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Hypomorphic Rag1 Mutations Alter the Preimmune Repertoire at Early Stages of Lymphoid Development

Ott de Bruin et al.
Blood
July 2018
Authors and Affiliates
L M Ott de Bruin 1 2, M Bosticardo 3, A Barbieri 4, S G Lin 5, J H Rowe 1, P L Poliani 6, K Ching 4, D Eriksson 7, N Landegren 7, O Kämpe 7, J P Manis 4, L D Notarangelo 3; 1Division of Immunology, Boston Children's Hospital, Harvard Medical School, Boston, MA. 2Department of Pediatric Immunology, Wilhelmina Children's Hospital, Utrecht University Medical Center, Utrecht, The Netherlands. 3Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD. 4Department of Laboratory Medicine, Boston Children's Hospital, Harvard Medical School, Boston, MA. 5Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA. 6Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy; and. 7Center for Molecular Medicine, Department of Medicine (Solna), Karolinska Institutet, Stockholm, Sweden.