Therapeutic Area: Oncology

Novel technologies and emerging biomarkers for personalized cancer immunotherapy

Yuan et al.
Journal for ImmunoTherapy of Cancer
Papers
May 2016
Authors and Affiliates
Yuan J1, Hegde PS2, Clynes R3, Foukas PG4, Harari A5, Kleen TO6, Kvistborg P7, Maccalli C8, Maecker HT9, Page DB10, Robins H11, Song W12, Stack EC13, Wang E14, Whiteside TL15, Zhao Y16, Zwierzina H17, Butterfield LH18, Fox BA10. 1Memorial Sloan-Kettering Cancer Center, 1275 New York Ave Box 386, New York, NY 10065 USA. 2Genentech, Inc., 1 DNA Way South, San Francisco, CA 94080 USA. 3Bristol-Myers Squibb, 3551 Lawrenceville Road, Princeton, NJ 08648 USA. 4Center of Experimental Therapeutics and Ludwig Institute of Cancer Research, University Hospital of Lausanne, Rue du Bugnon 21, 1011 Lausanne, Switzerland ; Department of Pathology, University of Athens Medical School, "Attikon" University Hospital, 1st Rimini St, 12462 Haidari, Greece. 5Center of Experimental Therapeutics and Ludwig Institute of Cancer Research, University Hospital of Lausanne, Rue du Bugnon 21, 1011 Lausanne, Switzerland. 6Epiontis GmbH, Rudower Chaussee 29, 12489 Berlin, Germany. 7Netherlands Cancer Institute, Postbus 90203, 1006 BE Amsterdam, Netherlands. 8Italian Network for Biotherapy of Tumors (NIBIT)-Laboratory, c/o Medical Oncology and Immunotherapy, University Hospital of Siena, V.le Bracci,16, Siena, 53100 Italy. 9Stanford University Medical Center, 299 Campus Drive, Stanford, CA 94303 USA.10Earle A. Chiles Research Institute, Providence Cancer Center, 4805 NE Glisan Street, Portland, OR 97213 USA. 11Adaptive Technologies, Inc., 1551 Eastlake Avenue East Suite 200, Seattle, WA 98102 USA. 12AstraZeneca, One MedImmune Way, Gaithersburg, MD 20878 USA. 13PerkinElmer, 68 Elm Street, Hopkinton, MA 01784 USA. 14Sidra Medical and Research Center, PO Box 26999, Doha, Qatar. 15University of Pittsburgh Cancer Institute, 5117 Centre Ave, Suite 1.27, Pittsburgh, PA 15213 USA. 16National Cancer Institute, 9609 Medical Center Drive, Rockville, MD 20850 USA. 17Innsbruck Medical University, Medizinische Klinik, Anichstrasse 35, Innsbruck, A-6020 Austria. 18Department of Medicine, Surgery and Immunology, University of Pittsburgh Cancer Institute, 5117 Centre Avenue, Pittsburgh, PA 15213 USA.

Immunodynamics: a cancer immunotherapy trials network review of immune monitoring in immuno-oncology clinical trials

