NoisET: Noise Learning and Expansion Detection of T-Cell Receptors

Koraichi MB, et al.
Journal of Physical Chemistry A
December 2022
Authors and Affiliates
Meriem Bensouda Koraichi 1, Maximilian Puelma Touzel 2, Andrea Mazzolini 1, Thierry Mora 1, Aleksandra M Walczak 1; 1 Laboratoire de physique de l' École normale supérieure, CNRS, PSL University, Sorbonne Université, and Université de Paris, Paris75005, France. 2 MILA, University of Montreal, MontrealH2S 3H1, Canada.

Thymic epithelial cells require lipid kinase Vps34 for CD4 but not CD8 T cell selection

Postoak JL, et al.
Journal of Experimental Medicine
September 2022
Authors and Affiliates
J Luke Postoak 1, Wenqiang Song 1, Guan Yang 1, Xingyi Guo 2, Shiyun Xiao 3, Cherie E Saffold 1, Jianhua Zhang 4,5, Sebastian Joyce 1,6, Nancy R Manley 3, Lan Wu 1, Luc Van Kaer 1; 1 Department of Pathology, Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, TN. 2 Department of Biomedical Informatics, Vanderbilt University School of Medicine, Nashville, TN. 3 Department of Genetics, University of Georgia, Athens, GA. 4 Department of Pathology, University of Alabama at Birmingham, Birmingham, AL. 5 Birmingham Veterans Affairs Medical Center, Birmingham, AL. 6 Department of Veterans Affairs, Tennessee Valley Healthcare System, Nashville, TN.

Ixazomib, lenalidomide and dexamethasone consolidation with randomized ixazomib or lenalidomide maintenance after autologous transplant in newly diagnosed multiple myeloma.

Slade M, et al.
September 2022
Authors and Affiliates
Michael Slade 1, Thomas G. Martin2, Nitya Nathwani3, Mark A. Fiala 1, Michael P. Rettig1, Feng Gao1, Abhinav Deol4,Francis K. Buadi 5, Jonathan L. Kaufman 6, Craig C. Hofmeister 6, Tara K. Gregory7, Jesus Berdeja 8, Ajai Chari9,Ashley Rosko10 and Ravi Vij1 1Washington University School of Medicine, St. Louis, MO, USA. 2University of California- San Francisco, San Francisco, CA, USA. 3Judy and Bernard Briskin Center for Multiple Myeloma Research, City of Hope Comprehensive Cancer Center, Duarte, CA, USA. 4Karmanos Cancer Institute, Wayne State University, Detroit, MI, USA. 5Mayo Clinic, Rochester,MN, USA. 6Emory University, Atlanta, GA, USA. 7Sarah Cannon Research Institute, Denver, CO, USA. 8Sarah Cannon Research Institute, Nashville, TN, USA. 9Icahn School of Medicine at Mount Sinai, New York City, NY, USA. 10Ohio State University, Columbus, OH, USA.

Genesis of the αβ T-cell receptor

Dupic T, et al.
August 2022
Authors and Affiliates
Thomas Dupic 1,2, Quentin Marcou 2, Aleksandra M Walczak 2, Thierry Mora 2; 1 Laboratoire de physique théorique et hautes énergies, CNRS and Sorbonne Université, 4 Place Jussieu, 75005 Paris, France. 2 Laboratoire de physique de l'ENS, CNRS, Sorbonne Université, and École normale supérieure (PSL), 24 rue Lhomond, 75005 Paris, France.

Partial RAG deficiency in humans induces dysregulated peripheral lymphocyte development and humoral tolerance defect with accumulation of T-bet + B cells

