Therapeutic Area: Other Immune Biology

Effector TH17 Cells Give Rise to Long-Lived TRM Cells that Are Essential for an Immediate Response against Bacterial Infection

Vesely et al.
Cell
August 2019
immuneAccess
Authors and Affiliates
Amezcua Vesely MC1, Pallis P2, Bielecki P2, Low JS2, Zhao J3, Harman CCD1, Kroehling L2, Jackson R2, Bailis W2, Licona-Limón P4, Xu H2, Iijima N2, Pillai PS5, Kaplan DH6, Weaver CT7, Kluger Y8, Kowalczyk MS9, Iwasaki A1, Pereira JP2, Esplugues E10, Gagliani N11, Flavell RA12.; 1 Department of Immunobiology, School of Medicine, Yale University, New Haven, CT, USA; Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT, USA. 2 Department of Immunobiology, School of Medicine, Yale University, New Haven, CT, USA. 3 Department of Immunobiology, School of Medicine, Yale University, New Haven, CT, USA; Department of Pathology, Yale School of Medicine, New Haven, CT 06510, USA; Program of Computational Biology and Bioinformatics, Yale University, New Haven, CT 06520, USA. 4 Departamento de Biología Celular y del Desarrollo, Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, Ciudad de México, México. 5 Department of Immunobiology, School of Medicine, Yale University, New Haven, CT, USA; Koch Institute for Integrative Cancer Research and Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02142, USA. 6 Department of Dermatology and Immunology, University of Pittsburgh, Pittsburgh, PA 15261, USA. 7 Departments of Pathology, University of Alabama at Birmingham, Birmingham, AL 35294, USA. 8 Department of Pathology, Yale School of Medicine, New Haven, CT 06510, USA; Program of Computational Biology and Bioinformatics, Yale University, New Haven, CT 06520, USA; Applied Mathematics Program, Yale University, New Haven, CT 06511, USA. 9 Broad Institute of MIT and Harvard, Cambridge, MA, USA. 10 Department of Immunobiology, School of Medicine, Yale University, New Haven, CT, USA; Laboratory of Molecular and Cellular Immunology, Principe Felipe Research Center (CIPF), 46012 Valencia, Spain. 11 Department of Immunobiology, School of Medicine, Yale University, New Haven, CT, USA; I. Medical Department and Department of General, Visceral and Thoracic Surgery, University Medical Center Hamburg-Eppendorf 20246 Hamburg, Germany; Immunology and Allergy Unit, Department of Medicine Solna, Karolinska Institute, 17176 Stockholm, Sweden. Electronic address: n.gagliani@uke.de. 12 Department of Immunobiology, School of Medicine, Yale University, New Haven, CT, USA; Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT, USA. Electronic address: richard.flavell@yale.edu

Human CD4+ CD103+ cutaneous resident memory T cells are found in the circulation of healthy individuals

Klicznik et al.
Science Immunology
July 2019
Authors and Affiliates
Klicznik MM1, Morawski PA2, Höllbacher B1,2, Varkhande SR1, Motley SJ2, Kuri-Cervantes L3, Goodwin E3, Rosenblum MD4, Long SA2, Brachtl G5, Duhen T2, Betts MR3, Campbell DJ6,7, Gratz IK8,2,9; 1 Department of Biosciences, University of Salzburg, Salzburg, Austria. 2 Benaroya Research Institute, Seattle, WA 98101, USA. 3 Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. 4 Department of Dermatology, University of California, San Francisco, San Francisco, CA 94143, USA. 5 Experimental and Clinical Cell Therapy Institute, Spinal Cord and Tissue Regeneration Center, Paracelsus Medical University, Salzburg, Austria. 6 Benaroya Research Institute, Seattle, WA 98101, USA. campbell@benaroyaresearch.org iris.gratz@sbg.ac.at. 7 Department of Immunology, University of Washington School of Medicine, Seattle, WA 98109, USA. 8 Department of Biosciences, University of Salzburg, Salzburg, Austria. campbell@benaroyaresearch.org iris.gratz@sbg.ac.at. 9 EB House Austria, Department of Dermatology, University Hospital of the Paracelsus Medical University, Salzburg, Austria.

