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Type 1 diabetes immunotherapy using polyclonal regulatory T cells

Jeffrey A. Bluestone
Papers
Science Translational Medicine
November 2015
Authors and Affiliates
Jeffrey A. Bluestone1, Jane H. Buckner2, Mark Fitch3, Stephen E. Gitelman4, Shipra Gupta2, Marc K. Hellerstein3, Kevan C. Herold5, Angela Lares1, Michael R. Lee1, Kelvin Li6, Weihong Liu1, S. Alice Long2, Lisa M. Masiello1, Vinh Nguyen7, Amy L. Putnam1, Mary Rieck1, Peter H. Sayre8 and Qizhi Tang7 1 Diabetes Center, University of California, San Francisco, San Francisco, CA 94143, USA. 2 Translational Research Program, Benaroya Research Institute at Virginia Mason, Seattle, WA 98101, USA. 3 Department of Nutritional Sciences and Toxicology, University of California, Berkeley, Berkeley, CA 94720, USA. 4 Department of Pediatrics, University of California, San Francisco, San Francisco, CA 94143, USA. 5 Departments of Immunobiology and Internal Medicine, Yale University School of Medicine, New Haven, CT 06520, USA. 6 KineMed Inc., Emeryville, CA 94608, USA. 7 Department of Surgery, University of California, San Francisco, San Francisco, CA 94143, USA. 8 Division of Hematology-Oncology, Department of Medicine, University of California, San Francisco, San Francisco, CA 94143, USA.

IL-21-driven neoplasms in SJL mice mimic some key features of human angioimmunoblastic T-cell lymphoma

Jain et al.
American Journal of Pathology
Papers
November 2015
Authors and Affiliates
Jain S1, Chen J2, Nicolae A3, Wang H1, Shin DM4, Adkins EB5, Sproule TJ6, Leeth CM7, Sakai T1, Kovalchuk AL1, Raffeld M3,Ward JM1, Rehg JE8, Waldmann TA2, Jaffe ES3, Roopenian DC5, Morse HC 3rd9. 1Virology and Cellular Immunology Section, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, Rockville, Maryland. 2Lymphoid Malignancies Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland. 3Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland. 4Virology and Cellular Immunology Section, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, Rockville, Maryland; Department of Food and Nutrition, Seoul National University, Seoul, Republic of Korea. 5Jackson Laboratory, Bar Harbor, Maine; Genetics Program, Tufts University Sackler School of Graduate Biomedical Sciences, Boston, Massachusetts. 6Jackson Laboratory, Bar Harbor, Maine. 7Genetics Program, Tufts University Sackler School of Graduate Biomedical Sciences, Boston, Massachusetts; Department of Animal and Poultry Sciences, College of Agriculture and Life Sciences, Virginia Polytechnic Institute and State University, Blacksburg, Virginia. 8Department of Pathology, St. Jude Children's Research Hospital, Memphis, Tennessee. 9Virology and Cellular Immunology Section, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, Rockville, Maryland

Intrathecal BCR transcriptome in multiple sclerosis versus other neuroinflammation: Equally diverse and compartmentalized, but more mutated, biased and overlapping with the proteome

Johansen et al.
Clinical Immunology
Papers
October 2015
Authors and Affiliates
Johansen JN1, Vartdal F2, Desmarais C3, Tutturen AE4, de Souza GA5, Lossius A6, Holmøy T7. 1Department of Immunology and Transfusion Medicine, Oslo University Hospital Rikshospitalet, Oslo, Norway. 2Department of Immunology and Transfusion Medicine, Oslo University Hospital Rikshospitalet, Oslo, Norway; Institute of Clinical Medicine, University of Oslo, Oslo, Norway. 3Adaptive Biotechnologies, Seattle, WA, USA. 4Centre for Immune Regulation, Department of Immunology and Transfusion Medicine, Oslo University Hospital Rikshospitalet, Oslo, Norway. 5Centre for Immune Regulation, Department of Immunology and Transfusion Medicine, Oslo University Hospital Rikshospitalet, Oslo, Norway; Centre for Immune Regulation, Department of Immunology, University of Oslo, Oslo, Norway. 6Department of Immunology and Transfusion Medicine, Oslo University Hospital Rikshospitalet, Oslo, Norway; Institute of Clinical Medicine, University of Oslo, Oslo, Norway; Department of Neurology, Oslo University Hospital Rikshospitalet, Oslo, Norway. Electronic address: andreas.lossius@rr-research.no. 7Institute of Clinical Medicine, University of Oslo, Oslo, Norway; Department of Neurology, Akershus University Hospital, Lørenskog, Norway.

