T Cell Repertoire Evolution after Allogeneic Bone Marrow Transplantation: An Organizational Perspective

Meier JA., et al.
Biology of Blood and Marrow Transplantation
February 2021
Authors and Affiliates
Jeremy A Meier 1, Mahdee Haque 1, Mohamed Fawaz 1, Hamdi Abdeen 1, David Coffey 2, Andrea Towlerton 2, Ahmed Abdeen 1, Abdullah Toor 1, Edus Warren 2, Jason Reed 3, Christopher G Kanakry 4, Armand Keating 5, Leo Luznik 6, Amir A Toor 7; 1 Bone Marrow Transplant Program, Massey Cancer Center, Virginia Commonwealth University, Richmond, Virginia. 2 Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington. 3 Department of Physics, Virginia Commonwealth University, Richmond, Virginia. 4 Experimental Transplantation and Immunology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland. 5 Princess Margaret Cancer Center, Toronto, Ontario, Canada. 6 Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland. 7 Bone Marrow Transplant Program, Massey Cancer Center, Virginia Commonwealth University, Richmond, Virginia. Electronic address: amir.toor@vcuhealth.org

Characterization of human T cell receptor repertoire data in eight thymus samples and four related blood samples

Heikkilä N., et al.
Data in Brief
January 2021
Authors and Affiliates
Nelli Heikkilä 1,2, Iivari Kleino 1, Reetta Vanhanen 1,2, Dawit A. Yohannes 1,3, Ilkka P. Mattila 4, Jari Saramäki 5, T. Petteri Arstila 1,2; 1 Research Programs Unit, Translational Immunology, University of Helsinki, Haartmaninkatu 3, 00290 Helsinki, Finland 2 Medicum, Department of Bacteriology and Immunology, University of Helsinki, Haartmaninkatu 3, 00290 Helsinki, Finland 3 Department of Medical and Clinical Genetics, University of Helsinki, Haartmaninkatu 8, 00290 Helsinki 4 Department of Pediatric Cardiac and Transplantation Surgery, Hospital for Children and Adolescents, Helsinki University Central Hospital, Stenbäckinkatu 9, 00290 Helsinki, Finland 5 Department of Computer Science, Aalto University, Konemiehentie 2, 02150 Espoo, Finland

CDR3 and V genes show distinct reconstitution patterns in T cell repertoire post-allogeneic bone marrow transplantation

Tickotsky-Moskovitz N., et al.
Immunogenetics
January 2021
Authors and Affiliates
Nili Tickotsky-Moskovitz 1, Yoram Louzoun 2, Shirit Dvorkin 3, Adi Rotkopf 4, Amir Asher Kuperman 4,5, Sol Efroni 1; 1 The Goodman Faculty of Life Sciences, Bar Ilan University, Ramat Gan, Israel. 2 Department of Mathematics, Bar Ilan University, Ramat Gan, Israel. louzouy@math.biu.ac.il. 3 Department of Mathematics, Bar Ilan University, Ramat Gan, Israel. 4 Azrieli Faculty of Medicine, Bar-Ilan University, Safed, Israel. 5 Blood Coagulation Service and Pediatric Hematology Clinic, Galilee Medical Center, Nahariya, Israel.

The TCR repertoire of α-synuclein-specific T cells in Parkinson’s disease is surprisingly diverse

Singhania A., et al.
Scientific Reports
January 2021
Authors and Affiliates
Akul Singhania 1, John Pham 1, Rekha Dhanwani 1, April Frazier 1, Juliana Rezende Dutra 2, Karen S Marder 2, Elizabeth Phillips 3,4, Simon Mallal 3,4, Amy W Amara 5, David G Standaert 5, David Sulzer 2,6,7, Bjoern Peters 1,8, Alessandro Sette 1,8, Cecilia S Lindestam Arlehamn 9; 1 Division of Vaccine Discovery, La Jolla Institute for Immunology, La Jolla, CA, 92037, USA. 2 Department of Neurology, Columbia University Medical Center, New York, NY, 10032, USA. 3 Institute for Immunology and Infectious Diseases, Murdoch University, Perth, WA, 6150, Australia. 4 Vanderbilt University School of Medicine, Nashville, TN, 37235, USA. 5 Department of Neurology, University of Alabama at Birmingham, Birmingham, AL, 35233, USA. 6 Department of Psychiatry, Columbia University Medical Center, New York, NY, 10032, USA. 7 Department of Pharmacology, Columbia University Medical Center, New York, NY, 10032, USA. 8 Department of Medicine, University of California San Diego, La Jolla, CA, 92093, USA. 9 Division of Vaccine Discovery, La Jolla Institute for Immunology, La Jolla, CA, 92037, USA. cecilia@lji.org.

