Therapeutic Area: Other Immune Biology

Longitudinal immunosequencing in healthy people reveals persistent T cell receptors rich in public receptors

Chu et al.
bioRxiv
Papers
February 2018
Authors and Affiliates
Nathaniel D. Chu1,2,3, Haixin Sarah Bi1,3,4, Ryan O. Emerson5, Anna M. Sherwood5, Michael E. Birnbaum1, Harlan S. Robins5,6, Eric J. Alm1,3,7 1Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA. 2Microbiology Graduate Program, Massachusetts Institute of Technology, Cambridge, MA. 3Center for Microbiome Informatics and Therapeutics, Massachusetts Institute of Technology, Cambridge, MA. 4Computational and Systems Biology Program, Massachusetts Institute of Technology, Cambridge, MA. 5Adaptive Biotechnologies, Seattle, WA. 6Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America 7Broad Institute, Cambridge, MA.

T cell Phenotype and T cell receptor repertoire in Patients with Major Depressive Disorder

Patas et al.
Frontiers in Immunology
Papers
February 2018
immuneAccess
Authors and Affiliates
Kostas Patas1, Anne Willing1, Cüneyt Demiralay2, Jan Broder Engler1, Andreea Lupu1,3, Caren Ramien1, Tobias Schäfer4, Christian Gach4, Laura Stumm2, Kenneth Chan5, Marissa Vignali5, Petra C. Arck6, Manuel A. Friese1, Ole Pless4, Klaus Wiedemann2, Agorastos Agorastos2 and Stefan M. Gold1,7 1Institut für Neuroimmunologie und Multiple Sklerose (INIMS), Universitätsklinikum Hamburg-Eppendorf, Hamburg, Germany, 2Klinik für Psychiatrie und Psychotherapie, Universitätsklinikum Hamburg-Eppendorf, Hamburg, Germany, 3Immunomodulation Group, Cantacuzino National Research Institute, Bucharest, Romania, 4Fraunhofer IME ScreeningPort, Hamburg, Germany, 5Adaptive Biotechnologies, Seattle, WA, Unites States, 6Experimentelle Feto-Maternale Medizin, Universitätsklinikum Hamburg-Eppendorf, Hamburg, Germany, 7Charité – Universitätsmedizin Berlin, Humboldt Universität zu Berlin, Berlin Institute of Health (BIH), Klinik für Psychiatrie und Psychotherapie, Campus Benjamin Franklin (CBF), Berlin, Germany

Pilot trial of K562/GM-CSF whole-cell vaccination in MDS patients

Robinson et al.
Leukemia & Lymphoma
Papers
February 2018
Authors and Affiliates
Tara M. Robinsona, Gabrielle T. Princea, Chris Thoburnb, Erica Warlickc, Anna Fergusona, Yvette L. Kasamona, Ivan M. Borrelloa, Allan Hessa and B. Douglas Smitha aDepartment of Medical Oncology, Johns Hopkins University School of Medicine, Baltimore, MD, USA; bDepartment of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, USA; cDepartment of Medicine, University of Minnesota Medical Center, St. Paul/Minneapolis, MN, USA

Public Clonotypes and Convergent Recombination Characterize the Naïve CD8+ T-Cell Receptor Repertoire of Extremely Preterm Neonates

Carey et al.
Frontiers in Immunology
Papers
December 2017
immuneAccess
Authors and Affiliates
Alison J. Carey1,2, Jennifer L. Hope3, Yvonne Mueller3, Adam J. Fike2, Ogan K. Kumova2, David V. Zessen3, 4, Eric A. Steegers5, Mirjam van der Burg3, Peter Katsikis3 1Pediatrics, Drexel University, United States, 2Microbiology and Immunology, Drexel University, United States, 3Immunology, Erasmus Medical Center, Erasmus University Rotterdam, Netherlands, 4Biostatistics, Erasmus Medical Center, Erasmus University Rotterdam, Netherlands, 5Obstetrics and Gynecology, Erasmus Medical Center, Erasmus University Rotterdam, Netherlands

Phenotypic and functional complexity of brain-infiltrating T cells in Rasmussen encephalitis

Nimer et al.
Neurology
Papers
December 2017
Authors and Affiliates
Faiez Al Nimer, MD, PhD*, Ivan Jelcic, PhD*, Christian Kempf, MD, Tom Pieper, MD, Herbert Budka, MD, Mireia Sospedra, PhD, Roland Martin, MD From the Neuroimmunology and Multiple Sclerosis Research Section (F.A.N., I.J., C.K., M.S., R.M.), Department of Neurology, University Hospital Zurich, Switzerland; Neuropediatric Clinic and Clinic for Neurorehabilitation (T.P.), Epilepsy Center for Children and Adolescents, Schoen Klinik Vogtareuth, Germany; and Institute of Neuropathology (H.B.), University Hospital Zurich, Switzerland.

