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Regression of metastatic Merkel cell carcinoma following transfer of polyomavirus-specific T cells and therapies capable of re-inducing HLA class-I

Chapuis et al.
Cancer Immunology Research
Papers
January 2014
Authors and Affiliates
Chapuis AG1, Afanasiev OK2, Iyer JG3, Paulson KG2, Parvathaneni U4, Hwang JH5, Lai I1, Roberts IM1, Sloan HL1, Bhatia S6, Shibuya KC1, Gooley T1, Desmarais C7, Koelle DM8, Yee C1, Nghiem P2. 1Program in Immunology, Fred Hutchinson Cancer Research Center (FHCRC), Seattle, WA, USA, 2Department of Pathology, University of Washington, Seattle, WA, USA ; Department of Medicine (Dermatology), University of Washington, Seattle, WA, USA, 3Department of Medicine (Dermatology), University of Washington, Seattle, WA, USA, 4Division of Radiation Oncology, UWMC, Seattle, WA, USA, 5Division of Gastroenterology, UWMC, Seattle, WA, USA, 6Department of Medicine (Medical Oncology), University of Washington, Seattle, WA, USA, 7Adaptive Biotechnologies, Seattle, WA, USA, 8Department of Medicine (Dermatology), University of Washington, Seattle, WA, USA ; Department of Laboratory Medicine, University of Washington, Seattle, WA, USA ; Department of Global Health, University of Washington, Seattle, WA, USA ; Vaccine and Infectious Disease Division, FHCRC, Seattle, WA, USA ; Benaroya Research Institute, Seattle, WA, USA.

Tumor-Associated Immune Parameters for Personalized Patient Care

Pagès
Papers
Science Translational Medicine
December 2013
Authors and Affiliates
Franck Pagès Laboratory of Immunology, Immunomonitoring Platform, Georges Pompidou European Hospital, AP-HP, Paris Descartes University, Laboratory of Integrative Cancer Immunology, INSERM U872, Cordeliers Research Center, Paris, France.

Human autoimmunity after lymphocyte depletion is caused by homeostatic T-cell proliferation

Jones et al.
Papers
Proceedings of the National Academy of Sciences
December 2013
Authors and Affiliates
Joanne L. Jonesa, 1, Sara A. J. Thompsona, Priscilla Lohb, Jessica L. Daviesa, Orla C. Tuohya, Allison J. Currya, Laura Azzopardia, Grant Hill-Cawthornea,c, Michael T. Faheyb,d, Alastair Compstona, and Alasdair J. Colesa. a Department of Clinical Neurosciences, University of Cambridge, Cambridge CB2 0QQ, United Kingdom; b Division of Mathematics, Informatics and Statistics, Commonwealth Scientific and Industrial Research Organization, Clayton South, VIC 3169, Australia; c Sydney Institute for Emerging Infections and Biosecurity, University of Sydney, Sydney, NSW 2006, Australia; and d Biostatistics Unit, Monash University, Melbourne, VIC 3004 Australia.

Human Treg responses allow sustained recombinant adeno-associated virus-mediated transgene expression

Mueller et al.
Journal of Clinical Investigation
Papers
December 2013
Authors and Affiliates
Christian Mueller1, Jeffrey D. Chulay2, Bruce C. Trapnell3, Margaret Humphries1, Brenna Carey3, Robert A. Sandhaus4, Noel G. McElvaney5, Louis Messina1, Qiushi Tang1, Farshid N. Rouhani6, Martha Campbell-Thompson6, Ann Dongtao Fu6, Anthony Yachnis6, David R. Knop2, Guo-jie Ye2, Mark Brantly6, Roberto Calcedo7, Suryanarayan Somanathan7, Lee P. Richman8, Robert H. Vonderheide8, Maigan A. Hulme6, Todd M. Brusko6, James M. Wilson7, and Terence R. Flotte1, 8 1University of Massachusetts Medical School, Worcester, Massachusetts, USA. 2Applied Genetic Technologies Corp., Alachua, Florida, USA. 3Cincinnati Children’s Hospital, Cincinnati, Ohio, USA. 4National Jewish Health, Denver, Colorado, USA. 5Beaumont Hospital, Dublin, Ireland. 6University of Florida College of Medicine, Gainesville, Florida, USA. 7Gene Therapy Program and 8Abramson Family Cancer Research Institute, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.

Ultra-deep T-cell receptor sequencing reveals the complexity and intratumour heterogeneity of T-cell clones in renal cell carcinomas

Marco et al.
Journal of Pathology
Papers
December 2013
Authors and Affiliates
Marco Gerlinger,1,2 Sergio A Quezada,3 Karl S Peggs,3 Andrew JS Furness,3,4 Rosalie Fisher,4 Teresa Marafioti,5Vishvesh H Shende,5 Nicholas McGranahan,1,6 Andrew J Rowan,1 Steven Hazell,4 David Hamm,7 Harlan S Robins,8Lisa Pickering,4 Martin Gore,4 David L Nicol,4 James Larkin,4 and Charles Swanton1,3 1Cancer Research UK, London Research Institute, UK, 2Barts Cancer Institute, Barts and the London School of Medicine and Dentistry, London, UK, 3UCL Cancer Institute, London, UK, 4Royal Marsden Hospital, London, UK, 5Departments of Pathology and Histopathology, University College Hospital, London, UK, 6Centre for Mathematics and Physics in the Life Sciences and Experimental Biology (CoMPLEX), University College London, UK, 7Adaptive Biotechnologies, Seattle, WA, USA, 8Fred Hutchinson Cancer Research Center, Seattle, WA, USA.

Digital genomic quantification of tumor-infiltrating lymphocytes

Robins et al.
Papers
Science Translational Medicine
December 2013
Authors and Affiliates
Robins HS1, Ericson NG, Guenthoer J, O’Briant KC, Tewari M, Drescher CW, Bielas JH. 1Herbold Computational Biology Program, Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.

High-throughput sequencing of T cell receptors reveals a homogeneous repertoire of tumor-infiltrating lymphocytes in ovarian cancer

Emerson et al.
Journal of Pathology
Papers
December 2013
Authors and Affiliates
Ryan O. Emerson,#1 Anna M. Sherwood,#1 Mark J. Rieder,1 Jamie Guenthoer,2 David W. Williamson,1 Christopher S. Carlson,2 Charles W. Drescher,2,3 Muneesh Tewari,2,3 Jason H. Bielas,2 and Harlan S. Robins2 1Adaptive Biotechnologies, Seattle, WA. 2Fred Hutchinson Cancer Research Center, Seattle, WA. 3University of Washington School of Medicine, Seattle, WA. #Contributed equally.

Peripheral blood mononuclear cells of patients with breast cancer can be reprogrammed to enhance anti-HER-2/neu reactivity and overcome myeloid-derived suppressor cells

Payne et al.
Breast Cancer Research and Treatment
Papers
November 2013
Authors and Affiliates
Kyle K Payne,1 Christine K Zoon,1 Wen Wan,1 Khin Marlar,2 Rebecca C Keim,1 Mehrab Nasiri Kenari,2 Latif Kazim,2Harry D Bear,1 and Masoud H Manjili1 1Virginia Commonwealth University - Massey Cancer Center, Richmond, VA, USA, 2Roswell Park Cancer Institute, Buffalo, NY, USA.