Identifying and Tracking Low-Frequency Virus-Specific TCR Clonotypes Using High-Throughput Sequencing

Wolf K1, Hether T2, Gilchuk P3, Kumar A3, Rajeh A4, Schiebout C4, Maybruck J5, Buller RM1, Ahn TH6, Joyce S3, DiPaolo RJ7. 1 Department of Molecular Microbiology and Immunology, Saint Louis University, Saint Louis, MO 63104, USA. 2 Adaptive Biotechnologies, Seattle, WA 98102, USA. 3 Department of Veterans Affairs, Tennessee Valley Healthcare System, Nashville, TN 37212, USA; Department of Pathology, Microbiology, and Immunology, Vanderbilt University, Nashville, TN 37232, USA. 4 Program in Bioinformatics and Computational Biology, Saint Louis University, Saint Louis, MO 63104, USA. 5 Federal Bureau of Investigation, Washington, DC 20535, USA. 6 Department of Computer Science, Saint Louis University, Saint Louis, MO 63104, USA; Program in Bioinformatics and Computational Biology, Saint Louis University, Saint Louis, MO 63104, USA. 7 Department of Molecular Microbiology and Immunology, Saint Louis University, Saint Louis, MO 63104, USA. Electronic address: richard.dipaolo@health.slu.edu.