Therapeutic Area: Other Immune Biology

Clonal expansion of CD4+ cytotoxic T lymphocytes in patients with IgG4-related disease

Mattoo et al.
Papers
The Journal of Allergy and Clinical Immunology
May 2016
Authors and Affiliates
Hamid Mattoo1, Vinay S. Mahajan1, Takashi Maehara2, Vikram Deshpande1, Emanuel Della-Torre1, Zachary S. Wallace1, Maria Kulikova1, Jefte M. Drijvers1, Joe Daccache1, Mollie N. Carruthers1, Flavia Castellino1, James R. Stone1, John H. Stone3, Shiv Pillai4. 1Massachusetts General Hospital, Harvard Medical School, Boston, Mass. 2Massachusetts General Hospital, Harvard Medical School, Boston, Mass; Section of Oral and Maxillofacial Oncology, Division of Maxillofacial Diagnostic and Surgical Sciences, Fukuoka, Japan. 3Massachusetts General Hospital, Harvard Medical School, Boston, Mass. 4Massachusetts General Hospital, Harvard Medical School, Boston, Mass.

CD8+ T-cell pathogenicity in Rasmussen encephalitis elucidated by large-scale T-cell receptor sequencing

Schneider-Hohendorf et al.
Nature Communications
Papers
April 2016
Authors and Affiliates
Tilman Schneider-Hohendorf1, Hema Mohan1, Christian G. Bien2, Johanna Breuer1, Albert Becker3, Dennis Gorlich4, Tanja Kuhlmann5, Guido Widman6, Sebastian Herich1, Christiane Elpers7, Nico Melzer1, Klaus Dornmair8,9,10, Gerhard Kurlemann7, Heinz Wiendl1, & Nicholas Schwab1 1Department of Neurology, University of Munster, Germany. 2 Epilepsy Center Bethel, Bielefeld, Germany. 3 Institute of Neuropathology, University Hospital Bonn, Bonn, Germany. 4 Institute of Biostatistics and Clinical Research, University of Munster, Munster, Germany. 5Department of Neuropathology, University of Munster, Munster, Germany. 6Department of Epileptology, University of Bonn, Bonn, Germany. 7 Children’s Hospital of the University Medical Center, University of Munster, Munster, Germany. 8 Institute for Clinical Neuroimmunology, Ludwig-Maximilians-University Munich, Munich, Germany. 9 Biomedical Center, Ludwig-Maximilians-University Munich, Munich, Germany. 10 Munich Cluster for Systems Neurology (SyNergy), Ludwig-Maximilians-University Munich, Munich, Germany.

Ligase-4 Deficiency Causes Distinctive Immune Abnormalities in Asymptomatic Individuals

Felgentreff et al.
Journal of Clinical Immunology
Papers
April 2016
Authors and Affiliates
Kerstin Felgentreff1,2 & Sachin N. Baxi1 & Yu Nee Lee1 & Kerry Dobbs1 & Lauren A. Henderson1 & Krisztian Csomos3 & Erdyni N. Tsitsikov4 & Mary Armanios5 & Jolan E. Walter1,3 & Luigi D. Notarangelo1,6 1Division of Immunology, Boston Children’s Hospital, Harvard Medical School, Boston, MA, USA. 2 Department of Pediatrics and Adolescent Medicine, Ulm University Medical Center, Ulm, Germany. 3 Pediatric Allergy and Immunology and the Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA. 4 Department of Laboratory Medicine, Boston Children’s Hospital, Harvard Medical School, Boston, MA, USA. 5 Departments of Oncology, Pathology and McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA. 6 Harvard Stem Cell Institute, Harvard University, Boston, MA, USA.

Origin and evolution of the T cell repertoire after posttransplantation cyclophosphamide

Kanakry et al.
Journal of Clinical Investigation
Papers
April 2016
immuneAccess
Authors and Affiliates
Christopher G. Kanakry,1 David G. Coffey,2,3 Andrea M.H. Towlerton,2 Ante Vulic,1 Barry E. Storer,2 Jeffrey Chou,2,3 Cecilia C.S. Yeung,2,4 Christopher D. Gocke,1 Harlan S. Robins,5 Paul V. O’Donnell,2,3 Leo Luznik,1 and Edus H. Warren2,3 1 Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA. 2 Clinical Research Division, Fred Hutchinson Cancer Research Center (FHCRC), Seattle, Washington, USA. 3 Department of Medicine and 4 Department of Pathology, University of Washington, Seattle, Washington, USA. 5 Public Health Sciences Division, FHCRC, Seattle, Washington, USA.

Conventional and Regulatory CD4+ T Cells That Share Identical TCRs Are Derived from Common Clones

Wolf et al.
Papers
PLOS ONE
April 2016
Authors and Affiliates
Kyle J. Wolf1, Ryan O. Emerson2, Jeanette Pingel1, R. Mark Buller1, Richard J. DiPaolo1 1 Department of Molecular Microbiology and Immunology, Saint Louis University, School of Medicine, Saint Louis, Missouri, United States of America, 2 Adaptive Biotechnologies Corporation, Seattle, Washington, United States of America Abstract Reference

IL-25/IL-33–responsive TH2 cells characterize nasal polyps with a default TH17 signature in nasal mucosa

Lam et al.
Papers
The Journal of Allergy and Clinical Immunology
December 2015
Authors and Affiliates
Emily P. S. Lam, PhD,1,8 Harsha H. Kariyawasam, FRCP, PhD,2,8 Batika M. J. Rana, PhD,3,8 Stephen R. Durham, MD, FRCP,4,8 Andrew N. J. McKenzie, PhD,3 Nicholas Powell, MRCP, PhD,5 Nara Orban, MD,4 Melissa Lennartz-Walker, MSc,1,8 Claire Hopkins, FRCS (ORL-HNS),7 Sun Ying, MD, PhD,1 Joanne Rimmer, FRCS (ORL-HNS),2 Valerie J. Lund, MD, FRCS,2 David J. Cousins, PhD,5,8 and Stephen J. Till, FRCP, PhD1,8 1The Division of Asthma, Allergy and Lung Biology, Guy’s Hospital, King’s College London; 2the Allergy and Medical Rhinology Section, Royal National Throat Nose Ear Hospital, University College London; 3the Medical Research Council Laboratory of Molecular Biology, Cambridge; 4the Section of Allergy and Clinical Immunology, National Heart and Lung Institute, Imperial College London; 5the Division of Transplantation Immunology and Mucosal Biology and Medical Research Council Centre for Transplantation, King’s College London; 6the Department of Infection, Immunity and Inflammation, NIHR Leicester Respiratory Biomedical Research Unit, Leicester Institute for Lung Health, University of Leicester; 7the Department of ENT, Guy’s and St Thomas’ Hospital, London; and 8the Medical Research Council and Asthma UK Centre in Allergic Mechanisms of Asthma, London.

The difficult–and often delayed–diagnosis of CTCL

Weed et al.
Papers
Science Translational Medicine Editorial
October 2015
Authors and Affiliates
Weed J1, Girardi M1 1Department of Dermatology, Yale School of Medicine, 333 Cedar Street, New Haven, CT 06520, USA.