Therapeutic Area: Other Immune Biology
The overlap of skin and blood T-cell clones in early-stage mycosis fungoides
Joffe D, et al.
Blood Advances
August 2023
Authors and Affiliates
Daniel Joffe 1, Safiyyah Bhatti 1, Lauren Banner 1, Romsin Zaya 1, Laura Gleason 1, Anjali Mishra 2, Ilan R Kirsch 3, Pierluigi Porcu 4, Neda Nikbakht 1;
1 Thomas Jefferson University, Philadelphia, Pennsylvania, United States.
2 Thomas Jefferson University and Sidney Kimmel Cancer Center, Philadelphia, Pennsylvania, United States.
3 Adaptive Biotechnologies, Seattle, Washington, United States.
4 Sidney Kimmel Cancer Center, Philadelphia, Pennsylvania, United States.
Identification of human exTreg cells as CD16+CD56+ cytotoxic CD4+ T cells
Freuchet A, et al.
Nature Immunology
August 2023
Authors and Affiliates
Antoine Freuchet 1, Payel Roy 1, Sujit Silas Armstrong 1, Mohammad Oliaeimotlagh 2, Sunil Kumar 2, Marco Orecchioni 1,2, Amal J Ali 1, Amir Khan 2, Jeffrey Makings 1, Qingkang Lyu 2, Holger Winkels 3,4, Erpei Wang 1, Christopher Durant 1, Yanal Ghosheh 1, Rishab Gulati 1, Felix Nettersheim 1, Klaus Ley 5,6;
1 La Jolla Institute for Immunology, La Jolla, CA, USA.
2 Immunology Center of Georgia, Augusta University, Augusta, GA, USA.
3 University of Cologne, Faculty of Medicine and University Hospital Cologne, Clinic III for Internal Medicine, Cologne, Germany.
4 Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany.
5 La Jolla Institute for Immunology, La Jolla, CA, USA. kley@augusta.edu.
6 Immunology Center of Georgia, Augusta University, Augusta, GA, USA. kley@augusta.edu.
Tissue-specific features of the T cell repertoire after allogeneic hematopoietic cell transplantation in human and mouse
Authors and Affiliates
Susan DeWolf 1, Yuval Elhanati 2, Katherine Nichols 3, Nicholas R Waters 3, Chi L Nguyen 3, John B Slingerland 3, Natasia Rodriguez 4, Olga Lyudovyk 2, Paul A Giardina 3, Anastasia I Kousa 3, Hana Andrlová 3, Nick Ceglia 2, Teng Fei 5, Rajya Kappagantula 6,7, Yanyun Li 7, Nathan Aleynick 7, Priscilla Baez 4, Rajmohan Murali 7, Akimasa Hayashi 7,8, Nicole Lee 3, Brianna Gipson 3, Madhumitha Rangesa 4, Zoe Katsamakis 3, Anqi Dai 3, Amanda G Blouin 7, Maria Arcila 7, Ignas Masilionis 9, Ronan Chaligne 9, Doris M Ponce 4,10, Heather J Landau 4,10, Ioannis Politikos 4,10, Roni Tamari 4,10, Alan M Hanash 4,10,11, Robert R Jenq 12, Sergio A Giralt 4,10, Kate A Markey 4,13,14, Yanming Zhang 7, Miguel-Angel Perales 4,10, Nicholas D Socci 15, Benjamin D Greenbaum 2,16, Christine A Iacobuzio-Donahue 6, Travis J Hollmann 7,17, Marcel R M van den Brink 3,4,10, Jonathan U Peled 4,10;
1 Leukemia Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
2 Computational Oncology, Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
3 Department of Immunology, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
4 Adult Bone Marrow Transplantation Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
5 Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
6 David M. Rubenstein Center for Pancreatic Cancer Research, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
7 Department of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
8 Department of Pathology, Kyorin University, Mitaka City, Tokyo, Japan.
9 Program for Computational and System Biology, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
10 Weill Cornell Medical College, New York, NY, USA.
11 Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
12 Departments of Genomic Medicine and Stem Cell Transplantation Cellular Therapy, Division of Cancer Medicine, University of Texas MD Anderson Cancer Center, Houston, TX, USA.
13 Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
14 Division of Medical Oncology, University of Washington, Seattle, WA, USA.
15 Bioinformatics Core Facility, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
16 Physiology, Biophysics, and Systems Biology, Weill Cornell Medicine, Weill Cornell Medical College, New York, NY, USA.
17 Bristol Myers Squibb, Lawrenceville, NJ 08540, USA.
Impact of age and telomere length on circulating T cells and rejection risk after lung transplantation for idiopathic pulmonary fibrosis
Snyder ME, et al.
Journal of Heart and Lung Transplantation
August 2023
Authors and Affiliates
Mark E Snyder 1, Michaela R Anderson 2, Luke J Benvenuto 3, Rachel M Sutton 4, Anna Bondonese 4, Ritchie Koshy 4, Robin Burke 4, Sarah Clifford 4, Andrew Craig 4, Carlo J Iasella 5, Stefanie J Hannan 4, Iulia Popescu 4, Yingze Zhang 4, Pablo G Sanchez 6, Jonathan K Alder 4, John F McDyer 7;
1 Department of Medicine, University of Pittsburgh; Department of Immunology, University of Pittsburgh; Starzl Transplantation Institute, Pittsburgh, PA. Electronic address: snyderme2@upmc.edu.
