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Shared transcriptional profiles of atypical B cells suggest common drivers of expansion and function in malaria, HIV, and autoimmunity

Holla P, et al.
Science Advances
June 2021
Authors and Affiliates
Prasida Holla 1, Brian Dizon 2, Abhijit A Ambegaonkar 1, Noga Rogel 3, Ella Goldschmidt 3, Arun K Boddapati 4, Haewon Sohn 1, Dan Sturdevant 5, James W Austin 6, Lela Kardava 6, Li Yuesheng 7, Poching Liu 7, Susan Moir 6, Susan K Pierce 8, Asaf Madi 9; 1 Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD, USA. 2 National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, USA. 3 Department of Pathology, Sackler School of Medicine, Tel Aviv University, Israel. 4 NIAID Collaborative Bioinformatics Resource, National Institutes of Health, Bethesda, MD, USA. 5 RML Genomics Unit, Research Technologies Section, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, USA. 6 Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA. 7National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA. 8Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD, USA. asafmadi@gmail.com spierce@nih.gov. 9Department of Pathology, Sackler School of Medicine, Tel Aviv University, Israel. asafmadi@gmail.com spierce@nih.gov.

Identification of antigen-specific TCR sequences based on biological and statistical enrichment in unselected subjects

Smith NP, et al.
JCI Insight
June 2021
Authors and Affiliates
Neal P Smith 1, Bert Ruiter 1, Yamini V Virkud 1, Ang A Tu 2, Brinda Monian 2, James J Moon 1, J Christopher Love 2, Wayne G Shreffler 1; 1 Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Boston, United States of America. 2 Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, United States of America.

Clonal analysis of immunodominance and cross-reactivity of the CD4 T cell response to SARS-CoV-2

Low JS, et al.
Science
June 2021
Authors and Affiliates
Jun Siong Low 1, Daniela Vaqueirinho 1, Federico Mele 1, Mathilde Foglierini 1, Josipa Jerak 1, Michela Perotti 1, David Jarrossay 1, Sandra Jovic 1, Laurent Perez 1, Rosalia Cacciatore 2, Tatiana Terrot 3, Alessandra Franzetti Pellanda 4, Maira Biggiogero 4, Christian Garzoni 4, Paolo Ferrari 5,6,7, Alessandro Ceschi 3,5,8,9, Antonio Lanzavecchia 10, Federica Sallusto 11,12, Antonino Cassotta 11; 1 Institute for Research in Biomedicine, Università della Svizzera Italiana, 6500 Bellinzona, Switzerland. 2 Laboratory of Immunogenetics, Department of Transfusion Medicine and Immuno-Hematology, Fondazione I.R.C.C.S. Policlinico S. Matteo, 27100 Pavia, Italy. 3 Clinical Trial Unit, Ente Ospedaliero Cantonale, 6500 Bellinzona, Switzerland. 4 Clinic of Internal Medicine and Infectious Diseases, Clinica Luganese Moncucco, 6900 Lugano, Switzerland. 5 Faculty of Biomedical Sciences, Università della Svizzera italiana, 6900 Lugano, Switzerland. 6 Department of Internal Medicine, Ente Ospedaliero Cantonale, 6500 Bellinzona, Switzerland. 7 Prince of Wales Hospital Clinical School, University of New South Wales, Sydney, New South Wales 2052, Australia. 8 Division of Clinical Pharmacology and Toxicology, Institute of Pharmacological Sciences of Southern Switzerland, Ente Ospedaliero Cantonale, 6900 Lugano, Switzerland. 9 Department of Clinical Pharmacology and Toxicology, University Hospital Zurich, 8091 Zurich, Switzerland. 10 National Institute of Molecular Genetics, 20122 Milano, Italy. 11 Institute for Research in Biomedicine, Università della Svizzera Italiana, 6500 Bellinzona, Switzerland. federica.sallusto@irb.usi.ch antonino.cassotta@irb.usi.ch. 12 Institute of Microbiology, ETH Zürich, 8093 Zurich, Switzerland.

