Deep phenotyping of Tregs identifies an immune signature for idiopathic aplastic anemia and predicts response to treatment

Shahram Kordasti,1,2,* Benedetta Costantini,1,2,* Thomas Seidl,1,* Pilar Perez Abellan,2 Marc Martinez Llordella,3 Donal McLornan,2 Kirsten E. Diggins,4 Austin Kulasekararaj,2 Cinzia Benfatto,1 Xingmin Feng,5 Alexander Smith,1,2 Syed A. Mian,1 Rossella Melchiotti,6 Emanuele de Rinaldis,6 Richard Ellis,6 Nedyalko Petrov,6 Giovanni A. M. Povoleri,3 Sun Sook Chung,1 N. Shaun B. Thomas,1 Farzin Farzaneh,1 Jonathan M. Irish,4 Susanne Heck,6 Neal S. Young,5 Judith C. W. Marsh,1,2 and Ghulam J. Mufti1,2 1Department of Haematological Medicine, King’s College London, London, United Kingdom; 2Haematological Medicine, King’s College Hospital, London, United Kingdom; 3Division of Transplantation Immunology & Mucosal Biology, King’s College London, London, United Kingdom; 4Department of Cancer Biology, Vanderbilt University, Nashville, TN; 5Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD; and 6National Institute for Health Research Biomedical Research Centre, King’s College London, London, United Kingdom