Therapeutic Area: Oncology

A dendritic cell vaccine increases the breadth of diversity of melanoma neoantigen-specific T cells

Carreno et al.
Papers
ScienceXpress
April 2015
Authors and Affiliates
Carreno BM1, Magrini V2, Becker-Hapak M1, Kaabinejadian S3, Hundal J2, Petti AA2, Ly A2, Lie WR4, Hildebrand WH3, Mardis ER2, Linette GP1 Department of Medicine, Division of Oncology, Washington University School of Medicine, St. Louis, MO1; Genome Institute, Washington University School of Medicine, St. Louis MO2; Department of Microbiology and Immunology, University of Oklahoma Health Science Center, Oklahoma City, OK3; EMD Millipore Corporation, Billerica, MA4

Changes in peanut-specific T-cell clonotype with oral immunotherapy

Bégin et al.
Papers
The Journal of Allergy and Clinical Immunology
April 2015
Authors and Affiliates
Bégin, P1, Nadeau, KC2. 1Department of Pediatrics, Sainte-Justine Hospital, Montreal, Quebec, Canada; Department of Medicine, University of Montreal Health Center, Montreal, Quebec, Canada. 2Division of Allergy, Immunology and Rheumatology, Sean N. Parker Center for Allergy Research at Stanford University, Stanford University School of Medicine, Stanford, Calif

Radiation and dual checkpoint blockade activate non-redundant immune mechanisms in cancer

Twyman-Saint et al.
Nature
Papers
March 2015
Authors and Affiliates
Twyman-Saint Victor C1,2, Rech AJ2, Maity A3,4, Rengan R3,4, Pauken KE5,6, Stelekati E5,6, Benci JL2,3, Xu B2,3, Dada H2,3, Odorizzi PM5,6, Herati RS1,6, Mansfield KD5,6, Patsch D3, Amaravadi RK1,4, Schuchter LM1,4, Ishwaran H7, Mick R4,8, Pryma DA4,9, Xu X4,10, Feldman MD4,10, Gangadhar TC1,4, Hahn SM3,4, Wherry EJ4,5,6, Vonderheide RH1,2,4,6, Minn AJ2,3,4,6 Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA1; Abramson Family Cancer Research Institute Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA2; Department of Radiation Oncology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA3; Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA4; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA5; Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA6; Division of Biostatistics, Department of Public Heath Sciences, University of Miami, Miami, FL7; Department of Biostatistics and Epidemiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA8; Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA9; Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA10

BTLA marks a less-differentiated tumor-infiltrating lymphocyte subset in melanoma with enhanced survival properties

Haymaker et al.
OncoImmunology
Papers
March 2015
Authors and Affiliates
Haymaker CL1, Wu RC2, Ritthipichai K3, Bernatchez C4, Forget MA1, Chen JQ5, Liu H6, Wang E7, Marincola F8, Hwu P5,Radvanyi LG9. 1Department of Melanoma Medical Oncology; The University of Texas MD Anderson Cancer Center ; Houston, TX USA. 2Department of Melanoma Medical Oncology; The University of Texas MD Anderson Cancer Center ; Houston, TX USA ; MD/PhD Program; University of Texas Medical School at Houston ; Houston, TX USA ; Graduate Program in Immunology; University of Texas Graduate School of Biomedical Sciences ; Houston, TX USA ; University of Texas Southwestern Medical Center; Department of Internal Medicine ; Dallas, TX USA. 3Department of Melanoma Medical Oncology; The University of Texas MD Anderson Cancer Center ; Houston, TX USA ; Graduate Program in Immunology; University of Texas Graduate School of Biomedical Sciences ; Houston, TX USA. 4Department of Melanoma Medical Oncology; The University of Texas MD Anderson Cancer Center ; Houston, TX USA ; University of Texas Southwestern Medical Center; Department of Internal Medicine ; Dallas, TX USA. 5Department of Melanoma Medical Oncology; The University of Texas MD Anderson Cancer Center ; Houston, TX USA ; Lion Biotechnologies ; Tampa, FL USA. 6Infectious Disease and Immunogenetics Section; Department of Transfusion Medicine; Clinical Center and trans-NIH Center for Human Immunology; National Institutes of Health ; Bethesda, MD USA. 7Infectious Disease and Immunogenetics Section; Department of Transfusion Medicine; Clinical Center and trans-NIH Center for Human Immunology; National Institutes of Health ; Bethesda, MD USA ; Sidra Medical Research Hospital ; Doha, Qatar. 8Surgery Branch; National Cancer Institute; National Institutes of Health ; Bethesda, MD USA ; Department of Immunology; H Lee Moffitt Cancer Center ; Tampa, FL USA. 9Department of Melanoma Medical Oncology; The University of Texas MD Anderson Cancer Center ; Houston, TX USA ; Lion Biotechnologies ; Tampa, FL USA ; Department of Immunology; H Lee Moffitt Cancer Center ; Tampa, FL USA.

