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Clonal expansion of CAR T cells harboring lentivector integration in the CBL gene following anti-CD22 CAR T-cell therapy

Shah et al.
Blood Advances
August 2019
Authors and Affiliates
Nirali N. Shah,1,* Haiying Qin,1,* Bonnie Yates,1 Ling Su,2 Haneen Shalabi,1 Mark Raffeld,3 Mark A. Ahlman,4 Maryalice Stetler-Stevenson,5 Constance Yuan,5 Shuang Guo,2 Siyuan Liu,2 Stephen H. Hughes,6 Terry J. Fry,1,7,8,† and Xiaolin Wu2,†; 1Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute (NCI), National Institutes of Health (NIH), Bethesda, MD; 2Cancer Research Technology Program, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, MD; 3Molecular Diagnostics Section, Laboratory of Pathology, Center for Cancer Research, NCI, NIH, Bethesda, MD; 4Radiology and Imaging Sciences, NIH Clinical Center, Bethesda, MD; 5Flow Cytometry, Department of Pathology, NCI, NIH, Bethesda, MD; 6HIV Dynamics and Replication Program, NCI, NIH, Frederick, MD; 7Department of Pediatrics, University of Colorado Anschutz Medical Campus, Aurora, CO; and 8Center for Cancer and Blood Disorders, Children’s Hospital Colorado, Aurora, CO