Therapeutic Area: Oncology

Hepatitis E Virus (HEV)-Specific T Cell Receptor Cross-Recognition: Implications for Immunotherapy

Soon CF., et al.
Frontiers in Immunology
September 2020
Authors and Affiliates
Chai Fen Soon 1,2, Shihong Zhang 1, Pothakamuri Venkata Suneetha 1, Dinler Amaral Antunes 3, Michael Peter Manns 1,2, Solaiman Raha 4, Christian Schultze-Florey 4,5, Immo Prinz 2,4, Heiner Wedemeyer 1,6,7, Margaret Sällberg Chen 8,9, Markus Cornberg 1,2,6,10,11; 1 Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hanover, Germany. 2 Cluster of Excellence RESIST (EXC 2155), Hannover Medical School, Hanover, Germany. 3 Department of Computer Science, Rice University, Houston, TX, United States. 4 Hannover Medical School, Institute of Immunology, Hanover, Germany. 5 Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Hanover, Germany. 6 German Center for Infection Research, Partner Site Hannover-Braunschweig, Hanover, Germany. 7 Department of Gastroenterology and Hepatology, University Clinic Essen, Essen, Germany. 8 Department of Dental Medicine and Department of Laboratory Medicine, Karolinska Institutet, Stockholm, Sweden. 9 Shanghai Tenth People's Hospital, Tongji University, Shanghai, China. 10 Centre for Individualised Infection Medicine, Hanover, Germany. 11 Helmholtz Centre for Infection Research, Braunschweig, Germany.

T cell receptor diversity and lineage relationship between virus-specific CD8 T cell subsets during chronic LCMV infection

Chang YM., et al.
Journal of Virology
September 2020
immuneAccess
Authors and Affiliates
Yun Min Chang 1,2,3, Andreas Wieland 1,2, Zheng-Rong Li 1,2,4, Se Jin Im 1,2,5, Donald J McGuire 1,2, Haydn T Kissick 1,2,6, Rustom Antia 1,4, Rafi Ahmed 7,2; 1 Emory Vaccine Center, Emory University School of Medicine, Atlanta, Georgia, USA. 2 Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, Georgia, USA. 3 Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University School of Medicine, Atlanta, Georgia, USA. 4 Department of Biology, Emory University, Atlanta, Georgia, USA. 5 Department of Immunology, Sungkyunkwan University School of Medicine, Suwon, Korea. 6 Department of Urology, Emory University School of Medicine, Atlanta, Georgia, USA. 7 Emory Vaccine Center, Emory University School of Medicine, Atlanta, Georgia, USA rahmed@emory.edu.

A peripheral immune signature of responsiveness to PD-1 blockade in patients with classical Hodgkin lymphoma

Cader FZ., et al.
Nature Medicine
September 2020
immuneAccess
Authors and Affiliates
Fathima Zumla Cader 1,2, Xihao Hu 3,4,5, Walter L Goh 6, Kirsty Wienand 1,7, Jing Ouyang 1, Elisa Mandato 1, Robert Redd 3, Lee N Lawton 1, Pei-Hsuan Chen 8, Jason L Weirather 8, Ron C J Schackmann 6,9, Bo Li 3 4,10, Wenjiang Ma 1,11, Philippe Armand 1, Scott J Rodig 12, Donna Neuberg 3, X Shirley Liu 13,14, Margaret A Shipp 15; 1 Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA. 2 AstraZeneca, City House, Cambridge, UK. 3 Department of Data Sciences, Dana-Farber Cancer Institute, Boston, MA, USA. 4 Harvard T.H. Chan School of Public Health, Boston, MA, USA. 5 GV20 Therapeutics LLC, Cambridge, MA, USA. 6 Department of Cell Biology, Harvard Medical School, Boston, MA, USA. 7 Department of Hematology and Oncology, Göttingen Comprehensive Cancer Center, Göttingen, Germany. 8 Center for Immuno-Oncology, Dana-Farber Cancer Institute, Boston, MA, USA. 9 Merus, Utrecht, the Netherlands. 10 Lyda Hill Department of Bioinformatics, UT Southwestern Medical Center, Dallas, TX, USA. 11 Clarion Healthcare, Boston, MA, USA. 12 Department of Pathology, Brigham and Women's Hospital, Boston, MA, USA. 13 Department of Data Sciences, Dana-Farber Cancer Institute, Boston, MA, USA. xsliu@ds.dfci.harvard.edu. 14 Harvard T.H. Chan School of Public Health, Boston, MA, USA. xsliu@ds.dfci.harvard.edu. 15 Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA. Margaret_Shipp@dfci.harvard.edu.

