Comprehensive T cell repertoire characterization of non-small cell lung cancer

Alexandre Reuben,#1,2 Jiexin Zhang,#3 Shin-Heng Chiou,#4 Rachel M. Gittelman,#5 Jun Li,6 Won-Chul Lee,6 Junya Fujimoto,7 Carmen Behrens,1,7 Xiaoke Liu,1 Feng Wang,6 Kelly Quek,1 Chunlin Wang,8 Farrah Kheradmand,9 Runzhe Chen,1 Chi-Wan Chow,7 Heather Lin,3 Chantale Bernatchez,10 Ali Jalali,11 Xin Hu,6 Chang-Jiun Wu,6 Agda Karina Eterovic,12 Edwin Roger Parra,7 Erik Yusko,5 Ryan Emerson,5 Sharon Benzeno,5 Marissa Vignali,5 Xifeng Wu,13 Yuanqing Ye,13 Latasha D. Little,6 Curtis Gumbs,6 Xizeng Mao,10 Xingzhi Song,6 Samantha Tippen,6 Rebecca L. Thornton,6 Tina Cascone,1 Alexandra Snyder,5 Jennifer A. Wargo,2,6 Roy Herbst,14 Stephen Swisher,15 Humam Kadara,7 Cesar Moran,16 Neda Kalhor,16 Jianhua Zhang,6 Paul Scheet,13 Ara A. Vaporciyan,15 Boris Sepesi,15 Don L. Gibbons,1 Harlan Robins,5,17 Patrick Hwu,10 John V. Heymach,1 Padmanee Sharma,18,19 James P. Allison,19 Veera Baladandayuthapani,20 Jack J. Lee,20 Mark M. Davis,corresponding author21 Ignacio I. Wistuba,corresponding author1,7 P. Andrew Futreal,corresponding author6 and Jianjun Zhangcorresponding author1,6; 1Department of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe, Houston, TX 77030 USA 2Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe, Houston, TX 77030 USA 3Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe, Houston, TX 77030 USA 4Institute for Immunity, Transplantation, and Infection Operations, Howard Hughes Medical Institute, 450 Serra Mall, Stanford, CA 94305 USA 5Adaptive Biotechnologies, 1551 Eastlake Ave East, Seattle, WA 98102 USA 6Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, 1515 Holcombe, Houston, TX 77030 USA 7Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe, Houston, TX 77030 USA 8iRepertoire, Inc., 800 Hudson Way, Suite 2304, Huntsville, AL 35806 USA 9Baylor College of Medicine, 1 Baylor Plaza, Houston, TX 77030 USA 10Department of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe, Houston, TX 77030 USA 11Department of Neurosurgery, The University of Texas MD Anderson Cancer Center, 1515 Holcombe, Houston, TX 77030 USA 12Department of Systems Biology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe, Houston, TX 77030 USA 13Department of Epidemiology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe, Houston, TX 77030 USA 14Department of Medical Oncology, 333 Cedar Street, Yale Cancer Center, New Haven, CT 06510 USA 15Department of Thoracic and Cardiovascular Surgery, The University of Texas MD Anderson Cancer Center, 1515 Holcombe, Houston, TX 77030 USA 16Department of Pathology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe, Houston, TX 77030 USA 17Computational Biology Program, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave North, Seattle, WA 98109 USA 18Department of Genitourinary Medical Oncology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe, Houston, TX 77030 USA 19Department of Immunology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe, Houston, TX 77030 USA 20Department of Biostatistics, The University of Texas MD Anderson Cancer Center, 1515 Holcombe, Houston, TX 77030 USA 21Department of Microbiology and Immunology, Howard Hughes Medical Institute, Stanford, 450 Serra Mall, Stanford, CA 94305 USA