Class I-restricted T-cell responses to a polymorphic peptide in a gene therapy clinical trial for α-1-antitrypsin deficiency

Roberto Calcedoa, Suryanarayan Somanathana, Qiuyue Qina, Michael R. Bettsb, Andrew J. Rechc, Robert H. Vonderheidec, Christian Muellerd, Terence R. Flotted, and James M. Wilsona aGene Therapy Program, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104; bDepartment of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104; cAbramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA19104; dDepartment of Pediatrics, University of Massachusetts Medical School, Worcester, MA 01655