Broadly reactive human CD4 + T cells against Enterobacteriaceae are found in the naïve repertoire and are clonally expanded in the memory repertoire

Cassotta A., et al.
January 2021
Authors and Affiliates
Antonino Cassotta 1,2, Jérémie D Goldstein 1, Greta Durini 1, David Jarrossay 1, Franca Baggi Menozzi 3, Mario Venditti 4, Alessandro Russo 5, Marco Falcone 5, Antonio Lanzavecchia 1, Maria Cristina Gagliardi 6, Daniela Latorre 1,2, Federica Sallusto 1,2; 1 Institute for Research in Biomedicine, Università della Svizzera italiana, Bellinzona, Switzerland. 2 Institute of Microbiology, ETH Zurich, Switzerland. 3 Servizio di Microbiologia EOLAB, Ente Ospedaliero Cantonale, Bellinzona, Switzerland. 4 Department of Public Health and Infectious Diseases, Sapienza University of Rome, Rome, Italy. 5 Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy. 6 Center for Gender Specific Medicine, Istituto Superiore di Sanità, Rome, Italy.

Population variability in the generation and selection of T-cell repertoires

Sethna Z., et al.
December 2020
Authors and Affiliates
Zachary Sethna 1, Giulio Isacchini 2,3, Thomas Dupic 2, Thierry Mora 2, Aleksandra M Walczak 2, Yuval Elhanati 4; 1 Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, New York, United States of America. 2 Laboratoire de physique de l'École Normale Supérieure, PSL University, CNRS, Sorbonne Université, Université de Paris 24 rue Lhomond, Paris, France. 3 Max Planck Institute for Dynamics and Self-organization, Am Faßberg 17, Göttingen, Germany. 4 Computational Oncology, Department of Epidemiology and Biostatistics, and Parker Institute for Cancer Immunotherapy, Memorial Sloan Kettering Cancer Center, New York, New York, United States of America.

Discovery of Marburg virus neutralizing antibodies from virus-naïve human antibody repertoires using large-scale structural predictions

Bozhanova NG., et al.
November 2020
Authors and Affiliates
Nina G Bozhanova 1,2, Amandeep K Sangha 1,2, Alexander M Sevy 2,3, Pavlo Gilchuk 3, Kai Huang , 5, Rachel S Nargi 3, Joseph X Reidy 3, Andrew Trivette 3, Robert H Carnahan 3,6, Alexander Bukreyev 4,5,7, James E Crowe Jr 3,6,8, Jens Meiler 9,2,10; 1 Department of Chemistry, Vanderbilt University, Nashville, TN 37235. 2 Center for Structural Biology, Vanderbilt University, Nashville, TN 37235. 3 Vanderbilt Vaccine Center, Vanderbilt University Medical Center, Nashville, TN 37232. 4 Department of Pathology, University of Texas Medical Branch, Galveston, TX 77555. 5 Galveston National Laboratory, University of Texas Medical Branch, Galveston, TX 77550. 6 Department of Pediatrics, Vanderbilt University Medical Center, Nashville TN 37232. 7 Department of Microbiology & Immunology, University of Texas Medical Branch, Galveston, TX 77555. 8 Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN 37232. 9 Department of Chemistry, Vanderbilt University, Nashville, TN 37235; jens@meilerlab.org. 10 Institute for Drug Discovery, Leipzig University Medical School, Leipzig, SAC 04103, Germany.

