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High-throughput T-cell receptor sequencing across chronic liver diseases reveals distinct disease-associated repertoires

Liaskou et al.
Hepatology
Papers
September 2015
Authors and Affiliates
Liaskou E1, Henriksen EK2,3,4, Holm K2,3,4, Kaveh F5, Hamm D6, Fear J1, Viken MK7, Hov JR2,3,4,8, Melum E2,3,4, Robins H9, Olweus J4,10,11, Karlsen TH2,3,4,8, Hirschfield GM1. 1Centre for Liver Research, National Institute for Health Research Birmingham Liver Biomedical Research Unit, University of Birmingham, Birmingham, UK. 2Norwegian PSC Research Center, Department of Transplantation Medicine, Division of Cancer Medicine, Surgery, and Transplantation, Oslo University Hospital Rikshospitalet, Oslo, Norway. 3Research Institute of Internal Medicine, Division of Cancer Medicine, Surgery, and Transplantation, Oslo University Hospital, Rikshospitalet, Oslo, Norway. 4K.G. Jebsen Inflammation Research Centre, Institute of Clinical Medicine, University of Oslo, Oslo, Norway. 5Department of Medical Genetics, Oslo University Hospital, Oslo, Norway. 6Adaptive Biotechnologies Corp., Seattle, WA. 7Institute of Immunology, Oslo University Hospital Rikshospitalet, Oslo, Norway. 8Section of Gastroenterology, Department of Transplantation Medicine, Division of Cancer Medicine, Surgery, and Transplantation, Oslo University Hospital, Rikshospitalet, Oslo, Norway. 9Fred Hutchinson Cancer Research Center, Seattle, WA. 10Department of Immunology, Institute for Cancer Research, Oslo University Hospital, Radiumhospitalet, Oslo, Norway. 11K.G. Jebsen Center for Cancer Immunotherapy, Institute of Clinical Medicine, University of Oslo, Oslo, Norway.

High-throughput sequencing reveals an altered T cell repertoire in X-linked agammaglobulinemia

Ramesh et al.
Clinical Immunology
Papers
September 2015
Authors and Affiliates
Ramesh M1, Simchoni N2, Hamm D3, Cunningham-Rundles C4. 1Montefiore Medical Center, Bronx, NY, United States. 2Icahn School of Medicine at Mount Sinai, New York, NY, United States. 3Adaptive Biotech, Seattle, WA, United States. 4Icahn School of Medicine at Mount Sinai, New York, NY, United States; Department of Pediatrics, The Immunology Institute, Box 1089, Icahn School of Medicine at Mount Sinai, 1425 Madison Avenue, New York, NY 10029, United States.

Altered BCR and TLR signals promote enhanced positive selection of autoreactive transitional B cells in Wiskott-Aldrich syndrome

Kolhatkar et al.
Journal of Experimental Medicine
Papers
September 2015
Authors and Affiliates
Kolhatkar NS1, Brahmandam A2, Thouvenel CD2, Becker-Herman S2, Jacobs HM2, Schwartz MA1, Allenspach EJ1, Khim S2,Panigrahi AK3, Luning Prak ET3, Thrasher AJ4, Notarangelo LD5, Candotti F6, Torgerson TR2, Sanz I7, Rawlings DJ8. 1Department of Immunology and Department of Pediatrics, University of Washington School of Medicine, Seattle, WA 98195. 2Department of Immunology and Department of Pediatrics, University of Washington School of Medicine, Seattle, WA 98195 Center for Immunity and Immunotherapies, Seattle Children's Research Institute, Seattle, WA 98101. 3Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104. 4Molecular Immunology Unit, Section of Molecular and Cellular Immunology, Centre for Immunodeficiency, University College London Institute of Child Health, London WC1N 1EH, England, UK. 5Department of Immunology, Children's Hospital Boston, Boston, MA 09210. 6Genetics and Molecular Biology Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892. 7Lowance Center for Human Immunology and Division of Rheumatology, Department of Medicine, Emory University, Atlanta, GA 30322 Lowance Center for Human Immunology and Division of Rheumatology, Department of Medicine, Emory University, Atlanta, GA 30322. 8Department of Immunology and Department of Pediatrics, University of Washington School of Medicine, Seattle, WA 98195 Department of Immunology and Department of Pediatrics, University of Washington School of Medicine, Seattle, WA 98195 Center for Immunity and Immunotherapies, Seattle Children's Research Institute, Seattle, WA 98101

High-throughput pairing of T cell receptor α and β sequences

Howie et al.
Papers
Science Translational Medicine
August 2015
Authors and Affiliates
Bryan Howie,1 Anna M. Sherwood,1 Ashley D. Berkebile,1 Jan Berka,1 Ryan O. Emerson,1 David W. Williamson,1 Ilan Kirsch,1 Marissa Vignali,1 Mark J. Rieder,1 Christopher S. Carlson,2 Harlan S. Robins1,2 1Adaptive Biotechnologies, Seattle, WA 98102, USA. 2Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.

Detection and Tracking of NY-ESO-1-Specific CD8+ T Cells by High-Throughput T Cell Receptor β (TCRB) Gene Rearrangements Sequencing in a Peptide-Vaccinated Patient.

