Triplet Therapy, Transplantation, and Maintenance until Progression in Myeloma.

Richardson PG, et al.
New England Journal of Medicine
June 2022
Authors and Affiliates
P.G. Richardson, S.J. Jacobus, E.A. Weller, H. Hassoun, S. Lonial, N.S. Raje, E. Medvedova, P.L. McCarthy, E.N. Libby, P.M. Voorhees, R.Z. Orlowski, L.D. Anderson, Jr., J.A. Zonder, C.P. Milner, C. Gasparetto, M.E. Agha, A.M. Khan, D.D. Hurd, K. Gowin, R.T. Kamble, S. Jagannath, N. Nathwani, M. Alsina, R.F. Cornell, H. Hashmi, E.L. Campagnaro, A.C. Andreescu, T. Gentile, M. Liedtke, K.N. Godby, A.D. Cohen, T.H. Openshaw, M.C. Pasquini, S.A. Giralt, J.L. Kaufman, A.J. Yee, E. Scott, P. Torka, A. Foley, M. Fulciniti, K. Hebert, M.K. Samur, K. Masone, M.E. Maglio, A.A. Zeytoonjian, O. Nadeem, R.L. Schlossman, J.P. Laubach, C. Paba-Prada, I.M. Ghobrial, A. Perrot, P. Moreau, H. Avet-Loiseau, M. Attal, K.C. Anderson, and N.C. Munshi, for the DETERMINATION Investigators The Department of Medical Oncology, Dana–Farber Cancer Institute, Jerome Lipper Multiple Myeloma Center (P.G.R., M.F., M.K.S., K.M., M.E.M., A.A.Z., O.N., R.L.S., J.P.L., C.P.-P., I.M.G., K.C.A., N.C.M.), the Department of Data Science, Dana–Farber Cancer Institute (S.J.J., K.H.), the Division of Hematology and Oncology, Boston Children’s Hospital (E.A.W.), the Center for Multiple Myeloma, Massachusetts General Hospital (N.S.R., A.J.Y.), Harvard Medical School (P.G.R., S.J.J., E.A.W., N.S.R., A.J.Y.. M.F., K.H., M.K.S., K.M., M.E.M., A.A.Z., O.N., R.L.S., J.P.L., C.P.-P., I.M.G., K.C.A., N.C.M.), and the Veterans Affairs Boston Healthcare System (N.C.M.), Boston, and the Department of Medical Oncology, Davenport–Mugar Cancer Center, Cape Cod Hospital, Hyannis (T.H.O.) — all in Massachusetts; Myeloma Service, the Department of Medicine, Memorial Sloan Kettering Cancer Center (H. Hassoun, S.A.G.), and the Division of Hematology and Medical Oncology, Icahn School of Medicine at Mount Sinai (S.J.), New York, the Department of Medicine, Roswell Park Comprehensive Cancer Center, Buffalo (P.L.M., P.T.), and State University of New York Upstate Medical University, Syracuse (T.G.) — all in New York; the Winship Cancer Institute of Emory University, Atlanta (S.L., J.L.K.); Knight Cancer Institute, Oregon Health and Science University, Portland (E.M., E.S.); the Division of Medical Oncology and Fred Hutchinson Cancer Research Center, University of Washington, Seattle (E.N.L.); the Department of Hematologic Oncology and Blood Disorders, Levine Cancer Institute, Atrium Health, Charlotte (P.M.V.), Duke University Medical Center, Durham (C.G.), and the Hematology and Oncology–Cancer Center, Atrium Health Wake Forest Baptist Medical Center, Winston-Salem (D.D.H.) — all in North Carolina; the Department of Lymphoma and Myeloma, University of Texas M.D. Anderson Cancer Center (R.Z.O.), and Center for Cell and Gene Therapy, Baylor College of Medicine and Houston Methodist Hospital (R.T.K.), Houston, and Myeloma, Waldenstrom’s, and Amyloidosis Program, Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas (L.D.A.) — all in Texas; the Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit (J.A.Z.), and the Division of Hematology and Oncology, Department of Internal Medicine, University of Michigan, Ann Arbor (E.L.C.) — both in Michigan; the Division of Hematology and Oncology, University of Mississippi Medical Center, Jackson (C.P.M.); University of Pittsburgh Medical Center Hillman Cancer Center, Pittsburgh (M.E.A.), and the Abramson Cancer Center, University of Pennsylvania, Philadelphia (A.D.C.) — both in Pennsylvania; the Division of Hematology, Ohio State University Comprehensive Cancer Center, Columbus (A.M.K.); the Department of Bone Marrow Transplant and Cellular Therapy, University of Arizona, Tucson (K.G.); Judy and Bernard Briskin Center for Multiple Myeloma Research, City of Hope Comprehensive Cancer Center, Duarte (N.N.), and the Department of Medicine, Division of Hematology, Stanford University, Stanford (M.L.) — both in California; the Department of Blood and Marrow Transplant and Cellular Immunotherapy, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida (M. Alsina); Vanderbilt University Medical Center, Nashville (R.F.C.); the Division of Hematology Oncology, Medical University of South Carolina, Charleston (H. Hashmi); Northern Light Eastern Maine Medical Center Cancer Care, Brewer (A.C.A.), and the Cancer Care Center of Maine, Bangor (T.H.O.); O’Neal Comprehensive Cancer Center, the University of Alabama at Birmingham, Birmingham (K.N.G.); the Center for International Blood and Marrow Transplant Research (CIBMTR), Division of Hematology andOncology, Department of Medicine, Medical College of Wisconsin, Milwaukee (M.C.P.); the National Marrow Donor Program, CIBMTR, Minneapolis (A.F.); and the Department of Hematology (A.P., M. Attal) and Unit for Genomics in Myeloma (H.A.-L.), Institut Universitaire du Cancer de Toulouse–Oncopole, University Hospital, Toulouse, and the Department of Hematology, University Hospital Hôtel-Dieu, Nantes (P.M.) — both in France.

