Therapeutic Area: Other Immune Biology
Key Residues at Third CDR3β Position Impact Structure and Antigen Recognition of Human Invariant NK TCRs
Chamoto et al
Journal of Immunology
Papers
December 2016
Authors and Affiliates
Kenji Chamoto*,1, Tingxi Guo*,†,1, Stephen W. Scally‡, Yuki Kagoya*, Mark Ancruzowski*,†, Chung-Hsi Wang*,†, Muhammed A. Rahman*, Kayoko Saso*, Marcus O. Butler*,†,§, Priscilla P. L. Chiu¶,‖, Jean-Philippe Julien†,‡,# and Naoto Hirano*,†
*Tumor Immunotherapy Program, Campbell Family Institute for Breast Cancer Research, Campbell Family Cancer Research Institute, Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario M5G 2M9, Canada; †Department of Immunology, University of Toronto, Toronto, Ontario M5S 1A8, Canada; ‡Program in Molecular Structure and Function, The Hospital for Sick Children Research Institute, Toronto, Ontario M5G 0A4, Canada; §Department of Medicine, University of Toronto, Toronto, Ontario M5S 1A8, Canada; ¶Division of Pediatric Surgery, The Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada; ‖Department of Surgery, University of Toronto, Toronto, Ontario M5S 1A8, Canada; and #Department of Biochemistry, University of Toronto, Toronto, Ontario M5S 1A8, Canada
Efficient Culture of Human Naive and Memory B Cells for Use as APCs
Authors and Affiliates
Kuei-Ying Su,*,†,1 Akiko Watanabe,*,1 Chen-Hao Yeh,* Garnett Kelsoe,*,‡ and Masayuki Kuraoka*
*Department of Immunology, Duke University, Durham, NC 27710; †Tzu Chi Med- ical Center, Hualien 970, Taiwan; and ‡Human Vaccine Institute, Duke University, Durham, NC 27710
Discrete TCR Binding Kinetics Control Invariant NKT Cell Selection and Central Priming
Tleugabulova et al.
Journal of Immunology
Papers
October 2016
Authors and Affiliates
Mayra Cruz Tleugabulova*, Nichole K. Escalante*, Shenglou Deng†, Stephanie Fieve*, June Ereño-Orbea‡, Paul B. Savage†, Jean-Philippe Julien*,‡,§ and Thierry Mallevaey*
*Department of Immunology, University of Toronto, Toronto, Ontario M5S 1A8, Canada; †Department of Chemistry and Biochemistry, Brigham Young University, Provo, UT 84602; ‡The Hospital for Sick Children Research Institute, Toronto, Ontario M5G 0A4, Canada; and §Department of Biochemistry, University of Toronto, Toronto, Ontario M5S 1A8, Canada
ABC transporters and NR4A1 identify a quiescent subset of tissue-resident memory T cells
Boddupalli et al.
Papers
The Journal of Clinical Investigation
September 2016
Authors and Affiliates
Chandra Sekhar Boddupalli1, Shiny Nair1, Simon M. Gray2, Heba N. Nowyhed3, Rakesh Verma1. Joanna A. Gibson4,Clara Abraham1, Deepak Narayan5, Juan Vasquez6, Catherine C. Hedrick3, Richard A. Flavell2,7, Kavita M. Dhodapkar6,
Susan M. Kaech2,7, and Madhav V. Dhodapkar1,2
1Department of Medicine, and 2Department of Immunobiology, Yale School of Medicine, New Haven, Connecticut, USA. 3La Jolla Institute for Allergy and Immunology, Division of Inflammation Biology, La Jolla, California, USA. 4Department of Pathology, 5Department of Surgery, 6Department of Pediatrics, and 7Howard Hughes Medical Institute, Yale School of Medicine, New Haven, Connecticut, USA.
Accelerated Loss of TCR Repertoire Diversity in Common Variable Immunodeficiency
Wong et al.