De novo prediction of cancer-associated T cell receptors for noninvasive cancer detection

Beshnova D., et al.
Science Translational Medicine
September 2020
Authors and Affiliates
Daria Beshnova 1, Jianfeng Ye 1, Oreoluwa Onabolu 2, Benjamin Moon 3, Wenxin Zheng 4, Yang-Xin Fu 3,5, James Brugarolas 2, Jayanthi Lea 4, Bo Li 6,5; 1 Lyda Hill Department of Bioinformatics, UT Southwestern Medical Center, Dallas, TX 75390, USA. 2 Department of Internal Medicine, UT Southwestern Medical Center, Dallas, TX 75390, USA. 3 Department of Pathology, UT Southwestern Medical Center, Dallas, TX 75390, USA. 4 Department of Obstetrics and Gynecology, UT Southwestern Medical Center, Dallas, TX 75390, USA. 5 Department of Immunology, UT Southwestern Medical Center, Dallas, TX 75390, USA. 6 Lyda Hill Department of Bioinformatics, UT Southwestern Medical Center, Dallas, TX 75390, USA

Epigenetic Suppression of Transgenic T-cell Receptor Expression via Gamma-Retroviral Vector Methylation in Adoptive Cell Transfer Therapy

Nowicki TS., et al.
Cancer Discovery
September 2020
Authors and Affiliates
Theodore S Nowicki 1, Colin Farrell 2, Marco Morselli 3, Liudmilla Rubbi 4, Katie M Campbell 5, Mignonette H Macabali 6, Beata Berent-Maoz 5, Begona Comin-Anduix 7, Matteo Pellegrini 8, Antoni Ribas 9; 1 Pediatrics, Hematology-Oncology, University of California Los Angeles 2 Human Genetics, University of California Los Angeles. 3 Molecular, Cell and Developmental Biology, University of California Los Angeles. 4 Molecular, Cell, and Developmental Biology, University of California Los Angeles. 5 Department of Medicine, University of California Los Angeles. 6 Department of Medicine, Division of Hematology-Oncology, University of California Los Angeles. 7 Surgical Oncology, University of California Los Angeles. 8 Department of Molecular, Cell, and Developmental Biology, University of California Los Angeles. 9 Department of Medicine, Jonsson Comprehensive Cancer Center at University of California, Los Angeles, Los Angeles.

Augmented Lipocalin-2 is Associated with COPD and Counteracts Lung Adenocarcinoma Development