The difficult–and often delayed–diagnosis of CTCL

Weed et al.
Papers
Science Translational Medicine Editorial
October 2015
Authors and Affiliates
Weed J1, Girardi M1 1Department of Dermatology, Yale School of Medicine, 333 Cedar Street, New Haven, CT 06520, USA.

T-cell receptor profiling in cancer

Kirsch et al.
Molecular Oncology
Papers
September 2015
Authors and Affiliates
Kirsch I1, Vignali M2, Robins H3. 1Adaptive Biotechnologies, Seattle, WA, USA. 2Adaptive Biotechnologies, Seattle, WA, USA. 3Adaptive Biotechnologies, Seattle, WA, USA; Fred Hutchinson Cancer Research Center, Seattle, WA, USA.

Central role of Th2/Tc2 lymphocytes in pattern II multiple sclerosis lesions.

Planas et al.
Annals of Clinical and Translational Neurology
Papers
September 2015
Authors and Affiliates
Planas R1, Metz I2, Ortiz Y1, Vilarrasa N1, Jelčić I1, Salinas-Riester G3, Heesen C4, Brück W2, Martin R1, Sospedra M1. 1Neuroimmunology and MS Research (nims), Department of Neurology, University Zurich Frauenklinikstrasse 26, 8091, Zürich, Switzerland. 2Institute of Neuropathology, University Medical Center Göttingen Göttingen, Germany. 3Department of Developmental Biochemistry, DNA Microarray and Deep-Sequencing Facility, Faculty of Medicine, University Medical Center Göttingen Göttingen, Germany. 4Institute for Neuroimmunology and Clinical MS Research (inims), Center for Molecular Neurobiology (ZMNH), University Medical Center Hamburg-Eppendorf Falkenried 94, 20251, Hamburg, Germany.

High-throughput T-cell receptor sequencing across chronic liver diseases reveals distinct disease-associated repertoires

Liaskou et al.
Hepatology
Papers
September 2015
Authors and Affiliates
Liaskou E1, Henriksen EK2,3,4, Holm K2,3,4, Kaveh F5, Hamm D6, Fear J1, Viken MK7, Hov JR2,3,4,8, Melum E2,3,4, Robins H9, Olweus J4,10,11, Karlsen TH2,3,4,8, Hirschfield GM1. 1Centre for Liver Research, National Institute for Health Research Birmingham Liver Biomedical Research Unit, University of Birmingham, Birmingham, UK. 2Norwegian PSC Research Center, Department of Transplantation Medicine, Division of Cancer Medicine, Surgery, and Transplantation, Oslo University Hospital Rikshospitalet, Oslo, Norway. 3Research Institute of Internal Medicine, Division of Cancer Medicine, Surgery, and Transplantation, Oslo University Hospital, Rikshospitalet, Oslo, Norway. 4K.G. Jebsen Inflammation Research Centre, Institute of Clinical Medicine, University of Oslo, Oslo, Norway. 5Department of Medical Genetics, Oslo University Hospital, Oslo, Norway. 6Adaptive Biotechnologies Corp., Seattle, WA. 7Institute of Immunology, Oslo University Hospital Rikshospitalet, Oslo, Norway. 8Section of Gastroenterology, Department of Transplantation Medicine, Division of Cancer Medicine, Surgery, and Transplantation, Oslo University Hospital, Rikshospitalet, Oslo, Norway. 9Fred Hutchinson Cancer Research Center, Seattle, WA. 10Department of Immunology, Institute for Cancer Research, Oslo University Hospital, Radiumhospitalet, Oslo, Norway. 11K.G. Jebsen Center for Cancer Immunotherapy, Institute of Clinical Medicine, University of Oslo, Oslo, Norway.

High-throughput sequencing reveals an altered T cell repertoire in X-linked agammaglobulinemia

Ramesh et al.
Clinical Immunology
Papers
September 2015
Authors and Affiliates
Ramesh M1, Simchoni N2, Hamm D3, Cunningham-Rundles C4. 1Montefiore Medical Center, Bronx, NY, United States. 2Icahn School of Medicine at Mount Sinai, New York, NY, United States. 3Adaptive Biotech, Seattle, WA, United States. 4Icahn School of Medicine at Mount Sinai, New York, NY, United States; Department of Pediatrics, The Immunology Institute, Box 1089, Icahn School of Medicine at Mount Sinai, 1425 Madison Avenue, New York, NY 10029, United States.
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