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MRD-driven phase 2 study of daratumumab, carfilzomib, lenalidomide and dexamethasone in newly diagnosed multiple myeloma

Bhutani M, et al.
Blood Advances
November 2024
Authors and Affiliates
Manisha Bhutani,1,* Myra Robinson,2 David Foureau,3 Shebli Atrash,1 Barry Paul,1 Fei Guo 3, Jason M Grayson 4, Anna Ivanina-Foureau, 3 Mauricio Pineda-Roman,1 Cindy Varga,1 Reed Friend,1 Christopher J. Ferreri,1 Xhevahire Begic,5 Sarah Norek,5 Tiffany Drennan,6 Michelle B Anderson,2 James T. Symanowski,2 Peter M. Voorhees,1,** and Saad Z. Usmani7,*** 1Department of Hematologic Oncology and Blood Disorders, Atrium Health Levine Cancer Institute, Wake Forest University School of Medicine, Charlotte, NC, USA 2Department of Biostatistics and Data Sciences, Levine Cancer Institute, Atrium Health, Charlotte, NC, USA 3Immune Monitoring Core Laboratory, Atrium Health Levine Cancer Institute, Charlotte, NC, USA 4Department of Microbiology and Immunology, Wake Forest School of Medicine, Winston- Salem, NC, USA 5Atrium Health Wake Forest Baptist Comprehensive Cancer Center Data Coordinating Center, Levine Cancer Institute, Charlotte, NC 6Clinical Trials Unit, Levine Cancer Institute, Atrium Health, Charlotte, NC, USA 7Myeloma Service, Division of Hematologic Oncology, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA

MRD-negative duration following latest line of therapy predicts long-term PFS in real-world multiple myeloma patients

Chen L, et al.
Blood Advances
November 2024
Authors and Affiliates
Lucia Y Chen1, Santiago Thibaud2, Saoirse Bodnar2, Ajai Chari3, Joshua Richter2, Hearn Jay Cho2, Larysa J Sanchez2, Cesar Rodriguez2, Adriana C Rossi2, Shambavi Richard2, Samir Parekh2, Sundar Jagannath2* 1. Weatherall Institute of Molecular Medicine, Oxford University, UK 2. Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, USA 3. University of California, San Francisco, California, USA

Venetoclax-obinutuzumab for previously untreated chronic lymphocytic leukemia: 6-year results of the randomized phase 3 CLL14 study

Al-Sawaf O, et al.
Blood
October 2024
Authors and Affiliates
Othman Al-Sawaf,1 Sandra Robrecht,1 Can Zhang,1 Stefano Olivieri,2 Yi Meng Chang,3 Anna Maria Fink,1 Eugen Tausch,4 Christof Schneider,4 Matthias Ritgen,5 Karl-Anton Kreuzer,1 Liliya Sivchev,6 Carsten Utoft Niemann,7 Anthony Schwarer,8 Javier Loscertales,9 Robert Weinkove,10,11 Dirk Strumberg,12 Allanah Kilfoyle,13 Beenish S. Manzoor,14 Dureshahwar Jawaid,14 Nnadozie Emechebe,14 Jacob Devine,15 Michelle Boyer,16 Eva D. Runkel,14 Barbara Eichhorst,1 Stephan Stilgenbauer,4 Yanwen Jiang,15 Michael Hallek,1 and Kirsten Fischer1 1Department I of Internal Medicine, Faculty of Medicine and University Hospital of Cologne, Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf, German Chronic Lymphocytic Leukemia Study Group, University of Cologne, Cologne, Germany; 2F. Hoffmann-La Roche Ltd, Basel, Switzerland; 3F. Hoffmann- La Roche Ltd, Mississauga, ON, Canada; 4Division of CLL, Department III of Internal Medicine, University Hospital Ulm, Ulm, Germany; 5Universitätsklinikum Schleswig Holstein, Kiel, Germany; 6Multiprofile Hospital for Active Treatment Pazardjik, Pazardzhik, Bulgaria; 7Rigshospitalet, Copenhagen, Denmark; 8Box Hill Hospital, Box Hill, VIC, Australia; 9Hospital De La Princesa, Madrid, Spain; 10Te Rerenga Ora Wellington Blood and Cancer Centre, Te Whatu Ora Health New Zealand Capital, Wellington, New Zealand; 11Cancer Immunotherapy Program, Malaghan Institute of Medical Research, Wellington, New Zealand; 12Evangelisches Krankenhaus Herne, Herne, Germany; 13Palmerston North Hospital, Palmerston North, New Zealand; 14AbbVie Inc, Chicago, IL; 15Genentech Inc, South San Francisco, CA; and 16F. Hoffmann-La Roche Ltd, Welwyn, United Kingdom

