Epigenetic Suppression of Transgenic T-cell Receptor Expression via Gamma-Retroviral Vector Methylation in Adoptive Cell Transfer Therapy

Theodore S Nowicki 1, Colin Farrell 2, Marco Morselli 3, Liudmilla Rubbi 4, Katie M Campbell 5, Mignonette H Macabali 6, Beata Berent-Maoz 5, Begona Comin-Anduix 7, Matteo Pellegrini 8, Antoni Ribas 9; 1 Pediatrics, Hematology-Oncology, University of California Los Angeles 2 Human Genetics, University of California Los Angeles. 3 Molecular, Cell and Developmental Biology, University of California Los Angeles. 4 Molecular, Cell, and Developmental Biology, University of California Los Angeles. 5 Department of Medicine, University of California Los Angeles. 6 Department of Medicine, Division of Hematology-Oncology, University of California Los Angeles. 7 Surgical Oncology, University of California Los Angeles. 8 Department of Molecular, Cell, and Developmental Biology, University of California Los Angeles. 9 Department of Medicine, Jonsson Comprehensive Cancer Center at University of California, Los Angeles, Los Angeles.