Therapeutic Area: Other Immune Biology

Identifying the inheritable component of human thymic T cell repertoire generation in monozygous twins

Heikkilä et al.
European Journal of Immunology
December 2019
Authors and Affiliates
Heikkilä N1,2, Vanhanen R1,2, Yohannes DA1,3, Saavalainen P1,3, Meri S1,2, Jokiranta TS2, Jarva H2, Mattila IP4, Hamm D5, Sormunen S6, Saramäki J6, Arstila TP1,2; 1 Research Programs Unit, Translational Immunology, University of Helsinki, Helsinki, Finland. 2 Medicum, Department of Bacteriology and Immunology, University of Helsinki, Helsinki, Finland. 3 Medicum, Department of Medical and Clinical Genetics, University of Helsinki, Helsinki, Finland. 4 Department of Pediatric Cardiac and Transplantation Surgery, Hospital for Children and Adolescents, Helsinki University Central Hospital, Helsinki, Finland. 5 Adaptive Biotechnologies, Seattle, Washington. 6 Department of Computer Science, Aalto University, Finland.

Epigenetic and transcriptional analysis supports human regulatory T cell commitment at the CD4+CD8+ thymocyte stage

Vanhanen et al.
Cellular Immunology
December 2019
Authors and Affiliates
Vanhanen R1, Leskinen K2, Mattila IP3, Saavalainen P2, Arstila TP4; 1 Translational Immunology Research Program, University of Helsinki, 00014 Helsinki, Finland. Electronic address: reetta.vanhanen@helsinki.fi. 2 Translational Immunology Research Program, University of Helsinki, 00014 Helsinki, Finland. 3 Department of Pediatric Cardiac and Transplantation Surgery, Hospital for Children and Adolescents, Helsinki University Central Hospital, 00290 Helsinki, Finland. 4 Translational Immunology Research Program, University of Helsinki, 00014 Helsinki, Finland; Medicum, University of Helsinki, 00014 Helsinki, Finland.

B cell clonal expansion within immune infiltrates in human cardiac allograft vasculopathy

Moore et al.
American Journal of Transplantation
December 2019
Authors and Affiliates
Moore C1,2,3, Gao B1,4, Roskin KM2,3,5, Vasilescu EM6, Addonizio L7, Givertz MM8, Madsen JC1,9, Zorn E1,10. 1 Center for Transplantation Science, Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA. 2 Division of Biomedical Informatics, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA. 3 Division of Immunobiology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA. 4 Transplant Center, The First Hospital of Jilin University, Changchun, China. 5 Department of Pediatrics, University of Cincinnati, College of Medicine, Cincinnati, Ohio, USA. 6 Department of Pathology & Cell Biology, Columbia University Medical Center, New York, New York, USA. 7 Division of Cardiothoracic Surgery, Department of Surgery, Columbia University Medical Center, New York, New York, USA. 8 Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA. 9 Division of Cardiac Surgery, Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA. 10 Columbia Center for Translational Immunology, Columbia University Medical Center, New York, New York, USA.

The Utility of T-Cell Clonality in Differential Diagnostics of Acute Graft-versus-Host Disease from Drug Hypersensitivity Reaction

Chang et al.
Journal of Investigative Dermatology
December 2019
Authors and Affiliates
Li-Wei Chang1, Linda T. Doan2, Paul Fields3, Marissa Vignali3 and Oleg E. Akilov1,* 1Department of Dermatology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA; 2Department of Dermatology, University of California Irvine, Irvine, California, USA; and 3Adaptive Biotechnologies, Seattle, Washington, USA *Corresponding author e-mail: akilovoe@ upmc.edu