Miyai et al.
Papers
PLOS ONE
August 2015
Authors and Affiliates
Miyai M1, Eikawa S2, Hosoi A1, Iino T1, Matsushita H1, Isobe M3, Uenaka A3, Udono H2, Nakajima J4, Nakayama E3, Kakimi K1. 1Department of Immunotherapeutics, The University of Tokyo Hospital, Bunkyo-ku, Tokyo, Japan. 2Department of Immunology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Okayama, Japan. 3Faculty of Health and Welfare, Kawasaki University of Medical Welfare, Kurashiki, Okayama, Japan. 4Department of Thoracic Surgery, The University of Tokyo Hospital, Bunkyo-ku, Tokyo, Japan.

Adult Low-Hypodiploid Acute B-Lymphoblastic Leukemia With IKZF3 Deletion and TP53 MutationComparison With Pediatric Patients

Fang et al.
American Journal of Clinical Pathology
Papers
August 2015
Authors and Affiliates
Fang M1, Becker PS2, Linenberger M2, Eaton KD3, Appelbaum FR3, Dreyer Z4, Airewele G4, Redell M4, Lopez-Terrada D4,Patel A5, Rabin KR4, Lu X6 1From the Fred Hutchinson Cancer Research Center, Seattle, WA; University of Washington, Seattle; Seattle Cancer Care Alliance, Seattle, WA; 2From the Fred Hutchinson Cancer Research Center, Seattle, WA; University of Washington, Seattle; 3From the Fred Hutchinson Cancer Research Center, Seattle, WA; University of Washington, Seattle; Seattle Cancer Care Alliance, Seattle, WA; 4Texas Children's Cancer and Hematology Centers and Department of Pediatrics, Baylor College of Medicine, Houston; 5Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX; and. 6Department of Hematopathology, University of Texas MD Anderson Cancer Center, Houston.

A high density of tertiary lymphoid structure B cells in lung tumors is associated with increased CD4+ T cell receptor repertoire clonality

Zhu et al.
OncoImmunology
Papers
June 2015
Authors and Affiliates
Zhu W1, Germain C2, Liu Z1, Sebastian Y1, Devi P2, Knockaert S2, Brohawn P1, Lehmann K1, Damotte D3, Validire P4, Yao Y1, Valge-Archer V5, Hammond SA6, Dieu-Nosjean MC2, Higgs BW1 1Translational Sciences; MedImmune ; Gaithersburg, MD USA. 2Laboratory "Cancer, Immune Control, and Escape"; INSERM UMRS 1138; Cordeliers Research Center ; Paris, France ; University Sorbonne; University Pierre and Marie Curie; UMRS 1138 ; Paris, France ; University Sorbonne Paris Cité; University Paris Descartes; UMRS 1138 ; Paris, France. 3Laboratory "Cancer, Immune Control, and Escape"; INSERM UMRS 1138; Cordeliers Research Center ; Paris, France ; University Sorbonne; University Pierre and Marie Curie; UMRS 1138 ; Paris, France ; University Sorbonne Paris Cité; University Paris Descartes; UMRS 1138 ; Paris, France ; Department of Pathology; Cochin Hospital; AP-HP ; Paris, France. 4Laboratory "Cancer, Immune Control, and Escape"; INSERM UMRS 1138; Cordeliers Research Center ; Paris, France ; University Sorbonne; University Pierre and Marie Curie; UMRS 1138 ; Paris, France ; University Sorbonne Paris Cité; University Paris Descartes; UMRS 1138 ; Paris, France ; Department of Pathology; Institut Mutualiste Montsouris ; Paris, France. 5Oncology Research; MedImmune ; Cambridge, UK. 6Oncology Research; MedImmune ; Gaithersburg, MD USA. Abstract Reference

Longitudinal analysis of peripheral blood T cell receptor diversity in patients with systemic lupus erythematosus by next-generation sequencing

Thapa et al.
Papers
June 2015
Authors and Affiliates
Dharma R Thapa1, Raffi Tonikian1, 2, Chao Sun1, Mei Liu1, Andrea Dearth1, Michelle Petri3,Francois Pepin4, Ryan O Emerson4 and Ann Ranger1 Biogen, 250 Binney Street, Cambridge1, MA 02142, USA. Novartis Pharmaceuticals Canada Inc, 385 Bouchard Blvd., Dorval, QC H9S 1A9, Canada2. Johns Hopkins University School of Medicine, 1830 East Monument Street, Suite 7500, Baltimore, MD 21205, USA3. Adaptive Biotechnologies, 1551 Eastlake Ave E, #200, Seattle, WA 98102, USA4 .

TCR ITAM multiplicity is required for the generation of follicular helper T-cells

Hwang et al.
Nature Communications
Papers
June 2015
Authors and Affiliates
Hwang S1, Palin AC1, Li L1, Song KD1, Lee J1, Herz J2, Tubo N3, Chu H3, Pepper M3, Lesourne R1, Zvezdova E1, Pinkhasov J1, Jenkins MK3, McGavern D2, Love PE1. 1Program in Genomics of Differentiation, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Room 2B-210, Building 6B, Bethesda, Maryland 20892, USA. 2Viral Immunology and Intravital Imaging Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA. 3Department of Microbiology, Center for Immunology, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA.
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