Therapeutic Area: Other Immune Biology

NKG2D receptor signaling shapes T cell thymic education

Perez C, et al.
journal of leukocyte biology
December 2023
Authors and Affiliates
Cynthia Perez 1, Lourdes Plaza-Rojas 2, Justin C Boucher 2, Mate Z Nagy 2, Elena Kostenko 2, Kushal Prajapati 1, Brianna Burke 1, Michael Delos Reyes 1, Anna L Austin 2, Shubin Zhang 1,3, Phong T Le 1,3, José A Guevara-Patino 1,2; 1 Department of Cancer Biology, Loyola University Chicago, 2160 S. First Ave, Maywood, IL 60153, United States. 2 Department of Immunology, H. Lee Moffitt Cancer Center and Research Institute, 12902 Magnolia Drive, Tampa, FL 33612, United States. 3 Department of Microbiology and Immunology, Loyola University Chicago, 2160 S. First Ave, Maywood, IL 60153, United States.

The Cyclin D3 Protein Enforces Monogenic TCRβ Expression by Mediating TCRβ Protein-Signaled Feedback Inhibition of Vβ Recombination

Culberson EJ, at al.
Journal of Immunology
December 2023
Authors and Affiliates
Erica J Culberson 1, Kymberle C Shields 1, Rebecca A Glynn 1,2, Brittney M Allyn 1,3, Katharina E Hayer 1,4,5, Craig H Bassing 1,2,3; 1 Department of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA. 2 Cell and Molecular Biology Graduate Group, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA. 3 Immunology Graduate Group, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA. 4 Biomedical Engineering Doctoral Degree Program, School of Biomedical Engineering, Science and Health Systems, Drexel University, Philadelphia, PA. 5 Department of Biomedical and Health Informatics, Children's Hospital of Philadelphia, Perelman School of Medicine, Philadelphia, PA.

TCRseq Reveals Selected Donor-reactive CD8+ T cell Clones Resist Anti-Thymocyte Globulin Depletion after Kidney Transplantation

Ningoo M, et al.
American Journal of Transplantation
December 2023
Authors and Affiliates
Mehek Ningoo 1, Pamela Cruz-Encarnación 1, Calla Khilnani 1, Peter S Heeger 2, Miguel Fribourg 3; 1 Translational Transplant Research Center, Division of Nephrology, Department of Medicine; Immunology Institute Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. 2 Comprehensive Transplant Center, Cedars-Sinai Medical Center, Los Angeles, CA, 90048, USA. 3 Translational Transplant Research Center, Division of Nephrology, Department of Medicine; Immunology Institute Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. Electronic address: miguel.fribourg@mssm.edu.

Plasticity of intragraft alloreactive T cell clones in human gut correlates with transplant outcomes

Fu J, et al.
Journal of Experimental Medicine
December 2023
immuneAccess
Authors and Affiliates
Jianing Fu 1, Zicheng Wang 2, Mercedes Martinez 3, Aleksandar Obradovic 1, Wenyu Jiao 1, Kristjana Frangaj 1, Rebecca Jones 1, Xinzheng V Guo 4, Ya Zhang 4, Wan-I Kuo 4, Huaibin M Ko 5, Alina Iuga 5, Constanza Bay Muntnich 1, Adriana Prada Rey 1, Kortney Rogers 1, Julien Zuber 1, Wenji Ma 2, Michelle Miron 6, Donna L Farber 6,7, Joshua Weiner 1,7, Tomoaki Kato 7, Yufeng Shen 2, Megan Sykes 1,6,7; 1 Department of Medicine, Columbia Center for Translational Immunology, Columbia University, New York, NY, USA. 2Department of Systems Biology, Center for Computational Biology and Bioinformatics, Columbia University, New York, NY, USA. 3 Department of Pediatrics, Columbia University, New York, NY, USA. 4 Human Immune Monitoring Core, Herbert Irving Comprehensive Cancer Center, Columbia University , New York, NY, USA. 5 Department of Pathology and Cell Biology, Columbia University, New York, NY, USA. 6 Department of Microbiology and Immunology, Columbia University, New York, NY, USA. 7 Department of Surgery, Columbia University, New York, NY, USA.

Daratumumab, Bortezomib, Lenalidomide, and Dexamethasone for Multiple Myeloma.

Sonneveld P, et al.
New England Journal of Medicine
December 2023
Authors and Affiliates
Pieter Sonneveld, Meletios A Dimopoulos, Mario Boccadoro, Hang Quach, P Joy Ho, Meral Beksac, Cyrille Hulin, Elisabetta Antonioli, Xavier Leleu, Silvia Mangiacavalli, Aurore Perrot, Michele Cavo, Angelo Belotti, Annemiek Broijl, Francesca Gay, Roberto Mina, Inger S Nijhof, Niels W C J van de Donk, Eirini Katodritou, Fredrik Schjesvold, Anna Sureda Balari, Laura Rosiñol, Michel Delforge, Wilfried Roeloffzen, Tobias Silzle, Annette Vangsted, Hermann Einsele, Andrew Spencer, Roman Hajek, Artur Jurczyszyn, Sarah Lonergan, Tahamtan Ahmadi, Yanfang Liu, Jianping Wang, Diego Vieyra, Emilie M J van Brummelen, Veronique Vanquickelberghe, Anna Sitthi-Amorn, Carla J de Boer, Robin Carson, Paula Rodriguez-Otero, Joan Bladé, Philippe Moreau; PERSEUS Trial Investigators