IgG4‐related disease: Association with a rare gene variant expressed in cytotoxic T cells

Newman et al.
Molecular Genetics and Genomic Medicine
April 2019
Authors and Affiliates
Newman JH1, Shaver A2, Sheehan JH3, Mallal S4, Stone JH5, Pillai S6, Bastarache L7, Riebau D8, Allard-Chamard H6, Stone WM6, Perugino C6, Pilkinton M4, Smith SA4, McDonnell WJ4, Capra JA3, Meiler J3, Cogan J1,9, Xing K6, Mahajan VS6, Mattoo H6, Hamid R1,9, Phillips JA 3rd1,9; Undiagnosed Disease Network. 1 Vanderbilt Center for Undiagnosed Disease, Vanderbilt University, Nashville, Tennessee. 2 Department of Pathology, Microbiology and of Immunology, Vanderbilt University, Nashville, Tennessee. 3 Department of Biochemistry and Center for Structural Biology, Vanderbilt University, Nashville, Tennessee. 4 Department of Medicine, Center for Translational Immunology and Infectious Diseases, Vanderbilt University, Nashville, Tennessee. 5 Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts. 6 Ragon Institute of MGH, MIT and Harvard Medical School, Boston, Massachusetts. 7 BioVU, Vanderbilt University Medical Center, Vanderbilt University, Nashville, Tennessee. 8 Department of Neurology, Vanderbilt University, Nashville, Tennessee. 9 Department of Pediatrics, Division of Medical Genetics, Vanderbilt University, Nashville, Tennessee.

Molecular constraints on CDR3 for thymic selection of MHC-restricted TCRs from a random pre-selection repertoire.

Lu et al.
Nature Communications
March 2019
immuneAccess
Authors and Affiliates
Lu J1, Van Laethem F2, Bhattacharya A2, Craveiro M2, Saba I2, Chu J1, Love NC2, Tikhonova A2, Radaev S1, Sun X3, Ko A3, Arnon T4,5, Shifrut E4, Friedman N4, Weng NP3, Singer A6, Sun PD7 1 Structural Immunology Section, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, Rockville, MD, 20852, USA. 2 Experimental Immunology Branch, National Cancer Institute, Bethesda, MD, 20892, USA. 3 Lymphocyte Differentiation Section, Laboratory of Molecular Biology and Immunology, National Institute on Aging, National Institute of Health, Baltimore, MD, 21224, USA. 4 Department of Immunology, Weizmann Institute of Science, 76100, Rehovot, Israel. 5 Department of Physics and Astronomy, Alfred University, 1 Saxon Drive, Alfred, NY, 14802, USA. 6 Experimental Immunology Branch, National Cancer Institute, Bethesda, MD, 20892, USA. singera@nih.gov. 7 Structural Immunology Section, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, Rockville, MD, 20852, USA. psun@nih.gov.

Helios+ and Helios− Treg subpopulations are phenotypically and functionally distinct and express dissimilar TCR repertoires

Thornton et al.
European Journal of Immunology
March 2019
immuneAccess
Authors and Affiliates
Thornton AM1, Lu J2, Korty PE1, Kim YC1, Martens C3, Sun PD2, Shevach EM1 1 Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA. 2 Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA. 3 Rocky Mountain Laboratories Genomics Unit, Research Technology Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, USA.

Preliminary analysis of spatial-temporal homogeneity and heterogeneity of TCR β chain CDR3 repertoires in BALB/c mice

Li et al.
International Journal of Molecular Epidemiology and Genetics
February 2019
Authors and Affiliates
Yuehong Li,1,* Long Ma,1,* Xiaoheng Dong,1,* Yurong Pan,1 Bin Shi,2 Xiaoyan He,1 Teng Zhang,1 Suhong Sun,3 and Xinsheng Yao1 1 Department of Immunology, Research Center for Medicine and Biology, Innovation and Practice Base for Graduate Students Education, Zunyi Medical University, Zunyi 563003, China, 2 Department of Laboratory Medicine, Zunyi Medical University, Zunyi 563003, China, 3 Department of Breast Surgery, The First Affiliated Hospital of Zunyi Medical College, Zunyi 563003, China,

Human Intestinal Allografts Contain Functional Hematopoietic Stem and Progenitor Cells that Are Maintained by a Circulating Pool