Distinct immune signatures in chronic lymphocytic leukemia and Richter syndrome

Wang Y, et al.
Blood Cancer Journal
May 2021
Authors and Affiliates
Yucai Wang 1, Sutapa Sinha 1, Linda E Wellik 1, Charla R Secreto 1, Karen L Rech 2, Timothy G Call 1, Sameer A Parikh 1, Saad S Kenderian 1, Eli Muchtar 1, Suzanne R Hayman 1, Amber B Koehler 1, Daniel L Van Dyke 3, Jose F Leis 4, Susan L Slager 5, Haidong Dong 6, Neil E Kay 1, Rong He 7, Wei Ding 8; 1 Division of Hematology, Mayo Clinic, Rochester, MN, USA. 2 Division of Hematopathology, Mayo Clinic, Rochester, MN, USA. 3 Division of Laboratory Genetics and Genomics, Mayo Clinic, Rochester, MN, USA. 4 Division of Hematology and Medical Oncology, Mayo Clinic, Phoenix, AZ, USA. 5 Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, MN, USA. 6 Department of Immunology, Mayo Clinic, Rochester, MN, USA. 7 Division of Hematopathology, Mayo Clinic, Rochester, MN, USA. He.Rong@mayo.edu. 8 Division of Hematology, Mayo Clinic, Rochester, MN, USA. Ding.Wei@mayo.edu.

Engineered red blood cells as an off-the-shelf allogeneic anti-tumor therapeutic

Zhang X, et al.
Nature Communications
May 2021
Authors and Affiliates
Xuqing Zhang 1, Mengyao Luo 1, Shamael R Dastagir 1, Mellissa Nixon 1, Annie Khamhoung 1, Andrea Schmidt 1, Albert Lee 1, Naren Subbiah 1, Douglas C McLaughlin 1, Christopher L Moore 1, Mary Gribble 1, Nicholas Bayhi 1, Viral Amin 1, Ryan Pepi 1, Sneha Pawar 1, Timothy J Lyford 1, Vikram Soman 1, Jennifer Mellen 1, Christopher L Carpenter 1, Laurence A Turka 1, Thomas J Wickham 1, Tiffany F Chen 2; 1 Rubius Therapeutics, Inc., Cambridge, MA, USA. 2 Rubius Therapeutics, Inc., Cambridge, MA, USA. tiffany.chen@rubiustx.com.

Multi-omic profiling of lung and liver tumor microenvironments of metastatic pancreatic cancer reveals site-specific immune regulatory pathways

Ho WJ, et al.
Genome Biology
May 2021
Authors and Affiliates
Won Jin Ho 1,2,3, Rossin Erbe 1,4, Ludmila Danilova 1, Zaw Phyo 1, Emma Bigelow 1, Genevieve Stein-O'Brien 4, Dwayne L Thomas 2nd 1,5, Soren Charmsaz 1, Nicole Gross 1, Skylar Woolman 1, Kayla Cruz 1, Rebecca M Munday 1,4, Neeha Zaidi 1,3, Todd D Armstrong 1, Marcelo B Sztein 6, Mark Yarchoan 1, Elizabeth D Thompson 1,3,4, Elizabeth M Jaffee 7,8,9, Elana J Fertig 10,11,12,13; 1 Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins School of Medicine, 550 N Broadway Suite 1101E, Baltimore, MD, 21209, USA. 2 The Johns Hopkins Cancer Convergence Institute, Baltimore, USA. 3 Skip Viragh Center for Pancreatic Cancer, Bloomberg-Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University School of Medicine, 4M07 Bunting Blaustein Cancer Research Building, 1650 Orleans Street, Baltimore, MD, 21287, USA. 4 McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University, Baltimore, USA. 5 Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, USA. 6 Center for Vaccine Development and Global Health, University of Maryland School of Medicine, Baltimore, MD, USA. 7 Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins School of Medicine, 550 N Broadway Suite 1101E, Baltimore, MD, 21209, USA. ejaffee@jhmi.edu. 8 The Johns Hopkins Cancer Convergence Institute, Baltimore, USA. ejaffee@jhmi.edu. 9 Skip Viragh Center for Pancreatic Cancer, Bloomberg-Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University School of Medicine, 4M07 Bunting Blaustein Cancer Research Building, 1650 Orleans Street, Baltimore, MD, 21287, USA. ejaffee@jhmi.edu. 10 Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins School of Medicine, 550 N Broadway Suite 1101E, Baltimore, MD, 21209, USA. ejfertig@jhmi.edu. 11 McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University, Baltimore, USA. ejfertig@jhmi.edu. 12 Department of Applied Mathematics and Statistics, Johns Hopkins University Whiting School of Engineering, Baltimore, MD, USA. ejfertig@jhmi.edu. 13 Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, USA. ejfertig@jhmi.edu.

