Therapeutic Area: Oncology
Immunogenicity of somatic mutations in human gastrointestinal cancers.
Tran et al.
Papers
Science
December 2015
Authors and Affiliates
Tran E1, Ahmadzadeh M1, Lu YC1, Gros A1, Turcotte S1, Robbins PF1, Gartner JJ1, Zheng Z1, Li YF1, Ray S1, Wunderlich JR1, Somerville RP1, Rosenberg SA2.
1Surgery Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. 2Surgery Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Type 1 diabetes immunotherapy using polyclonal regulatory T cells
Jeffrey A. Bluestone
Papers
Science Translational Medicine
November 2015
Authors and Affiliates
Jeffrey A. Bluestone1, Jane H. Buckner2, Mark Fitch3, Stephen E. Gitelman4, Shipra Gupta2, Marc K. Hellerstein3, Kevan C. Herold5, Angela Lares1, Michael R. Lee1, Kelvin Li6, Weihong Liu1, S. Alice Long2, Lisa M. Masiello1, Vinh Nguyen7, Amy L. Putnam1, Mary Rieck1, Peter H. Sayre8 and Qizhi Tang7
1 Diabetes Center, University of California, San Francisco, San Francisco, CA 94143, USA. 2 Translational Research Program, Benaroya Research Institute at Virginia Mason, Seattle, WA 98101, USA. 3 Department of Nutritional Sciences and Toxicology, University of California, Berkeley, Berkeley, CA 94720, USA. 4 Department of Pediatrics, University of California, San Francisco, San Francisco, CA 94143, USA. 5 Departments of Immunobiology and Internal Medicine, Yale University School of Medicine, New Haven, CT 06520, USA. 6 KineMed Inc., Emeryville, CA 94608, USA. 7 Department of Surgery, University of California, San Francisco, San Francisco, CA 94143, USA. 8 Division of Hematology-Oncology, Department of Medicine, University of California, San Francisco, San Francisco, CA 94143, USA.
IL-21-driven neoplasms in SJL mice mimic some key features of human angioimmunoblastic T-cell lymphoma
Jain et al.
American Journal of Pathology
Papers
November 2015
Authors and Affiliates
Jain S1, Chen J2, Nicolae A3, Wang H1, Shin DM4, Adkins EB5, Sproule TJ6, Leeth CM7, Sakai T1, Kovalchuk AL1, Raffeld M3,Ward JM1, Rehg JE8, Waldmann TA2, Jaffe ES3, Roopenian DC5, Morse HC 3rd9.
1Virology and Cellular Immunology Section, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, Rockville, Maryland.
2Lymphoid Malignancies Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland.
3Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland.
4Virology and Cellular Immunology Section, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, Rockville, Maryland; Department of Food and Nutrition, Seoul National University, Seoul, Republic of Korea.
5Jackson Laboratory, Bar Harbor, Maine; Genetics Program, Tufts University Sackler School of Graduate Biomedical Sciences, Boston, Massachusetts.
6Jackson Laboratory, Bar Harbor, Maine.
7Genetics Program, Tufts University Sackler School of Graduate Biomedical Sciences, Boston, Massachusetts; Department of Animal and Poultry Sciences, College of Agriculture and Life Sciences, Virginia Polytechnic Institute and State University, Blacksburg, Virginia.
8Department of Pathology, St. Jude Children's Research Hospital, Memphis, Tennessee.
9Virology and Cellular Immunology Section, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, Rockville, Maryland
T-cell receptor profiling in cancer
Kirsch et al.
Molecular Oncology
Papers
September 2015
Authors and Affiliates
Kirsch I1, Vignali M2, Robins H3.
1Adaptive Biotechnologies, Seattle, WA, USA. 2Adaptive Biotechnologies, Seattle, WA, USA. 3Adaptive Biotechnologies, Seattle, WA, USA; Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
High-throughput pairing of T cell receptor α and β sequences
Howie et al.
Papers
Science Translational Medicine
August 2015
Authors and Affiliates
Bryan Howie,1 Anna M. Sherwood,1 Ashley D. Berkebile,1 Jan Berka,1 Ryan O. Emerson,1 David W. Williamson,1 Ilan Kirsch,1 Marissa Vignali,1 Mark J. Rieder,1 Christopher S. Carlson,2 Harlan S. Robins1,2
1Adaptive Biotechnologies, Seattle, WA 98102, USA. 2Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
Detection and Tracking of NY-ESO-1-Specific CD8+ T Cells by High-Throughput T Cell Receptor β (TCRB) Gene Rearrangements Sequencing in a Peptide-Vaccinated Patient.