Csomos K, et al.
Nature Immunology
August 2022
Authors and Affiliates
Krisztian Csomos 1, Boglarka Ujhazi 2, Peter Blazso 2,3, Jose L Herrera 4,5, Christopher M Tipton 6, Tomoki Kawai 7, Sumai Gordon 2, Maryssa Ellison 2, Kevin Wu 2, Matthew Stowell 2, Lauren Haynes 2, Rachel Cruz 2, Bence Zakota 2, Johnny Nguyen 8, Michelle Altrich 9, Christoph B Geier 10, Svetlana Sharapova 11, Joseph F Dasso 2, Jennifer W Leiding 2, Grace Smith 12, Waleed Al-Herz 13, Mayra de Barros Dorna 14, Olajumoke Fadugba 15, Eva Fronkova 16, Veronika Kanderova 16, Michael Svaton 16, Sarah E Henrickson 17,18, Joseph D Hernandez 19, Taco Kuijpers 20, Snezhina Mihailova Kandilarova 21, Elizaveta Naumova 21, Tomas Milota 22, Anna Sediva 22, Despina Moshous 23,24,25, Benedicte Neven 23,24,26, Tara Saco 27, Ravishankar Sargur 28, Sinisa Savic 29,30, John Sleasman 31, Gauri Sunkersett 32, Brant R Ward 33, Masanobu Komatsu 4,5, Stefania Pittaluga 12, Attila Kumanovics 34, Manish J Butte 35, Michael P Cancro 36, Shiv Pillai 37, Eric Meffre 38,39, Luigi D Notarangelo 7, Jolan E Walter 40,41; 1 Division of Pediatric Allergy/Immunology, University of South Florida at Johns Hopkins All Children's Hospital, St. Petersburg, FL, USA. kcsomos@usf.edu. 2 Division of Pediatric Allergy/Immunology, University of South Florida at Johns Hopkins All Children's Hospital, St. Petersburg, FL, USA. 3 Department of Pediatrics, University of Szeged, Szeged, Hungary. 4 Cancer and Blood Disorders Institute and Department of Surgery, Johns Hopkins All Children's Hospital, St. Petersburg, FL, USA. 5 Department of Orthopaedic Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA. 6 Department of Medicine, Division of Rheumatology, Emory University, Atlanta, GA, USA. 7 Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD, USA. 8 Department of Pathology & Laboratory Medicine, Johns Hopkins All Children's Hospital, St Petersburg, FL, USA. 9 Eurofins Viracor Laboratories, Lee Summit's, MO, USA. 10 Immunology Outpatient Clinic, Vienna, Austria. 11 Belarusian Research Center for Pediatric Oncology, Minsk, Belarus. 12 Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA. 13 Department of Pediatrics, Faculty of Medicine, Kuwait University, Kuwait City, Kuwait. 14 Department of Pediatrics, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brasil. 15 Division of Pulmonary, Allergy and Critical Care, Perelman School of Medicine, University of Pennsylvania, Pennsylvania, PA, USA. 16 Childhood Leukemia Investigation Prague, Department of Pediatric Hematology and Oncology, Second Faculty of Medicine, Charles University and University Hospital Motol, Prague, Czech Republic. 17 Allergy Immunology Division, Department of Pediatrics, The Children's Hospital of Philadelphia, Philadelphia, PA, USA. 18 Institute for Immunology, the University of Pennsylvania, Philadelphia, PA, USA. 19 Department of Pediatrics, Division of Allergy, Immunology and Rheumatology, Stanford University, Stanford, CA, USA. 20 Deptartment of Pediatric Immunology, Rheumatology and Infectious Diseases, Emma Children's Hospital, Academic Medical Center, Amsterdam, Netherlands. 21 Department of Clinical Immunology, University Hospital Alexandrovska, Medical University, Sofia, Bulgaria. 22 Department of Immunology, Second Faculty of Medicine Charles University and University Hospital Motol, Prague, Czech Republic. 23 Université de Paris, Paris, France. 24 Pediatric Hematology-Immunology and Rheumatology Unit, Necker-Enfants Malades Université Hospital, Assistance Publique-Hôpitaux de Paris, Paris, France. 25 Laboratory of Genome Dynamics in the Immune System, INSERM UMR1163, Institut Imagine, Paris, France. 26 Laboratory of Immunogenetics of Pediatric Autoimmune Diseases, INSERM UMR1163, Institut Imagine, Paris, France. 27 Windom Allergy, Asthma and Sinus, Sarasota, FL, USA. 28 Department of Immunology and Allergy, Sheffield Teaching Hospitals, Sheffield, UK. 29 Department of Clinical Immunology and Allergy, St James's University Hospital, Leeds, UK. 30 National Institute for Health Research-Leeds Musculoskeletal Biomedical Research Centre and Leeds Institute of Rheumatic and Musculoskeletal Medicine, St James's University Hospital, Leeds, UK. 31 Division of Allergy, Immunology and Pulmonary Medicine, Duke University School of Medicine, Durham, NC, USA. 32 Cancer and Blood Disorder Institute, Johns Hopkins All Children's Hospital, St. Petersburg, FL, USA. 33 Division of Allergy and Immunology, Children's Hospital of Richmond, Virginia Commonwealth University, Richmond, VA, USA. 34 Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA. 35 Division of Immunology, Allergy, and Rheumatology, Department of Pediatrics and Jeffrey Modell Diagnostic and Research Center, University of California, Los Angeles, Los Angeles, CA, USA. 36 Department of Pathology, Perelman School of Medicine, University of Pennsylvania, Pennsylvania, PA, USA. 37 Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of technology and Harvard University, Cambridge, MA, USA. 38 Department of Immunobiology, Yale University, New Haven, CT, USA. 39 Section of Rheumatology, Allergy and Clinical Immunology, Yale School of Medicine, New Haven, CT, USA. 40 Division of Pediatric Allergy/Immunology, University of South Florida at Johns Hopkins All Children's Hospital, St. Petersburg, FL, USA. jolanwalter@usf.edu. 41 Division of Allergy and Immunology, Massachusetts General Hospital for Children, Boston, MA, USA. jolanwalter@usf.edu.