Fu et al.
Cell Stem Cell
February 2019
immuneAccess
Authors and Affiliates
Fu J1, Zuber J1, Martinez M2, Shonts B1, Obradovic A1, Wang H1, Lau SP1, Xia A1, Waffarn EE1, Frangaj K1, Savage TM1, Simpson MT1, Yang S1, Guo XV3, Miron M4, Senda T5, Rogers K1, Rahman A3, Ho SH1, Shen Y6, Griesemer A5, Farber DL7, Kato T8, Sykes M9. 1 Columbia Center for Translational Immunology, Department of Medicine, Columbia University, New York, NY 10032, USA. 2 Department of Pediatrics, Columbia University, New York, NY 10032, USA. 3 Human Immune Monitoring Center, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. 4 Columbia Center for Translational Immunology, Department of Medicine, Columbia University, New York, NY 10032, USA; Department of Microbiology & Immunology, Columbia University, New York, NY 10032, USA. 5 Columbia Center for Translational Immunology, Department of Medicine, Columbia University, New York, NY 10032, USA; Department of Surgery, Columbia University, New York, NY 10032, USA. 6 Center for Computational Biology and Bioinformatics, Department of Systems Biology, Columbia University, New York, NY 10032, USA. 7 Columbia Center for Translational Immunology, Department of Medicine, Columbia University, New York, NY 10032, USA; Department of Microbiology & Immunology, Columbia University, New York, NY 10032, USA; Department of Surgery, Columbia University, New York, NY 10032, USA. 8 Department of Surgery, Columbia University, New York, NY 10032, USA. 9 Columbia Center for Translational Immunology, Department of Medicine, Columbia University, New York, NY 10032, USA; Department of Microbiology & Immunology, Columbia University, New York, NY 10032, USA; Department of Surgery, Columbia University, New York, NY 10032, USA. Electronic address: megan.sykes@columbia.edu.

High frequency of shared clonotypes in human B cell receptor repertoires

Soto et al.
Nature
February 2019
Authors and Affiliates
Soto C1,2, Bombardi RG1, Branchizio A1, Kose N1, Matta P1, Sevy AM3, Sinkovits RS4, Gilchuk P1, Finn JA3, Crowe JE Jr5,6,7. 1 The Vanderbilt Vaccine Center, Vanderbilt University Medical Center, Nashville, TN, USA. 2 Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN, USA. 3 Chemical and Physical Biology Program, Vanderbilt University, Nashville, TN, USA. 4 San Diego Supercomputer Center, University of California, San Diego, San Diego, CA, USA. 5 The Vanderbilt Vaccine Center, Vanderbilt University Medical Center, Nashville, TN, USA. james.crowe@vanderbilt.edu. 6 Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN, USA. james.crowe@vanderbilt.edu. 7 Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA. james.crowe@vanderbilt.edu.

Identifying and Tracking Low-Frequency Virus-Specific TCR Clonotypes Using High-Throughput Sequencing

Wolf et al.
Cancer Reports
November 2018
Authors and Affiliates
Wolf K1, Hether T2, Gilchuk P3, Kumar A3, Rajeh A4, Schiebout C4, Maybruck J5, Buller RM1, Ahn TH6, Joyce S3, DiPaolo RJ7. 1 Department of Molecular Microbiology and Immunology, Saint Louis University, Saint Louis, MO 63104, USA. 2 Adaptive Biotechnologies, Seattle, WA 98102, USA. 3 Department of Veterans Affairs, Tennessee Valley Healthcare System, Nashville, TN 37212, USA; Department of Pathology, Microbiology, and Immunology, Vanderbilt University, Nashville, TN 37232, USA. 4 Program in Bioinformatics and Computational Biology, Saint Louis University, Saint Louis, MO 63104, USA. 5 Federal Bureau of Investigation, Washington, DC 20535, USA. 6 Department of Computer Science, Saint Louis University, Saint Louis, MO 63104, USA; Program in Bioinformatics and Computational Biology, Saint Louis University, Saint Louis, MO 63104, USA. 7 Department of Molecular Microbiology and Immunology, Saint Louis University, Saint Louis, MO 63104, USA. Electronic address: richard.dipaolo@health.slu.edu.