Polyclonal, newly derived T cells with low expression of inhibitory molecule PD-1 in tonsils define the phenotype of lymphocytes in children with Periodic Fever, Aphtous Stomatitis, Pharyngitis and Adenitis (PFAPA) syndrome

Dytrych et al.
Molecular Immunology
Papers
January 2015
Authors and Affiliates
Dytrych P1, Krol P2, Kotrova M3, Kuzilkova D3, Hubacek P3,4, Krol L3, Katra R1, Hrusak O3, Kabelka Z1, Dolezalova P2, Kalina T3, Fronkova E3 Department of ENT, Charles University, 2nd Faculty of Medicine, Charles University Prague and University Hospital Motol, Czech Republic1; Pediatric Rheumatology Unit, Department of Pediatrics and Adolescent Medicine, Charles University Prague and General University Hospital in Prague, 1st Faculty of Medicine, Czech Republic2; CLIP, Department of Paediatric Haematology/Oncology, 2nd Faculty of Medicine, Charles University in Prague and University Hospital Motol Czech Republic3; Department of Medical Microbiology, 2nd Faculty of Medicine, Charles University in Prague and University Hospital Motol, Czech Republic4

The Analysis Of Clonal Diversity And Therapy Responses Using STAT3 Mutations As A Molecular Marker In Large Granular Lymphocytic Leukemia

Rajala et al.
Haematologica
Papers
January 2015
Authors and Affiliates
Rajala HL1, Olson T2, Clemente MJ3, Lagström S4, Ellonen P4, Lundan T5, Hamm DE6, Zaman SA4, Lopez Marti JM4,Andersson EI1, Jerez A7, Porkka K1, Maciejewski JP3, Loughran TP2, Mustjoki S8. 1Hematology Research Unit, Department of Hematology, University of Helsinki and Helsinki University Central Hospital Cancer Center, Helsinki, Finland. 2University of Virginia Cancer Center, Charlottesville, VA, USA. 3Department of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH, USA. 4Institute for Molecular Medicine (FIMM), University of Helsinki, Finland. 5Department of Clinical Chemistry and TYKSLAB, University of Turku and Turku University Central Hospital, Finland. 6Adaptive Biotechnologies Corp, Seattle, WA, USA. 7Department of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH, USA Hematology and Medical Oncology Department, Hospital Universitario Morales Meseguer, Universidad de Murcia, IMIB-Arrixaca, Murcia, Spain. 8Hematology Research Unit, Department of Hematology, University of Helsinki and Helsinki University Central Hospital Cancer Center, Helsinki, Finland

Emergence of a STAT3 Mutated NK Clone in LGL Leukemia

Yan et al.
Leukemia Research Reports
Papers
December 2014
Authors and Affiliates
Yan Y1, Olson TL2, Nyland SB2, Feith DJ2, Loughran Jr TP2 Department of Medicine, York Hospital, York, PA1; University of Virginia Cancer Center, Charlottesville, VA2