Therapeutic Area: Oncology
mRNA vaccine-induced neoantigen-specific T cell immunity in patients with gastrointestinal cancer
Cafri G., et al.
JCI
Journal of Clinical Investigation
October 2020
Authors and Affiliates
Gal Cafri 1 2, Jared J Gartner 1, Tal Zaks 3, Kristen Hopson 3, Noam Levin 1, Biman C Paria 1, Maria R Parkhurst 1, Rami Yossef 1, Frank J Lowery 1, Mohammad S Jafferji 1, Todd D Prickett 1, Stephanie L Goff 1, Christine T McGowan 1, Samantha Seitter 1, Mackenzie L Shindorf 1, Anup Parikh 1, Praveen D Chatani 1, Paul F Robbins 1, Steven A Rosenberg 1;
1 Surgery Branch, National Cancer Institute (NCI), NIH, Bethesda, Maryland, USA.
2 Sheba Medical Center, Ramat Gan, Israel.
3 Moderna Inc., Cambridge, Massachusetts, USA.
Analysis of the Heterogeneity of CD4+CD25+ T Cell TCR β CDR3 Repertoires in Breast Tumor Tissues, Lung Metastatic Tissues, and Spleens from 4T1 Tumor-Bearing BALB/c Mice
Zhang T,. et al.
Journal of Immunology Research
October 2020
Authors and Affiliates
Teng Zhang 1 2, Fangfang Duan 2, Danhua Su 2, Long Ma 2, Jiezuan Yang 3, Bin Shi 4, Xiaoyan He 2, Rui Ma 2, Suhong Sun 1, Xinsheng Yao 2;
1 Department of Breast Surgery, The Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou, China
2 Department of Immunology, Research Center for Medicine & Biology, Innovation & Practice Base for Graduate Students Education, Zunyi Medical University, Zunyi, Guizhou, China
3 Department of Infectious Diseases, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China
4 Department of Laboratory Medicine, Zunyi Medical University, Zunyi, Guizhou, China
Lymphocytic infiltration in stage II microsatellite stable colorectal tumors: A retrospective prognosis biomarker analysis
Authors and Affiliates
Rebeca Sanz-Pamplona 1,2,3, Marilena Melas 4, Asaf Maoz 5, Stephanie L Schmit 6, Hedy Rennert 7, Flavio Lejbkowicz 7, Joel K Greenson 8, Xavier Sanjuan 9, Maria Lopez-Zambrano 9, M Henar Alonso 1,2,3 10, Chenxu Qu 11, Kevin J McDonnell 11, Gregory E Idos 11, Marissa Vignali 12, Ryan Emerson 12, Paul Fields 12, Elisabet Guinó 1,2,3, Cristina Santos 1,2,13, Ramon Salazar 1,2,13, Harlan S Robins 12,14, Gad Rennert 7, Stephen B Gruber 11, Victor Moreno 1,2,3,10;
1 Catalan Institute of Oncology (ICO), Hospitalet de Llobregat, Barcelona, Spain.
2 ONCOBELL Program, Bellvitge Biomedical Research Institute (IDIBELL), Hospitalet de Llobregat, Barcelona, Spain.
3 Consortium for Biomedical Research in Epidemiology and Public Health (CIBERESP), Spain.
4 Nationwide Children's Hospital, Columbus, Ohio, United States of America.
5 Department of Medicine, Boston University School of Medicine, Boston, Massachusetts, United States of America.
6 H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, United States of America.
7 Carmel Medical Center, and Technion, Haifa, Israel.
8 University of Michigan Medical School, Ann Arbor, Michigan, United States of America.
9 University Hospital Bellvitge (HUB-IDIBELL), L'Hospitalet de Llobregat, Barcelona, Spain.
10 Department of Clinical Sciences, Faculty of Medicine, University of Barcelona, Barcelona, Spain.
11 City of Hope National Medical Center, Duarte, California, United States of America.
12 Adaptive Biotechnologies, Seattle, Washington, United States of America.
13 Consortium for Biomedical Research in Oncology (CIBERONC), Spain.
14 Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America.
Serial Assessment of Circulating T lymphocyte Phenotype and Receptor Repertoire During Treatment of Non-Muscle Invasive Bladder Cancer with Adoptive T Cell Immunotherapy
Wang X., et al.
