar der Technischen Universität München, München, Germany. 10 Core Facility Experimental Pathology, School of Medicine, Klinikum rechts der Isar der Technischen Universität München, München, Germany. 11 German Cancer Consortium (DKTK), partner-site Munich, and German Cancer Research Center (DKFZ) Heidelberg, Heidelberg, Germany. 12 Klinik und Poliklinik für Innere Medizin III, Klinikum rechts der Isar der Technischen Universität München, München, Germany angela.krackhardt@tum.de.

Simple Measurement of IgA Predicts Immunity and Mortality in Ataxia-Telangiectasia

Zielen S, et al.
Journal of Clinical Immunology
September 2021
Authors and Affiliates
Stefan Zielen 1, Ruth Pia Duecker 2, Sandra Woelke 1, Helena Donath 1, Sharhzad Bakhtiar 3, Aileen Buecker 1, Hermann Kreyenberg 3, Sabine Huenecke 3, Peter Bader 3, Nizar Mahlaoui 4, Stephan Ehl 5, Sabine M El-Helou 5,6,7, Barbara Pietrucha 8, Alessandro Plebani 9, Michiel van der Flier 10, Koen van Aerde 11, Sara S Kilic 12, Shereen M Reda 13, Larysa Kostyuchenko 14, Elizabeth McDermott 15, Nermeen Galal 16, Claudio Pignata 17, Juan Luis Santos Pérez 18, Hans-Juergen Laws 19, Tim Niehues 20, Necil Kutukculer 21, Markus G Seidel 22, Laura Marques 23, Peter Ciznar 24, John David M Edgar 25, Pere Soler-Palacín 26, Horst von Bernuth 27,28,29, Renate Krueger 27, Isabelle Meyts 30, Ulrich Baumann 31, Maria Kanariou 32, Bodo Grimbacher 5,6,33, Fabian Hauck 34, Dagmar Graf 35, Luis Ignacio Gonzalez Granado 36, Seraina Prader 37, Ismail Reisli 38, Mary Slatter 39, Carlos Rodríguez-Gallego 40, Peter D Arkwright 41, Claire Bethune 42, Elena Deripapa 43, Svetlana O Sharapova 44, Kai Lehmberg 45, E Graham Davies 46, Catharina Schuetz 47, Gerhard Kindle 5,48, Ralf Schubert 1; 1 Division of Allergology, Pulmonology and Cystic Fibrosis, Department for Children and Adolescents, Goethe University, Frankfurt, Germany. 2 Division of Allergology, Pulmonology and Cystic Fibrosis, Department for Children and Adolescents, Goethe University, Frankfurt, Germany. RuthPia.Duecker@kgu.de. 3 Division for Stem Cell Transplantation, Immunology and Intensive Care Unit, Department for Children and Adolescents, Goethe University, Frankfurt, Germany. 4 Pediatric Immunology-Hematology and Rheumatology Unit, French National Reference Center for Primary Immune Deficiencies (CEREDIH), Necker Children's University Hospital, Assistance Publique-Hôpitaux de Paris (AP-HP), Paris, France. 5 Institute for Immunodeficiency, Center for Chronic Immunodeficiency (CCI), Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany. 6 RESIST - Cluster of Excellence 2155 To Hanover Medical School, Satellite Center Freiburg, Freiburg, Germany. 7 Department of Rheumatology and Immunology, Hannover Medical School, Hannover, Germany. 8 Department of Immunology, The Children's Memorial Health Institute, Av. Dzieci Polskich 20, 04-730, Warsaw, Poland. 9 Pediatrics Clinic and Institute for Molecular Medicine A. Nocivelli, Department of Clinical and Experimental Sciences, University of Brescia and ASST-Spedali Civili di Brescia, Brescia, Italy. 10 Section Pediatric Infectious Diseases, Laboratory of Medical Immunology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, the Netherlands. 11 Department of Pediatrics, Amalia's Children Hospital, Radboud University Medical Center, Nijmegen, the Netherlands. 12 Department of Pediatric Immunology and Rheumatology, the School of Medicine, Uludag University, Bursa, Turkey. 13 Department of Pediatrics, Children's Hospital, Faculty of Medicine, Ain Shams University, Cairo, Egypt. 14 Center of Pediatric Immunology, Western Ukrainian Specialized Children's Medical Centre, Lviv, Ukraine. 15 Clinical Immunology and Allergy Unit, Nottingham University Hospitals, Nottingham, UK. 16 Department of Pediatrics, Cairo University Specialized Pediatric Hospital, Cairo, Egypt. 17 Department of Translational Medical Sciences, Section of Pediatrics, Federico II University, Naples, Italy. 