Therapeutic Area: Other Immune Biology

Parallel T-cell cloning and deep sequencing of human MAIT cells reveal stable oligoclonal TCRB repertoire

Lepore et al.
Nature Communications
Papers
May 2014
Authors and Affiliates
Marco Lepore1, Artem Kalinicenko1, Alessia Colone2, Bhairav Paleja2, Amit Singhal2, Andreas Tschumi3, Bernett Lee2, Michael Poidinger2, Francesca Zolezzi2, Luca Quagliata4, Peter Sander3,5, Evan Newell2, Antonio Bertoletti6, Luigi Terracciano4, Gennaro De Libero1,2 & Lucia Mori1,2 1Experimental Immunology, Department of Biomedicine, University Hospital Basel, 4031 Basel, Switzerland. 2 SIgN, Singapore Immunology Network, Agency for Science, Technology and Research, Singapore 138648, Singapore. 3Institute of Medical Microbiology, University of Zurich, 8006 Zurich, Switzerland. 4Institute of Pathology, University Hospital Basel, 4031 Basel, Switzerland. 5National Centre for Mycobacteria, Gloriastrasse 30/32, 8006 Zurich, Switzerland. 6Emerging Infectious Diseases, Duke-NUS Graduate Medical School, Singapore 169857, Singapore.

Quantifying selection in immune receptor repertoires

Elhanati et al.
Cornell University Library
Papers
April 2014
Authors and Affiliates
Yuval Elhanati,a Anand Murugan,b Curtis G. Callan, Jr.c, Thierry Mora,d and Aleksandra M. Walczaka aLaboratoire de Physique Théorique, Unité Mixte de Recherche 8549, dLaboratoire de Physique Statistique, Unité Mixte de Recherche 8550, Centre National de la Recherche Scientifique and École Normale Supérieure, 75005 Paris, France, bDepartment of Applied Physics, Stanford University, Stanford, CA, 94305; and, cJoseph Henry Laboratories, Princeton University, Princeton, NJ, 08544.

Human Treg responses allow sustained recombinant adeno-associated virus-mediated transgene expression

Mueller et al.
Journal of Clinical Investigation
Papers
December 2013
Authors and Affiliates
Christian Mueller1, Jeffrey D. Chulay2, Bruce C. Trapnell3, Margaret Humphries1, Brenna Carey3, Robert A. Sandhaus4, Noel G. McElvaney5, Louis Messina1, Qiushi Tang1, Farshid N. Rouhani6, Martha Campbell-Thompson6, Ann Dongtao Fu6, Anthony Yachnis6, David R. Knop2, Guo-jie Ye2, Mark Brantly6, Roberto Calcedo7, Suryanarayan Somanathan7, Lee P. Richman8, Robert H. Vonderheide8, Maigan A. Hulme6, Todd M. Brusko6, James M. Wilson7, and Terence R. Flotte1, 8 1University of Massachusetts Medical School, Worcester, Massachusetts, USA. 2Applied Genetic Technologies Corp., Alachua, Florida, USA. 3Cincinnati Children’s Hospital, Cincinnati, Ohio, USA. 4National Jewish Health, Denver, Colorado, USA. 5Beaumont Hospital, Dublin, Ireland. 6University of Florida College of Medicine, Gainesville, Florida, USA. 7Gene Therapy Program and 8Abramson Family Cancer Research Institute, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.

Unifying Model for Molecular Determinants of the Preselection VBeta Repertoire

Gopalakrishnan et al.
Papers
Proceedings of the National Academy of Sciences
August 2013
Authors and Affiliates
Gopalakrishnan S1, Majumder K1, Predues A1, Huang Y1, Koues OI1, Verma-Gaur J2,3, Lofuercio S.3,4, Su AI3,4, Feeney AJ2,3, Artyomov MN1, Oltz EM1 1Department of Pathology and Immunology, Washington University School of Medicine, in St. Louis, 2Department of Immunology and Microbial Science, 4Department of Molecular and Experimental Medicine, 3The Scripps Research Institute, La Jolla

Fractal Organization of the Human T Cell Repertoire in Health and After Stem Cell Transplantation

Meier et al.
Biology of Blood Marrow Transplant
Papers
March 2013
Authors and Affiliates
Jeremy Meier1, Catherine Roberts1, Kassi Avent2, Allison Hazlett1, Jennifer Berrie2, Kyle Payne2, David Hamm3, Cindy Desmarais3, Catherine Sanders3, Kevin T. Hogan4, Kellie J. Archer5, Masoud H. Manjili2, Amir A. Toor1. 1Bone Marrow Transplant Program, Department of Internal Medicine, Virginia Commonwealth University, Richmond, VA 23298, USA. 2Department of Microbiology and Immunology, Virginia Commonwealth University, Richmond, Virginia. 3Adaptive Biotechnologies, Seattle, Washington. 4Massey Cancer Center, Richmond, Virginia. 5Department of Biostatistics, Virginia Commonwealth University, Richmond, Virginia

Immune Recovery in Adult Patients Following Myeloablative Dual Umbilical Cord Blood, Matched Sibling, and Matched Unrelated Donor Hematopoietic Cell Transplantation

Kanda et al.
Biology of Blood and Marrow Transplantation
Papers
December 2012
Authors and Affiliates
Junya Kanda, MD,1,6,* Lun-Wei Chiou, MD,1,* Paul Szabolcs, MD,2 Gregory D. Sempowski, PhD,3 David A. Rizzieri, MD,1 Gwynn D. Long, MD,1 Keith M. Sullivan, MD,1 Cristina Gasparetto, MD,1 John P. Chute, MD,1 Ashley Morris, PharmD,1 Jacalyn McPherson,1 Jeffrey Hale,3 John Andrew Livingston, MD,1 Gloria Broadwater, MS,4 Donna Niedzwiecki, PhD,5 Nelson J. Chao, MD,1 and Mitchell E. Horwitz, MD1,** 1Division of Cellular Therapy, Department of Medicine, Duke University Medical Center, Durham, NC 2Department of Pediatrics, Duke University Medical Center, Durham, NC 3Department of Medicine and Human Vaccine Institute, Duke University School of Medicine, Durham, NC 4Cancer Statistical Center, Duke University Medical Center, Durham, NC 5Department of Biostatistics and Bioinformatics, Duke University Medical Center, Durham, NC 6Division of Hematology, Saitama Medical Center, Jichi Medical University, Saitama, Japan. **Corresponding author: Mitchell E. Horwitz, MD, Division of Cellular Therapy, Department of Medicine, Duke University Medical Center, 2400 Pratt Street, DUMC 3961, Durham, NC 27705, USA. *J.K. and L.C. equally contributed to this work.