A subset of cytotoxic effector memory T cells enhances CAR T cell efficacy in a model of pancreatic ductal adenocarcinoma

Konduri V, et al.
Science Translational Medicine
May 2021
Authors and Affiliates
Vanaja Konduri 1, Sujith K Joseph 2,3, Tiara T Byrd 2,3, Zeid Nawas 2,3, Jonathan Vazquez-Perez 1, Colby J Hofferek 1, Matthew M Halpert 1, Dongliang Liu 4, Zhengdong Liang 4, Yunyu Baig 1, Vita S Salsman 2,3, Damilola Oyewole-Said 1, Anna Tsimelzon 5, Briana A Burns 1, Changyi Chen , 6, Jonathan M Levitt 1,5,7, Qizhi Yao 1,4,8,9, Nabil M Ahmed 2,3,8, Meenakshi Hegde 2,3,8, William K Decker 10,2,8; 1 Department of Pathology and Immunology, Baylor College of Medicine, Houston, TX 77030, USA. 2 Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, TX 77030, USA. 3 Department of Pediatrics, Division of Hematology and Oncology, Baylor College of Medicine, Houston, TX 77030, USA. 4 Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, TX 77030, USA. 5 Lester and Sue Smith Breast Center, Baylor College of Medicine, Houston, TX 77030, USA. 6 Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA. 7 Scott Department of Urology, Baylor College of Medicine, Houston, TX 77030, USA. 8 Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, TX 77030, USA. 9 Michael E. DeBakey VA Medical Center, Center for Translational Research on Inflammatory Diseases (CTRID), Houston, TX 77030, USA. 10 Department of Pathology and Immunology, Baylor College of Medicine, Houston, TX 77030, USA. decker@bcm.edu.

A vaccine targeting mutant IDH1 in newly diagnosed glioma

Platten M, et al.
Nature
May 2021
Authors and Affiliates
Michael Platten 1,2,3, Lukas Bunse 4,5, Antje Wick 6,7, Theresa Bunse 4,5, Lucian Le Cornet 8, Inga Harting 9, Felix Sahm 10,11, Khwab Sanghvi 4, Chin Leng Tan 4, Isabel Poschke 4,12, Edward Green 4, Sune Justesen 13, Geoffrey A Behrens 14, Michael O Breckwoldt 9, Angelika Freitag 8, Lisa-Marie Rother 8, Anita Schmitt 15, Oliver Schnell 16, Jörg Hense 17, Martin Misch 18, Dietmar Krex 19, Stefan Stevanovic 20, Ghazaleh Tabatabai 21, Joachim P Steinbach 22, Martin Bendszus 9, Andreas von Deimling 10,11, Michael Schmitt 15, Wolfgang Wick 6,7,23; 1 DKTK (German Cancer Consortium) Clinical Cooperation Unit (CCU) Neuroimmunology and Brain Tumor Immunology, German Cancer Research Center (DKFZ), Heidelberg, Germany. m.platten@dkfz.de. 2 Department of Neurology, Medical Faculty Mannheim, MCTN, University of Heidelberg, Mannheim, Germany. m.platten@dkfz.de. 3 Immune Monitoring Unit, National Center for Tumor Diseases (NCT), Heidelberg, Germany. m.platten@dkfz.de. 4 DKTK (German Cancer Consortium) Clinical Cooperation Unit (CCU) Neuroimmunology and Brain Tumor Immunology, German Cancer Research Center (DKFZ), Heidelberg, Germany. 5 Department of Neurology, Medical Faculty Mannheim, MCTN, University of Heidelberg, Mannheim, Germany. 6 Neurology Clinic, Heidelberg University Hospital, University of Heidelberg, Heidelberg, Germany. 7 NCT, Heidelberg, Germany. 8 NCT Trial Center, NCT, Heidelberg, Germany. 9 Department of Neuroradiology, Heidelberg University Hospital, University of Heidelberg, Heidelberg, Germany. 10 DKTK CCU Neuropathology, DKFZ, Heidelberg, Germany. 11 Department of Neuropathology, Heidelberg University Hospital, University of Heidelberg, Heidelberg, Germany. 12 Immune Monitoring Unit, National Center for Tumor Diseases (NCT), Heidelberg, Germany. 13 Immunitrack, Copenhagen, Denmark. 14 DKMS Life Science Lab GmbH, Dresden, Germany. 15 Department of Internal Medicine V, Heidelberg University Hospital, University of Heidelberg, Heidelberg, Germany. 16 Department of Neurosurgery, University of Freiburg, Freiburg, Germany. 17 Department of Medical Oncology, West German Cancer Center, University Hospital Essen, University of Duisburg-Essen, Essen, Germany. 18 Department of Neurosurgery, Charité Medical Center, University of Berlin, Berlin, Germany. 19 Department of Neurosurgery, Carl Gustav Carus University Hospital, University of Dresden, Dresden, Germany. 20 Institute of Cell Biology, Department of Immunology, University of Tübingen, Tübingen, Germany. 21 Department of Neurology, University of Tübingen, Tübingen, Germany. 22 Dr. Senckenberg Institute of Neurooncology, Frankfurt, Germany. 23 DKTK CCU Neurooncology, DKFZ, Heidelberg, Germany.

