A Public BCR Present in a Unique Dual-Receptor-Expressing Lymphocyte from Type 1 Diabetes Patients Encodes a Potent T Cell Autoantigen

Ahmed R1, Omidian Z1, Giwa A2, Cornwell B1, Majety N1, Bell DR3, Lee S3, Zhang H4, Michels A5, Desiderio S6, Sadegh-Nasseri S1, Rabb H7, Gritsch S8, Suva ML9, Cahan P10, Zhou R11, Jie C12, Donner T7, Hamad ARA13; Author information 1 Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. 2 Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. 3 Computational Biology Center, IBM Thomas J. Watson Research Center, Yorktown Heights, NY 10598, USA. 4 Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA. 5 Barbara Davis Center for Diabetes, University of Colorado, Aurora, CO 80045, USA. 6 Department of Molecular Biology and Genetics and Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. 7 Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. 8 Department of Pathology and Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA, 02114, USA. 9 Department of Pathology and Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA, 02114, USA; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA. 10 Department of Molecular Biology and Genetics and Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. 11 Computational Biology Center, IBM Thomas J. Watson Research Center, Yorktown Heights, NY 10598, USA; Department of Chemistry, Columbia University, New York, NY 10027, USA. Electronic address: rz24@columbia.edu. 12 Department of Biochemistry and Nutrition, Des Moines University, Des Moines, IA 50312, USA. 13 Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. Electronic address: ahamad@jhmi.edu.