Crossreactive public TCR sequences undergo positive selection in the human thymic repertoire

Khosravi-Maharlooei M1, Obradovic A1, Misra A1, Motwani K2, Holzl M1, Seay HR2, DeWolf S1, Nauman G1,3, Danzl N1, Li H1, Ho SH1, Winchester R4, Shen Y5, Brusko TM2, Sykes M1,3,6; Columbia Center for Translational Immunology, Department of Medicine, Columbia University Medical Center, Columbia University, New York, New York, USA. 2 Department of Pathology, Immunology and Laboratory Medicine, University of Florida, Gainesville, Florida, USA. 3 Department of Microbiology and Immunology, Columbia University Medical Center, Columbia University, New York, New York, USA. 4 Division of Rheumatology, Department of Medicine. 5 Center for Computational Biology and Bioinformatics, and. 6 Department of Surgery, Columbia University Medical Center, Columbia University, New York, New York, USA.