Zanubrutinib, Obinutuzumab, and Venetoclax for First-Line Treatment of Mantle Cell Lymphoma with a TP53 Mutation

Kumar A, et al.
Blood
October 2024
Authors and Affiliates
Anita Kumar, MD1, Jacob Soumerai, MD2, Jeremy S. Abramson, MD2, Jeffrey A. Barnes, MD2, PhD, Philip Caron, MD1, Shalini Chhabra, MD1, Maria Chabowska, BSc1, Ahmet Dogan, MD1, PhD1, Lorenzo Falchi, MD1, Clare Grieve, MPH1, Julie E. Haydu, MD PhD2, Patrick Connor Johnson, MD2, Ashlee Joseph BS1, Hailey E. Kelly2, Alyssa Labarre1, Jennifer Kimberly Lue, MD1, Rosalba Martignetti2, Joanna Mi, NP1, Alison Moskowitz, MD1, Colette Owens, MD1, Sean Plummer2, Madeline Puccio2, Gilles Salles, MD, PhD1, Venkatraman Seshan, PhD1, Elizabeth Simkins2, Natalie Slupe1, Honglei Zhang, MD1, and Andrew D. Zelenetz, MD, PhD1 1. Memorial-Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY, USA 2. Massachusetts General Hospital Cancer Center, 55 Fruit Street, Boston, MA, USA

Outcomes After Brexucabtagene Autoleucel Administered as a Standard Therapy for Adults With Relapsed/Refractory B-Cell ALL

Roloff G, et al.
J Clin Oncol
October 2024
Authors and Affiliates
Gregory W. Roloff, MD1; Ibrahim Aldoss, MD2 ; Noam E. Kopmar, MD3 ; Chenyu Lin, MD4 ; Simone E. Dekker, MD, PhD5; Vishal K. Gupta, MD6 ; Timothy E. O’Connor, MD7; Nikeshan Jeyakumar, MD8; Ibrahim N. Muhsen, MD9 ; Yannis Valtis, MD10 ; Naveed Ahmed, DO10; Amy Zhang, MPH8; Katharine Miller, PhD, MPH8 ; Kaitlyn C. Dykes, MD11; Mohamed Ahmed, MD12; Evan C. Chen, MD13 ; Santiago Mercadal, MD14 ; Marc Schwartz, MD15; Sean I. Tracy, MD, PhD16 ; Bhagirathbhai Dholaria, MBBS17 ; Akash Mukherjee, MD18; Minoo Battiwalla, MD, MS19 ; Aaron C. Logan, MD, PhD20 ; Abdullah Ladha, MD21 ; Caitlin Guzowski, MBA22; Rasmus T. Hoeg, MD23; Talal Hilal, MBBCh24 ; Jozal Moore, MD25; Matthew P. Connor, MD26 ; LaQuisa C. Hill, MD27 ; Stephanie B. Tsai, MD7; Joshua P. Sasine, MD, PhD12 ; Melhem M. Solh, MD22 ; Vamsi K. Kota, MD28 ; Divya Koura, MD11; Muthu Veeraputhiran, MD18; Jessica T. Leonard, MD5; Noelle V. Frey, MD, MS26 ; Jae H. Park, MD10 ; Marlise R. Luskin, MD, MSCE13 ; Veronika Bachanova, MD, PhD16; Ahmed Galal, MD4; Vinod Pullarkat, MD2; Wendy Stock, MD1 ; Ryan D. Cassaday, MD3 ; Bijal D. Shah, MD, MS29; Rawan Faramand, MD29; and Lori Muffly, MD, MS8 ; on behalf of the ROCCA Consortium 1Section of Hematology/Oncology, Department of Medicine, University of Chicago, Chicago, IL 2Division of Leukemia, Department of Hematology and Hematopoitic Cell Transplantation, City of Hope National Medical Center, Duarte, CA 3Division of Hematology and Oncology, Department of Medicine, University of Washington School of Medicine, Seattle, WA 4Division of Hematologic Malignancies and Cellular Therapy, Duke University School of Medicine, Durham, NC 5Division of Hematology-Oncology, Knight Cancer Institute, Oregon Health & Science University, Portland, OR 6Division of Hematology & Oncology, University of California Los Angeles, Los Angeles, CA 7Division of Hematology/Oncology, Cardinal Bernardin Cancer Center, Loyola University Medical Center, Maywood, IL 8Division of Blood and Marrow Transplantation and Cellular Therapy, Stanford University, Stanford, CA 9Section of Hematology and Oncology, Department of Medicine, Baylor College of Medicine, Houston, TX 10Memorial Sloan Kettering Cancer Center, New York, NY 11Department of Medicine, Division of Hematology and Oncology, University of California San Diego Moores Cancer Center, San Diego, CA 12Cedars-Sinai Medical Center, Los Angeles, CA 13Adult Leukemia Program, Dana-Farber Cancer Institute, Boston, MA 14Transplant and Cellular Therapy Program, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT 15University of Colorado Anschutz School of Medicine, Aurora, CO 16Division of Hematology, Oncology and Transplantation, University of Minnesota, Minneapolis, MN 17Division of Hematology and Oncology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 18University of Arkansas Medical Center, Little Rock, AK 19Sarah Cannon Transplant and Cell Therapy Network, Nashville, TN 20Department of Medicine, Division of Hematology and Blood and Marrow Transplantation, University of California, San Francisco, CA 21Department of Hematology, Norris Cancer Center, University of Southern California, Los Angeles, CA 22Blood and Marrow Transplant Program, Northside Hospital, Atlanta, GA 23Department of Internal Medicine, Division of Hematology and Oncology, University of California Davis School of Medicine, Sacramento, CA 24Division of Hematology and Medical Oncology, Mayo Clinic, Phoenix, AZ 25Division of Hematology/Oncology, Department of Medicine, James P. Wilmot Cancer Institute, University of Rochester Medical Center, Rochester, NY 26Division of Hematology-Oncology, Department of Medicine, University of Pennsylvania, Philadelphia, PA 27Center for Cell and Gene Therapy, Baylor College of Medicine and Houston Methodist Hospital, Houston, TX 28Georgia Cancer Center, Augusta University, Augusta, GA 29Moffitt Cancer Center, Tampa, FL