Ciltacabtagene Autoleucel, an Anti-B-cell Maturation Antigen Chimeric Antigen Receptor T-Cell Therapy, for Relapsed/Refractory Multiple Myeloma: CARTITUDE-1 2-Year Follow-Up.

Martin T, et al.
Journal of Clinical Oncology
June 2022
Authors and Affiliates
Thomas Martin, MD1; Saad Z. Usmani, MD2; Jesus G. Berdeja, MD3; Mounzer Agha, MD4; Adam D. Cohen, MD5; Parameswaran Hari, MD6;David Avigan, MD7; Abhinav Deol, MD8; Myo Htut, MD9; Alexander Lesokhin, MD2; Nikhil C. Munshi, MD10,11; Elizabeth O’Donnell, MD12; A. Keith Stewart, MBChB13; Jordan M. Schecter, MD14; Jenna D. Goldberg, MD14; Carolyn C. Jackson, MD, MPH14; Tzu-Min Yeh, MS14; Arnob Banerjee, MD15; Alicia Allred, PhD15; Enrique Zudaire, PhD15; William Deraedt, MSc16; Yunsi Olyslager, MSc16; Changwei Zhou, PhD17; Lida Pacaud, MD17; Deepu Madduri, MD14; Andrzej Jakubowiak, MD18; Yi Lin, MD, PhD19; and Sundar Jagannath, MD20 1UCSF Helen Diller Family Comprehensive Cancer Center, San Francisco, CA 2Memorial Sloan Kettering Cancer Center, New York, NY 3Sarah Cannon Research Institute, Nashville, TN 4UPMC Hillman Cancer Center, Pittsburgh, PA 5Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA 6Medical College of Wisconsin, Milwaukee, WI 7Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 8Karmanos Cancer Institute, Wayne State University, Detroit, MI 9 City of Hope Comprehensive Cancer Center, Duarte, CA 10Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 11VA Boston Healthcare System, West Roxbury, MA 12Massachusetts General Hospital, Harvard Medical School, Boston, MA 13University Health Network and the Princess Margaret Cancer Centre, Toronto, ON, Canada 14Janssen R&D, Raritan, NJ 15Janssen R&D, Spring House, PA 16Janssen R&D, Beerse, Belgium 17Legend Biotech, Inc, Piscataway, NJ 18University of Chicago, Chicago, IL 19Mayo Clinic, Rochester, MN 20Mount Sinai Medical Center, New York, NY

A phase 1 study of donor regulatory T-cell infusion plus low-dose interleukin-2 for steroid-refractory chronic graft-vs-host disease

Whangbo J, et al.
Blood Advances
May 2022
Authors and Affiliates
Jennifer Whangbo 1, Sarah Nikiforow 2, Haesook T Kim 2, Jonathan Wahl 2, Carol G Reynolds 3, Sharmila Chamling Rai 4, Soomin Kim 5, Andrew Thomas Burden 2, Ana Alho 6, João F Lacerda 7, Edwin P Alyea 8, Corey S Cutler 9, Vincent T Ho 2, Joseph H Antin 2, Robert J Soiffer 2, Jerome Ritz 2, John Koreth 2; 1 Boston Children's Hospital, United States. 2 Dana-Farber Cancer Institute, Boston, Massachusetts, United States. 3 Dana-Farber Cancer Institute, BOSTON, Massachusetts, United States. 4 Dana Farber Cancer Institute, Quincy, Massachusetts, United States. 5 Dana-Farber Cancer Institute, Seoul, Korea, Republic of. 6 Instituto de Medicina Molecular, Faculdade de Medicina da Universidade de Lisboa, Algés, Portugal. 7 Instituto de Medicina Molecular, Faculdade de Medicina Universidade de Lisboa, Lisbon, Portugal. 8 Division of Hematologic Malignancies, Dana-Farber Cancer Institute and Harvard Medical School, United States. 9 Dana Farber Cancer Institute, Boston, Massachusetts, United States.

