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Single-cell atlas of the human neonatal small intestine affected by necrotizing enterocolitis

Egozi A, et al.
PLOS Biology
August 2023
Authors and Affiliates
Adi Egozi 1, Oluwabunmi Olaloye 2, Lael Werner 3,4, Tatiana Silva 2, Blake McCourt 2, Richard W Pierce 2,5, Xiaojing An 6, Fujing Wang 6, Kong Chen 6, Jordan S Pober 5,7, Dror Shouval 3,4, Shalev Itzkovitz 1, Liza Konnikova 2,5,7,8; 1 Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel. 2 Department of Pediatrics, Yale School of Medicine, New Haven, Connecticut, United States of America. 3 Institute of Gastroenterology, Nutrition and Liver Diseases, Schneider Children's Medical Center of Israel, Petah Tikva, Israel, affiliated to the Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel. 4 Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel. 5 Program in Human and Translational Immunology, Yale School of Medicine, New Haven, Connecticut, United States of America. 6 Department of Medicine, University of Pittsburgh Medical Center Montefiore Hospital, Pittsburgh, Pennsylvania, United States of America. 7 Department of Immunobiology, Yale School of Medicine, New Haven, Connecticut, United States of America. 8 Department of Obstetrics, Gynecology and Reproductive Sciences, Yale School of Medicine, New Haven, Connecticut, United States of America.

Reprogramming of Tumor-reactive Tumor-infiltrating Lymphocytes to Human-induced Pluripotent Stem Cells

Islam SMR, et al.
Cancer Research Communication
August 2023
Authors and Affiliates
S M Rafiqul Islam 1,2, Takuya Maeda 1,2, Naritaka Tamaoki 1,2, Meghan L Good 1,2, Rigel J Kishton 1,2, Biman C Paria 1, Zhiya Yu 1, Marta Bosch-Marce 1, Nicole M Bedanova 3, Chengyu Liu 4, Michael J Kruhlak 5, Nicholas P Restifo 1,2, Raul Vizcardo 1,2; 1 Surgery Branch, NCI, NIH, Bethesda, Maryland. 2 Center for Cell-Based Therapy, NCI, NIH, Bethesda, Maryland. 3 Experimental Pathology Laboratory, NCI, NIH, Bethesda, Maryland. 4 Transgenic Core, Division of Intramural Research, National Heart, Lung and Blood Institute, NIH, Bethesda, Maryland. 5 CCR Microscopy Core Facility, NCI, NIH, Bethesda, Maryland.

Addition of Metastasis-Directed Therapy to Intermittent Hormone Therapy for Oligometastatic Prostate Cancer: The EXTEND Phase 2 Randomized Clinical Trial

Tang C, et al.
JAMA Oncology
August 2023
Authors and Affiliates
Chad Tang 1,2,3, Alexander D Sherry 1, Cara Haymaker 2, Tharakeswara Bathala 4, Suyu Liu 5, Bryan Fellman 5, Lorenzo Cohen 6, Ana Aparicio 7, Amado J Zurita 7, Alexandre Reuben 8, Enrica Marmonti 2, Stephen G Chun 1, Jay P Reddy 1, Amol Ghia 1, Sean McGuire 1, Eleni Efstathiou 7, Jennifer Wang 7, Jianbo Wang 7, Patrick Pilie 7, Craig Kovitz 7, Weiliang Du 9, Samantha J Simiele 9, Rachit Kumar 10, Yerko Borghero 10, Zheng Shi 11, Brian Chapin 12, Daniel Gomez 13, Ignacio Wistuba 2, Paul G Corn 7; 1 Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston. 2 Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston. 3 Department of Investigational Cancer Therapeutics, The University of Texas MD Anderson Cancer Center, Houston. 4 Department of Abdominal Imaging, The University of Texas MD Anderson Cancer Center, Houston. 5 Department of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston. 6 Department of Palliative, Rehabilitation and Integrative Medicine, The University of Texas MD Anderson Cancer Center, Houston. 7 Department of Genitourinary Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston. 8 Department of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston. 9 Department of Radiation Physics, The University of Texas MD Anderson Cancer Center, Houston. 10 Department of Radiation Oncology, Banner MD Anderson Cancer Center, Gilbert, Arizona. 11 Department of Radiation Oncology, The University of Texas Health Science Center at San Antonio. 12 Department of Urology, The University of Texas MD Anderson Cancer Center, Houston. 13 Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, New York.