Treekitkarnmongkol W., et al.
American Journal of Respiratory and Critical Care Medicine
September 2020
Authors and Affiliates
Warapen Treekitkarnmongkol 1, Maya Hassane 2, Ansam Sinjab 1, Kyle Chang 3, Kieko Hara 1, Zahraa Rahal 4, Jiexin Zhang 5, Wei Lu 1, Smruthy Sivakumar 3, Tina L McDowell 1 3, Jacob Kantrowitz 6, Jianling Zhou 1, Wenhua Lang 1, Li Xu 1, Joshua K Ochieng 1, Sayuri Nunomura-Nakamura 7, Shanshan Deng 8, Carmen Behrens 1, Maria Gabriela Raso 1, Junya Fukuoka 9, Alexandre Reuben 10, Edwin J Ostrin 8, Edwin Parra 1, Luisa M Solis 1, Avrum E Spira 6, Florencia McAllister 11, Tina Cascone 10, Ignacio I Wistuba 1, Seyed Javad Moghaddam 8, Paul A Scheet 1, Junya Fujimoto 1, Humam Kadara 12; 1 University of Texas MD Anderson Cancer Center, 4002, Translational Molecular Pathology, Houston, Texas, United States. 2 American University of Beirut Faculty of Medicine, 66978, Biochemistry and Molecular Genetics, Beirut, Lebanon. 3 University of Texas MD Anderson Cancer Center, 4002, Epidemiology, Houston, Texas, United States. 4 American University of Beirut Faculty of Medicine, 66978, Beirut, Lebanon. 5 University of Texas MD Anderson Cancer Center, 4002, Bioinformatics and Computer Biology, Houston, Texas, United States. 6 Boston University, 1846, Medicine, Boston, Massachusetts, United States. 7 Nagasaki University School of Medicine Graduate School of Biomedical Sciences, 200674, Nagasaki, Japan. 8 University of Texas MD Anderson Cancer Center, 4002, Pulmonary Medicine, Houston, Texas, United States. 9 Nagasaki University School of Medicine Graduate School of Biomedical Sciences, 200674, Department of Pathology, Nagasaki, Japan. 10 University of Texas MD Anderson Cancer Center, 4002, Thoracic/Head and Neck Medical Oncology, Houston, Texas, United States. 11 University of Texas MD Anderson Cancer Center, 4002, Clinical Cancer Prevention, Houston, Texas, United States. 12 University of Texas MD Anderson Cancer Center, 4002, Translational Molecular Pathology, Houston, Texas, United States

Clonality and antigen-specific responses shape the prognostic effects of tumor-infiltrating T cells in ovarian cancer

Tsuji T., et al.
Oncotarget
September 2020
Authors and Affiliates
Takemasa Tsuji 1,2, Kevin H Eng 3,4,2, Junko Matsuzaki 1, Sebastiano Battaglia 1, J Brian Szender 5, Anthony Miliotto 1, Sacha Gnjatic 6, Wiam Bshara 7, Carl D Morrison 7, Shashikant Lele 5, Ryan O Emerson 8, Jianmin Wang 3, Song Liu 3, Harlan Robins 8, Amit A Lugade 1, Kunle Odunsi 1,5; 1 Center for Immunotherapy, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA. 2 These authors contributed equally to this work. 3 Biostatistics and Bioinformatics, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA. 4 Department of Cancer Genetics and Genomics, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA. 5 Department of Gynecologic Oncology, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA. 6 Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. 7 Department of Pathology, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA. 8 Adaptive Biotechnologies, Seattle, WA, USA.

B Cells Improve Overall Survival in HPV-Associated Squamous Cell Carcinomas and Are Activated by Radiation and PD-1 Blockade

Kim SS., et al.
Clinical Cancer Research
September 2020
Authors and Affiliates
Sangwoo S Kim 1,2, Sarek Shen 2,3, Sayuri Miyauchi 1, P Dominick Sanders 1, Ida Franiak-Pietryga 1, Loren Mell 1, J Silvio Gutkind 4, Ezra E W Cohen 5, Joseph A Califano 3, Andrew B Sharabi 6; 1 Department of Radiation Medicine and Applied Sciences, Moores Cancer Center, University of California, San Diego, La Jolla, California. 2 School of Medicine, Moores Cancer Center, University of California, San Diego, La Jolla, California. 3 Department of Surgery, Division of Otolaryngology, Moores Cancer Center, University of California, San Diego, La Jolla, California. 4 Department of Pharmacology, Moores Cancer Center, University of California, San Diego, La Jolla, California. 5 Department of Medicine, Division of Hematology-Oncology, Moores Cancer Center, University of California, San Diego, La Jolla, California. 6 Department of Radiation Medicine and Applied Sciences, Moores Cancer Center, University of California, San Diego, La Jolla, California

Tumor response and endogenous immune reactivity after administration of HER2 CAR T cells in a child with metastatic rhabdomyosarcoma