18 Infectious Diseases and Immunodeficiencies Unit, Service of Pediatrics, Hospital Universitario Virgen de Las Nieves, Granada, Spain. 19 Department of Pediatric Oncology, Hematology and Clinical Immunology, Medical Faculty, Center of Child and Adolescent Health, Heinrich-Heine University, Duesseldorf, Germany. 20 Centre for Child and Adolescent Health, Helios Klinikum Krefeld, Krefeld, Germany. 21 Faculty of Medicine, Department of Pediatric Immunology, Ege University, Izmir, Turkey. 22 Research Unit for Pediatric Hematology and Immunology, Division of Pediatric Hemato-Oncology, Department of Pediatrics and Adolescent Medicine, Medical University Graz, Graz, Austria. 23 Pediatric Department, Infectious Diseases and Immunodeficiencies Unit, Porto Hospital Center, Porto, Portugal. 24 Pediatric Department, Faculty of Medicine, Children University Hospital in Bratislava, Comenius University in Bratislava, Bratislava, Slovakia. 25 The Royal Hospitals & Queen's University, Belfast, UK. 26 Pediatric Infectious Diseases and Immunodeficiencies Unit, Vall D'Hebron Research Institute, Hospital Universitari Vall D'Hebron, Universitat Autònoma de Barcelona, Barcelona, Catalonia, Spain. 27 Department of Pediatric Pneumology, Immunology and Intensive Care, Charité - Universitätsmedizin Berlin, Berlin, Germany. 28 Department of Immunology, Labor Berlin Charité - Vivantes GmbH, Berlin, Germany. 29 Berlin Center for Regenerative Therapies (BCRT), Charité - Universitätsmedizin Berlin, Berlin, Germany. 30 Department of Pediatrics, University Hospitals Leuven, and the Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, KU Leuven, Leuven, Belgium. 31 Department of Paediatric Pulmonology, Allergy and Neonatology, Hannover Medical School, Hannover, Germany. 32 Department of Immunology and Histocompatibility, Centre for Primary Immunodeficiencies, "Aghia Sophia" Children's Hospital, Athens, Greece. 33 DZIF-German Center for Infection Research, Satellite Center Freiburg, Freiburg, Germany; Centre for Integrative Biological Signalling Studies, Albert-Ludwigs University, Freiburg, Germany. 34 Department of Pediatrics, Dr. Von Hauner Children's Hospital, University Hospital, Ludwig-Maximilians-University Munich, Munich, Germany. 35 MVZ Dr. Reising-Ackermann Und Kollegen, Leipzig, Germany. 36 Primary Immunodeficiencies Unit, Pediatrics, Hospital 12 Octubre, Complutense University School of Medicine, Madrid, Spain. 37 Division of Immunology and Children's Research Center, University Children's Hospital Zurich, Zurich, Switzerland. 38 Department of Pediatrics, Division of Pediatric Immunology and Allergy, Meram Medical Faculty, Necmettin Erbakan University, Konya, Turkey. 39 Primary Immunodeficiency Group, Paediatric Immunology and Haematopoietic Stem Cell Transplantation, Translational and Clinical Research Institute, Great North Childrens' Hospital, Newcastle University, Newcastle upon Tyne, UK. 40 Department of Immunology, Dr. Negrin University Hospital of Gran Canaria, University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. 41 Lydia Becker Institute of Immunology and Inflammation, University of Manchester and Royal Manchester Children's Hospital, Manchester, UK. 42 University Hospital Plymouth NHS Trust, Plymouth, UK. 43 National Medical Research Center of Pediatric Hematology, Oncology and Immunology, Moscow, Russia. 44 Research Department, Belarusian Research Center for Pediatric Oncology, Hematology and Immunology, Minsk region, Minsk, Belarus. 45 Division for Pediatric Stem Cell Transplantation and Immunology, Clinic for Pediatric Hematology and Oncology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany. 46 Great Ormond Street Hospital and UCL Great Ormond Street Institute of Child Health, London, UK. 47 Department of Pediatrics, Medizinische Fakultät Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany. 48 FREEZE Biobank, Center for Biobanking, Medical Center and Faculty of Medicine, University of Freiburg, Breisacher Str. 115, 79106, Freiburg, Germany.