Capture Rate of V(D)J Sequencing for Minimal Residual Disease Detection in Multiple Myeloma.

Hultcrantz M, et al.
Clinical Cancer Research
May 2022
Authors and Affiliates
Malin Hultcrantz1,2, Even H. Rustad3, Venkata Yellapantula1, Allison Jacob4, Theresia Akhlaghi1,Neha Korde1, Sham Mailankody1, Alexander M. Lesokhin1, Hani Hassoun1, Eric L. Smith1, Oscar B. Lahoud5,Heather J. Landau5, Gunjan L. Shah5, Michael Scordo5, David J. Chung5, Sergio Giralt5, Elli Papaemmanuil3,and Ola Landgren6 1Myeloma Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, Manhattan, New York. 2Karolinska Institute, Department of Medicine, Solna, Stockholm, Sweden. 3Department of Cancer Immunology, Oslo University Hospital Radiumhospitalet, Oslo, Norway. 4Adaptive Biotechnologies, Seattle, Washington. 5Adult Bone Marrow Transplant Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, Manhattan, New York. 6Myeloma Program, Sylvester Comprehensive Cancer Center, University of Miami, Miami, Florida.

Peripheral differentiation patterns of human T cells

Heikkilä N, et al.
European Journal of Immunology
May 2022
Authors and Affiliates
Nelli Heikkilä 1, Iivo Hetemäki 1, Silja Sormunen 2, Helena Isoniemi 3, Eliisa Kekäläinen 4, Jari Saramäki 2, T Petteri Arstila 1; 1 Translational Immunology Research Program (TRIMM), Research Programs Unit (RPU), Department of Bacteriology and Immunology, Medicum, Faculty of Medicine, University of Helsinki, Helsinki, Finland. 2 Department of Computer Science, Aalto University, Espoo, Finland. 3 Division of Transplantation and Liver Surgery, Helsinki University Central Hospital, Helsinki, Finland. 4 Translational Immunology Research Program (TRIMM), Research Programs Unit (RPU), Department of Bacteriology and Immunology, Medicum, Faculty of Medicine, HUSLAB Clinical Microbiology, University of Helsinki, and Helsinki University Central Hospital, Helsinki, Finland.

Modulation of tissue resident memory T cells by glucocorticoids after acute cellular rejection in lung transplantation

Snyder ME, et al.
Journal of Experimental Medicine
May 2022
Authors and Affiliates
Mark E Snyder 1,2,3, Kaveh Moghbeli 1, Anna Bondonese 1, Andrew Craig 1, Iulia Popescu 1, Li Fan 1, Tracy Tabib 1, Robert Lafyatis 1, Kong Chen 1, Humberto E Trejo Bittar 4, Elizabeth Lendermon 1, Joseph Pilewski 1, Bruce Johnson 1, Silpa Kilaru 1, Yingze Zhang 1, Pablo G Sanchez 5, Jonathan K Alder 1, Peter A Sims 6, John F McDyer 1,3; 1 Department of Medicine, University of Pittsburgh, Pittsburgh, PA. 2 Department of Immunology, University of Pittsburgh, Pittsburgh, PA. 3 Starzl Transplantation Institute, University of Pittsburgh, Pittsburgh, PA. 4 Department of Pathology, University of Pittsburgh, Pittsburgh, PA. 5 Department of Surgery, University of Pittsburgh, Pittsburgh, PA. 6 Department of Systems Biology, Columbia University Irving Medical Center, New York, NY.

Phase 1 TRANSCEND CLL 004 study of lisocabtagene maraleucel in patients with relapsed/refractory CLL or SLL.

