IL-15 promotes activation and expansion of CD8+ T cells in HIV-1 infection

Souheil-Antoine Younes,1 Michael L. Freeman,1 Joseph C. Mudd,2Carey L. Shive,1 Arnold Reynaldi,3 Soumya Panigrahi,1 Jacob D. Estes,4Claire Deleage,4 Carissa Lucero,4 Jodi Anderson,5 Timothy W. Schacker,5 Miles P. Davenport,3 Joseph M. McCune,6 Peter W. Hunt,7Sulggi A. Lee,7 Sergio Serrano-Villar,8 Robert L. Debernardo,9 Jeffrey M. Jacobson,10 David H. Canaday,1 Rafick-Pierre Sekaly,11 Benigno Rodriguez,1 Scott F. Sieg,1 and Michael M. Lederman1 1Center for AIDS Research, Department of Medicine, Case Western Reserve University and University Hospitals, Case Medical Center, Cleveland, Ohio, USA. 2Immunopathogenesis Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, Maryland, USA. 3Kirby Institute for Infection and Immunity, University of New South Wales, Sydney, New South Wales, Australia. 4AIDS and Cancer Virus Program, Leidos Biomedical Research Inc., Frederick National Laboratory for Cancer Research, Frederick, Maryland, USA. 5Department of Medicine, University of Minnesota, Minneapolis, Minnesota, USA. 6Division of Experimental Medicine and7HIV/AIDS Division, Department of Medicine, UCSF, San Francisco, California, USA. 8Department of Infectious Diseases, University Hospital Ramón y Cajal, Madrid, Spain. 9Lerner College of Medicine, Cleveland Clinic, Cleveland, Ohio, USA. 10Lewis Katz School of Medicine, Temple University, Philadelphia, Pennsylvania, USA. 11Department of Pathology, Case Western Reserve University, Cleveland, Ohio, USA.