September 2020
Authors and Affiliates
Xiaoli Wang 1, Guoliang Qiao 1, Ni Jiang 1, Michael A Morse 2, Xinna Zhou 1, Shuo Wang 1, Jiangping Wu 1, Yuguang Song 1, Yanjie Zhao 1, Lei Zhou 1, Yanhua Yuan 1, Amy Hobeika 2, Jun Ren 1, Herbert Kim Lyerly 1;
1 Capital Medical University Affiliated Beijing Shijitan Hospital, Beijing, China
2 Duke University Medical Center, Durham, NC, USA
Exhaustion of tumour-infiltrating T-cell receptor repertoirediversity is an age-dependent indicator of immunological fit-ness independently predictive of clinical outcome in Burkittlymphoma
Authors and Affiliates
Johannes Rieken 1, Veronica Bernard 2, Hanno M Witte 1,3, Wolfgang Peter 4, Hartmut Merz 2, Vito Olschewski 1, Lars Hertel 5, Hendrik Lehnert 6, Harald Biersack 1, Nikolas von Bubnoff 1, Alfred C Feller 2, Niklas Gebauer 1;
1 Department of Haematology and Oncology, University Hospital of Schleswig-Holstein, Luebeck, Germany.
2 Hämatopathologie Lübeck, Reference Centre for Lymph Node Pathology and Haematopathology, Lübeck, Germany.
3 Department of Haematology and Oncology, Federal Armed Hospital Ulm, Ulm, Germany.
4 HLA Typing Laboratory of the Stefan-Morsch-Foundation, Birkenfeld, Germany.
5 Department of Neuro- and Bioinformatics, University Hospital of Schleswig-Holstein, Luebeck, Germany.
6 Department of Internal Medicine I, University Hospital of Schleswig-Holstein, Luebeck, Germany.
CBFB-MYH11 fusion neoantigen enables T cell recognition and killing of acute myeloid leukemia
Biernacki MA., et al.
JCI
Journal of Clinical Investigation
September 2020
Authors and Affiliates
Melinda A Biernacki 1,2, Kimberly A Foster 1, Kyle B Woodward 1, Michael E Coon 1, Carrie Cummings 1, Tanya M Cunningham 1, Robson G Dossa 1, Michelle Brault 1, Jamie Stokke 1,3, Tayla M Olsen 1, Kelda Gardner 2, Elihu Estey 1,2, Soheil Meshinchi 1,3, Anthony Rongvaux 1,4, Marie Bleakley 1,3;
1 Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.
2 Department of Medicine.
3 Department of Pediatrics, and.
4 Department of Immunology, University of Washington, Seattle, Washington, USA.
IL-32γ potentiates tumor immunity in melanoma
Gruber T., et al.
JCI Insight
September 2020
Authors and Affiliates
Thomas Gruber 1,2, Mirela Kremenovic 1,2, Hassan Sadozai 1,2, Nives Rombini 1, Lukas Baeriswyl 1, Fabienne Maibach 1, Robert L Modlin 3, Michel Gilliet 4, Diego von Werdt 1,2, Robert E Hunger 5, S Morteza Seyed Jafari 5, Giulia Parisi 6, Gabriel Abril-Rodriguez 6, Antoni Ribas 6, Mirjam Schenk 1;
1 Institute of Pathology, Experimental Pathology, and.
2 Graduate School Cellular and Biomedical Sciences, University of Bern, Bern, Switzerland.
3 Division of Dermatology, Department of Medicine and Department of Microbiology, Immunology and Molecular Genetics, David Geffen School of Medicine at UCLA, Los Angeles, California, USA.
4 Department of Dermatology, Lausanne University Hospital, Lausanne, Switzerland.
5 Department of Dermatology, Inselspital, University Hospital of Bern, University of Bern, Bern, Switzerland.
6 Division of Hematology-Oncology, Department of Medicine, David Geffen School of Medicine at UCLA, and UCLA Jonsson Comprehensive Cancer Center, UCLA, Los Angeles, California, USA.
Radiation induces dynamic changes to the T cell repertoire in renal cell carcinoma patients
Authors and Affiliates
Jacky Chow 1, Nicholas C Hoffend 1, Scott I Abrams 1, Thomas Schwaab 1,2, Anurag K Singh 3, Jason B Muhitch 4,2;
1 Department of Immunology, Roswell Park Comprehensive Cancer Center, Buffalo, NY 14263.
2 Department of Urology, Roswell Park Comprehensive Cancer Center, Buffalo, NY 14263.
3 Department of Radiation Medicine, Roswell Park Comprehensive Cancer Center, Buffalo, NY 14263.
4 Department of Immunology, Roswell Park Comprehensive Cancer Center, Buffalo, NY 14263; jason.muhitch@roswellpark.org.
Integrated genomic analysis reveals mutated ELF3 as a potential gallbladder cancer vaccine candidate
Pandey A., et al.