Kohrt et al.
Journal for ImmunoTherapy of Cancer
Journal of Immunotherapy
Papers
May 2016
Authors and Affiliates
Holbrook E. Kohrt1, Paul C. Tumeh2, Don Benson3, Nina Bhardwaj4, Joshua Brody5, Silvia Formenti6, Bernard A. Fox7, Jerome Galon8, Carl H. June9, Michael Kalos10, Ilan Kirsch11, Thomas Kleen12, Guido Kroemer13, Lewis Lanier14, Ron Levy15, H. Kim Lyerly16, Holden Maecker17, Aurelien Marabelle18, Jos Melenhorst19, Jeffrey Miller20, Ignacio Melero21, Kunle Odunsi22, Karolina Palucka23, George Peoples24, Antoni Ribas25, Harlan Robins26, William Robinson27, Tito Serafini28, Paul Sondel29, Eric Vivier30, Jeff Weber31, Jedd Wolchok32, Laurence Zitvogel33, Mary L. Disis34, Martin A. Cheever35 and on behalf of the Cancer Immunotherapy Trials Network (CITN) 1Division of Oncology, Stanford Cancer Institute, Stanford University Medical Center, Stanford, CA, USA.2Division of Dermatology, Department of Medicine, University of California Los Angeles, Los Angeles, CA USA.3Division of Hematology/Oncology, Ohio State University, Columbus, OH USA.4Medicine, Hematology and Medical Oncology, Mount Sinai Hospital, New York, NY USA.5Medicine, Hematology and Medical Oncology, Mount Sinai Hospital, Ruttenberg Treatment Center, New York, NY USA. 6Department of Radiation Oncology, New York Weill Cornell Medical Center, New York, NY USA.7SOM-Molecular Microbiology & Immunology Department, Laboratory of Molecular and Tumor Immunology, OHSU Cancer Institute, Portland, OR USA. 8INSERM, Integrative Cancer Immunology Team, Cordeliers Research Center, Paris, France. 9Perelman School of Medicine, University of Pennsylvania, Pathology and Laboratory Medicine, Philadelphia, PA USA.10Cancer Immunobiology, Eli Lilly & Company, New York, NY USA. 11Translational Medicine, Adaptive Biotechnologies Corp, Seattle, WA USA. 12Immune Monitoring, Epiontis GmbH, Berlin, Germany. 13Faculty of Medicine, University of Paris Descartes, Paris, France. 14Department of Microbiology and Immunology, University of California, San Francisco, CA USA. 15Division of Oncology, Stanford School of Medicine, Stanford, CA USA. 16Duke University School of Medicine, Durham, NC USA. 17Human Immune Monitoring Center Shared Resource, Stanford Cancer Institute, Stanford, CA USA.18Léon Bérard Cancer Center, Lyon, France. 19Product Development and Correlative Sciences, Smilow Center for Translational Research, Philadelphia, PA USA. 20Division of Hematology, Experimental Therapeutics, University of Minnesota, Oncology and Transplantation, Minneapolis, MN USA. 21Centro de Investigacion Medica Aplicada, Universidad de Navarra, Avda. Pamplona, Spain. 22Center for Immunotherapy, Roswell Park Cancer Institute, Buffalo, NY USA. 23Baylor Institute for Immunology Research, Dallas, TX USA. 24Cancer Vaccine Development Program, Brooke Army Medical Center, Houston, TX USA. 25Tumor Immunology Program Area, Jonsson Comprehensive Cancer Center, University of California, Los Angeles, CA USA. 26Adaptive Biotechnologies, Seattle, WA USA. 27Division of Immunology and Rheumatology, Department of Medicine, Stanford University School of Medicine, Stanford, CA USA. 28Atreca, Inc, Redwood City, CA USA. 29Cellular & Molecular Pathology Graduate Program, University of Wisconsin-Madison, Madison, WI USA. 30Centre d'Immunologie de Marseille-Luminy, Marseille, France. 31Moffitt Cancer Center, Tampa, FL USA. 32Immunology Program, Memorial Sloan-Kettering Cancer Center, New York, NY USA. 33Institut National de la Santé et Recherche Médicale, Institut GrustaveRoussy, Villejuif, France. 34Tumor Vaccine Group, University of Washington, Seattle, WA USA.35Fred Hutchinson Cancer Research Center, Seattle, WA 98109-1023 USA.

CD19 CAR–T cells of defined CD4+:CD8+ composition in adult B cell ALL patients

Turtle et al.
Papers
The Journal of Clinical Investigation
April 2016
Authors and Affiliates
Cameron J. Turtle,1,2 Laïla-Aïcha Hanafi,1 Carolina Berger,1,2 Theodore A. Gooley,1 Sindhu Cherian,3 Michael Hudecek,1 Daniel Sommermeyer,1Katherine Melville,1 Barbara Pender,1 Tanya M. Budiarto,1 Emily Robinson,1 Natalia N. Steevens,1 Colette Chaney,1 Lorinda Soma,3 Xueyan Chen,3 Cecilia Yeung,3,4 Brent Wood,3,4 Daniel Li,5 Jianhong Cao,1 Shelly Heimfeld,1 Michael C. Jensen,1,6 Stanley R. Riddell,1,2,7 and David G. Maloney1,2 1 Clinical Research Division, Fred Hutchinson Cancer Research Center (FHCRC), Seattle, Washington, USA. 2 Department of Medicine, 3 Department of Laboratory Medicine, and 4 Department of Pathology, University of Washington, Seattle, Washington, USA. 5 Juno Therapeutics, Seattle, Washington, USA. 6 Seattle Children’s Research Institute, Seattle, Washington, USA. 7 Institute for Advanced Study, Technical University of Munich, Munich, Germany