Dynamic changes in the T cell receptor repertoire during treatment with radiotherapy combined with an immune checkpoint inhibitor

Öjlert ÅK, et al.
Molecular Oncology
September 2021
Authors and Affiliates
Åsa Kristina Öjlert 1, Daniel Nebdal 1, Igor Snapkov 2, Vibeke Olsen 1, Joel Kidman 3,4, Victor Greiff 2, Jonathan Chee 3,4, Åslaug Helland 1,5,6; 1 Department of Cancer Genetics, Institute for Cancer Research, Oslo University Hospital, Norway. 2 Department of Immunology, University of Oslo, Norway. 3 National Centre for Asbestos Related Diseases, Institute of Respiratory Health, University of Western Australia, Perth, WA, Australia. 4 School of Biomedical Sciences, University of Western Australia, Perth, WA, Australia. 5 Department of Clinical Medicine, University of Oslo, Norway. 6 Department of Oncology, Oslo University Hospital, Norway.

CD4+ T cell and M2 macrophage infiltration predict dedifferentiated liposarcoma patient outcomes

Schroeder BA, et al.
Journal for ImmunoTherapy of Cancer
September 2021
Authors and Affiliates
Brett A Schroeder 1,2, Natalie A LaFranzo 3, Bonnie J LaFleur 4, Rachel M Gittelman 5, Marissa Vignali 5, Shihong Zhang 2, Kevin C Flanagan 3, Julie Rytlewski 6, Laura Riolobos 7, Brian C Schulte 8, Teresa S Kim 9, Eleanor Chen 10, Kimberly S Smythe 2, Michael J Wagner 2,11, Jose G Mantilla 12, Jean S Campbell 13, Robert H Pierce 2, Robin L Jones 14, Lee D Cranmer 15, Seth M Pollack 16,17; 1 National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA. 2 Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA. 3 Cofactor Genomics, San Francisco, California, USA. 4 BIO5 Institute, University of Arizona, Tucson, Arizona, USA. 5 Adaptive Biotechnologies Corp, Seattle, Washington, USA. 6 Bristol Myers Squibb, Seattle, Washington, USA. 7 UW Medicine Cancer Vaccine Institute, University of Washington, Seattle, Washington, USA. 8 Division of Oncology, Northwestern University Department of Medicine, Chicago, Illinois, USA. 9 Department of Surgery, University of Washington, Seattle, Washington, USA. 10 Department of Laboratory Medicine and Pathology, University of Washington, Seattle, Washington, USA. 11 Division of Oncology, University of Washington, Seattle, Washington, USA. 12 Pathology, University of Washington Medical Center, Seattle, Washington, USA. 13 Sensei Bio, Boston, Massachusetts, USA. 14 Sarcoma, Royal Marsden Hospital NHS Trust, London, UK. 15 Seattle Cancer Care Alliance, Seattle, Washington, USA. 16 Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA Seth.pollack@northwestern.edu. 17 Division of Oncology, Northwestern University, Chicago, Illinois, USA.

Expansion of Unique Hepatitis C Virus-Specific Public CD8 + T Cell Clonotypes during Acute Infection and Reinfection

Mazouz S, et al.
Journal of Immunology
August 2021
Authors and Affiliates
Sabrina Mazouz 1,2, Maude Boisvert 1, Mohamed S Abdel-Hakeem 1,2, Omar Khedr 1, Julie Bruneau 1,3, Naglaa H Shoukry 4,5; 1 Centre de Recherche du Centre Hospitalier de l'Université de Montréal, Montreal, Quebec, Canada. 2 Département de Microbiologie, Infectiologie et Immunologie, Université de Montreal, Montreal, Quebec, Canada. 3 Département de Médecine Familiale et de Médecine d'Urgence, Université de Montréal, Montreal, Quebec, Canada; and. 4 Centre de Recherche du Centre Hospitalier de l'Université de Montréal, Montreal, Quebec, Canada; naglaa.shoukry@umontreal.ca. 5 Département de Médecine, Université de Montréal, Montreal, Quebec, Canada.