T-cell receptor diversity in minimal change disease in the NEPTUNE study

Liu S, et al.
August 2022
Authors and Affiliates
Shiying Liu 1,2, William S Bush 1,2,3, Kristy Miskimen 1,2,3, Agustin Gonzalez-Vicente 4, Jessica N Cooke Bailey 1,2, Ioanna Konidari 5, Jacob L McCauley 5, John R Sedor 4, John F O'Toole 4, Dana C Crawford 6,7,8; 1 Department of Population and Quantitative Health Sciences, Case Western Reserve University, Cleveland, OH, USA. 2 Cleveland Institute for Computational Biology, Case Western Reserve University, Cleveland, OH, USA. 3 Department of Genetics and Genome Sciences, Case Western Reserve University, Cleveland, OH, USA. 4 Glickman Urological and Kidney Disease and Lerner Research Institutes, Cleveland Clinic, Cleveland, OH, USA. 5 John P. Hussman Institute for Human Genomics, Miller School of Medicine, University of Miami, Miami, FL, USA. 6 Department of Population and Quantitative Health Sciences, Case Western Reserve University, Cleveland, OH, USA. dana.crawford@case.edu. 7 Cleveland Institute for Computational Biology, Case Western Reserve University, Cleveland, OH, USA. dana.crawford@case.edu. 8 Department of Genetics and Genome Sciences, Case Western Reserve University, Cleveland, OH, USA. dana.crawford@case.edu.

Depth of response and response kinetics of isatuximab plus carfilzomib and dexamethasone in relapsed multiple myeloma.

Martin T, et al.
Blood Advances
August 2022
Authors and Affiliates
Thomas Martin,1 Joseph Mikhael,2 Roman Hajek,3 Kihyun Kim,4 Kenshi Suzuki,5 Cyrille Hulin,6 Mamta Garg,7 Hang Quach,8 Hanlon Sia,9 Anup George,10 Tatiana Konstantinova,11 Marie-Laure Risse,12 Gaelle Asset,13 Sandrine Macé,12 Helgi van de Velde,14 and Philippe Moreau15 1Department of Medicine, University of California, San Francisco, CA; 2Translational Genomics Research Institute, City of Hope Cancer Center, Phoenix, AZ; 3Department of Hemato-Oncology, University Hospital Ostrava, Faculty of Medicine, University of Ostrava, Ostrava, Czech Republic; 4Division of Hematology-Oncology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.; 5Department of Hematology, Japanese Red Cross Medical Center, Tokyo, Japan; 6Department of Hematology, University Hospital Bordeaux, Bordeaux, France; 7Department of Haematology, Leicester Royal Infirmary, University Hospitals of Leicester NHS Trust, Leicester, UK; 8Department of Haematology, St Vincent's Hospital, University of Melbourne, Vic, Australia; 9Cancer Care & Haematology Unit, The Tweed Hospital, Tweed Heads, NSW, Australia; 10Wellington Blood and Cancer Center, Wellington, New Zealand; 11Hematology Department, Regional Hospital #1, Ekaterinburg, Russia; 12Sanofi Research and Development, Vitry-Sur-Seine, France; 13Sanofi Research and Development, Chilly-Mazarin, France; 14Sanofi, Cambridge, MA; 15Department of Hematology, University Hospital of Nantes, Nantes, France

Impact of autologous hematopoietic cell transplantation on disease burden quantified by next-generation sequencing in multiple myeloma treated with quadruplet therapy.