COVID-19 Vaccine Response in People with Multiple Sclerosis Treated with Dimethyl Fumarate, Diroximel Fumarate, Natalizumab, Ocrelizumab, or Interferon Beta Therapy

Jaber A, et al.
Neurology and Therapy
August 2023
Authors and Affiliates
Aliya Jaber 1, Meera Patel 1, Andrew Sylvester 1, Mary Yarussi 1, J Tamar Kalina 2, Jason P Mendoza 2, Robin L Avila 2, Matthew A Tremblay 3; 1 Multiple Sclerosis Comprehensive Care Center, RWJ Barnabas Health, Livingston, NJ, USA. 2 Biogen, Weston, MA, USA. 3 Multiple Sclerosis Comprehensive Care Center, RWJ Barnabas Health, Livingston, NJ, USA. Matthew.Tremblay@rwjbh.org.

Achievement of operational tolerance in a pediatric liver transplant recipient following successful hematopoietic stem cell transplantation from a different donor

Algeri M, et al.
American Journal of Transplantation
August 2023
Authors and Affiliates
Mattia Algeri 1, Enrico Velardi 1, Marco Spada 2, Federica Galaverna 1, Roberto Carta 1, Luciana Vinti 1, Giuseppe Palumbo 3, Stefania Gaspari 1, Andrea Pietrobattista 4, Emilia Boccieri 1, Marco Becilli 1, Paola Francalanci 5, Valentina Bertaina 1, Pietro Merli 1, Franco Locatelli 6; 1 Department of Pediatric Hematology and Oncology,Cell and Gene Therapy,Bambino Gesù Children's Hospital,IRCCS,Rome,Italy. 2 Hepatobiliopancreatic Surgery, Liver and Kidney Transplantation Unit, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy. 3 Department of Pediatric Hematology and Oncology,Cell and Gene Therapy,Bambino Gesù Children's Hospital,IRCCS,Rome,Italy; University Department of Pediatrics, Bambino Gesù Children's Hospital, University of Rome Tor Vergata, Rome, Italy. 4 Department of Pathology, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy. 5 Hepatology and Liver Transplant Unit, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy. 6 Department of Pediatric Hematology and Oncology,Cell and Gene Therapy,Bambino Gesù Children's Hospital,IRCCS,Rome,Italy; Department of Life Sciences and Public Health, Catholic University of the Sacred Heart, Rome, Italy. Electronic address: franco.locatelli@opbg.net.

Immunologic Predictors for Clinical Responses during Immune Checkpoint Blockade in Patients with Myelodysplastic Syndromes

Lee SE, et al.
Clinical Cancer Research
August 2023
Authors and Affiliates
Sung-Eun Lee 1,2, Feng Wang 3, Maison Grefe 4, Abel Trujillo-Ocampo 4, Wilfredo Ruiz-Vasquez 4, Koichi Takahashi 3,5, Hussein A Abbas 5, Pamella Borges 5,6, Dinler Amaral Antunes 6, Gheath Al-Atrash 1,4,5, Naval Daver 5, Jeffrey J Molldrem 1,4,5, Andrew Futreal 3, Guillermo Garcia-Manero 4, Jin S Im 1,4,5; 1 Department of Stem Cell Transplantation and Cellular Therapy, Division of Cancer Medicine, The University of Texas M.D. Anderson Cancer Center, Houston, Texas. 2 Department of Hematology, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, South Korea. 3 Department of Genomic Medicine, Division of Cancer Medicine, The University of Texas M.D. Anderson Cancer Center, Houston, Texas. 4 Department of Hematopoietic Biology and Malignancy, Division of Cancer Medicine, The University of Texas M.D, Anderson Cancer Center, Houston, Texas. 5 Department of Leukemia, Division of Cancer Medicine, The University of Texas M.D. Anderson Cancer Center, Houston, Texas. 6 Department of Biology and Biochemistry, The University of Houston, Houston, Texas.