Sex- and age-specific aspects of human peripheral T-cell dynamics

Mika J, et al.
Frontiers in Immunology
November 2023
Authors and Affiliates
Justyna Mika 1, Kengo Yoshida 2, Yoichiro Kusunoki 2, Serge M Candéias 3, Joanna Polanska 1; 1 Department of Data Science and Engineering, Silesian University of Technology, Gliwice, Poland. 2 Department of Molecular Biosciences, Radiation Effects Research Foundation, Hiroshima, Japan. 3 Université Grenoble Alpes, Commissariat à l'Energie Atomique et aux Energies Alternatives (CEA), Centre National de la Recherche Scientifique (CNRS), Interdisciplinary Research Institute of Grenoble (IRIG), Laboratory of Chemistry and Biology of Metals (LCBM), Grenoble, France.

Renal tubular epithelial cells are constitutive non-cognate stimulators of resident T cells

Sadasivam M, et al.
Cell Reports
November 2023
Authors and Affiliates
Mohanraj Sadasivam 1, Chunfa Jie 2, Abdel Rahim A Hamad 3; 1 Department of Pathology, Johns Hopkins University School of Medicine, 720 Rutland Avenue, Ross 664G, Baltimore, MD 21205, USA. 2 Department of Biochemistry and Nutrition, Des Moines University, 3200 Grand Avenue, Ryan Hall 230, Des Moines, IA 50266, USA. 3 Department of Pathology, Johns Hopkins University School of Medicine, 720 Rutland Avenue, Ross 664G, Baltimore, MD 21205, USA; Department of Medicine, Johns Hopkins University School of Medicine, 720 Rutland Avenue, Ross 664G, Baltimore, MD 21205, USA. Electronic address: ahamad@jhmi.edu.

Analysis of CDR3 Sequences from T-Cell Receptor β in Acute Respiratory Distress Syndrome

Hey S, et al.
Biomolecules
October 2023
Authors and Affiliates
Sara Hey 1, Dayjah Whyte 1, Minh-Chau Hoang 1, Nick Le 1, Joseph Natvig 1, Claire Wingfield 1, Charles Onyeama 2, Judie Howrylak 3, Inimary T Toby 1; 1 Department of Biology, University of Dallas, Irving, TX 75062, USA. 2 T.C Pediatrics, Bedford, TX 76021, USA. 3 Pulmonary, Allergy and Critical Care Division, Penn State Milton S. Hershey Medical Center, Hershey, PA 17033, USA.

Immunophenotypic correlates of sustained MRD negativity in patients with multiple myeloma

Coffey DG, et al.
Nature Communications
October 2023
immuneAccess
Authors and Affiliates
David G Coffey 1,2, Francesco Maura 3, Edgar Gonzalez-Kozlova 4, J Javier Diaz-Mejia 5, Ping Luo 5, Yong Zhang 6, Yuexin Xu 7, Edus H Warren 7, Travis Dawson 4, Brian Lee 4, Hui Xie 4, Eric Smith 8, Amanda Ciardiello 9, Hearn J Cho 4,10, Adeeb Rahman 4, Seunghee Kim-Schulze 4, Benjamin Diamond 3, Alexander Lesokhin 9, Dickran Kazandjian 3, Trevor J Pugh 5,11,12, Damian J Green 7, Sacha Gnjatic 4, Ola Landgren 13; 1 Division of Myeloma, Sylvester Comprehensive Cancer Center, University of Miami, Miami, FL, USA. davidcoffey@miami.edu. 2 Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA. davidcoffey@miami.edu. 3 Division of Myeloma, Sylvester Comprehensive Cancer Center, University of Miami, Miami, FL, USA. 4 Icahn School of Medicine at Mount Sinai, New York, NY, USA. 5 Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada. 6 Office of Oncologic Diseases, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, MD, USA. 7 Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA. 8 Dana-Farber Cancer Institute, Boston, MA, USA. 9 Myeloma Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA. 10 Multiple Myeloma Research Foundation, Norwalk, USA. 11 Ontario Institute for Cancer Research, Toronto, ON, Canada. 12 Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada. 13 Division of Myeloma, Sylvester Comprehensive Cancer Center, University of Miami, Miami, FL, USA. col15@miami.edu.

Elranatamab in relapsed or refractory multiple myeloma: the MagnetisMM-1 phase 1 trial.

Bahlis, N, et al.
Nature Medicine
October 2023
Authors and Affiliates
Nizar J Bahlis, Caitlin L Costello, Noopur S Raje, Moshe Y Levy, Bhagirathbhai Dholaria, Melhem Solh, Michael H Tomasson, Michael A Damore, Sibo Jiang, Cynthia Basu, Athanasia Skoura, Edward M Chan, Suzanne Trudel, Andrzej Jakubowiak, Cristina Gasparetto, Michael P Chu, Andrew Dalovisio, Michael Sebag, Alexander M Lesokhin