ERG Controls B Cell Development by Promoting Igh V-to-DJ Recombination

Søndergaard et al.
Cell Reports
November 2019
immuneAccess
Authors and Affiliates
Søndergaard E1, Rauch A2, Michaut M3, Rapin N3, Rehn M1, Wilhelmson AS1, Camponeschi A4, Hasemann MS1, Bagger FO3, Jendholm J1, Knudsen KJ1, Mandrup S2, Mårtensson IL4, Porse BT5; 1 The Finsen Laboratory, Rigshospitalet, Faculty of Health Sciences, University of Copenhagen, 2200 Copenhagen N, Denmark; Biotech Research and Innovation Centre (BRIC), University of Copenhagen, 2200 Copenhagen N, Denmark; Danish Stem Cell Centre (DanStem) Faculty of Health Sciences, University of Copenhagen, 2200 Copenhagen N, Denmark. 2 Department of Biochemistry and Molecular Biology, University of Southern Denmark, 5230 Odense, Denmark. 3 The Finsen Laboratory, Rigshospitalet, Faculty of Health Sciences, University of Copenhagen, 2200 Copenhagen N, Denmark; Biotech Research and Innovation Centre (BRIC), University of Copenhagen, 2200 Copenhagen N, Denmark; Danish Stem Cell Centre (DanStem) Faculty of Health Sciences, University of Copenhagen, 2200 Copenhagen N, Denmark; The Bioinformatics Centre, Department of Biology, Faculty of Natural Sciences, University of Copenhagen, 2200 Copenhagen N, Denmark. 4 Department of Rheumatology and Inflammation Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, 405 30 Gothenburg, Sweden. 5 The Finsen Laboratory, Rigshospitalet, Faculty of Health Sciences, University of Copenhagen, 2200 Copenhagen N, Denmark; Biotech Research and Innovation Centre (BRIC), University of Copenhagen, 2200 Copenhagen N, Denmark; Danish Stem Cell Centre (DanStem) Faculty of Health Sciences, University of Copenhagen, 2200 Copenhagen N, Denmark. Electronic address: bo.porse@finsenlab.dk.

Maturation of the Human Intestinal Immune System Occurs Early in Fetal Development

Stras et al.
Developmental Cell
November 2019
Authors and Affiliates
Stras SF1, Werner L2, Toothaker JM3, Olaloye OO1, Oldham AL1, McCourt CC1, Lee YN4, Rechavi E4, Shouval DS5, Konnikova L6; 1 Division of Newborn Medicine, Department of Pediatrics, UPMC Children's Hospital of Pittsburgh, Pittsburgh, PA 15224, USA. 2 Pediatric Gastroenterology Unit, Edmond and Lily Safra Children's Hospital, Sheba Medical Center, Tel Hashomer 52621, Israel; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 6997801, Israel. 3 Department of Immunology, University of Pittsburgh, Pittsburgh, PA 15213, USA. 4 Pediatric Department A, Edmond and Lily Safra Children's Hospital, Sheba Medical Center, Tel Hashomer 52621, Israel; Immunology Service, Edmond and Lily Safra Children's Hospital, Sheba Medical Center, Tel Hashomer 52621, Israel; Jeffrey Modell Foundation Center, Edmond and Lily Safra Children's Hospital, Sheba Medical Center, Tel Hashomer 52621, Israel; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 6997801, Israel. 5 Pediatric Gastroenterology Unit, Edmond and Lily Safra Children's Hospital, Sheba Medical Center, Tel Hashomer 52621, Israel; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 6997801, Israel. Electronic address: dror.shouval@gmail.com. 6 Division of Newborn Medicine, Department of Pediatrics, UPMC Children's Hospital of Pittsburgh, Pittsburgh, PA 15224, USA; Department of Immunology, University of Pittsburgh, Pittsburgh, PA 15213, USA; Department of Developmental Biology, University of Pittsburgh, Pittsburgh, PA 15213, USA. Electronic address: liza.konnikova@chp.edu.

