CD49a Expression Defines Tissue-Resident CD8+ T Cells Poised for Cytotoxic Function in Human Skin

Stanley Cheuk,1 Heinrich Schlums,2 Irene Gallais Serezal,1,3 Elisa Martini,1 Samuel C. Chiang,2 Nicole Marquardt,3 Anna Gibbs,1 Ebba Detlofsson,1 Andrea Introini,1 Marianne Forkel,3 Charlotte Hoog,4 Annelie Tjernlund,1 Jakob Michaelsson,3 Lasse Folkersen,5 Jenny Mjosberg,3 Lennart Blomqvist,6 Marcus Ehrstrom,7 Mona Stahle,1,3 Yenan T. Bryceson,2,8 and Liv Eidsmo1,3 1Department of Medicine Solna, Karolinska Institutet, Stockholm 171 77, Sweden, 2Center for Hematology and Regenerative Medicine, Department of Medicine Huddinge, Karolinska Institutet, Stockholm 171 77, Sweden, 3Dermatology Department, Karolinska University Hospital, Stockholm 141 86, Sweden, 4Unit for Inflammation, Gastroenterology and Rheumatology, Department of Medicine, Huddinge, Karolinska Institutet, Stockholm 171 77, Sweden, 5Center for Biological Sequence Analysis, Department of Systems Biology, Technical University of Denmark, Building 208, DK-2800 Kongens Lyngby 2800, Denmark, 6Unit for Endocrinology and Diabetes, Department of Medicine, Huddinge, Karolinska Institutet, Stockholm 171 77, Sweden, 7Department of Reconstructive Plastic Surgery, Karolinska University Hospital Solna, Stockholm 171 76, Sweden, 8Broegelmann Research Laboratory, Department of Clinical Science, University of Bergen, Bergen 5021, Norway