Hegde M., et al.
Nature Communications
September 2020
Authors and Affiliates
Meenakshi Hegde 1,2,3, Sujith K Joseph 4,5,6, Farzana Pashankar 7, Christopher DeRenzo 4,5,6, Khaled Sanber 4,5,6,8, Shoba Navai 4,5,6, Tiara T Byrd 4,5,6, John Hicks 9, Mina L Xu 10, Claudia Gerken 4,5,6, Mamta Kalra 4,5,6, Catherine Robertson 5, Huimin Zhang 5, Ankita Shree 4,5,6, Birju Mehta 5, Olga Dakhova 5, Vita S Salsman 4,5,6, Bambi Grilley 4,5,6, Adrian Gee 4,5,6, Gianpietro Dotti 11,12, Helen E Heslop 4,5,6,8, Malcolm K Brenner 4,5,6,8, Winfried S Wels 13,14,15, Stephen Gottschalk 4,5,6,9, Nabil Ahmed 16,17,18,19; 1 Texas Children's Cancer and Hematology Centers, Texas Children's Hospital, Baylor College of Medicine, Houston, TX, USA. mghegde@bcm.edu. 2 Center for Cell and Gene Therapy, Texas Children's Hospital, Houston Methodist Hospital, Baylor College of Medicine, Houston, TX, USA. mghegde@bcm.edu. 3 Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA. mghegde@bcm.edu. 4 Texas Children's Cancer and Hematology Centers, Texas Children's Hospital, Baylor College of Medicine, Houston, TX, USA. 5 Center for Cell and Gene Therapy, Texas Children's Hospital, Houston Methodist Hospital, Baylor College of Medicine, Houston, TX, USA. 6 Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA. 7 Department of Pediatrics, Yale University School of Medicine, New Haven, CT, USA. 8 Department of Medicine, Baylor College of Medicine, Houston, TX, USA. 9 Department of Pathology and Immunology, Baylor College of Medicine, Houston, TX, USA. 10 Department of Pathology, Yale University School of Medicine, New Haven, CT, USA. 11 Department of Microbiology and Immunology at University of North Carolina, Chapel Hill, NC, USA. 12 Lineberger Cancer Center at University of North Carolina, Chapel Hill, NC, USA. 13 Georg-Speyer-Haus, Institute for Tumor Biology and Experimental Therapy, Frankfurt, Germany. 14 German Cancer Consortium (DKTK), Partner Site Frankfurt/Mainz, Frankfurt, Germany. 15 Frankfurt Cancer Institute, Goethe University, Frankfurt, Germany. 16 Texas Children's Cancer and Hematology Centers, Texas Children's Hospital, Baylor College of Medicine, Houston, TX, USA. 17 Center for Cell and Gene Therapy, Texas Children's Hospital, Houston Methodist Hospital, Baylor College of Medicine, Houston, TX, USA. 18 Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA. 19 Department of Pathology and Immunology, Baylor College of Medicine, Houston, TX, USA

T cell fraction impacts oncologic outcomes in human papillomavirus associated oropharyngeal squamous cell carcinoma

Van Abel KM., et al.
September 2020
Authors and Affiliates
Kathryn M Van Abel 1, David M Routman 2, Eric J Moore 3, Daniel J Ma 2, Linda X Yin 3, Paul A Fields 4, Matt Schofield 4, Kathleen R Bartemes 3, Kyriakos Chatzopoulos 5, Daniel L Price 3, Jeffrey R Janus 3, Jan L Kasperbauer 3, Katharine A Price 6, Ashish V Chintakuntlawar 6, Michelle A Neben-Wittich 2, Robert L Foote 2, Joaquin J Garcia 5; 1 Department of Otolaryngology-Head and Neck Surgery, Mayo Clinic, Rochester, MN 55905, USA. Electronic address: vanabel.kathryn@mayo.edu. 2 Department of Radiation Oncology, Mayo Clinic, Rochester, MN 55905, USA. 3 Department of Otolaryngology-Head and Neck Surgery, Mayo Clinic, Rochester, MN 55905, USA. 4 Adaptive Biotechnologies, Seattle, WA 98102, USA; Department of Pathology and Clinical Medicine, Mayo Clinic, Rochester, MN 55905, USA. 5 Department of Pathology and Laboratory Medicine, Mayo Clinic, Rochester, MN 55905, USA. 6 Department of Medical Oncology, Mayo Clinic, Rochester, MN 55905, USA.