Miyai et al.
Papers
PLOS ONE
August 2015
Authors and Affiliates
Miyai M1, Eikawa S2, Hosoi A1, Iino T1, Matsushita H1, Isobe M3, Uenaka A3, Udono H2, Nakajima J4, Nakayama E3, Kakimi K1.
1Department of Immunotherapeutics, The University of Tokyo Hospital, Bunkyo-ku, Tokyo, Japan. 2Department of Immunology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Okayama, Japan. 3Faculty of Health and Welfare, Kawasaki University of Medical Welfare, Kurashiki, Okayama, Japan. 4Department of Thoracic Surgery, The University of Tokyo Hospital, Bunkyo-ku, Tokyo, Japan.
Adult Low-Hypodiploid Acute B-Lymphoblastic Leukemia With IKZF3 Deletion and TP53 MutationComparison With Pediatric Patients
Fang et al.
American Journal of Clinical Pathology
Papers
August 2015
Authors and Affiliates
Fang M1, Becker PS2, Linenberger M2, Eaton KD3, Appelbaum FR3, Dreyer Z4, Airewele G4, Redell M4, Lopez-Terrada D4,Patel A5, Rabin KR4, Lu X6
1From the Fred Hutchinson Cancer Research Center, Seattle, WA; University of Washington, Seattle; Seattle Cancer Care Alliance, Seattle, WA; 2From the Fred Hutchinson Cancer Research Center, Seattle, WA; University of Washington, Seattle; 3From the Fred Hutchinson Cancer Research Center, Seattle, WA; University of Washington, Seattle; Seattle Cancer Care Alliance, Seattle, WA; 4Texas Children's Cancer and Hematology Centers and Department of Pediatrics, Baylor College of Medicine, Houston; 5Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX; and. 6Department of Hematopathology, University of Texas MD Anderson Cancer Center, Houston.
A high density of tertiary lymphoid structure B cells in lung tumors is associated with increased CD4+ T cell receptor repertoire clonality
Zhu et al.
OncoImmunology
Papers
June 2015
Authors and Affiliates
Zhu W1, Germain C2, Liu Z1, Sebastian Y1, Devi P2, Knockaert S2, Brohawn P1, Lehmann K1, Damotte D3, Validire P4, Yao Y1, Valge-Archer V5, Hammond SA6, Dieu-Nosjean MC2, Higgs BW1
1Translational Sciences; MedImmune ; Gaithersburg, MD USA. 2Laboratory "Cancer, Immune Control, and Escape"; INSERM UMRS 1138; Cordeliers Research Center ; Paris, France ; University Sorbonne; University Pierre and Marie Curie; UMRS 1138 ; Paris, France ; University Sorbonne Paris Cité; University Paris Descartes; UMRS 1138 ; Paris, France. 3Laboratory "Cancer, Immune Control, and Escape"; INSERM UMRS 1138; Cordeliers Research Center ; Paris, France ; University Sorbonne; University Pierre and Marie Curie; UMRS 1138 ; Paris, France ; University Sorbonne Paris Cité; University Paris Descartes; UMRS 1138 ; Paris, France ; Department of Pathology; Cochin Hospital; AP-HP ; Paris, France. 4Laboratory "Cancer, Immune Control, and Escape"; INSERM UMRS 1138; Cordeliers Research Center ; Paris, France ; University Sorbonne; University Pierre and Marie Curie; UMRS 1138 ; Paris, France ; University Sorbonne Paris Cité; University Paris Descartes; UMRS 1138 ; Paris, France ; Department of Pathology; Institut Mutualiste Montsouris ; Paris, France. 5Oncology Research; MedImmune ; Cambridge, UK. 6Oncology Research; MedImmune ; Gaithersburg, MD USA.
Abstract Reference
Human CD45RA− FoxP3hi Memory-Type Regulatory T Cells Show Distinct TCR Repertoires With Conventional T Cells and Play an Important Role in Controlling Early Immune Activation
Lei, et al.
American Journal of Transplantation
Papers
June 2015
Authors and Affiliates
H. Lei, L. Kuchenbecker, M. Streitz, B. Sawitzki, K. Vogt, S. Landwehr-Kenzel, J. Millward, K. Juelke, N. Babel, A. Neumann, P. Reinke, H.-D. Volk