TET2 guards against unchecked BATF3-induced CAR T cell expansion

Jain N, et al.
Nature
August 2023
Authors and Affiliates
Nayan Jain 1,2, Zeguo Zhao 2, Judith Feucht 2,3, Richard Koche 4, Archana Iyer 2, Anton Dobrin 1,2, Jorge Mansilla-Soto 2, Julie Yang 4, Yingqian Zhan 4, Michael Lopez 2, Gertrude Gunset 2, Michel Sadelain 5; 1 Louis V. Gerstner Jr Graduate School of Biomedical Sciences, Memorial Sloan Kettering Cancer Centre, New York, NY, USA. 2 Centre for Cell Engineering and Immunology Program, Memorial Sloan Kettering Cancer Centre, New York, NY, USA. 3 University Children's Hospital, Tübingen, Germany. 4 Centre for Epigenetics Research, Memorial Sloan Kettering Cancer Centre, New York, NY, USA. 5 Centre for Cell Engineering and Immunology Program, Memorial Sloan Kettering Cancer Centre, New York, NY, USA. m-sadelain@ski.mskcc.org.

The overlap of skin and blood T-cell clones in early-stage mycosis fungoides.

Joffe D, et al.
Blood Advances
August 2023
Authors and Affiliates
Daniel Joffe BS1, Safiyyah Bhatti MD1,2, Lauren Banner BS1, Romsin Zaya BS1, Laura Gleason BS1, Anjali Mishra PhD2, Ilan Kirsch MD3, Pierluigi Porcu MD2, Neda Nikbakht MD, PhD1 1 - Department of Dermatology and Cutaneous Biology, Thomas Jefferson University, Philadelphia, PA 2 - Department of Medical Oncology, Thomas Jefferson University, Philadelphia, PA 3 - Adaptive Biotechnologies, Seattle, WA

A Specific CD44lo CD25lo Subpopulation of Regulatory T Cells Inhibits Anti-Leukemic Immune Response and Promotes the Progression in a Mouse Model of Chronic Lymphocytic Leukemia

Goral A, et al.
Frontiers in Immunology
August 2023
Authors and Affiliates
Agnieszka Goral 1, Malgorzata Firczuk 1, Klaudyna Fidyt 1, Marta Sledz 1, Francesca Simoncello 2, Karolina Siudakowska 1, Giulia Pagano 3, Etienne Moussay 3, Jérôme Paggetti 3, Patrycja Nowakowska 1, Stefania Gobessi 4, Joanna Barankiewicz 5, Aleksander Salomon-Perzynski 5, Federica Benvenuti 2, Dimitar G Efremov 4, Przemyslaw Juszczynski 5, Ewa Lech-Maranda 5, Angelika Muchowicz 1; 1 Department of Immunology, Medical University of Warsaw, Warsaw, Poland. 2 Cellular Immunology, International Centre for Genetic Engineering and Biotechnology, Trieste, Italy. 3 Tumor-Stroma Interactions, Department of Cancer Research, Luxembourg Institute of Health, Luxembourg, Luxembourg. 4 Molecular Hematology, International Centre for Genetic Engineering and Biotechnology, Trieste, Italy. 5 Department of Experimental Hematology, Institute of Hematology and Transfusion Medicine, Warsaw, Poland.

Analysis of thymic generation of shared T-cell receptor α repertoire associated with recognition of tumor antigens shows no preference for neoantigens over wild-type antigens

Mattila J, et al.
cancer medicine
August 2023
Authors and Affiliates
Joonatan Mattila 1, Silja Sormunen 2, Nelli Heikkilä 1 3, Ilkka P Mattila 4, Jari Saramäki 2, T Petteri Arstila 1; 1 Research Programs Unit, Translational Immunology, Haartmaninkatu 3 (PL 21) 00014, and Medicum, University of Helsinki, Helsinki, Finland. 2 Department of Computer Science, Aalto University, Espoo, Finland. 3 Faculty of Medicine, Center for Vaccinology, Department of Pathology and Immunology, University of Geneva, Geneva, Switzerland. 4 Department of Pediatric Cardiac and Transplantation Surgery, Hospital for Children and Adolescents, Helsinki University Central Hospital, Helsinki, Finland.
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