Bal S, et al.
American Journal of Hematology
July 2022
Authors and Affiliates
Susan Bal, MD1,2, Binod Dhakal, MD3, Rebecca W. Silbermann, MD4,Timothy M. Schmidt, MD5, Bhagirathbhai Dholaria, MD6, Smith Giri, MD1,2,Saurabh Chhabra, MD3, Eva Medvedova, MD4, Kelly N. Godby, MD1,2, Anita D'Souza, MD3, Aric C. Hall, MD5, Pamela Hardwick, RN1,2, Jim Omel, MD7, Robert F. Cornell, MD6, Parameswaran Hari, MD3, Natalie S. Callander, MD5, and Luciano J. Costa, MD, PhD1,2 1Division of Hematology/Oncology, University of Alabama at Birmingham, Birmingham, AL 2O’Neal Comprehensive Cancer Center at University of Alabama at Birmingham, Birmingham, AL 3Division of Hematology/Oncology, Department of Medicine, Medical College of Wisconsin, Milwaukee, WI 4Oregon Health & Science University, Portland, OR 5University of Wisconsin, Madison, WI 6Department of Medicine, Division of Hematology and Oncology, Vanderbilt University Medical Center, Nashville, TN 7Independent Patient Advocate, Omaha, NE

Elotuzumab and Weekly Carfilzomib, Lenalidomide, and Dexamethasone in Patients With Newly Diagnosed Multiple Myeloma Without Transplant Intent: A Phase 2 Measurable Residual Disease-Adapted Study.

Derman BA, et al.
JAMA Oncology
July 2022
Authors and Affiliates
Benjamin A. Derman, MD; Ankit Kansagra, MD; Jeffrey Zonder, MD; Andrew T. Stefka, BS; David L. Grinblatt, MD; Larry D. Anderson Jr, MD, PhD; Sandeep Gurbuxani, MD, PhD; Sunil Narula, MD; Shayan Rayani, MD;Ajay Major, MD; Andrew Kin, MD; Ken Jiang, BS; Theodore Karrison, PhD; Jagoda Jasielec, MD; Andrzej J. Jakubowiak, MD, PhD University of Chicago Medical Center, Chicago, Illinois (Derman, Stefka, Gurbuxani, Narula, Rayani, Major, Jiang, Karrison, Jasielec, Jakubowiak); Simmons Comprehensive Cancer Center, UT Southwestern Medical Center, Dallas, Texas (Kansagra, Anderson); Karmanos Cancer Institute, Wayne State University, Detroit, Michigan (Zonder, Kin); NorthShore University Health Systems, Evanston, Illinois (Grinblatt).

High-sensitivity next-generation sequencing MRD assessment in ALL identifies patients at very low risk of relapse.

Short NJ, et al.
Blood Advances
July 2022
Authors and Affiliates
Nicholas J. Short,1 Hagop Kantarjian,1 Farhad Ravandi,1 Marina Konopleva,1 Nitin Jain,1 Rashmi Kanagal-Shamanna,2 Keyur P. Patel,2 Walid Macaron,1 Tapan M. Kadia,1 Sa Wang,2 Jeffrey L. Jorgensen,2 Joseph D. Khoury,2 Musa Yilmaz,1 Partow Kebriaei,3 Koichi Takahashi,1 Guillermo Garcia-Manero,1 Naval Daver,1 Sean M. Post,1 Xuelin Huang,4 Steven M. Kornblau,1 Sara Pelletier,1 Wilmer Flores,1 Jairo Matthews,1 Rebecca Garris,1 and Elias Jabbour1 1Department of Leukemia, 2Department of Hematopathology, 3Department of Stem Cell Transplantation & Cellular Therapy, and 4Department of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, TX