Long-term skin-resident memory T cells proliferate in situ and are involved in human graft-versus-host disease

Strobl J., et al.
November 2020
Authors and Affiliates
Johanna Strobl 1, Ram Vinay Pandey 1, Thomas Krausgruber 2, Nadine Bayer 1, Lisa Kleissl 1,3, Bärbel Reininger 1, Pablo Vieyra-Garcia 4, Peter Wolf 4, Maaia-Margo Jentus 1, Margit Mitterbauer 5, Philipp Wohlfarth 5, Werner Rabitsch 5, Georg Stingl 1, Christoph Bock 2,3,6, Georg Stary 7,2,3; 1 Department of Dermatology, Medical University of Vienna, 1090 Vienna, Austria. 2 CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, 1090 Vienna, Austria. 3 Ludwig Boltzmann Institute for Rare and Undiagnosed Diseases, 1090 Vienna, Austria. 4 Department of Dermatology and Venereology, Medical University of Graz, 8036 Graz, Austria. 5 Department of Internal Medicine I, Hematopoietic Stem Cell Transplantation Unit, Medical University of Vienna, 1090 Vienna, Austria. 6 Department of Laboratory Medicine, Medical University of Vienna, 1090 Vienna, Austria. 7 Department of Dermatology, Medical University of Vienna, 1090 Vienna, Austria. georg.stary@meduniwien.ac.at.

Isatuximab as monotherapy and combined with dexamethasone in patients with relapsed/refractory multiple myeloma

Dimopoulos MA., et al.
November 2020
Authors and Affiliates
Meletios A Dimopoulos 1, Sara Bringhen 2, Pekka M Anttila 3, Marcelo Capra 4, Michele Cavo 5, Craig Emmitt Cole 6, Cristina Gasparetto 7, Vania Tietsche de Moraes Hungria 8, Matthew W Jenner 9, Vladimir I Vorobyev 10, Eduardo Patricio Yanez Ruiz 11, Jian Y Yin 12, Rao Saleem 12, Maeva Hellet 13, Sandrine Macé 14, Bruno Paiva 15, Ravi Vij 16; 1 National and Kapodistrian University of Athens, Athens, Greece. 2 University of Torino, Azienda Ospedaliero-Universitaria Città della Salute e della Scienza di Torino, Torino, Italy. 3 Helsinki University and Helsinki University Hospital, Helksinki, Finland. 4 Hospital Mãe de Deus, Porto Alegre, Brazil. 5 Seràgnoli Institute of Hematology, Bologna, Italy. 6 Michigan State University, East Lansing, Michigan, United States. 7 Duke University. 8 Clinica Sao Germano, São Paulo, Brazil. 9 University Hospital Southampton, Southampton, United Kingdom. 10 S.P. Botkin Hospital, Moscow, Russian Federation. 11 Universidad de la Frontera, Temuco, Chile. 12 Sanofi, Bridgewater, New Jersey, United States. 13 Ividata (for Sanofi), Paris, France. 14 Sanofi, Paris, France. 15 Clinica Universidad de Navarra, Pamplona, Spain. 16 Washington University, St Louis, Missouri, United States.

Human thymic T cell repertoire is imprinted with strong convergence to shared sequences

Heikkilä N., et al.
Molecular Immunology
September 2020
Authors and Affiliates
Nelli Heikkilä a,*, Reetta Vanhanen b, Dawit A. Yohannes c, Iivari Kleino d, Ilkka P. Mattila e, Jari Saramäki f, T. Petteri Arstila g; a Research Programs Unit, Translational Immunology and Medicum, Department of Bacteriology and Immunology, University of Helsinki. Haartmaninkatu 3, 00290 Helsinki, Finland b Research Programs Unit, Translational Immunology and Medicum, Department of Bacteriology and Immunology, University of Helsinki. Haartmaninkatu 3, 00290 Helsinki, Finland c Research Programs Unit, Translational Immunology and Medicum, Department of Medical and Clinical Genetics, University of Helsinki. Haartmaninkatu 8, 00290 Helsinki, Finland d Research Programs Unit, Translational Immunology, University of Helsinki. Haartmaninkatu 3, 00290 Helsinki, Finland e Department of Pediatric Cardiac and Transplantation Surgery, Hospital for Children and Adolescents, Helsinki University Central Hospital. Stenbäckinkatu 9, 00290 Helsinki, Finland f Department of Computer Science, Aalto University. Konemiehentie 2, 02150 Espoo, Finland g Research Programs Unit, Translational Immunology and Medicum, Department of Bacteriology and Immunology, University of Helsinki. Haartmaninkatu 3, 00290 Helsinki, Finland