Human thymopoiesis is influenced by a common genetic variant within the TCRA-TCRD locus

Clave E1,2, Araujo IL1,2, Alanio C3,4,5, Patin E6,7,8, Bergstedt J9, Urrutia A3,4,5,10, Lopez-Lastra S5,11, Li Y5,11, Charbit B3, MacPherson CR3, Hasan M3, Melo-Lima BL1,2, Douay C1,2, Saut N12,13, Germain M14,15, Trégouët DA14,15, Morange PE12,13, Fontes M10,16, Duffy D3,4,5, Di Santo JP5,11, Quintana-Murci L6,7,8, Albert ML17,4,5,10, Toubert A18,2,19; Milieu Intérieur Consortium. Author information 1 Université Paris Diderot, Sorbonne Paris Cité, Institut Universitaire d'Hématologie, 75010 Paris, France. 2 INSERM, UMRS-1160, Alloimmunity-Autoimmunity-Transplantation, 75010 Paris, France. 3 Center for Translational Research, Technology Core, Institut Pasteur, 75015 Paris, France. 4 Dendritic Cell Immunobiology, Department of Immunology, Institut Pasteur, 75015 Paris, France. 5 INSERM, UMRS-1223, 75015 Paris, France. 6 Human Evolutionary Genetics, Department of Genomes and Genetics, Institut Pasteur, 75015 Paris, France. 7 CNRS UMR-2000, 75015 Paris, France. 8 Center of Bioinformatics, Biostatistics and Integrative Biology, Institut Pasteur, 75015 Paris, France. 9 Department of Automatic Control, Lund University, Lund SE-221, Sweden. 10 Department of Cancer Immunology, Genentech, South San Francisco, CA 94080, USA. 11 Innate Immunity Unit, Institut Pasteur, 75015 Paris, France. 12 Laboratory of Haematology, La Timone Hospital, 13005 Marseille, France. 13 Aix Marseille University, INSERM, UMRS-1260, INRA U1260, Center for Cardiovascular and Nutrition Research (C2VN), 13005 Marseille, France. 14 Sorbonne Université, Université Paris 6/UPMC, INSERM, UMRS-1166, Genomics and Pathophysiology of Cardiovascular Diseases, 75013 Paris, France. 15 Institute for Cardiometabolism and Nutrition, 75013 Paris, France. 16 International Group for Data Analysis, Institut Pasteur, 75015 Paris, France. 17 Center for Translational Research, Technology Core, Institut Pasteur, 75015 Paris, France. antoine.toubert@univ-paris-diderot.fr albert.matthew@gene.com. 18 Université Paris Diderot, Sorbonne Paris Cité, Institut Universitaire d'Hématologie, 75010 Paris, France. antoine.toubert@univ-paris-diderot.fr albert.matthew@gene.com. 19 Laboratoire d'Immunologie et d'Histocompatibilité, Hôpital Saint-Louis, AP-HP, 75010 Paris, France.