Compartmental analysis of T cell clonal dynamics as a function of pathologic response to neoadjuvant PD-1 blockade in resectable non-small cell lung cancer

Jiajia Zhang1,2, Zhicheng Ji3 , Justina X. Caushi1,2, Margueritta El Asmar1,2, Valsamo Anagnostou1,2, Tricia R. Cottrell1,2,4, Hok Yee Chan1,2, Prerna Suri1,2, Haidan Guo1,2, Taha Merghoub5 , Jamie E. Chaft5 , Joshua E. Reuss1,2, Ada J. Tam1,2, Richard L. Blosser1,2, Mohsen Abu-Akeel5 , John-William Sidhom1,2, Ni Zhao3 , Jinny S. Ha2,6, David R. Jones7 , Kristen A. Marrone1,2, Jarushka Naidoo1,2, Edward Gabrielson1,2, Janis M. Taube1,2,4, Victor E. Velculescu1,2, Julie R. Brahmer1,2, Franck Housseau1,2, Matthew D. Hellmann5 , Patrick M. Forde1,2, Drew M. Pardoll1,2, Hongkai Ji3 , and Kellie N. Smith1,2; 1 The Bloomberg-Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University School of Medicine, Baltimore, Maryland. 2 The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland. 3 Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland. 4 Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland. 5 Thoracic Oncology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center and Weill Cornell Medical Center, New York, New York. 6 Division of Thoracic Surgery, Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland. 7 Thoracic Service, Department of Surgery, Memorial Sloan Kettering Cancer Center and Weill Cornell Medical Center, New York, New York