Therapeutic Area: Other Immune Biology

The molecular and phenotypic makeup of fetal human skin T lymphocytes

Reitermaier R, et al.
October 2021
Authors and Affiliates
René Reitermaier 1, Tanya Ayub 1, Julia Staller 1, Philip Kienzl 1, Nikolaus Fortelny 2, Pablo Augusto Vieyra-Garcia 3, Christof Worda 4, Christian Fiala 5 6, Clement Staud 7, Wolfgang Eppel 4, Anke Scharrer 8, Thomas Krausgruber 9, Adelheid Elbe-Bürger 1; 1 Department of Dermatology, Medical University of Vienna, Austria. 2 Department of Biosciences, University of Salzburg, Salzburg, Austria. 3 Department of Dermatology, Medical University of Graz, Graz, Austria. 4 Department of Obstetrics & Gynecology, Medical University of Vienna, Austria. 5 Gynmed Clinic, Vienna, Austria. 6 Department of Women's and Children's Health, Division of Obstetrics and Gynaecology, Karolinska Institute and Karolinska University Hospital, Stockholm, Sweden. 7 Department of Surgery, Division of Plastic and Reconstructive Surgery, Medical University of Vienna, Austria. 8 Department of Pathology, Medical University of Vienna, Austria. 9 CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria.

Intrathymic differentiation of natural antibody-producing plasma cells in human neonates

Cordero H, et al.
October 2021
immuneAccess
Authors and Affiliates
Hector Cordero 1, Rodney G King 2, Pranay Dogra 1,3, Chloe Dufeu 1, Sarah B See 1, Alexander M Chong 4, Anne-Catrin Uhlemann 4, Siu-Hong Ho 1, David M Kalfa 5, Emile A Bacha 5, John F Kearney 2, Emmanuel Zorn 6; 1 Columbia Center for Translational Immunology, Columbia University Medical Center, New York, NY, 10032, USA. 2 Department of Microbiology, University of Alabama at Birmingham, Birmingham, AL, 35294, USA. 3 Department of Microbiology and Immunology, Columbia University Medical Center, New York, NY, 10032, USA. 4 Division of Infectious Diseases in the College of Physicians and Surgeons, Columbia University Medical Center, New York, NY, 10032, USA. 5 Division of Cardiac, Thoracic and Vascular Surgery, Columbia University Medical Center, New York, NY, 10032, USA. 6 Columbia Center for Translational Immunology, Columbia University Medical Center, New York, NY, 10032, USA. ez2184@cumc.columbia.edu.

Integrated analysis toolset for defining and tracking alloreactive T-cell clones after human solid organ and hematopoietic stem cell transplantation

Obradovic A, et al.
October 2021
Authors and Affiliates
Aleksandar Obradovic a,b, Yufeng Shen b, Megan Sykes a,c,d, Jianing Fu a; a Columbia Center for Translational Immunology, Department of Medicine, Columbia University, New York, NY 10032, United States b Department of Systems Biology, Columbia University, New York, NY 10032, United States c Department of Surgery, Columbia University, New York, NY 10032, United States d Department of Microbiology & Immunology, Columbia University, New York, NY 10032, United States

Self-mediated positive selection of T cells sets an obstacle to the recognition of nonself

Koncz B, et al.
September 2021
Authors and Affiliates
Balázs Koncz 1, Gergő M Balogh 1, Benjamin T Papp 1,2, Leó Asztalos 1,2, Lajos Kemény 1,3,4, Máté Manczinger 5,3,4,6; 1 Department of Dermatology and Allergology, University of Szeged, 6720 Szeged, Hungary. 2 Szeged Scientists Academy, 6720 Szeged, Hungary. 3 Magyar Tudományos Akadémia - Szegedi Tudományegyetem (MTA-SZTE) Dermatological Research Group, Eötvös Loránd Research Network (ELKH), University of Szeged, 6720 Szeged, Hungary. 4 Hungarian Centre of Excellence for Molecular Medicine - University of Szeged (HCEMM-USZ) Skin Research Group, 6720 Szeged, Hungary. 5 Department of Dermatology and Allergology, University of Szeged, 6720 Szeged, Hungary; manczinger.mate@med.u-szeged.hu. 6 Biological Research Centre, Institute of Biochemistry, Synthetic and Systems Biology Unit, Eötvös Loránd Research Network (ELKH), 6726 Szeged, Hungary.

HSCT corrects primary immunodeficiency and immune dysregulation in patients with POMP-related auto-inflammatory disease

Martinez CA, et al.
Blood
September 2021
immuneAccess
Authors and Affiliates
Caridad A Martinez 1, Frederic Ebstein 2, Sarah K Nicholas 3, Marietta De Guzman 3, Lisa R Forbes 3, Ottavia M Delmonte 4, Marita Bosticardo 5, Riccardo Castagnoli 4, Robert Krance 3, Luigi D Notarangelo 6, Elke Krüger 2, Jordan S Orange 7, M Cecilia Poli 8; 1 Texas Children's Hospital, Houston, Texas, United States. 2 Universitätsmedizin Greifswald, Greifswald, Germany. 3 Texas Children´s Hospital, United States. 4 NIH, Bethesda, Maryland, United States. 5 National Institutes of Health, Bethesda, Maryland, United States. 6 NIAID, National Institutes of Health, Bethesda, Maryland, United States. 7 Columbia University, New York, New York, United States. 8 Baylor College of Medicina, United States.