Nature Communications
September 2020
Authors and Affiliates
Akhilesh Pandey 1,2,3, Eric W Stawiski 4,5,6, Steffen Durinck 7,8, Harsha Gowda 9,10, Leonard D Goldstein 7,8, Mustafa A Barbhuiya 9,11, Markus S Schröder 8,12, Sreelakshmi K Sreenivasamurthy 9, Sun-Whe Kim 13, Sameer Phalke 14, Kushal Suryamohan 15, Kayla Lee 15, Papia Chakraborty 15, Vasumathi Kode 15, Xiaoshan Shi 15, Aditi Chatterjee 9, Keshava Datta 9, Aafaque A Khan 9, Tejaswini Subbannayya 9, Jing Wang 15, Subhra Chaudhuri 8, Sanjiv Gupta 16, Braj Raj Shrivastav 17, Bijay S Jaiswal 8, Satish S Poojary 18, Shushruta Bhunia 18, Patricia Garcia 19, Carolina Bizama 19, Lorena Rosa 20, Wooil Kwon 13, Hongbeom Kim 13, Youngmin Han 13, Thakur Deen Yadav 21, Vedam L Ramprasad 14, Amitabha Chaudhuri 15, Zora Modrusan 8, Juan Carlos Roa 19, Pramod Kumar Tiwari 18, Jin-Young Jang 22, Somasekar Seshagiri 23,24;
1 Institute of Bioinformatics, Bangalore, Karnataka, 560066, India. pandey.akhilesh@mayo.edu.
2 Manipal Academy of Higher Education (MAHE), Manipal, Karnataka, 576104, India. pandey.akhilesh@mayo.edu.
3 Center for Individualized Medicine and Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, 55905, USA. pandey.akhilesh@mayo.edu.
4 Bioinformatics and Computational Biology Department, Genentech Inc, South San Francisco, CA, 94080, USA. eric.s@medgenome.com.
5 Molecular Biology Department, Genentech Inc., South San Francisco, CA, 94080, USA. eric.s@medgenome.com.
6 Research and Development Department, MedGenome Inc, Foster City, CA, 94404, USA. eric.s@medgenome.com.
7 Bioinformatics and Computational Biology Department, Genentech Inc, South San Francisco, CA, 94080, USA.
8 Molecular Biology Department, Genentech Inc., South San Francisco, CA, 94080, USA.
9 Institute of Bioinformatics, Bangalore, Karnataka, 560066, India.
10 QIMR Berghofer Medical Research Institute, Brisbane, QLD, 4006, Australia.
11 Department of Pathology and Laboratory Medicine, Pennsylvania State University College of Medicine, Hershey, PA, 17033, USA.
12 SciGenom Labs, Cochin, Kerala, 682037, India.
13 Department of Surgery, Division of Hepatobiliary and Pancreatic Surgery, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, 08826, South Korea.
14 Research and Development Department, MedGenome Labs Pvt. Ltd., Bangalore, Karnataka, 560099, India.
15 Research and Development Department, MedGenome Inc, Foster City, CA, 94404, USA.
16 Department of Pathology, Cancer Hospital and Research Institute, Gwalior, Madhya Pradesh, 474009, India.
17 Department of Surgical Oncology, Cancer Hospital and Research Institute, Gwalior, Madhya Pradesh, 474009, India.
18 Jiwaji University, Gwalior, Madhya Pradesh, 474011, India.
19 Department of Pathology, Millennium Institute on Immunology and Immunotherapy, School of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile.
20 Applied Molecular and Cellular Biology PhD Program Universidad De la Frontera, Temuco, Chile.
21 Department of Surgery, Postgraduate Institute of Medical Education and Research, Chandigarh, 160012, India.
22 Department of Surgery, Division of Hepatobiliary and Pancreatic Surgery, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, 08826, South Korea. jangjy4@snu.ac.kr.
23 Molecular Biology Department, Genentech Inc., South San Francisco, CA, 94080, USA. sekar@sgrf.org.
24 SciGenom Research Foundation, 3rd Floor, Narayana Nethralaya Building, Narayana Health City, #258/A, Bommasandra, Hosur Road, Bangalore, Karnataka, 560099, India. sekar@sgrf.org.