Human Intestinal Allografts Contain Functional Hematopoietic Stem and Progenitor Cells that Are Maintained by a Circulating Pool

Fu J1, Zuber J1, Martinez M2, Shonts B1, Obradovic A1, Wang H1, Lau SP1, Xia A1, Waffarn EE1, Frangaj K1, Savage TM1, Simpson MT1, Yang S1, Guo XV3, Miron M4, Senda T5, Rogers K1, Rahman A3, Ho SH1, Shen Y6, Griesemer A5, Farber DL7, Kato T8, Sykes M9. 1 Columbia Center for Translational Immunology, Department of Medicine, Columbia University, New York, NY 10032, USA. 2 Department of Pediatrics, Columbia University, New York, NY 10032, USA. 3 Human Immune Monitoring Center, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. 4 Columbia Center for Translational Immunology, Department of Medicine, Columbia University, New York, NY 10032, USA; Department of Microbiology & Immunology, Columbia University, New York, NY 10032, USA. 5 Columbia Center for Translational Immunology, Department of Medicine, Columbia University, New York, NY 10032, USA; Department of Surgery, Columbia University, New York, NY 10032, USA. 6 Center for Computational Biology and Bioinformatics, Department of Systems Biology, Columbia University, New York, NY 10032, USA. 7 Columbia Center for Translational Immunology, Department of Medicine, Columbia University, New York, NY 10032, USA; Department of Microbiology & Immunology, Columbia University, New York, NY 10032, USA; Department of Surgery, Columbia University, New York, NY 10032, USA. 8 Department of Surgery, Columbia University, New York, NY 10032, USA. 9 Columbia Center for Translational Immunology, Department of Medicine, Columbia University, New York, NY 10032, USA; Department of Microbiology & Immunology, Columbia University, New York, NY 10032, USA; Department of Surgery, Columbia University, New York, NY 10032, USA. Electronic address: megan.sykes@columbia.edu.