Therapeutic Area: Other Immune Biology

Long-term robustness of a T-cell system emerging from somatic rescue of a genetic block in T-cell development

Kury P., et al.
EBio Medicine
September 2020
immuneAccess
Authors and Affiliates
Patrick Kury 1, Marita Führer 2, Sebastian Fuchs 3, Myriam R Lorenz 4, Orlando Bruno Giorgetti 5, Shahrzad Bakhtiar 6, Andreas P Frei 3, Paul Fisch 7, Thomas Boehm 5, Klaus Schwarz 8, Carsten Speckmann 9, Stephan Ehl 10; 1 Institute for Immunodeficiency, Center for Chronic Immunodeficiency (CCI), Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Breisacher Straße 115, 79106 Freiburg, Germany; Faculty of Biology, University of Freiburg, Schaenzlestrasse 1, D-79104 Freiburg, Germany. 2 Institute for Clinical Transfusion Medicine and Immunogenetics Ulm, German Red Cross Blood Service, Baden-Wuerttemberg - Hessen, Ulm, Germany. 3 Roche Pharma Research and Early Development, Immunology, Infectious Diseases and Ophthalmology (I2O) Discovery and Translational Area, Roche Innovation Center Basel, Basel, Switzerland. 4 Institute for Transfusion Medicine, University of Ulm, Ulm, Germany. 5 Department of Developmental Immunology, Max Planck Institute of Immunobiology and Epigenetics Freiburg, Freiburg, Germany. 6 Division for Pediatric Stem-Cell Transplantation, Immunology and Intensive Medicine, University Hospital Frankfurt, Frankfurt/Main, Germany. 7 Department of Pathology, Faculty of Medicine, University of Freiburg, Freiburg, Germany. 8 Institute for Clinical Transfusion Medicine and Immunogenetics Ulm, German Red Cross Blood Service, Baden-Wuerttemberg - Hessen, Ulm, Germany; Institute for Transfusion Medicine, University of Ulm, Ulm, Germany. 9 Institute for Immunodeficiency, Center for Chronic Immunodeficiency (CCI), Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Breisacher Straße 115, 79106 Freiburg, Germany; Center for Pediatrics, Department of Pediatric Hematology and Oncology, University Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany. 10 Institute for Immunodeficiency, Center for Chronic Immunodeficiency (CCI), Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Breisacher Straße 115, 79106 Freiburg, Germany; CIBBS -Centre for Integrative Biological Signaling Studies, University of Freiburg, Freiburg, Germany. Electronic address: stephan.ehl@uniklinik-freiburg.de.

Benchmarking of T cell receptor repertoire profiling methods reveals large systematic biases

Barennes P., et al.
Nature Biotechnology
September 2020
Authors and Affiliates
Pierre Barennes 1,2, Valentin Quiniou 1,2, Mikhail Shugay 3,4,5, Evgeniy S Egorov 4, Alexey N Davydov 6, Dmitriy M Chudakov 3,4,5,6, Imran Uddin 7, Mazlina Ismail 7, Theres Oakes 7, Benny Chain 7, Anne Eugster 8, Karl Kashofer 9, Peter P Rainer 10,11, Samuel Darko 12, Amy Ransier 12, Daniel C Douek 12, David Klatzmann 1,2, Encarnita Mariotti-Ferrandiz 13,14; 1 Sorbonne Université, INSERM, Immunology-Immunopathology-Immunotherapy (i3), Paris, France. 2 AP-HP, Hôpital Pitié-Salpêtrière, Biotherapy (CIC-BTi) and Inflammation-Immunopathology-Biotherapy Department (i2B), Paris, France. 3 Center of Life Sciences, Skoltech, Moscow, Russia. 4 Genomics of Adaptive Immunity Department, Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Moscow, Russia. 5 Center for Precision Genome Editing and Genetic Technologies for Biomedicine, Pirogov Russian National Research Medical University, Moscow, Russia. 6 Adaptive Immunity Group, Central European Institute of Technology, Brno, Czechia. 7 Division of Infection and Immunity, University College London, London, UK. 8 DFG-Centre for Regenerative Therapies Dresden, Faculty of Medicine Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany. 9 Diagnostic and Research Institute of Pathology, Medical University of Graz, Graz, Austria. 10 Division of Cardiology, Medical University of Graz, Graz, Austria. 11 BioTechMed-Graz, Graz, Austria. 12 Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA. 13 Sorbonne Université, INSERM, Immunology-Immunopathology-Immunotherapy (i3), Paris, France. encarnita.mariotti@sorbonne-universite.fr. 14 AP-HP, Hôpital Pitié-Salpêtrière, Biotherapy (CIC-BTi) and Inflammation-Immunopathology-Biotherapy Department (i2B), Paris, France. encarnita.mariotti@sorbonne-universite.fr.