Measurable Residual Disease Testing Following Non-Intensive Chemoimmunotherapy Is Predictive of Need for Maintenance Therapy in Previously Untreated Mantle Cell Lymphoma: A Wisconsin Oncology Network Study

Chang J, et al.
Clinical Lymphoma Myeloma & Leukemia
October 2024
Authors and Affiliates
Julie E. Chang MD,1 Danielle McQuinn MD, 1 Meredith Hyun MS,2 KyungMann Kim PhD,2,3 Vaishalee P Kenkre MD,1 Saurabh A. Rajguru MD,1 Priyanka A. Pophali MD,1 Mariah Endres,3 Mitch Howard,3 Tim Wassenaar MD, MS,4 Ruth Callaway Warren MD,5 Ryan J Mattison MD,1 Kari B Wisinski MD1 Christopher D Fletcher MD1 1Department of Medicine, University of Wisconsin School of Medicine and Public Health 2Department of Biostatistics and Medical Informatics, University of Wisconsin School of Medicine and Public Health 3University of Wisconsin Carbone Cancer Center, Madison, WI 4ProHealth Care, Waukesha, WI 5Green Bay Oncology, St. Vincent Regional Cancer Center, Green Bay, WI

A.R.R.O.W.2: once- vs twice-weekly carfilzomib, lenalidomide, and dexamethasone in relapsed/refractory multiple myeloma

Dimopoulos M, et al.
Blood Advances
October 2024
Authors and Affiliates
Meletios A. Dimopoulos,1 Daniel Coriu,2,3 Sosana Delimpasi,4 Ivan ˇ Spiˇcka,5 Terry Upchurch,6 Belle Fang,6 Rakhshandra Talpur,6 Edward Faber,7 Meral Beksac,8 and Xavier Leleu9 1Department of Clinical Therapeutics, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece; 2Department of Hematology, Fundeni Clinical Institute, Bucharest, Romania; 3Department of Haematology, “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania; 4Department of Hematology and Bone Marrow Transplantation Unit, Evangelismos Hospital, Athens, Greece; 5First Department of Medicine, Department of Hematology, First Faculty of Medicine, Charles University and General Hospital, Prague, Czech Republic; 6Amgen Inc, Thousand Oaks, CA; 7Oncology Hematology Care, Inc, Cincinnati, OH; 8Hematology, Ankara Liv Hospital, Istinye University, Ankara, Turkey; and 9Department of Hematology and Cellular Therapy, CIC U1402 CHU de Poitiers, Poitiers, France

Discontinuation of maintenance therapy in multiple myeloma guided by multimodal measurable residual disease negativity(MRD2STOP)

Derman B, et al.
Blood Cancer Journal
October 2024
Authors and Affiliates
Benjamin A. Derman1✉, Ajay Major 2, Jennifer Cooperrider1, Ken Jiang1, Aubrianna Ramsland1, Theodore Karrison3, Tadeusz Kubicki 1 and Andrzej J. Jakubowiak1 1Section of Hematology/Oncology, University of Chicago, Chicago, IL, USA. 2Division of Hematology, University of Colorado School of Medicine, Aurora, CO, USA. 3Department of Public Health Sciences, University of Chicago, Chicago, IL, USA.