Tumor-infiltrating lymphocyte treatment for anti-PD-1-resistant metastatic lung cancer: a phase 1 trial

Creelan BC, et al.
Nature Medicine
August 2021
Authors and Affiliates
Benjamin C Creelan #,1, Chao Wang #,2, Jamie K Teer 3, Eric M Toloza 2, Jiqiang Yao 3, Sungjune Kim 4, Ana M Landin 5, John E Mullinax 6, James J Saller 7, Andreas N Saltos 2, David R Noyes 4, Leighann B Montoya 8, Wesley Curry 8, Shari A Pilon-Thomas 4, Alberto A Chiappori 2, Tawee Tanvetyanon 2, Frederic J Kaye 9, Zachary J Thompson 2, Sean J Yoder 10, Bin Fang 10, John M Koomen 10, Amod A Sarnaik 2, Dung-Tsa Chen 3, Jose R Conejo-Garcia 2, Eric B Haura #,2, Scott J Antonia #,11; 1 Department of Thoracic Oncology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, USA. ben.creelan@moffitt.org. 2 Department of Thoracic Oncology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, USA. 3 Department of Bioinformatics and Biostatistics, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, USA. 4 Department of Immunology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, USA. 5 Cell Therapy Facility, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, USA. 6 Department of Sarcoma, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, USA. 7 Department of Pathology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, USA. 8 Immune and Cellular Therapy Program, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, USA. 9 Department of Medicine, University of Florida College of Medicine, Gainesville, FL, USA. 10 Chemical Biology & Molecular Medicine, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, USA. 11 Duke Cancer Institute, Duke University School of Medicine, Durham, NC, USA. # Contributed equally.

Phase Ib study of patients with metastatic castrate-resistant prostate cancer treated with different sequencing regimens of atezolizumab and sipuleucel-T

Dorff T, et al.
Journal for ImmunoTherapy of Cancer
August 2021
Authors and Affiliates
Tanya Dorff 1, Yosuke Hirasawa 2, Jared Acoba 3, Ian Pagano 3, David Tamura 3, Sumanta Pal 1, Minlu Zhang 4, Rebecca Waitz 4, Abhilash Dhal 4, Winston Haynes 4, John Shon 4, Mark Scholz 5, Hideki Furuya 2, Owen T M Chan 3, Jeffrey Huang 3, Charles Rosser 6; 1 Department of Medical Oncology and Therapeutics Research, City of Hope National Medical Center, Duarte, California, USA. 2 Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA. 3 University of Hawaii Cancer Center, Honolulu, Hawaii, USA. 4 Serimmune, Goleta, California, USA. 5 Prostate Oncology Specialists, Marina del Rey, California, USA. 6 Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA charles.rosser@cshs.org.

GIANA allows computationally-efficient TCR clustering and multi-disease repertoire classification by isometric transformation

Zhang H, et al.
Nature Communications
August 2021
Authors and Affiliates
Hongyi Zhang 1, Xiaowei Zhan 2, Bo Li 3,4; 1 Lyda Hill Department of Bioinformatics, UT Southwestern Medical Center, Dallas, TX, USA. 2 Department of Population and Data Science, UT Southwestern Medical Center, Dallas, TX, USA. 3 Lyda Hill Department of Bioinformatics, UT Southwestern Medical Center, Dallas, TX, USA. bo.li@utsouthwestern.edu. 4 Department of Immunology, UT Southwestern Medical Center, Dallas, TX, USA. bo.li@utsouthwestern.edu.

Systemic inhibition of PTPN22 augments anticancer immunity

Ho WJ, et al.
JCI
August 2021
Authors and Affiliates
Won Jin Ho 1, Sarah Croessmann 2, Jianping Lin 3, Zaw H Phyo 1, Soren Charmsaz 1, Ludmila Danilova 1, Aditya A Mohan 1, Nicole E Gross 1, Fangluo Chen 1, Jiajun Dong 3, Devesh Aggarwal 3, Yunpeng Bai 3, Janey Wang 4, Jing He 4, James M Leatherman 1, Mark Yarchoan 1, Todd D Armstrong 1, Neeha Zaidi 1, Elana J Fertig 1, Joshua C Denny 4, Ben H Park 2, Zhong-Yin Zhang 3, Elizabeth M Jaffee 5; 1 Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, United States of America. 2 Department of Medicine, Vanderbilt University Medical Center, Nashville, United States of America. 3 Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, United States of America. 4 Department of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, United States of America. 5 Sidney Kimmel Comprehensive Cancer Center, John Hopkins University, Baltimore, United States of America.