Ultra-efficient sequencing of T Cell receptor repertoires reveals shared responses in muscle from patients with Myositis

Montagne JM., et al.
EBio Medicine
September 2020
Authors and Affiliates
Janelle M Montagne 1, Xuwen Alice Zheng 1, Iago Pinal-Fernandez 2, Jose C Milisenda 3, Lisa Christopher-Stine 4, Thomas E Lloyd 5, Andrew L Mammen 2, H Benjamin Larman 6; 1 Division of Immunology, Pathology Department, Johns Hopkins University School of Medicine, Baltimore, MD, USA; Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, USA. 2 Muscle Disease Unit, Laboratory of Muscle Stem Cells and Gene Regulations, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, USA; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA. 3 Internal Medicine Department, Hospital Clinic, Universitat de Barcelona, Barcelona, Spain and Centro de Investigación Médica en Red Enfermedades Raras. 4 Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD, USA. 5 Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA. 6 Division of Immunology, Pathology Department, Johns Hopkins University School of Medicine, Baltimore, MD, USA; Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, USA. Electronic address: hlarman1@jhmi.edu.

Atypical TRAV1-2- T cell receptor recognition of the antigen-presenting molecule MR1

Awad W., et al.
J. Biol. Chem.
September 2020
Authors and Affiliates
Wael Awad 1, Erin W Meermeier 2, Maria L Sandoval-Romero 1, Jerome Le Nours 3, Aneta H Worley 4, Megan D Null 2, Ligong Liu 5, James McCluskey 6, David P Fairlie 7, David M Lewinsohn 8, Jamie Rossjohn 9; 1 Monash University, Australia. 2 Oregon Health & Science University, United States. 3 Monash University. 4 VA Portland Health Care Center, United States. 5 The University of Queensland. 6 Department of Microbiology & Immunology, The Peter Doherty Institute for Infection,The University of Melbourne, Victoria 3010, Australi, Australia. 7 Institute for Molecular Bioscience, Australia. 8 Oregon Health Sciences. 9 Biochemistry & Molecular Biology, Monash University, Australia.

An Integrated Multi-omic Single-Cell Atlas of Human B Cell Identity

Glass DR., et al.
Immunity
September 2020
Authors and Affiliates
David R Glass 1, Albert G Tsai 2, John Paul Oliveria 3, Felix J Hartmann 2, Samuel C Kimmey 4, Ariel A Calderon 1, Luciene Borges 2, Marla C Glass 5, Lisa E Wagar 6, Mark M Davis 6, Sean C Bendall 7; 1 Immunology Graduate Program, Stanford University, Stanford, CA, 94305, USA; Department of Pathology, Stanford University, Stanford, CA, 94305, USA. 2 Department of Pathology, Stanford University, Stanford, CA, 94305, USA. 3 Department of Pathology, Stanford University, Stanford, CA, 94305, USA; Department of Medicine, Division of Respirology, McMaster University, Hamilton, ON, L8S4K1, Canada. 4 Department of Pathology, Stanford University, Stanford, CA, 94305, USA; Department of Developmental Biology, Stanford University, Stanford CA, 94305, USA. 5 Department of Surgery, Stanford University, Stanford CA, 94305, USA. 6 Department of Microbiology and Immunology, Stanford University, Stanford CA, 94305, USA. 7 Immunology Graduate Program, Stanford University, Stanford, CA, 94305, USA; Department of Pathology, Stanford University, Stanford, CA, 94305, USA.

Immunotyping of clinically divergent p.Phe508del homozygous monozygous cystic fibrosis twins

Schamschula et al.
Journal of Cystic Fibrosis
June 2020
Authors and Affiliates
Esther Schamschula 1, Wolfgang Hagmann 2, Yassen Assenov 2, Silke Hedtfeld 3, Ahmed K Farag 4, Lennart M Roesner 4, Lutz Wiehlmann 5, Frauke Stanke 6, Sebastian Fischer 3, Angela Risch 7, Burkhard Tümmler 8; 1Department of Biosciences, Paris Lodron University of Salzburg, Salzburg, Austria. 2Division of Epigenomics, DKFZ - German Cancer Research Center, Heidelberg, Germany. 3Clinic for Pediatric Pneumology, Allergology and Neonatology, Hannover Medical School, Hannover, Germany. 4Department of Dermatology and Allergy, Division of Immunodermatology and Allergy Research, Hannover Medical School, Hannover, Germany. 5Clinic for Pediatric Pneumology, Allergology and Neonatology, Hannover Medical School, Hannover, Germany; Research Core Unit Genomics, Hannover Medical School, Hannover, Germany. 6Clinic for Pediatric Pneumology, Allergology and Neonatology, Hannover Medical School, Hannover, Germany; Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), German Center for Lung Research, Hannover Medical School, Hannover, Germany. 7Department of Biosciences, Paris Lodron University of Salzburg, Salzburg, Austria; Division of Epigenomics, DKFZ - German Cancer Research Center, Heidelberg, Germany; Translational Lung Research Center Heidelberg (TLRC-H), German Center for Lung Research (DZL), Heidelberg, Germany. 8Clinic for Pediatric Pneumology, Allergology and Neonatology, Hannover Medical School, Hannover, Germany; Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), German Center for Lung Research, Hannover Medical School, Hannover, Germany. Electronic address: tuemmler.burkhard@mh-hannover.de.