Safety and Efficacy of Standard of Care Ciltacabtagene Autoleucel for Relapsed/Refractory Multiple Myeloma

Sidana S, et al.
Blood
October 2024
Authors and Affiliates
Surbhi Sidana1*, Krina K. Patel2*, Lauren C. Peres*3, Radhika Bansal4, Mehmet H. Kocoglu5, Leyla Shune6, Shebli Atrash7, Kinaya Smith8, Shonali Midha9, Christopher Ferreri,7, Binod Dhakal8, Danai Dima10, Patrick Costello9, Charlotte Wagner11, Ran Reshef12, Hitomi Hosoya1, Lekha Mikkilineni1, Djordje Atanackovic5, Saurabh Chhabra13, Ricardo Parrondo14, Omar Nadeem9, Hashim Mann,15 Nilesh Kalariya2, Vanna Hovanky1, Gabriel De Avila3, Ciara L Freeman3, Frederick L. Locke3, Melissa Alsina3, Sandy Wong16, Megan Herr17, Myo Htut18, Joseph McGuirk6, Douglas W. Sborov11, Jack Khouri10, Thomas Martin16, Murali Janakiram18*, Yi Lin4*, and Doris K. Hansen3* *S.S, K.K.P, L.C.P are co-first authors; M.J, Y.L, and D.K.H are co-senior authors. Affiliations: 1. Stanford University School of Medicine 2. The University of Texas MD Anderson Cancer Center, 3. Moffitt Cancer Center, 4. Mayo Clinic, Rochester, 5. University of Maryland School of Medicine, 6. University of Kansas Medical Center, 7. Levine Cancer Institute, 8. Medical College of Wisconsin, 9. Dana-Farber Cancer Institute, 10. Cleveland Clinic Taussig Cancer Center. 11. Huntsman Cancer Institute at the University of Utah, 12. Columbia University Irving Medical Center, 13. Division of Hematology/Oncology, Department of Medicine, Mayo Clinic, Phoenix, Arizona, 14. Mayo Clinic, Jacksonville 15. Virginia Commonwealth University, 16. University of California San Francisco, 17. Rosewell Park Cancer Center, 18. City of Hope Comprehensive Cancer Center,

Daratumumab with lenalidomide as maintenance after transplant in newly diagnosed multiple myeloma: the AURIGA study

Badros A, et al.
Blood
September 2024
Authors and Affiliates
Ashraf Badros,1 Laahn Foster,2 Larry D. Anderson Jr,3 Chakra P. Chaulagain,4 Erin Pettijohn,5 Andrew J. Cowan,6 Caitlin Costello,7 Sarah Larson,8 Douglas W. Sborov,9 Kenneth H. Shain,10 Rebecca Silbermann,11 Nina Shah,12* Alfred Chung,12 Maria Krevvata,13 Huiling Pei,14 Sharmila Patel,15 Vipin Khare,15 Annelore Cortoos,15 Robin Carson,13 Thomas S. Lin,15 and Peter Voorhees16 1Greenebaum Comprehensive Cancer Center, University of Maryland, Baltimore, MD, United States; 2Division of Hematology Oncology, University of Virginia, Charlottesville, VA, United States; 3Myeloma, Waldenstrom’s and Amyloidosis Program, Simmons Comprehensive Cancer Center, UT Southwestern Medical Center, Dallas, TX, United States; 4Department of Hematology and Oncology, Myeloma and Amyloidosis Program, Cleveland Clinic Florida, Weston, FL, United States; 5Cancer and Hematology Centers of Western Michigan, Grand Rapids, MI, United States; 6Division of Medical Oncology, Fred Hutch Cancer Center/University of Washington, Seattle, WA, United States; 7Moores Cancer Center, University of California San Diego, La Jolla, CA, United States; 8Division of Hematology and Oncology, David Geffen School of Medicine at UCLA, Los Angeles, CA, United States; 9Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, United States; 10Department of Malignant Hematology, H. Lee Moffitt Cancer Center, Tampa, FL, United States; 11Knight Cancer Institute, Oregon Health & Science University, Portland, OR, United States; 12Department of Medicine, University of California San Francisco, San Francisco, CA, United States; 13Janssen Research & Development, LLC, Spring House, PA, United States; 14Janssen Research & Development, LLC, Titusville, NJ, United States; 15Janssen Scientific Affairs, LLC, a Johnson & Johnson company, Horsham, PA, United States; 16Levine Cancer Institute, Atrium Health Wake Forest University School of Medicine, Charlotte, NC, United States.