Therapeutic Area: Other Immune Biology

High-throughput T-cell receptor sequencing across chronic liver diseases reveals distinct disease-associated repertoires

Liaskou et al.
Hepatology
Papers
September 2015
Authors and Affiliates
Liaskou E1, Henriksen EK2,3,4, Holm K2,3,4, Kaveh F5, Hamm D6, Fear J1, Viken MK7, Hov JR2,3,4,8, Melum E2,3,4, Robins H9, Olweus J4,10,11, Karlsen TH2,3,4,8, Hirschfield GM1. 1Centre for Liver Research, National Institute for Health Research Birmingham Liver Biomedical Research Unit, University of Birmingham, Birmingham, UK. 2Norwegian PSC Research Center, Department of Transplantation Medicine, Division of Cancer Medicine, Surgery, and Transplantation, Oslo University Hospital Rikshospitalet, Oslo, Norway. 3Research Institute of Internal Medicine, Division of Cancer Medicine, Surgery, and Transplantation, Oslo University Hospital, Rikshospitalet, Oslo, Norway. 4K.G. Jebsen Inflammation Research Centre, Institute of Clinical Medicine, University of Oslo, Oslo, Norway. 5Department of Medical Genetics, Oslo University Hospital, Oslo, Norway. 6Adaptive Biotechnologies Corp., Seattle, WA. 7Institute of Immunology, Oslo University Hospital Rikshospitalet, Oslo, Norway. 8Section of Gastroenterology, Department of Transplantation Medicine, Division of Cancer Medicine, Surgery, and Transplantation, Oslo University Hospital, Rikshospitalet, Oslo, Norway. 9Fred Hutchinson Cancer Research Center, Seattle, WA. 10Department of Immunology, Institute for Cancer Research, Oslo University Hospital, Radiumhospitalet, Oslo, Norway. 11K.G. Jebsen Center for Cancer Immunotherapy, Institute of Clinical Medicine, University of Oslo, Oslo, Norway.

High-throughput sequencing reveals an altered T cell repertoire in X-linked agammaglobulinemia

Ramesh et al.
Clinical Immunology
Papers
September 2015
Authors and Affiliates
Ramesh M1, Simchoni N2, Hamm D3, Cunningham-Rundles C4. 1Montefiore Medical Center, Bronx, NY, United States. 2Icahn School of Medicine at Mount Sinai, New York, NY, United States. 3Adaptive Biotech, Seattle, WA, United States. 4Icahn School of Medicine at Mount Sinai, New York, NY, United States; Department of Pediatrics, The Immunology Institute, Box 1089, Icahn School of Medicine at Mount Sinai, 1425 Madison Avenue, New York, NY 10029, United States.

Common clonal origin of central and resident memory T cells following skin immunization

Gaide et al.
Nature Medicine
Papers
May 2015
immuneAccess
Authors and Affiliates
Gaide O1, Emerson RO2, Jiang X1, Gulati N3, Nizza S1, Desmarais C2, Robins H4, Krueger JG3, Clark RA1, Kupper TS1 1Department of Dermatology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA. 2Adaptive Biotech, Seattle, Washington, USA. 3Laboratory for Investigative Dermatology, Rockefeller University, New York, New York, USA. 4Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.

Dynamics of the Cytotoxic T Cell Response to a Model of Acute Viral Infection

DeWitt et al.
J Virol.
Papers
April 2015
immuneAccess
Authors and Affiliates
DeWitt WS1, Emerson RO1, Lindau P2, Vignali M1, Snyder TM1, Desmarais C1, Sanders C1, Utsugi H3, Warren EH3, McElrath J3, Makar KW3, Wald A4, Robins HS5 Adaptive Biotechnologies, Seattle, WA1; Fred Hutchinson Cancer Research Center, Seattle, USA Molecular & Cellular Graduate Program, University of Washington, Seattle, USA Medical Scientist Training Program, University of Washington, Seattle, WA2; Fred Hutchinson Cancer Research Center, Seattle, WA3; Division of Allergy and Infectious Diseases, University of Washington, Seattle, WA4; Adaptive Biotechnologies, Seattle USA, Fred Hutchinson Cancer Research Center, Seattle, WA5

Functional Heterogeneity of Human Memory CD4+ T Cell Clones Primed By Pathogens or Vaccines

Becattini et al.
Papers
ScienceXpress
December 2014
immuneAccess
Authors and Affiliates
Becattini S1,2, Latorre D1, Mele F1, Foglierini M1, De Gregorio C1, Cassotta A1, Fernandez B1, Kelderman S3, Schumacher TN3, Corti D1, Lanzavecchia A1,2, Sallusto F1 Institute for Research in Biomedicine, Universita della Svizzera Italiana, Bellinzona, Switzerland1; Institute of Microbiology, ETH Zurich, Zurich, Switzerland2; Division of Immunology, Netherlands Cancer Institute, Amsterdam, Netherlands3

Defining the alloreactive T cell repertoire using high-throughput sequencing of mixed lymphocyte reaction culture.

Emerson et al.
Papers
PLOS ONE
November 2014
Authors and Affiliates
Emerson RO1, Mathew JM2, Konieczna IM3, Robins HS4, Leventhal JR3. 1Adaptive Biotechnologies Corporation, Seattle, Washington, United States of America. 2Department of Surgery, Comprehensive Transplant center, Northwestern University, Chicago, Illinois, United States of America; Department of Microbiology-Immunology, Northwestern University, Chicago, Illinois, United States of America. 3Department of Surgery, Comprehensive Transplant center, Northwestern University, Chicago, Illinois, United States of America. 4Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America.

De novo oligoclonal expansions of circulating plasmablasts in active and relapsing IgG4 -related disease

Mattoo et al.
Journal of Allergy and Clinical Immunology
Papers
September 2014
immuneAccess
Authors and Affiliates
Mattoo H1, Mahajan VS1, Della-Torre E1, Sekigami Y1, Carruthers M1, Wallace ZS1, Deshpande V1, Stone JH2, Pillai S3. 1Massachusetts General Hospital and Harvard Medical School, Boston, Mass. 2Massachusetts General Hospital and Harvard Medical School, Boston, Mass. Electronic address: jhstone@partners.org. 3Massachusetts General Hospital and Harvard Medical School, Boston, Mass. Electronic address: pillai@helix.mgh.harvard.edu.