Biallelic interferon regulatory factor 8 mutation: A complex immunodeficiency syndrome with dendritic cell deficiency, monocytopenia, and immune dysregulation

Bigley et al.
Journal of Allergy and Clinical Immunology
Papers
November 2017
Authors and Affiliates
Venetia Bigley, MD, PhD,a,b Sheetal Maisuria, MSc,c Urszula Cytlak, PhD,a Laura Jardine, MD,a,b Matthew A. Care, PhD,d Kile Green, MSc,a Merry Gunawan, PhD,a Paul Milne, PhD,a Rachel Dickinson, PhD,a Sarah Wiscombe, MD,a David Parry, PhD,e Rainer Doffinger, MD, PhD,f Arian Laurence, MD, PhD,a,b Claudia Fonseca, Lic,g Oda Stoevesandt, PhD,g Andrew Gennery, MD, PhD,a,b Andrew Cant, MD, PhD,b Reuben Tooze, MD, PhD,d A. John Simpson, MD, PhD,a,b Sophie Hambleton, MD, PhD,a,b Sinisa Savic, MD, PhD,h Gina Doody, PhD,d and Matthew Collin, MD, PhDa,b aThe Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne; bNewcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne; cLeeds Institute of Rheumatic and Musculoskeletal Medicine, dLeeds Institute of Cancer and Pathology, eLeeds Institute of Biomedical and Clinical Sciences, and hthe National Institute for Health Research–Leeds Musculoskeletal Biomedical Research Unit and Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds; fthe Department of Clinical Biochemistry and Immunology, Addenbrookes Hospital, Cambridge; and gCambridge Protein Arrays, Babraham Research Campus, Cambridge.

Staged development of long lived TCRαβ Th17 resident memory T cell population to Candida albicans after skin infection

Park et al.
Journal of Allergy and Clinical Immunology
Papers
September 2017
Authors and Affiliates
Chang Ook Park, MD, PhD1,5, Xiujun Fu, MD, PhD2, Xiaodong Jiang, MD, PhD1, Youdong Pan, PhD1, Jessica E. Teague, PhD1, Nicholas Collins, PhD3, Tian Tian, MD, PhD1, John T. O’Malley, MD, PhD1, Ryan O. Emerson, PhD4, Ji Hye Kim, MS5, Yookyung Jung, PhD2, Rei Watanabe, MD, PhD1, Robert C. Fuhlbrigge, MD, PhD1, Francis R. Carbone, PhD3, Thomas Gebhardt, MD, PhD3, Rachael A. Clark, MD, PhD1, Charles P. Lin, PhD2, and Thomas S. Kupper, MD1 1Department of Dermatology, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, USA, 2Center for Systems Biology and Wellman Center for Photomedicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA, 3Department of Microbiology and Immunology, The University of Melbourne, Parkville, Australia, 4Adaptive Biotechnologies, Seattle, Washington, USA, 5Department of Dermatology and Cutaneous Biology Research Institute, Yonsei University, College of Medicine, Seoul, Korea

Deacetylase activity of histone deacetylase 3 is required for productive VDJ recombination and B-cell development

Stengel et al.
Papers
Proceedings of the National Academy of Sciences
August 2017
Authors and Affiliates
Kristy R. Stengela, Kelly R. Barnetta, Jing Wangb, Qi Liub, Emily Hodgesa, Scott W. Hieberta,b, and Srividya Bhaskarac aDepartment of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN 37232; bVanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN 37027; and cDepartment of Radiation Oncology and Oncological Sciences, University of Utah School of Medicine and Huntsman Cancer Institute, Salt Lake City, UT 84103

Adaptive from Innate: Human IFN-g+ CD4+ T Cells Can Arise Directly from CXCL8-Producing Recent Thymic Emigrants in Babies and Adults

Das et al.
Journal of Immunology
Papers
July 2017
Authors and Affiliates
Abhishek Das,* Kevin Rouault-Pierre,† Shraddha Kamdar,* Iria Gomez-Tourino,* Kristie Wood,‡ Ian Donaldson,x Charles A. Mein,x Dominique Bonnet,† Adrian C. Hayday,*,† and Deena L. Gibbons* *Peter Gorer Department of Immunobiology, King’s College London, London SE1 9RT, United Kingdom; †The Francis Crick Institute, London NW1 1AT, United Kingdom; ‡National Institute for Health Research Biomedical Research Centre Genomics Research Platform, Guy’s Hospital, London SE1 9RT, United Kingdom; and xGenome Centre, Barts and the London School of Medicine and Dentistry, John Vane Science Centre, London EC1M 6BQ, United Kingdom