Siddiqi T, et al.
Blood
March 2022
Authors and Affiliates
Tanya Siddiqi,1 Jacob D. Soumerai,2 Kathleen A. Dorritie,3 Deborah M. Stephens,4 Peter A. Riedell,5 Jon Arnason,6 Thomas J. Kipps,7 Heidi H. Gillenwater,8 Lucy Gong,8 Lin Yang,8 Ken Ogasawara,9 Jerill Thorpe,8 and William G. Wierda10 1Hematology/Hematopoietic Cell Transplantation, City of Hope National Medical Center, Duarte, CA, USA; 2Department of Medicine, Center for Lymphoma, Massachusetts General Hospital Cancer Center, Boston, MA, USA; 3 Division of Hematology-Oncology, UPMC Hillman Cancer Center, Pittsburgh, PA, USA; 4Internal Medicine/Division of Hematology and Hematologic Malignancies, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA; 5Hematopoietic Cellular Therapy Program, Section of Hematology/Oncology, Department of Medicine, University of Chicago, Chicago, IL, USA; 6Department of Medical Oncology, Beth Israel Deaconess Medical Center, Boston, MA, USA; 7Moores Cancer Center, Evelyn and Edwin Tasch Chair in Cancer Research, University of California San Diego, San Diego, CA, USA; 8Bristol Myers Squibb, Seattle, WA, USA; 9Bristol Myers Squibb, Princeton, NJ, USA; and 10Department of Leukemia, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA

Early versus late response to daratumumab-based triplet therapies in patients with multiple myeloma: a pooled analysis of trials POLLUX, CASTOR and MAIA.

Wang J, et al.
Leukemia & Lymphoma
February 2022
Authors and Affiliates
Jiasheng Wanga , Raul Arroyo-Suarezb, Srilatha Dasarib, Kanithra Sekaranb and William Tsec aDepartment of Hematology and Oncology, Seidman Cancer Center, University Hospitals Cleveland Medical Center, Cleveland, OH, USA; bDepartment of Internal Medicine, MetroHealth Medical Center, Cleveland, OH, USA; cDepartment of Hematology and Oncology, MetroHealth Medical Center, Case Western Reserve University, Cleveland, OH, USA

Prognostic value of minimal residual disease negativity in myeloma: combined analysis of POLLUX, CASTOR, ALCYONE, and MAIA.

Cavo M, et al.
Blood
February 2022
Authors and Affiliates
Michele Cavo,1 Jesus San-Miguel,2 Saad Z. Usmani,3 Katja Weisel,4 Meletios A. Dimopoulos,5 Herve Avet-Loiseau,  6 Bruno Paiva,2 Nizar J. Bahlis,7 Torben Plesner,8 Vania Hungria,9 Philippe Moreau,10 Maria-Victoria Mateos,11 Aurore Perrot,12 Shinsuke Iida,13 Thierry Facon,14 Shaji Kumar,15 Niels W. C. J. van de Donk,16 Pieter Sonneveld,17 Andrew Spencer,18 Maria Krevvata,19 Christoph Heuck,19 Jianping Wang,20 Jon Ukropec,21 Rachel Kobos,19 Steven Sun,20 Mia Qi,20 and Nikhil Munshi22,23 1IRCCS Azienda Ospedaliero-Universitaria di Bologna, Istituto di Ematologia “Seragnoli ”, Dipartimento di Medicina Specialistica, Diagnostica e Sperimentale, Universita di Bologna, Bologna, Italy;  2 Clınica Universidad de Navarra, Centro de Investigacion Medica Aplicada (CIMA), IDISNA, CIBER-ONC, Pamplona, Spain; 3Levine Cancer Institute/Atrium Health, Charlotte, NC; 4Department of Oncology, Hematology and Bone Marrow Transplantation with Section of Pneumology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; 5National and Kapodistrian University of Athens, Athens, Greece; 6Unite de Genomique du Myelome, IUC-Oncopole, Toulouse, France; 7Arnie Charbonneau Cancer Research Institute, University of Calgary, Calgary, AB, Canada; 8Vejle Hospital and University of Southern Denmark, Vejle, Denmark; 9 Clinica Medica Sao Germano, S ao Paulo, Brazil; 10Hematology, University Hospital Hotel-Dieu, CHU Nantes, Nantes, France; 11University Hospital of Salamanca/IBSAL/Cancer Research Center-IBMCC (USAL-CSIC), Salamanca, Spain; 12Hematology Department, University Cancer Institute IUCT, Toulouse, France; 13Department of Hematology and Oncology, Nagoya City University Graduate School of Medical Sciences, Mizuho-ku Nagoya, Japan; 14University of Lille, CHU Lille, Service des Maladies du Sang, Lille, France; 15Department of Hematology, Mayo Clinic Rochester, Rochester, MN; 16Department of Hematology, Amsterdam University Medical Center, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands; 17Erasmus MC, Rotterdam, The Netherlands; 18Malignant Haematology and Stem Cell Transplantation Service, Alfred Health-Monash University, Melbourne, Australia; 19Janssen Research & Development, LLC, Spring House, PA; 20Janssen Research & Development, LLC, Raritan, NJ; 21Janssen Global Medical Affairs, Horsham, PA; 22Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA; and 23Veterans Administration Boston Healthcare System, West Roxbury, MA