2 Department of Medicine, University of Pennsylvania, Philadelphia, PA.
3 Department of Medicine, Columbia University Irving Medical Center, New York, NY.
4 Department of Medicine, University of Pittsburgh.
5 Department of Medicine, University of Pittsburgh; Department of Pharmacology, University of Pittsburgh.
6 Department of Cardiothoracic Surgery, University of Pittsburgh.
7 Department of Medicine, University of Pittsburgh; Starzl Transplantation Institute, Pittsburgh, PA. Electronic address: mcdyerjf@upmc.edu.
A novel statistical method for decontaminating T-cell receptor sequencing data
Li R, et al.
Briefings in Bioinformatics
August 2023
Authors and Affiliates
Ruoxing Li 1,2, Mehmet Altan 3, Alexandre Reuben 3, Ruitao Lin 2, John V Heymach 3, Hai Tran 3, Runzhe Chen 3, Latasha Little 4, Shawna Hubert 3, Jianjun Zhang 3, Ziyi Li 2;
1 Department of Biostatistics and Data Science, The University of Texas Health Science Center at Houston, 77030, Texas, Houston, USA.
2 Department of Biostatistics, The University of Texas MD Anderson Cancer Center, 77030, Texas, Houston, USA.
3 Department of Thoracic-Head & Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, 77030, Texas, Houston, USA.
4 Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, 77030, Texas, Houston, USA.
Statistical inference reveals the role of length, GC content, and local sequence in V(D)J nucleotide trimming
Russell ML, et al.
eLIFE
August 2023
Authors and Affiliates
Magdalena L Russell 1,2, Noah Simon 3, Philip Bradley 1,4, Frederick A Matsen 4th 1,5,6,7;
1 Computational Biology Program, Fred Hutchinson Cancer Center, Seattle, United States.
2 Molecular and Cellular Biology Program, University of Washington, Seattle, United States.
3 Department of Biostatistics, University of Washington, Seattle, United States.
4 Institute for Protein Design, Department of Biochemistry, University of Washington, Seattle, United States.
5 Department of Genome Sciences, University of Washington, Seattle, United States.
6 Department of Statistics, University of Washington, Seattle, United States.
7 Howard Hughes Medical Institute, Seattle, United States.
Single-cell atlas of the human neonatal small intestine affected by necrotizing enterocolitis
Egozi A, et al.
PLOS Biology
August 2023
Authors and Affiliates
Adi Egozi 1, Oluwabunmi Olaloye 2, Lael Werner 3,4, Tatiana Silva 2, Blake McCourt 2, Richard W Pierce 2,5, Xiaojing An 6, Fujing Wang 6, Kong Chen 6, Jordan S Pober 5,7, Dror Shouval 3,4, Shalev Itzkovitz 1, Liza Konnikova 2,5,7,8;
1 Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel.
2 Department of Pediatrics, Yale School of Medicine, New Haven, Connecticut, United States of America.
3 Institute of Gastroenterology, Nutrition and Liver Diseases, Schneider Children's Medical Center of Israel, Petah Tikva, Israel, affiliated to the Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
4 Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
5 Program in Human and Translational Immunology, Yale School of Medicine, New Haven, Connecticut, United States of America.
6 Department of Medicine, University of Pittsburgh Medical Center Montefiore Hospital, Pittsburgh, Pennsylvania, United States of America.
7 Department of Immunobiology, Yale School of Medicine, New Haven, Connecticut, United States of America.
8 Department of Obstetrics, Gynecology and Reproductive Sciences, Yale School of Medicine, New Haven, Connecticut, United States of America.
The overlap of skin and blood T-cell clones in early-stage mycosis fungoides.
Joffe D, et al.
Blood Advances
August 2023
Authors and Affiliates
Daniel Joffe BS1, Safiyyah Bhatti MD1,2, Lauren Banner BS1, Romsin Zaya BS1, Laura Gleason BS1, Anjali Mishra PhD2, Ilan Kirsch MD3, Pierluigi Porcu MD2, Neda Nikbakht MD, PhD1 1 - Department of Dermatology and Cutaneous Biology, Thomas Jefferson University, Philadelphia, PA 2 - Department of Medical Oncology, Thomas Jefferson University, Philadelphia, PA 3 - Adaptive Biotechnologies, Seattle, WA
Idecabtagene vicleucel for relapsed and refractory multiple myeloma: post hoc 18-month follow-up of a phase 1 trial.
Lin Yi, et al.
Nature Medicine
August 2023
Authors and Affiliates
Yi Lin 1 , Noopur S. Raje2, Jesús G. Berdeja 3, David S. Siegel 4, Sundar Jagannath 5, Deepu Madduri5, Michaela Liedtke6, Jacalyn Rosenblatt7, Marcela V. Maus 2, Monica Massaro8, Fabio Petrocca8, Ashish Yeri8, Olivia Finney8, Andrea Caia9, Zhihong Yang9, Nathan Martin9, Timothy B. Campbell9, Julie Rytlewski9, Jaymes Fuller9, Kristen Hege9, Nikhil C. Munshi 10 & James N. Kochenderfer 11
1Mayo Clinic, Rochester, MN, USA. 2Massachusetts General Hospital Cancer Center and Harvard Medical School, Boston, MA, USA. 3Sarah Cannon Research Institute and Tennessee Oncology, Nashville, TN, USA. 4Hackensack University Medical Center, Hackensack, NJ, USA. 5Mount Sinai Medical Center, New York City, NY, USA. 6Stanford University Medical Center, Palo Alto, CA, USA. 7Beth Israel Deaconess Medical Center, Boston, MA, USA. 8 2SeventyBio, Inc, Cambridge, MA, USA. 9Bristol Myers Squibb, Princeton, NJ, USA. 10Dana-Farber Cancer Institute, Boston, MA, USA. 11Surgery Branch, National Cancer Institute/National Institutes of Health, Bethesda, MD, USA."