The RAG1 N-terminal region regulates the efficiency and pathways of synapsis for V(D)J recombination

Beilinson HA, et al.
Journal of Experimental Medicine
August 2021
immuneAccess
Authors and Affiliates
Helen A Beilinson 1, Rebecca A Glynn 2,3, Anurupa Devi Yadavalli 1,4, Jianxiong Xiao 1, Elizabeth Corbett 1, Huseyin Saribasak 1, Rahul Arya 3, Charline Miot 3, Anamika Bhattacharyya 5, Jessica M Jones 5, Jagan M R Pongubala 4, Craig H Bassing 2,3, David G Schatz 1,6; 1 Department of Immunobiology, Yale School of Medicine, Yale University, New Haven, CT. 2 Cell and Molecular Biology Graduate Group, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA. 3 Department of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA. 4 Department of Animal Biology, School of Life Sciences, University of Hyderabad, Hyderabad, India. 5 Department of Biochemistry and Molecular & Cellular Biology, Georgetown University, Washington, DC. 6 Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT.

Response to Hypomethylating Agents in Myelodysplastic Syndrome Is Associated With Emergence of Novel TCR Clonotypes

Abbas HA, et al.
Frontiers in Immunology
May 2021
immuneAccess
Authors and Affiliates
Hussein A Abbas 1, Patrick K Reville 1, Xianli Jiang 2, Hui Yang 3, Alexandre Reuben 4, Jin Seon Im 5,6, Latasha Little 7, Jefferson C Sinson 7, Ken Chen 2, Andrew Futreal 6,7, Guillermo Garcia-Manero 3; 1 Division of Cancer Medicine, Medical Oncology Fellowship, University of Texas MD Anderson Cancer Center, Houston, TX, United States. 2 Department of Bioinformatics and Computational Biology, University of Texas MD Anderson Cancer Center, Houston, TX, United States. 3 Department of Leukemia, University of Texas MD Anderson Cancer Center, Houston, TX, United States. 4 Department of Thoracic/Head & Neck Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, United States. 5 Department of Stem Cell Transplantation and Cellular Therapy, University of Texas MD Anderson Cancer Center, Houston, TX, United States. 6 Graduate School of Biomedical Sciences, The University of Texas MD Anderson Cancer Center, Houston, TX, United States. 7 Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, United States.

Gene Editing Rescues In vitro T Cell Development of RAG2-Deficient Induced Pluripotent Stem Cells in an Artificial Thymic Organoid System

Gardner CL, et al.,
Journal of Clinical Immunology
March 2021
Authors and Affiliates
Cameron L Gardner 1,2, Mara Pavel-Dinu 3, Kerry Dobbs 1, Marita Bosticardo 1, Paul K Reardon 2, Justin Lack 4,5, Suk See DeRavin 1, Kent Le 1, Ezekiel Bello 1, Francesca Pala 1, Ottavia M Delmonte 1, Harry Malech 1, Amelie Montel-Hagan 6, Gay Crooks 6, Oreste Acuto 7, Matthew H Porteus 8, Luigi D Notarangelo 9; 1 Immune Deficiency Genetics Section, Laboratory of Clinical Immunology and Microbiology, DIR, NIAID, NIH, 10 Center Drive, Bldg. 10 CRC, Room 5-3950, Bethesda, MD, 20892-1456, USA. 2 Sir William Dunn School of Pathology, University of Oxford, Oxford, OX14RE, UK. 3 Division of Stem Cell Transplantation and Regenerative Medicine, Department of Pediatrics, Stanford School of Medicine, Stanford University, Stanford, CA, USA. 4 NIAID Collaborative Bioinformatics Resource, NIAID, NIH, Bethesda, MD, USA. 5 Advanced Biomedical Computational Science (ABCS), Frederick National Laboratory for Cancer Research, Frederick, MD, USA. 6 Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA. 7 Sir William Dunn School of Pathology, University of Oxford, Oxford, OX14RE, UK. oreste.acuto@path.ox.ac.uk. 8 Division of Stem Cell Transplantation and Regenerative Medicine, Department of Pediatrics, Stanford School of Medicine, Stanford University, Stanford, CA, USA. mporteus@stanford.edu. 9 Immune Deficiency Genetics Section, Laboratory of Clinical Immunology and Microbiology, DIR, NIAID, NIH, 10 Center Drive, Bldg. 10 CRC, Room 5-3950, Bethesda, MD, 20892-1456, USA. luigi.notarangelo2@nih.gov.