IL-21-driven neoplasms in SJL mice mimic some key features of human angioimmunoblastic T-cell lymphoma

Jain S1, Chen J2, Nicolae A3, Wang H1, Shin DM4, Adkins EB5, Sproule TJ6, Leeth CM7, Sakai T1, Kovalchuk AL1, Raffeld M3,Ward JM1, Rehg JE8, Waldmann TA2, Jaffe ES3, Roopenian DC5, Morse HC 3rd9. 1Virology and Cellular Immunology Section, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, Rockville, Maryland. 2Lymphoid Malignancies Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland. 3Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland. 4Virology and Cellular Immunology Section, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, Rockville, Maryland; Department of Food and Nutrition, Seoul National University, Seoul, Republic of Korea. 5Jackson Laboratory, Bar Harbor, Maine; Genetics Program, Tufts University Sackler School of Graduate Biomedical Sciences, Boston, Massachusetts. 6Jackson Laboratory, Bar Harbor, Maine. 7Genetics Program, Tufts University Sackler School of Graduate Biomedical Sciences, Boston, Massachusetts; Department of Animal and Poultry Sciences, College of Agriculture and Life Sciences, Virginia Polytechnic Institute and State University, Blacksburg, Virginia. 8Department of Pathology, St. Jude Children's Research Hospital, Memphis, Tennessee. 9Virology and Cellular Immunology Section, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, Rockville, Maryland