Papers
The Journal of Immunology
August 2016
Authors and Affiliates
Gabriel K. Wong,1,2 David Millar,3,4 Sarah Penny,1 James M. Heather,5 Punam Mistry,1 Nico Buettner,1 Jane Bryon,6 Aarnoud P. Huissoon,2 and Mark Cobbold3,4
1Medical Research Council Centre for Immune Regulation, University of Birmingham, Edgbaston B15 2TT, United Kingdom; 2West Midlands Primary Immunodeficiency Centre, Birmingham Heartlands Hospital, Birmingham B9 5SS, United Kingdom; 3Cancer Center, Massachusetts General Hospital, Boston MA 02114; 4Department of Medicine, Harvard Medical School, Charlestown, MA 02129; 5Division of Infection and Immunity, University College London, London WC1E 6BT, United Kingdom; and 6Regional Genetics Laboratory, Birmingham Women’s Hospital, Birmingham B15 2TG, United Kingdom
A Public Database of Memory and Naive B- Cell Receptor Sequences
Authors and Affiliates
William S. DeWitt1, Paul Linda2,3, Thomas M. Snyder1, Anna M. Sherwood1, Marissa Vignali1, Christopher S. Carlson2, Philip D. Greenberg2, Natalie Duerkopp2, Ryan O. Emerson1, Harlan S. Robins1,2
1Adaptive Biotechnologies, Seattle, United States of America, 2Fred Hutchinson Cancer Research Center, Seattle, United States of America, 3University of Washington, Seattle, United States of America
Human TRAV1-2-negative MR1-restricted T cells detect S. pyogenes and alternatives to MAIT riboflavin-based antigens
Meermeier et al.
Nature Communications
Papers
August 2016
Authors and Affiliates
Erin W. Meermeier1, Bruno F. Laugel2, Andrew K. Sewell2, Alexandra J. Corbett3, Jamie Rossjohn2,4,5, James McCluskey3, Melanie J. Harriff6,7, Tamera Franks7, Marielle C. Gold1,6,7 & David M. Lewinsohn1,6,7
1 Department of Molecular Microbiology and Immunology, Oregon Health and Science University, Portland, Oregon 97239 USA. 2 Institute of Infection and Immunity, HenryWellcome Research Institute, Cardiff University School of Medicine, Cardiff CF14 4XN, UK. 3 Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Parkville, Victoria 3010, Australia. 4 Department of Biochemistry and Molecular Biology, School of Biomedical Sciences, Monash University, Clayton, Victoria 3800, Australia. 5 ARC Centre of Excellence in Advanced Molecular Imaging, Monash University, Clayton, Victoria 3800, Australia. 6 Department of Pulmonary and Critical Care Medicine, Oregon Health and Science University, Portland, Oregon 97239, USA. 7 Department of Research, VA Portland Health Care Center, Portland, Oregon 97239, USA
Analyzing the CDR3 Repertoire with respect to TCR—Beta Chain V-D-J and V-J Rearrangements in Peripheral T Cells using HTS
Ma et al
Papers
Scientific Reports
July 2016
Authors and Affiliates
Long Ma1, Liwen Yang1, Bin Shi2, Xiaoyan He1, Aihua Peng1, Yuehong Li1, Teng Zhang1, Suhong Sun3, Rui Ma1 & Xinsheng Yao1
1Department of Immunology, Research Center for Medicine & Biology, Innovation & Practice Base for Graduate Students Education, Zunyi Medical University, Zunyi 563003, China, 2 Department of Laboratory Medicine, Zunyi Medical University, Zunyi 563003, China, 3Department of Breast Surgery, The first Affiliated Hospital of Zunyi Medical University, Zunyi 563003, China
T cell receptor diversity in the human thymus
Authors and Affiliates
Reetta Vanhanena, Nelli Heikkiläa , Kunal Aggarwalb, David Hammc, Heikki Tarkkilaa, Tommi Pätiläd, T. Sakari Jokirantaa, Jari Saramäkib, T. Petteri Arstilaa
aMedicum, Department of Bacteriology and Immunology and Research Programs Unit, Immunobiology, University of Helsinki, 00014 Helsinki, Finland, bDepartment of Computer Science, Aalto University, FI-00076 Aalto, Espoo, Finland, cAdaptive Biotechnologies, 1551 Eastlake Ave. E, Seattle, WA, United States, dDepartment of Pediatric Cardiac and Transplantation Surgery, Hospital for Children and Adolescents, Helsinki University Central Hospital, 00290 Helsinki, Finland