Single-cell immune landscape of human atherosclerotic plaques

Fernandez et al.
Nature Medicine
October 2019
Authors and Affiliates
Fernandez DM1, Rahman AH2,3,4, Fernandez NF3, Chudnovskiy A2, Amir ED3, Amadori L4, Khan NS1, Wong CK1, Shamailova R1, Hill CA1, Wang Z5, Remark R2,6, Li JR7, Pina C7, Faries C7, Awad AJ8,9, Moss N1, Bjorkegren JLM4,10, Kim-Schulze S2,3,11, Gnjatic S2,3,12, Ma'ayan A5, Mocco J8, Faries P7, Merad M2,3,12, Giannarelli C13,14,15; 1 Cardiovascular Research Center, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA. 2 The Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. 3 Human Immune Monitoring Center, Icahn School of Medicine at Mount Sinai, New York, NY, USA. 4 Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA. 5 Mount Sinai Center for Bioinformatics, Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA. 6 Innate Pharma, Marseille, France. 7 Department of Surgery, Vascular Division, Icahn School of Medicine at Mount Sinai, New York, NY, USA. 8 Cerebrovascular Center, Department of Neurosurgery, Icahn School of Medicine at Mount Sinai, New York, NY, USA. 9 Department of Neurosurgery, Medical College of Wisconsin, Milwaukee, WI, USA. 10 Integrated Cardio MetabolicCentre, Department of Medicine, Karolinska Institutet, Karolinska Universitetssjukhuset, Huddinge, Sweden. 11 Hematology and Medical Oncology Division, The Tish Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. 12 Department of Oncological Sciences, The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. 13 Cardiovascular Research Center, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA. chiara.giannarelli@mssm.edu. 14 The Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. chiara.giannarelli@mssm.edu. 15 Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA. chiara.giannarelli@mssm.edu.

T cell repertoire remodeling following post-transplant T cell therapy coincides with clinical response

Smith et al.
Journal of Clinical Investigation
October 2019
immuneAccess
Authors and Affiliates
Smith C1,2, Corvino D1, Beagley L1, Rehan S1, Neller MA1, Crooks P1, Matthews KK1, Solomon M1, Le Texier L1, Campbell S3,4, Francis RS3,4, Chambers D4,5, Khanna R1,4.; 1 QIMR Centre for Immunotherapy and Vaccine Development, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia. 2 School of Biomedical Sciences, Faculty of Health, Queensland University of Technology, Brisbane, Queensland, Australia. 3 Department of Nephrology, Princess Alexandra Hospital, Brisbane, Queensland, Australia. 4 School of Clinical Medicine, The University of Queensland, Brisbane, Queensland, Australia. 5 Queensland Lung Transplant Service, The Prince Charles Hospital, Brisbane, Queensland, Australia.

mTORC1 as a cell-intrinsic rheostat that shapes development, preimmune repertoire, and function of B lymphocytes

Raybuck et al.
FASEB J
September 2019
Authors and Affiliates
Raybuck AL1, Lee K2, Cho SH1,3, Li J1, Thomas JW4, Boothby MR1,3,4,5.; 1 Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee, USA. 2 Department of Biomedical Science, Hallym University, Chuncheon, Gangwon-do, South Korea. 3 Vanderbilt Institute for Infection, Immunology, and Inflammation (VI4), Vanderbilt University Medical Center, Nashville, Tennessee, USA. 4 Departments of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA. 5 Department of Cancer Biology, Vanderbilt University Medical Center, Nashville, Tennessee, USA.

Dose-escalated interleukin-2 therapy for refractory chronic graft-versus-host disease in adults and children

Whangbo et al.
Blood Advances
September 2019
Authors and Affiliates
Whangbo JS1,2,3, Kim HT4,5, Mirkovic N6, Leonard L1,2, Poryanda S6, Silverstein S1,2, Kim S6, Reynolds CG6, Rai SC6, Verrill K1,2, Lee MA1,2,3, Margossian S1,2,3, Duncan C1,2,3, Lehmann L1,2,3, Huang J3,7, Nikiforow S3,6, Alyea EP 3rd3,6, Armand P3,6, Cutler CS3,6, Ho VT3,6, Blazar BR8, Antin JH3,6, Soiffer RJ3,6, Ritz J3,6, Koreth J3,6.; 1 Division of Hematology-Oncology, Boston Children's Hospital, Boston, MA. 2 Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston MA. 3 Harvard Medical School, Boston, MA. 4 Department of Data Sciences, Dana-Farber Cancer Institute, Boston, MA. 5 Harvard School of Public Health, Boston, MA. 6 Division of Hematologic Malignancies, Dana-Farber Cancer Institute, Boston MA. 7 Dermatology Program, Division of Immunology, Boston Children's Hospital, Boston, MA; and. 8 Masonic Cancer Center and Division of Blood and Marrow Transplantation, Department of Pediatrics, University of Minnesota, Minneapolis, MN.