T Cell Clonal Dynamics Determined by High-Resolution TCR-β Sequencing in Recipients after Allogeneic Hematopoietic Cell Transplantation

Leick et al.
Biology of Blood and Marrow Transplantation
May 2020
Authors and Affiliates
Mark Leick 1, Rachel M Gittelman 2, Erik Yusko 2, Catherine Sanders 2, Harlan Robins 2, Zachariah DeFilipp 1, Sarah Nikiforow 3, Jerome Ritz 3, Yi-Bin Chen 4 1Blood and Marrow Transplant Program, Massachusetts General Hospital, Boston, Massachusetts. 2Adaptive Biotechnologies, Seattle, Washington. 3Division of Hematological Malignancies, Dana-Farber Cancer Institute, Boston, Massachusetts. 4Blood and Marrow Transplant Program, Massachusetts General Hospital, Boston, Massachusetts. Electronic address: ychen6@partners.org.

Somatic mTOR Mutation in Clonally Expanded T Lymphocytes Associated With Chronic Graft Versus Host Disease

Kim et al.
Nature Communications
May 2020
immuneAccess
Authors and Affiliates
Daehong Kim 1 2, Giljun Park 1 2, Jani Huuhtanen 1 2, Sofie Lundgren 1 2, Rajiv K Khajuria 1, Ana M Hurtado 3, Cecilia Muñoz-Calleja 4, Laura Cardeñoso 5, Valle Gómez-García de Soria 6, Tzu Hua Chen-Liang 3, Samuli Eldfors 7, Pekka Ellonen 7, Sari Hannula 7, Matti Kankainen 1 2 8 9, Oscar Bruck 1 2 9, Anna Kreutzman 1 2, Urpu Salmenniemi 10, Tapio Lönnberg 11, Andrés Jerez 3, Maija Itälä-Remes 10, Mikko Myllymäki 1 2, Mikko A I Keränen 1 2 12, Satu Mustjoki 13 14 15; 1Hematology Research Unit Helsinki, Helsinki University Hospital Comprehensive Cancer Center, 00290, Helsinki, Finland. 2Translational Immunology Research Program and Department of Clinical Chemistry and Hematology, University of Helsinki, 00014, Helsinki, Finland. 3Hematology and Medical Oncology Department, Hospital Morales Meseguer. Centro Regional de Hemodonación, Universidad de Murcia, IMIB, 30008, Murcia, Spain. 4Department of Immunology, Hospital Universitario de La Princesa, Instituto de Investigación Sanitaria Princesa, 28006, Madrid, Spain. 5Department of Microbiology, Hospital Universitario de La Princesa, Instituto de Investigación Sanitaria Princesa, 28006, Madrid, Spain. 6Department of Hematology, Hospital Universitario de La Princesa, Instituto de Investigación Sanitaria Princesa, 28006, Madrid, Spain. 7Institute of Molecular Medicine Finland (FIMM), University of Helsinki, 00014, Helsinki, Finland. 8Department of Medical and Clinical Genetics, University of Helsinki and Helsinki University Hospital, 00014, Helsinki, Finland. 9iCAN Digital Precision Cancer Medicine, University of Helsinki and Helsinki University Hospital, 00014, Helsinki, Finland. 10Stem Cell transplantation unit, Turku University Hospital, 20521, Turku, Finland. 11Turku Bioscience Centre, University of Turku and Åbo Akademi University, 20520, Turku, Finland. 12Department of Hematology, Helsinki University Hospital Comprehensive Cancer Center, 00029, Helsinki, Finland. 13Hematology Research Unit Helsinki, Helsinki University Hospital Comprehensive Cancer Center, 00290, Helsinki, Finland. satu.mustjoki@helsinki.fi. 14Translational Immunology Research Program and Department of Clinical Chemistry and Hematology, University of Helsinki, 00014, Helsinki, Finland. satu.mustjoki@helsinki.fi. 15iCAN Digital Precision Cancer Medicine, University of Helsinki and Helsinki University Hospital, 00014, Helsinki, Finland. satu.mustjoki@helsinki.fi.

Blockade of BAFF Reshapes the Hepatic B Cell Receptor Repertoire and Attenuates Autoantibody Production in Cholestatic Liver Disease

Thapa et al.
Journal of Immunology
April 2020
Authors and Affiliates
Thapa M1, Tedesco D2, Gumber S3, Elrod EJ2, Han JH2, Kitchens WH4, Magliocca JF4, Adams AB4, Grakoui A1,5.; 1 Emory Vaccine Center, Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University School of Medicine, Atlanta, GA 30329; manoj.thapa@emory.edu arash.grakoui@emory.edu. 2 Emory Vaccine Center, Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University School of Medicine, Atlanta, GA 30329. 3 Division of Pathology and Laboratory Medicine, Yerkes Research Primate Center, Emory University School of Medicine, Atlanta, GA 30329. 4 Division of Transplantation, Department of Surgery, Emory University School of Medicine, Atlanta, GA 30329; and. 5 Division of Infectious Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, GA 30329.