Immune DNA signature of T-cell infiltration in breast tumor exomes

Levy et al.
bioRxiv
Papers
April 2016
Authors and Affiliates
Eric Levy,1,2 Rachel Marty,2,3 Valentina Garate-Calderon,4,5 Brian Woo,6 Michelle Dow,1,2 Ricardo Armisen,4,5 Hannah Carter,3,6,7 Olivier Harismendy,1,6 1Division of Biomedical Informatics, Department of Medicine, University of California San Diego 2Bioinformatics and Systems Biology Graduate Program, University of California San Diego 3Division of Medical Genetics, Department of Medicine, University of California San Diego 4Centro de Investigación y Tratamiento del Cancer, Facultad de Medicina, Universidad de Chile 5Center for Excellence in Precision Medicine, Pfizer Chile 6Moores Cancer Center, University of California San Diego 7Institute for Genomic Medicine, University of California San Diego.

TCR Sequencing Can Identify and Track Glioma-Infiltrating T Cells after DC Vaccination

Hsu et al.
Cancer Immunology Research
Papers
March 2016
immuneAccess
Authors and Affiliates
Melody S. Hsu1,2, Shaina Sedighim1, Tina Wang1,3, Joseph P. Antonios1,4, Richard G. Everson1, Alexander M. Tucker1, Lin Du5, Ryan Emerson6, Erik Yusko6, Catherine Sanders6, Harlan S. Robins6,7, William H. Yong8,9, Tom B. Davidson1,2,8, Gang Li5,8, Linda M. Liau1,8, and Robert M. Prins1,8,10, 1Department of Neurosurgery, David Geffen School of Medicine at UCLA, Los Angeles, California. 2Department of Pediatrics, David Geffen School of Medicine at UCLA, Los Angeles, California. 3Department of Medicine (Hematology/Oncology), David Geffen School of Medicine at UCLA, Los Angeles, California. 4Medical Scientist Training Program, David Geffen School of Medicine at UCLA, Los Angeles, California. 5Department of Biostatistics, David Geffen School of Medicine at UCLA, Los Angeles, California. 6Adaptive Biotechnologies, Seattle, Washington. 7Fred Hutchinson Cancer Research Center, Seattle, Washington. 8Jonsson Comprehensive Cancer Center, David Geffen School of Medicine at UCLA, Los Angeles, California. 9Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, Los Angeles, California. 10Department of Molecular and Medical Pharmacology, David Geffen School of Medicine at UCLA, Los Angeles, California.

Inclusion of Strep-tag II in design of antigen receptors for T-cell immunotherapy

Liu et al.
Nature Biotechnology
Papers
February 2016
Authors and Affiliates
Lingfeng Liu1, Daniel Sommermeyer1, Alexandra Cabanov1, Paula Kosasih1, Tyler Hill1 & Stanley R Riddell1–3 1Program in Immunology, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA. 2Department of Medicine, University of Washington, Seattle, Washington, USA. 3Institute for Advanced Study, Technical University of Munich, Munich, Germany

Prospective identification of neoantigen-specific lymphocytes in the peripheral blood of melanoma patients

Gros et al.
Nature Medicine
Papers
January 2016
Authors and Affiliates
Alena Gros, Maria R Parkhurst, Eric Tran, Anna Pasetto, Paul F Robbins, Sadia Ilyas, Todd D Prickett, Jared J Gartner, Jessica S Crystal, Ilana M Roberts, Kasia Trebska-McGowan, John R Wunderlich, James C Yang & Steven A Rosenberg. Surgery Branch, National Cancer Institute (NCI), National Institutes of Health, Bethesda, Maryland, USA.

The Evolution of Tumors in Mice and Humans with Germline p53 Mutations

Levine, AJ
Cold Spring Harbor Symposia on Quantitative Biology
December 2015
Authors and Affiliates
Levine AJ1, Chan CS2, Dudgeon C3, Puzio-Kuter A3, Hainaut P4. 1Institute for Advanced Study, Princeton, New Jersey 08540 Cancer Institute of New Jersey, New Brunswick, New Jersey 08903 2Cancer Institute of New Jersey, New Brunswick, New Jersey 08903 Department of Medicine, Rutgers Robert Wood Johnson Medical School, New Jersey 08903. 3Cancer Institute of New Jersey, New Brunswick, New Jersey 08903. 4Grenoble Institute for Research on Cancer, Grenoble 38706, France.