Functional characterization of CD4+ T-cell receptors cross-reactive for SARS-CoV-2 and endemic coronaviruses

Dykema AG, et al.
Journal of Clinical Investigation
May 2021
Authors and Affiliates
Arbor G Dykema 1, Boyang Zhang 2, Bezawit A Woldemeskel 3, Caroline C Garliss 3, Laurene S Cheung 4, Dilshad Choudhury 1, Jiajia Zhang 1, Luis Aparicio 1, Sadhana Bom 1, Rufiaat Rashid 1, Justina X Caushi 1, Emily Han-Chung Hsiue 1, Katherine Cascino 3, Elizabeth A Thompson 5, Abena K Kwaa 3, Dipika Singh 1, Sampriti Thapa 1, Alvaro A Ordonez 6, Andrew Pekosz 7, Franco R D'Alessio 3, Jonathan D Powell 1, Srinivasan Yegnasubramanian 1, Shibin Zhou 5, Drew M Pardoll 1, Hongkai Ji 2, Andrea L Cox 5, Joel N Blankson 3, Kellie N Smith 4; 1 Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, United States of America. 2 Department of Biostatistics, Johns Hopkins University School of Medicine, Baltimore, United States of America. 3 Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, United States of America. 4 The Bloomberg-Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University School of Medicine, Baltimore, United States of America. 5 Johns Hopkins University School of Medicine, Baltimore, United States of America. 6 Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, United States of America. 7 Department of Molecular Microbiology and Immunology, Johns Hopkins University School of Medicine, Baltimore, United States of America.

IL-15 mediated expansion of rare durable memory T cells following adoptive cellular therapy

Kohli K, et al.
Journal for ImmunoTherapy of Cancer
May 2021
Authors and Affiliates
Karan Kohli 1,2,3, Lu Yao 4, Theodore Scott Nowicki 5, Shihong Zhang 1, Ralph Graeme Black 1, Brett A Schroeder 1,2,6, Erik A Farrar 7, Jianhong Cao 1, Heather Sloan 1, Dawn Stief 1, Lee D Cranmer 1,2, Michael J Wagner 1,2, Douglas S Hawkins 8, Venu G Pillarisetty 3, Antoni Ribas 9, Jean Campbell 1,10, Robert H Pierce 1,10, Edward Y Kim 11, Robin L Jones 12, Stanley R Riddell 1,3,13, Cassian Yee 7, Seth M Pollack 14,3,15; 1 Fred Hutchinson Cancer Research Center, Clinical Research Division, Seattle, WA, USA. 2 Division of Oncology, University of Washington, Seattle, WA, USA. 3 Department of Surgery, University of Washington, Seattle, WA, USA. 4 Poseida Therapeutics, San Diego, CA, USA. 5 Division of Pediatric Hematology/Oncology, University of California, Los Angeles, California, USA. 6 Department of Internal Medicine, Virginia Mason Medical Center, Seattle, WA, USA. 7 MD Anderson, Houston, TX, USA. 8 Division of Hematology and Oncology, Seattle Children's Hospital, Seattle, WA, USA. 9 Division Hematology and Oncology, University of California, Los Angeles, UK. 10 Sensei Biotherapeutics, Gaithersburg, Boston, MD, USA. 11 Department of Radiation Oncology, University of Washington, Seattle, WA, USA. 12 Sarcoma, Royal Marsden Hospital and Institute of Cancer Research, London, UK. 13 Lyell Immunopharma, Seattle, WA, USA. 14 Fred Hutchinson Cancer Research Center, Clinical Research Division, Seattle, WA, USA Seth.pollack@northwestern.edu. 15 Division of Oncology, Northwestern University, Chicago, IL, USA.
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